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Effect of Low Level Subchronic Microwave Radiation on Rat Brain

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Biomedical and Environmental Sciences 2016年第12期29卷 858-867页

作者： pravin Suryakantrao Deshmukh Kanu Megha Namita Nasare Basu Dev Banerjee Rafat Sultana Ahmed mahesh pandurang Abegaonkar Ashok kumar Tripathi pramod kumari Mediratta Environmental Biochemistry and Molecular Biology Laboratory Department of Biochemistry.University College of Medical Sciences & G.T.B.Hospital(University of Delhi) Department of pharmacology University College of Medical Sciences & G.T.B.Hospital(University of Delhi) Centre for Applied Research in Electronics(CARE) Indian Institute of Technology

Objective The present study was designed to investigate the effects of subchronic low level microwave radiation （MWR） on cognitive function, heat shock protein 70 （HSp70） level and DNA damage in brain of Fischer rats. Methods Experiments were performed on male Fischer rats exposed to microwave radiation for 90 days at three different frequencies： 900, 2800, and 2450 MHz. Animals were divided into 4 groups： Group I： Sham exposed, Group I1： animals exposed to microwave radiation at 900 MHz and specific absorption rate （SAR） 5.953 x 10-4 W/kg, Group II1： animals exposed to 1800 MHz at SAR 5.835 x 20-4 W/kg and Group IV： animals exposed to 2450 MHz at SAR 6.672 x 10-4 W/kg. All the animals were tested for cognitive function using elevated plus maze and Morris water maze at the end of the exposure period and subsequently sacrificed to collect brain tissues. HSp70 levels were estimated by ELISA and DNA damage was assessed using alkaline comet assay. Results Microwave exposure at 900-2450 MHz with SAR values as mentioned above lead to decline in cognitive function, increase in HSp70 level and DNA damage in brain. Conclusion The results of the present study suggest that low level microwave exposure at frequencies 900, 2800, and 2450 MHz may lead to hazardous effects on brain.

关键词： Brain Cognitive function Comet assay DNA damage HSp70 Microwave radiation

Long-term and non-invasive in vivo tracking of DiD dye-labeled human hepatic progenitors in chronic liver disease models

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World Journal of Hepatology 2022年第10期14卷 1884-1898页

作者： Chaturvedula Tripura Srinivas Gunda Sandeep kumar Vishwakarma Avinash Raj Thatipalli Jedy Jose mahesh kumar Jerald Aleem Ahmed Khan Gopal pande Cell and Stem Cell Biology CSIR-Centre for Cellular and Molecular BiologyHyderabad 500007TelanganaIndia Central Laboratory for Stem Cell Research and Translational Medicine Centre for Liver Research and DiagnosticsDeccan College of Medical SciencesHyderabad 500058TelanganaIndia

BACKGROUND Chronic liver diseases(CLD)are the major public health burden due to the continuous increasing rate of global morbidity and *** inherent limitations of organ transplantation have led to the development of stem cell-based therapy as a supportive and promising therapeutic ***,identifying the fate of transplanted cells in vivo represents a crucial *** To evaluate the potential applicability of DiD dye as a cell labeling agent for longterm,and non-invasive in vivo tracking of transplanted cells in the *** Magnetically sorted,epithelial cell adhesion molecule positive(1×106 cells/mL)fetal hepatic progenitor cells were labeled with DiD dye and transplanted into the livers of CLD-severe combined immunodeficiency(SCID)***-infrared(NIR)imaging was performed for in vivo tracking of the DiD-labeled transplanted cells along with colocalization of hepatic markers for up to 80 *** existence of human cells within mouse livers was identified using Alu polymerase chain reaction and *** NIR fluorescence imaging of CLD-SCID mice showed a positive fluorescence signal of DiD at days 7,15,30,45,60,and 80 ***,positive staining of cytokeratin,c-Met,and albumin colocalizing with DiD fluorescence clearly demonstrated that the fluorescent signal of hepatic markers emerged from the DiD-labeled transplanted *** of liver function was also observed with serum levels of glutamic-oxaloacetic transaminase,glutamate-pyruvate transaminase,and *** detection of human-specific Alu sequence from the transplanted mouse livers provided evidence for the survival of transplanted cells at day *** DiD-labeling is promising for long-term and non-invasive in vivo cell tracking,and understanding the regenerative mechanisms incurred by the transplanted cells.

