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A framework for quantifying properties of 3-dimensional movement-based signals

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Current Zoology 2010年第3期56卷 327-336页

作者： Shaun TD new Richard A pETERS ARC Centre of Excellence in Vision Science Division of EvolutionEcology & GeneticsResearch School of BiologyThe Australian National University

Understanding how signal properties are optimized for the reliable transmission of information requires accurate de- scription of the signal in time and space. For movement-based signals where movement is restricted to a single plane, measure- ments from a single viewpoint can be used to consider a range of viewing positions based on simple geometric calculations. However, considerations of signal properties from a range of viewing positions for movements extending into three-dimensions （3D） are more problematic. We present here a new framework that overcomes this limitation, and enables us to quantify the extent to which movement-based signals are view-specific. To illustrate its application, a Jacky lizard tail flick signal was filmed with synchronized cameras and the position of the tail tip digitized for both recordings. Camera aligmnent enabled tl^e construction of a 3D display action pattern profile. We analyzed the profile directly and used it to create a detailed 3D animation. In the virtual environment, we were able to film the same signal from multiple viewing positions and using a computational motion analysis algorithm （gradient detector model） to measure local image velocity in order to predict view dependent differences in signal properties. This approach will enable consideration of a range of questions concerning movement-based signal design and evolu- tion that were previously out of reach [Current Zoology 56 （3）： 327-336, 2010].

关键词： Signal evolution Sensory Ecology Movement-based signal 3D Display Action pattern

Unlocking hypoglycemia–associated brain microvascular dysfunction:critical insights from proteomic analysis

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Neural Regeneration Research 2025年第6期20卷 1707-1708页

作者： Siva S.V.p.Sakamuri Anil Sakamuri Department of Chemistry Auburn University at MontgomeryMontgomeryALUSA Vascular Biology Center and Department of Medicine Medical College of Georgia at Augusta UniversityAugustaGAUSA

Hypoglycemia-a critical complication linked to worsened brain function in diabetic subjects:Hypoglycemia is characterized by a decline in circulatory glucose levels below sta nda rd physiological *** hypoglycemia,classified as level 1 hypoglycemia,is defined by blood glucose levels below 70 mg/dL and can be effectively addressed through carbohydrate *** hypoglycemia,denoted by blood glucose levels less than 54 mg/dL,poses a life-threatening risk if left *** with type 1 and type 2 diabetes undergoing insulin treatment are particularly susceptible to hypoglycemia due to impaired counterregulatory mechanisms.

关键词： impaired intake critical

Emerging roles of deubiquitinating enzymes in human cancer

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Acta pharmacologica Sinica 2007年第9期28卷 1325-1330页

作者： Jin-ming YANG Department of pharmacology,The Cancer Institute of new Jersey,University of Medicine and Dentistry of new Jersey/Robert Wood Johnson Medical School,new Brunswick,new Jersey 08903,USA Department of pharmacology The Cancer Institute of New Jersey University of Medicine and Dentistry of New Jersey/Robert Wood Johnson Medical School New Brunswick USA

protein modifications by the covalent linkage of ubiquitin have significant in-volvement in many cellular processes,including stress response,oncogenesis,viral infection,transcription,protein turnover,organelle biogenesis,DNA repair,cellular differentiation,and cell cycle *** ubiquitination and subse-quent degradation by the proteasome require the participation of bothubiquitinating enzymes and deubiquitinating *** deubiquitinatingenzymes constitute a large family in the ubiquitin system,the study of this class ofproteins is still in its infant *** studies have revealed a variety ofmolecular and biological functions of deubiquitinating enzymes and their associa-tion with human *** this review we will discuss the possible roles thatdeubiquitinating enzymes may play in cancers.

关键词： ubiquitin cancer deubiquitinating enzymes

Mapping problems,Fundamental Groups and Defect Measures

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Acta Mathematica Sinica,English Series 1999年第1期15卷 25-52页

作者： Fanghua LinCourant Institute of Mathematics,new York University,new York,NY 10012,USA Courant Institute of Mathematics New York University New York USA

We study all the possible weak limits of a minimizing sequence,for p-energy functionals, consisting of continuous maps between Riemannian manifolds subject to a Dirichlet boundary condition or a homotopy *** show that if p is not an integer,then any such weak limit is a strong limit and,in particular,a stationary p-harmonic map which is Cp>1,αp> continuous away from a closed subset of the Hausdorff dimension ≤n-[p]-*** p is an integer,then any such weak limit is a weakly p-harmonic map along with a（n-p）-rectifiable Radon measure μ.Moreover,the limiting map is Cp>1,αp> continuous away from a closed subset ∑=spt μ∪S with Hp>n-pp>（S）=***,we discuss the possible varifolds type theory for Sobolev mappings.

