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Keynote Speech 1:Fuzzy pattern Classification for Medical Data Analysis

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Keynote Speech 1:Fuzzy Pattern Classification for Medical Da...

2012 2nd International Conference on Education and Education Management(EEM 2012)

作者： Gerald schaefer Department of Computer Science Loughborough University

Medical diagnosis can often be cast as a pattern classification *** my talk,I w.ll present several fuzzy pattern classifiers and their application in the medical *** particular,I w.ll focus on fuzzy rule based approaches w.ich,in contrast to other pattern recognition approaches,might provide additional insight through the derived rules,and w.ich employ concepts from fuzzy logic theory to encode input patterns in these *** w.th a basic fuzzy classifier,I w.ll show.that it can be easily extended to perform cost sensitive classification,that classification performance can be improved through an error correction learning approach,and that a small yet pow.rful rule base can be generated through an optimisation approach based on genetic *** include diagnosis of breast cancer based on biopsy samples and based on thermography and cancer analysis based on gene expression data.

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In Search of Harmony

ChinAfrica 2015年第6期7卷 32-33页

作者： Simon schaefer Hannah Edinger Frontier Advisory

MIGRANT labor, both foreign and local, has played and continues to play an important role in the economic development and industrialization of nations such as the United States, Germany. the United Kingdom and more recently, China. As the economic hegemon of the region, South Africa thus shares a similar fate w.th countries in w.stern Europe and North America. It has become the destination of migrants in search for economic opportuni- ties and a better life.

关键词： economic development the United States United Kingdom North America

尿动力学质量控制(Ⅰ):典型值范围的建立及其在实时定量质量控制中的作用

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中华泌尿外科杂志 2006年第5期27卷 296-299页

作者：廖利民 w.rner schaefer 中国康复研究中心北京博爱医院泌尿外科 100068 美国匹兹堡大学老年医学系尿控研究室

目的通过分析尿动力学数据建立典型值范围（TVR）,并验证其在实时定量质量控制中的作用.方法对181例下尿路症状患者进行582次尿动力学测定,分析膀胱充盈前、开始和结束时以及排尿后的膀胱压（pves）、腹压（pabd）、逼尿肌压（pdet... 详细信息

目的通过分析尿动力学数据建立典型值范围（TVR）,并验证其在实时定量质量控制中的作用.方法对181例下尿路症状患者进行582次尿动力学测定,分析膀胱充盈前、开始和结束时以及排尿后的膀胱压（pves）、腹压（pabd）、逼尿肌压（pdet）、膀胱容积（MCC）、最大尿流率（Qmax）、排尿量（Vvoid）和膀胱顺应性（BC）,计算各参数的平均数、标准差及中位数,建立各参数的TVR,对与TVR相关的各种技术错误进行分类,并举出范例.结果初始静息状态下p ves、pabd及pdet的50%TVR分别为31～42、28～39及0～4 cm H2O（1 cm H2O=0.098kpa）,相关技术错误被分为Ⅰ、Ⅱ和Ⅲ型,发生率分别为9.8%（57/582）、4.5%（26/582）和1.4%（8/582）.MCC和BC的50%TVR分别为157～345 ml和26.6～70.8 ml/cm H2O;排尿期Qmax、***和V void的50%TVR分别为5.5～9.0 ml/s,57～92 cm H2O和167～315 ml.单纯尿流率测定中Qmax和V void各为8.0～9.2 ml/s和167～301 ml.排尿中和排尿末的技术错误分为Ⅳ、Ⅴ和Ⅵ型,发生率分别为0.7%（4/582）、1.9%（11/582）和1.4%（8/582）.结论 TVR对于尿动力学数据的可靠性检查和质量控制是不可缺少的有效工具,可用于尿动力学测定过程中的实时定量质量控制.

关键词：尿动力学质量控制典型值范围

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鲁奇炉加压气化的进一步发展——鲁尔100年新成果

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煤炭加工与综合利用 1985年第1期 74-80页

作者： w.schaefer 王秉周

一、引言自1976年以来,由鲁尔煤气股份公司、鲁尔煤炭股份公司和斯蒂亚格(Steag)股份公司组成的加压气化研究小组(ADV),进一步发展了鲁奇固定床加压气化。他们所研制的气体发生装置的型号命名为“鲁尔100”。该装置最重要的目标是:通过... 详细信息

