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potential Regulators of Sporadic ALS Development and Alternative Therapeutic Options

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Neuroscience & Medicine 2015年第1期6卷 5-12页

作者： Morenci M. manning Marie Kelly-Worden Ball State University Muncie USA

Amyotrophic Lateral Sclerosis (ALS) is the most common neurodegenerative disorder. It is also among the most lethal as life expectancy is between 2 and 5 years after diagnosis. Sporadic ALS (sALS) makes up 90% of all ALS cases with little known about the exact mechanism of pathogenesis. Many potential regulators of sALS development have been proposed, several of which are examined in this review with supporting evidence. Interplay among these factors is examined more closely in hopes of shedding more light on sALS pathophysiology. There is a paucity of effective treatment options as the only FDA-approved drug for use, riluzole, has a positive but modest benefit in improving survival. Other treatments available merely target ameliorating symptoms of ALS. Alternative treatment options are also discussed. This study ultimately aims to make relevant connections among factors implicated in sALS development and to highlight alternative forms of treatment in improving neuron function and status, albeit controversial.

关键词： Amyotrophic Lateral Sclerosis ALS Sporadic ALS Neurodegeneration

原油和源岩的钕同位素研究——在石油勘探中的应用潜力

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国外油气勘探 1992年第4期 96-105+134页

作者： L.K.manning 邹文

本文测定了若干产油盆地的油源岩,含水热解产物和原油的钕（Nd）同位素组成。源岩的Sm-Nd特征表明,它们的143ND/144ND值有很大差异,足以在区域和局部范围区分不同的源岩。含水热解产物的Nd同位素比值和它们的源岩相同,说明源岩的干酪根... 详细信息

本文测定了若干产油盆地的油源岩,含水热解产物和原油的钕（Nd）同位素组成。源岩的Sm-Nd特征表明,它们的143ND/144ND值有很大差异,足以在区域和局部范围区分不同的源岩。含水热解产物的Nd同位素比值和它们的源岩相同,说明源岩的干酪根与无机部分Nd同位素处于平衡。原油的Sm和Nd含量很低,说明在初次运移期间源岩中保留了与有机质伴生的金属,可能是因为所排出的烃类缺乏合适的螯合位置而引起的。经过广泛二次运移的原油,其Sm/Nd值高于相应的源岩和没有经过明显二次运移的原油。Sm与Nd这种显著的分馏作用的原因尚未搞清。早先推测的两对源岩—石油的成因联系,得到了原始Nd同位素比值相一致的支持。虽然这些还是初步的结果,但有关数据已表明Nd同位素比值有希望成为原油—源岩对比的一种手段。

关键词：地球化学勘探同位素法原油生油层油源对比

Rectangularisation Issues in Health Economics &Insurance: Measures and Mitigations

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Journal of Applied Mathematics and physics 2016年第7期4卷 1327-1335页

作者： S. Jayaprakash p. K. Dinakar Michael Ha Zhengjun Jiang Uthit Siriwan manning Li Chukwuemeka Okeagu Nanobi Data and Analytics private Ltd. Bangalore India The Institute of Actuaries of India Mumbai India Xi’an Jiaotong-Liverpool University Suzhou China Bryant College Beijing Institute of Technology Zhuhai China Faculty of Business Charisma University Turks and Caicos UK Bank of Communications Suzhou Branch Suzhou China

Aim: Actuaries are financial engineers who construct arrays of risk models combining mathematical techniques in order to carry out required actuarial calculations, such as reserve valuation and pricing. The main purpose is to identify some reliable models which price risk factors embedded in insurance products. Health insurance products which are very different in nature from life insurance products must be examined and priced carefully. This paper discusses predominantly two risks. Excess claims ratio and Rectangularisation risks. Background: The first author, Dr. S. Jayaprakash was responsible for Enterprise Risk Management with MetLife India. He was earlier associated with Life Insurance Corporation of India & Oracle Financial Services. Dr. p. K. Dinakar, the second author, qualified as Fellow of the Institute of Actuaries of India, was Chief Actuary of MetLife India Insurance. He was earlier associated with Life Insurance Corporation of India & Birla Sunlife. The third author, Dr. Michael Ha, FSA, MAAA, CFA, CpA (Australia), FRM, pRM, LLM, was Vice president of Strategic Business Initiatives Units at ING Life Insurance in its Taiwan operation. He started his actuarial career at MetLife, Canada. Earlier, the first and third authors worked on a research paper titled “Modeling policyholder Behavior through Insurance Resonant Marts for pricing Options and Guarantees” [1] which was presented at the 5th World Congress on Engineering and Technology. The seven authors decided to collaborate on the current research paper for health insurance design and financing purposes.