关键词： Defect measure Harmonic mapping Generalized varifold Rectifiability

Small molecule inhibitor DDQ-treated hippocampal neuronal cells show improved neurite outgrowth and synaptic branching

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Neural Regeneration Research 2025年第9期20卷 2624-2632页

作者： Jangampalli Adi pradeepkiran priyanka Rawat Arubala p.Reddy Erika Orlov pHemachandra Reddy Department of Internal Medicine Texas Tech University Health Sciences CenterLubbockTXUSA Department of Nutritional Sciences College of Human SciencesTexas Tech UniversityLubbockTXUSA Department of pharmacology&Neuroscience Texas Tech University Health Sciences CenterLubbockTXUSA Department of Neurology Texas Tech University Health Sciences CenterLubbockTXUSA Department of Speech Language and Hearing SciencesTexas Tech University Health Sciences CenterLubbockTXUSA Department of public Health Texas Tech University Health Sciences CenterLubbockTXUSA

The process of neurite outgrowth and branching is a crucial aspect of neuronal development and *** and dendrites,sometimes referred to as neurites,are extensions of a neuron's cellular body that are used to start *** we explored the effects of diethyl(3,4-dihydroxyphenethylamino)(quinolin-4-yl)methylphosphonate(DDQ)on neurite developmental features in HT22 neuronal *** this work,we examined the protective effects of DDQ on neuronal processes and synaptic outgrowth in differentiated HT22cells expressing mutant Tau(mTau)*** investigate DDQ chara cteristics,cell viability,biochemical,molecular,western blotting,and immunocytochemistry were *** outgrowth is evaluated through the segmentation and measurement of neural *** neural processes can be seen and measured with a fluorescence microscope by manually tracing and measuring the length of the neurite *** neuronal processes can be observed and quantified with a fluorescent microscope by manually tracing and measuring the length of the neuronal ***-treated mTau-HT22 cells(HT22 cells transfected with cDNA mutant Tau)were seen to display increased levels of synaptophysin,MAp-2,andβ-***,we confirmed and noted reduced levels of both total and p-Tau,as well as elevated levels of microtubule-associated protein 2,β-tubulin,synaptophysin,vesicular acetylcholine transporter,and the mitochondrial biogenesis protein-pe roxisome prolife rator-activated receptor-gamma coactivator-1α.In mTa u-expressed HT22 neurons,we observed DDQ enhanced the neurite characteristics and improved neurite development through increased synaptic *** findings conclude that mTa u-HT22(Alzheimer's disease)cells treated with DDQ have functional neurite developmental chara *** key finding is that,in mTa u-HT22 cells,DDQ preserves neuronal structure and may even enhance nerve development function with mTa u inhibition.

关键词： diethyl(3 4-dihydroxyphenethylamino)(quinolin-4-yl)methylphosphonate(DDQ) hippocampal neuronal cells HT22 neurite outgrowth neuronal development small molecule

Aggregation and assembly of crescent foldamers

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Science China Chemistry 2010年第1期53卷 45-51页

作者： GONG Bing Department of Chemistry,University at Buffalo,The State University of new York,Buffalo,new York 14260,USA Department of Chemistry University at Buffalo The State University of New York Buffalo USA

Recent studies have started to provide initial insights into the aggregation and assembly of two classes of back-rigidified foldamers with flat,curved backbones consisting of aromatic *** their persistent shape that presents large,well-defined aromatic surface areas,these crescent foldamers were found to undergo size-dependent aggregation in solution and pack into 1D assemblies in the solid *** aromatic oligoamides undergo stacking interactions not only in polar solvents but also in nonpolar ones,a unique property that is not associated with many other molecules that associate via π-π stacking *** stacking of oligo(m-phenylene ethynylenes) is similar to aromatic hydrocarbons,being promoted in polar solvents such as methanol while being discouraged in nonpolar solvents such as *** ready synthetic availability of crescent foldamers makes it possible to directly control the intermolecular interaction by tuning surface ***,the columnar assembly of these cavity-containing molecules provides a new strategy for constructing supramolecular nanotubular structures.

关键词： foldamer folding hydrogen bond π-π stacking aggregation assembly

From single to combinatorial therapies in spinal cord injuries for structural and functional restoration

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Neural Regeneration Research 2025年第3期20卷 660-670页

作者： Ernesto Doncel-pérez Gabriel Guízar-Sahagún Israel Grijalva-Otero Hospital Nacional de parapléjicos de Toledo Servicio de Salud de Castilla La Mancha(SESCAM)ToledoSpain Medical Research Unit for Neurological Diseases UMAE Hospital de EspecialidadesCentro Médico Nacional Siglo XXIIMSSCiudad de MéxicoMéxico