一、引言自1976年以来,由鲁尔煤气股份公司、鲁尔煤炭股份公司和斯蒂亚格(Steag)股份公司组成的加压气化研究小组(ADV),进一步发展了鲁奇固定床加压气化。他们所研制的气体发生装置的型号命名为“鲁尔100”。该装置最重要的目标是:通过提高压力至100巴,使其能较经济地生产合成天然气(SNG)或城市煤气,以及能将粗煤气转变成合成气。由于鲁尔煤气公司具有固定床气化的经验以及必要的设施,因此这个新的研究装置安装在多尔斯顿(Dorsten)地方的鲁奇煤气公司的厂区内,于1979年9月开

关键词：加压气化鲁奇粗煤气鲁尔甲烷德国沼气烷烃蒸汽分解固定床气化

尿动力学质量控制(Ⅱ):典型信号模式的识别及其在实时定性质量控制中的作用

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中华泌尿外科杂志 2006年第5期27卷 300-303页

作者：廖利民 w.rner schaefer 中国康复研究中心北京博爱医院泌尿外科 100068 美国匹兹堡大学老年医学系尿控研究室

目的通过分析充盈和排尿期膀胱测压数据识别和建立典型信号模式(TSp),并验证其在实时定性质量控制中的作用。方法对181例下尿路症状成年男性进行582次膀胱压力测定,识别和描述充盈和排尿期的膀胱压(pves)、腹压(pabd)和逼尿肌压(pdet)... 详细信息

目的通过分析充盈和排尿期膀胱测压数据识别和建立典型信号模式(TSp),并验证其在实时定性质量控制中的作用。方法对181例下尿路症状成年男性进行582次膀胱压力测定,识别和描述充盈和排尿期的膀胱压(pves)、腹压(pabd)和逼尿肌压(pdet)的曲线信号模式;分别在膀胱充盈开始、充盈中、排尿开始、排尿中及排尿后比较上述曲线的TSp:信号的细微结构(模式Ⅰ)、信号对呼吸和说话或轻微移动的应答(模式Ⅱ)、信号对规则咳嗽的应答(模式Ⅲ),辨别逼尿肌不稳定、腹肌收缩和直肠运动导致的信号巨观改变(模式Ⅳ)。比较对应信号的符合率,对膀胱测压的TSp进行系统描述,以控制信号质量。结果充盈开始时,91.8%(534/582)曲线在pves及pabd具有相同的Ⅰ、Ⅱ型信号、为“活”信号;74.8%(435/582)对咳嗽的应答相同,仅3.1%(18/582)出现腹肌或直肠收缩产生的巨观改变。在充盈期,98.3%(572/582)的pves及pabd的Ⅰ型和Ⅱ型信号相同,98.5%(573/582)对咳嗽的应答相同或相似,8.3%(48/582)出现腹肌收缩,33.7%(196/582)逼尿肌不稳定,17.4%(101/582)直肠收缩。在排尿开始前,94.0%(547/582)的pves及pabd对咳嗽应答相同。排尿期91.2%(531/582)为“活”信号,95.2%(554/582)为典型逼尿肌收缩模式,2.1%(12/582)直肠收缩,15.3%(89/582)盆底松弛。排尿后,91.2%(531/582)仍为“活”信号,87.5%(509/582)pves及pabd对咳嗽的应答相同。结论TSp是尿动力学测定中进行实时定性质量控制的有力工具,熟悉和辨认所描述的TSp并与典型值范围结合可使质量控制具体化,具备可操作性。

关键词：尿动力学质量控制典型信号模式

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High-fat diet and oral infection induced type 2 diabetes and obesity development under different genetic backgrounds

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Animal Models and Experimental Medicine 2023年第2期6卷 131-145页

作者： Iqbal M.Lone Nadav Ben Nun Aya Ghnaim Arne S.schaefer Yael Houri-Haddad Fuad A.Iraqi Department of Clinical Microbiology and Immunology Sackler Faculty of MedicineTel Aviv UniversityTel AvivIsrael Department of periodontology and Synoptic Dentistry Institute for Dental Craniofacial SciencesCharite-University of MedicineBerlinGermany Department of prosthodontics Dental SchoolThe Hebrew UniversityJerusalemIsrael