关键词： Claims Ratio Valuation De-Risk Rectangularisation Morbidity

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微博时代的群体动员机制及管理对策

重庆大学学报（社会科学版） 2014年第1期20卷 152-156页

作者：郑满宁中国人民大学新闻学院北京100089

微博成为重要的群体动员工具和平台之后,群体动员成本逐渐呈现出趋零化趋势,文章以"随手拍解救乞讨儿童"为案例,分析了微博群体动员的五个阶段,从动员主体、客体、动员方式和动员机制等几个方面重点分析了微博群体动员的特点和危害,在... 详细信息

微博成为重要的群体动员工具和平台之后,群体动员成本逐渐呈现出趋零化趋势,文章以"随手拍解救乞讨儿童"为案例,分析了微博群体动员的五个阶段,从动员主体、客体、动员方式和动员机制等几个方面重点分析了微博群体动员的特点和危害,在此基础上提出了应对微博时代群体动员的管理对策和建议。

关键词：微博群体动员弱者的武器应急管理

Blood glucose changes surrounding initiation of tumor-necrosis factor inhibitors and conventional disease-modifying anti-rheumatic drugs in veterans with rheumatoid arthritis

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World Journal of Diabetes 2018年第2期9卷 53-58页

作者： patrick R Wood Evan manning Joshua F Baker Bryant England Lisa Davis Grant W Cannon Ted R Mikuls Liron Caplan Denver Veterans Affairs Medical Center Division of Rheumatology University of Colorado philadelphia Veterans Affairs Medical Center Division of Rheumatology University of Pennsylvania Omaha Veterans Affairs Medical Center Division of Rheumatology University of Nebraska Denver Health and Hospital Division of Rheumatology University of Colorado George Wahlen Veterans Affairs Medical Center Division of Rheumatology University of Utah

AIM To determine the scope of acute hypoglycemic effects for certain anti-rheumatic medications in a large retrospective observational study. METHODS patients enrolled in the Veterans Affairs Rheumatoid Arthritis (VARA) registry were selected who, during follow-up, initiated treatment with tumor necrosis factor inhibitors (TNFi's, including etanercept, adalimumab, infliximab, golimumab, or certolizumab), prednisone, or conventional disease-modifying anti-rheumatic drugs(DMARDs), and for whom proximate random blood glucose (RBG) measurements were available within a window 2-wk prior to, and 6 mo following, medication initiation. Similar data were obtained for patients with proximate values available for glycosylated hemoglobin A1C values within a window 2 mo preceding, and 12 mo following, medication initiation. RBG and A1C measurements were compared before and after initiation events using paired t-tests, and multivariate regression analysis was performed including established comorbidities and *** Two thousands one hundred and eleven patients contributed at least one proximate measurement surrounding the initiation of any examined medication. A significant decrease in RBG was noted surrounding 653 individual hydroxychloroquine-initiation events(-3.68 mg/dL, p = 0.04), while an increase was noted for RBG surrounding 665 prednisone-initiation events(+5.85 mg/d L, p p p = 0.01) and hydroxychloroquine(β =-5.78, p = 0.01) use as predictors of lower post-medicationinitiation RBG and A1C values, respectively. Analysis by drug class suggested prednisone (or glucocorticoids) as predictive of higher medication-initiation event RBG among all start events as compared to DMARDs, while this analysis did not

关键词： Disease modifying anti-rheumatic drugs Drug toxicity Glucocorticoids Rheumatoid arthritis Tumor necrosis factor inhibitors

Examination of possible Flow Turbulence during Flow-Mediated Dilation Testing

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Open Journal of Medical Imaging 2011年第1期1卷 1-8页