Spinal cord injury results in paralysis, sensory disturbances, sphincter dysfunction, and multiple systemic secondary conditions, most arising from autonomic dysregulation. All this produces profound negative psychosocial implications for affected people, their families, and their communities;the financial costs can be challenging for their families and health institutions. Treatments aimed at restoring the spinal cord after spinal cord injury, which have been tested in animal models or clinical trials, generally seek to counteract one or more of the secondary mechanisms of injury to limit the extent of the initial damage. Most published works on structural/functional restoration in acute and chronic spinal cord injury stages use a single type of treatment: a drug or trophic factor, transplant of a cell type, and implantation of a biomaterial. Despite the significant benefits reported in animal models, when translating these successful therapeutic strategies to humans, the result in clinical trials has been considered of little relevance because the improvement, when present, is usually insufficient. Until now, most studies designed to promote neuroprotection or regeneration at different stages after spinal cord injury have used single treatments. Considering the occurrence of various secondary mechanisms of injury in the acute and sub-acute phases of spinal cord injury, it is reasonable to speculate that more than one therapeutic agent could be required to promote structural and functional restoration of the damaged spinal cord. Treatments that combine several therapeutic agents, targeting different mechanisms of injury, which, when used as a single therapy, have shown some benefits, allow us to assume that they will have synergistic beneficial effects. Thus, this narrative review article aims to summarize current trends in the use of strategies that combine therapeutic agents administered simultaneously or sequentially, seeking structural and functional restoratio

关键词： neural regeneration neuroprotection spinal cord injury repair spinal cord injury treatments structural restoration of spinal cord injury

Spastin and alsin protein interactome analyses begin to reveal key canonical pathways and suggest novel druggable targets

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Neural Regeneration Research 2025年第3期20卷 725-739页

作者： Benjamin R.Helmold Angela Ahrens Zachary Fitzgerald p.Hande Ozdinler Department of Neurology Feinberg School of MedicineNorthwestern UniversityChicagoILUSA Center for Molecular Innovation and Drug Discovery Center for Developmental TherapeuticsChemistry of Life Processes InstituteNorthwestern UniversityEvanstonILUSA Mesulam Center for Cognitive Neurology and Alzheimer’s Disease Feinberg School of MedicineNorthwestern UniversityChicagoILUSA Feinberg School of Medicine Les Turner ALS Center at Northwestern UniversityChicagoILUSA

Developing effective and long-term treatment strategies for rare and complex neurodegenerative diseases is challenging. One of the major roadblocks is the extensive heterogeneity among patients. This hinders understanding the underlying disease-causing mechanisms and building solutions that have implications for a broad spectrum of patients. One potential solution is to develop personalized medicine approaches based on strategies that target the most prevalent cellular events that are perturbed in patients. Especially in patients with a known genetic mutation, it may be possible to understand how these mutations contribute to problems that lead to neurodegeneration. protein–protein interaction analyses offer great advantages for revealing how proteins interact, which cellular events are primarily involved in these interactions, and how they become affected when key genes are mutated in patients. This line of investigation also suggests novel druggable targets for patients with different mutations. Here, we focus on alsin and spastin, two proteins that are identified as “causative” for amyotrophic lateral sclerosis and hereditary spastic paraplegia, respectively, when mutated. Our review analyzes the protein interactome for alsin and spastin, the canonical pathways that are primarily important for each protein domain, as well as compounds that are either Food and Drug Administration–approved or are in active clinical trials concerning the affected cellular pathways. This line of research begins to pave the way for personalized medicine approaches that are desperately needed for rare neurodegenerative diseases that are complex and heterogeneous.

关键词： ALS2 alsin amyotrophic lateral sclerosis hereditary spastic paraplegia neurodegenerative diseases personalized medicine precision medicine protein interactome protein-protein interactions SpAST spastin

Morpho-sedimentary unit signatures associated with micro-estuaries in Barnegat Bay national estuary,new Jersey,the USA

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Chinese Science Bulletin 2001年第S1期46卷 62-65页

作者： Norbert p. psutyDepartment of Marine and Coastal Sciences, Cook College, Rutgers University, new Brunswick, new Jersey 08901, USA (e-mail: psuty@ imcs.rutgers.edu) Department of Marine and Coastal Sciences Cook College Rutgers University New Brunswick USA

Incorporation of the Barnegat Bay into the US National Estuary program has triggered collection and collation of basic data sets appropriate to estuarine management. Gathering of water quality and quantity as well as basic geological data is adding to the knowledge of the complexity of the bay. An ongoing program of systematic sampling of bottom sediments in the large bay and intense sampling in the many micro-estuaries along the mainland margin is demonstrating the presence of localized mor-pho-sedimentological units related to the interaction of the fluvial, tidal, and wave processes active in the bay. Mean grain sizes and standard deviation measures assist in the development of signatures of bottom sediment types.

关键词： lagoon estuary bottom sediment wave and tidal dy- namics