关键词： Chronic liver diseases Cell transplantation Cell tracking and imaging DiD Hepatic progenitors

Molecular docking studies of anti-cancerous candidates in Hippophae rhamnoides and Hippophae salicifolia

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The Journal of Biomedical Research 2014年第5期28卷 406-415页

作者： Talambedu Usha Sushil kumar Middha Arvind kumar Goyal mahesh Karthik DA Manoj Syed Faizan peyush Goyal Hp prashanth Veena pande Department of Biochemistry and Biotechnology Maharani Lakshmi Ammanni College For Women Bamboo Technology Bodoland University Department of Biotechnology Sapthagiri College of Engineering Department of Biotechnology M S Ramaiah Institute of Technology Department of Biotechnology Bhimtal CampusKumaun University Ministry of Science Govt.of IndiaNew DelhiIndia

Actinorhizal plants contain numerous antioxidants that may play a crucial role in preventing the formation of tumors.H-Ras p21,a member of the Ras-GTpase family,is a promising target to treat various kinds of *** in silico docking study was carried out to identify the inhibitory potential of compounds of these plants against H-Ras by using Discovery Studio 3.5 and by using Autodock *** studies revealed that four compounds,isorhamnetin-7-rhamnoside,quercetin-3-glucoside-7-rhamnoside（present in ***）,zeaxanthin,and translutein（present in ***） significantly bind with binding energies-17.1534,-14.7936,-10.2105 and-17.2217 Kcal/mol,respectively,even though they slightly deviate from Lipinski＇s ***,distribution,metabolism,excretion and toxicity（ADME/tox） analyses of these compounds and their stereoisomers showed that they were less toxic and *** them,isorhamntein-7-rhamnoside showed ***,these compounds can be further investigated in vivo to optimize their formulation and concentration and to develop potential chemical entities for the prevention and treatment of cancers.

关键词： Hippophae H-Ras cancer docking Discovery Studio 3.5 H.rhamnoides H.salicifolia

Role of subjective visual vertical in patients with posterior canal benign paroxysmal positional vertigo as a prognostic marker after canalith repositioning maneuver

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Journal of Otology 2022年第3期17卷 111-115页

作者： Sanjeev Saxena Bhaumik patel Ravi Roy Himanshu Swami Sanajit kumar Singh Sunil Goyal Rajeev Chugh Devendra kumar Gupta Sween Banger mahesh Ravanikutty Sneha Yadav Department of ENT World College of Medical Science and ResearchJhajjarHaryanaIndia Department of ENT-HNS Army Hospital Research and ReferralNew DelhiIndia

Objective:To study the potential role of subjective visual vertical(SVV)as a prognostic marker for canalith repositioning maneuver(CRM)in patients with posterior canal benign paroxysmal positional vertigo(pC-BppV)for the Indian ***:SVV was examined in 30 patients with pC-BppV before and after canalith repositioning maneuver and after complete resolution of *** parameters included the mean of 10 angular tilt readings and direction of deviation,which were compared before and after CRM and following complete resolution of ***:The angle of SVV tilt was greater and deviated towards the affected ear before CRM in all patients,which decreased significantly shortly after CRM and continued to decrease after complete resolution of pC-BppV(pproves in response to CRM,which may be used as a prognostic marker in patients with pC-BppV receiving CRM.

关键词： Benign paroxysmal positional vertigo(BppV) Subjective visual vertical(SVV) Otoliths(canaliths) Canalith repositioning maneuver(CRM)

An Ensemble Based Approach for Sentiment Classification in Asian Regional Language

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Computer Systems Science & Engineering 2023年第3期44卷 2457-2468页

作者： mahesh B.Shelke Jeong Gon Lee Sovan Samanta Sachin N.Deshmukh G.Bhalke Daulappa Rahul B.Mannade Arun kumar Sivaraman Department of Computer Science and Information Technology Dr.Babasaheb Ambedkar Marathwada UniversityAurangabadMaharashtra431004India Division of Applied Mathematics Wonkwang University460Iksan daeroIksan SiJeonbuk54538Korea Department of Mathematics Tamralipta MahavidyalayaTamlukWest Bengal721636India Department of Electronics and Telecommunication Engineering AISSMSCOEPuneMaharashtra411001India Department of Information Technology Govemment College of EngineeringAurangabadMaharashtra431005India School of Computer Science and Engineering Vellore Institute of TechnologyChennai600127India

In today’s digital world,millions of individuals are linked to one another via the Internet and social *** opens up new avenues for information exchange with *** analysis(SA)has gotten a lot of attention during the last *** analyse the challenges of Sentiment Analysis(SA)in one of the Asian regional languages known as Marathi in this study by providing a benchmark setup in which wefirst produced an annotated dataset composed of Marathi text acquired from microblogging websites such as *** also choose domain experts to manually annotate Marathi microblogging posts with positive,negative,and neutral *** addition,to show the efficient use of the annotated dataset,an ensemble-based model for sentiment analysis was *** contrast to others machine learning classifier,we achieved better performance in terms of accuracy for ensemble classifier with 10-fold cross-validation(cv),outcomes as 97.77%,f-score is 97.89%.