作者： Lee Stoner manning Joseph Sabatier Joanna Mary Young 不详

The validity of the flow-mediated dilation (FMD) test has been doubted due to the lack of normalization to the primary stimulus, shear stress. Shear stress can be calculated using a simplified mathematical model based on poiseuille’s law. poiseuille’s law assumes that the blood velocity profile is parabolic. The presence of turbulence will violate this assumption. The Reynolds number (RE) is used to define critical values for the transition from laminar to turbulent flow. Between RE values of 2000 and 4000, flow enters a transitional phase where turbulence is possible. purpose: To determine whether brachial artery blood flow becomes turbulent during reactive hyperemia following forearm ischemia. Methods: Eleven healthy male subjects (25 ± 5 years) were tested. Brachial artery diameters and blood velocities were measured continuously following 2, 4, 6 and 10 minutes ischemia. The peak post-ischemic RE (REpeak) and RE integrated over 40 seconds (RE40) post-ischemia were calculated. Results: There was a significant change in REpeak (F4,7 = 98.573, p = ≤ 0.001) and RE40) (F4,7) = 50.613, p = ≤ 0.001) in response to ischemia. Within-subjects contrasts revealed a significant increase in REpeak and RE40 for each duration of ischemia versus baseline (p = ≤ 0.001). Following 4 minutes of ischemia there was approximately 12 seconds of potentially turbulent flow. Conclusion: Blood flow transitions between laminar and turbulent flow during ischemia-induced reactive hyperemia. This may limit the efficacy of estimating shear stress when using the standard FMD test protocol.

关键词： Flow Mediated Dilatation Blood Flow Shear Stress Turbulence Reynolds Number poiseuille’s Law

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旋喷桩加固技术在某隧道风积砂地层中的应用

现代隧道技术 2013年第3期50卷 158-162页

作者：徐智胡蔓宁中交第一公路勘察设计研究院有限公司西安710075

风积砂具有结构松散、粘聚力小、抗剪强度低等特点,在外力作用下极易松散变形。文章介绍了在某隧道风积砂地层中,采用常规长管棚注浆加固方案存在掌子面漏砂严重、变形难以控制以及施工进度缓慢等不足;提出通过在地表采用竖直旋喷桩加... 详细信息

风积砂具有结构松散、粘聚力小、抗剪强度低等特点,在外力作用下极易松散变形。文章介绍了在某隧道风积砂地层中,采用常规长管棚注浆加固方案存在掌子面漏砂严重、变形难以控制以及施工进度缓慢等不足;提出通过在地表采用竖直旋喷桩加固洞周围岩、在洞内采用水平旋喷桩进行超前支护,能防止漏砂、有效控制变形并提高施工进度。现场监控量测结果表明,采用长管棚注浆加固方案引起的隧道拱顶沉降值、周边收敛值分别是采用旋喷桩加固方案引起拱顶沉降值、周边收敛值的6.5倍和3.6倍;两方案工期相比,前者是后者的1.9倍。这说明采用旋喷桩加固风积砂,对控制隧道变形、提高施工工期,优势是非常明显的。

关键词：隧道风积砂旋喷桩应用

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传统吉祥纹样与现代婚庆用品包装设计

民族艺术研究 2010年第5期23卷 101-104,143页

作者：米满宁重庆大学艺术学院

本文简述了中国传统吉祥纹样的起源发展、种类以及社会功能,分析了传统吉祥纹样在婚庆用品包装设计中存在的问题,明确了传统吉祥纹样在婚庆用品包装设计中的原则,进而探讨了传统吉祥纹样在现代婚庆用品包装设计中的应用。

关键词：传统吉祥纹样婚庆用品包装设计

考虑均值无法解释的其他方法:分位数回归在卫生服务研究中的应用(英文)

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上海精神医学 2013年第1期25卷 55-59页

作者： Benjamin Lê COOK Willard G.manning Center for Multicultural Mental Health Research Cambridge Health Alliance/Harvard Medical SchoolBoston MA United States Harris School of public policy Studies University of ChicagoChicago IL United States

*** Health services and health economics research articles commonly use multivariate regression techniques to measure the relationship of health service utilization and health outcomes (the outcomes of interest) with ... 详细信息

关键词：多元回归方法医疗服务平均效应实用指南 logistic回归模型分位数社会经济因素最小二乘回归