Background:Type 2 diabetes(T2D)is an adult-onset and obese form of diabetes caused by an interplay betw.en genetic,epigenetic,and environmental ***,w. have assessed a cohort of 11 genetically different collaborative cross(CC)mouse lines comprised of both sexes for T2D and obesity developments in response to oral infection and high-fat diet(HFD)***:Mice w.re fed w.th either the HFD or the standard chow.diet(control group)for 12 w.eks starting at the age of 8 *** w.ek 5 of the experiment,half of the mice of each diet group w.re infected w.th porphyromonas gingivalis and Fusobacterium nucleatum bacteria *** the 12-w.ek experimental period,body w.ight(Bw.w.s recorded biw.ekly,and intraperitoneal glucose tolerance tests w.re performed at w.eks 6 and 12 of the experiment to evaluate the glucose tolerance status of ***:Statistical analysis has show. the significance of phenotypic variations betw.en the CC lines,w.ich have different genetic backgrounds and sex effects in different experimental *** heritability of the studied phenotypes w.s estimated and ranged betw.en 0.45 and *** applied machine learning methods to make an early call for T2D and its *** results show.d that classification w.th random forest could reach the highest accuracy classification(ACC=0.91)w.en all the attributes w.re ***:Using sex,diet,infection status,initial Bw.and area under the curve(AUC)at w.ek 6,w. could classify the final phenotypes/outcomes at the end stage of the experiment(at 12 w.eks).

关键词： collaborative cross genetic covariance heritability high-fat diet machine learning mouse model obesity type 2 diabetes

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Economic Impact of ANC Election Victory

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ChinAfrica 2014年第6期6卷 30-31页

作者： John de Villiers Simon schaefer

ON May 7, South Africans w.nt to the polls in throngs to exercise their constitutional right to vote. In a country w.ere the majority of the population w.sonce excluded from casting their votes and from participating ... 详细信息

关键词： ANC Economic Impact of ANC Election Victory

Analysis of the human Atox 1 homologue in w.lson patients

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w.rld Journal of Gastroenterology 2008年第15期14卷 2383-2387页

作者： Isabel Simon Mark schaefer Jürgen Reichert w.lfgang Stremmel Department of Gastroenterology University of HeidelbergGermany

AIM: To analyze the metallochaperone antioxidant-1 (Atox1) gene sequence in w.lson disease patients. METHODS: Mutation analysis of the four exons of the Atox1 gene including the intron- exon boundaries w.s performed in 63 w.lson disease patients by direct sequencing. RESULTS: From 63 selected patients no mutations w.re identified after the entire coding region including the intron- exon boundaries of Atox1 w.re sequenced. One know. polymorphism w.thin the Atox1 gene (5’UTR -99 T>C) in 31 (49%) of the w.lson patients as w.ll as one previously undescribed variation (5’UTR -68 C>T) in 2 of the w.lson patients could be detected. Statistical analyses revealed that the existence of a variation w.thin the Atox1- gene show.d a tendency tow.rds an earlier onset of the disease. CONCLUSION: Based on the data of this study, no major role can be attributed to Atox1 in the pathophysiology or clinical variation of w.lson disease.

关键词： Antioxidant-1 w.lson disease w.lson's disease protein Mutation analysis

Ion Coordination and Transport in Magnesium polymer Electrolytes Based on polyester-co-polycarbonate

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Energy Material Advances 2021年第1期2021卷 48-61页

作者： Bumjun park Rassmus Andersson Sarah G.pate Jiacheng Liu Casey pO’Brien Guiomar Hernández Jonas Mindemark Jennifer L.schaefer Department of Chemical and Biomolecular Engineering University of Notre DameNotre DameIN 46556USA Department of Chemistry-Ångström Laboratory Uppsala UniversityBox 538SE-75121 UppsalaSweden

Magnesium-ion-conducting solid polymer electrolytes have been studied for rechargeable Mg metal batteries,one of the beyond-Li-ion *** this paper,magnesium polymer electrolytes w.th magnesium bis(trifluoromethane)sulfonimide(Mg(TFSI)2)salt in poly(ε-caprolactone-co-trimethylene carbonate)(pCL-pTMC)w.re investigated and compared w.th the poly(ethylene oxide)(pEO)*** thermal properties and vibrational spectroscopy indicated that the total ion conduction in the pEO electrolytes w.s dominated by the anion conduction due to strong polymer coordination w.th fully dissociated Mg2+.On the other hand,in pCL-pTMC electrolytes,there is relatively w.aker polymer–cation coordination and increased anion–cation *** Mg-and F-rich particles w.re observed on the Cu electrodes after polarization tests in Cu|Mg cells w.th pCL-pTMC electrolyte,suggesting that Mg w.s conducted in the ion complex form(MgxTFSIy)to the copper w.rking electrode to be reduced w.ich resulted in anion ***,the Mg metal deposition/stripping w.s not favorable w.th either Mg(TFSI)2 in pCL-pTMC or Mg(TFSI)2 in pEO,w.ich inhibited quantitative analysis of magnesium conduction.A remaining challenge is thus to accurately assess transport numbers in these systems.

关键词： magnesium conduction anion