关键词： Sentiment analysis machine learning lexical resource ensemble classifier

Radiation dose analysis of computed tomography coronary angiography in Children with Kawasaki disease

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世界临床儿科杂志 2023年第4期12卷 230-236页

作者： mahesh Chandra Bhatt Manphool Singhal Rakesh kumar pilania Subhash Chand Bansal Niranjan Khandelwal pankaj Gupta Surjit Singh Department of Radiodiagnosis and Imaging Postgraduate Institute of Medical Education and ResearchChandigarh 160012India pediatric Allergy Immunology Unit Department of PediatricsAdvanced Pediatrics CentrePost Graduate Institute of Medical Education and ResearchChandigarh 160012India

BACKGROUND There is evolving role of computed tomography coronary angiography(CTCA)in non-invasive evaluation of coronary artery abnormalities in children with Kawasaki disease(KD).Despite this,there is lack of data on radiation dose in this group of children undergoing *** To audit the radiation dose of CTCA in children with *** Study(December 2013-February 2018)was performed on dual source CT scanner using adaptive prospective *** dose length product(DLp in ***)was *** radiation dose(millisieverts-mSv)was calculated by applying appropriate age adjusted conversion factors as per recommendations of International Commission on Radiological *** dose was compared across the groups(0-1,1-5,5-10,and>10 years).RESULTS Eighty-five children(71 boys,14 girls)with KD underwent *** median age was 5 years(range,2 mo-11 years).Median DLp and effective dose was 21 ***,interquartile ranges(IQR)=15(13,28)and 0.83 mSv,IQR=0.33(0.68,1.01)*** DLp increased significantly across the age *** effective dose in infants(0.63 mSv)was significantly lower than the other age groups(1-5 years 0.85 mSv,5-10 years 1.04 mSv,and>10 years 1.38 mSv)(pps of *** the CTCA studies were of diagnostic *** child required a repeat *** CTCA is feasible with submillisievert radiation dose in most children with ***,CTCA has the potential to be an important adjunctive imaging modality in children with KD.

关键词： Computed tomography coronary angiography Coronary artery abnormalities Dual source computed tomography Kawasaki disease Radiation exposure

轮式移动机器人的多目标优化力分布的鲁棒性分析

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轮式移动机器人的多目标优化力分布的鲁棒性分析

作者： mahesh kumar Isher 哈尔滨工程大学

学位级别：硕士

力分布及鲁棒性分析是崎岖地面上轮式移动机器人研究的一个组成部分。针对崎岖地面上的轮式机器人的三维力分布，本文提出了一种力分布的准静态力分析方法。该理论考虑了机器人在崎岖环境下所容许的最大切应力和内摩擦角，以避免车轮过... 详细信息

力分布及鲁棒性分析是崎岖地面上轮式移动机器人研究的一个组成部分。针对崎岖地面上的轮式机器人的三维力分布，本文提出了一种力分布的准静态力分析方法。该理论考虑了机器人在崎岖环境下所容许的最大切应力和内摩擦角，以避免车轮过度的打滑。在Matlab软件环境下，本文进行了针对典型地面的三维力分布的多目标优化，优化过程中主要以机器人的能量消耗和牵引力为目标函数。多目标优化方法用来获得在机器人牵引力和能耗方面的准静态力分布联立的方程组的解。在车轮与地面之间引入了地面力学模型，包括不同类型的约束条件。在典型三维地面模型上进行了仿真验证。力分布由于其在崎岖地面中重要的控制性，成为在自主机器人中所主要关注的。一种多目标进化算法，用来获得最好的解集，通过最小化电机的能量和平均等效摩擦系数来保证最小的滑移。 pareto最优解的鲁棒性作为主要而被关注。由于不同的地形特性，如土壤凝聚力（c）、剪切变形模量（k）和内部摩擦角（o）作为噪声导致而得到不同pareto解。可以发现，来自轮地特性的噪声c, k和o的值大2%时对结果敏感性产生较大的影响，而且在pareto解的前沿front较小处的解比较大斜率处的接的鲁棒性更好，该标准可以用于控制算法和控制系统的设计，是一种从pareto解中选择一个非劣解的可行准则之一。

关键词：力分布多目标优化鲁棒性 pareto最优解移动机器人

Immediate in-hospital outcomes after percutaneous revascularization of acute myocardial infarction complicated by cardiogenic shock

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世界心脏病学杂志:英文版(电子版) 2023年第9期15卷 439-447页

作者： Bashir Ahmed Solangi Jehangir Ali Shah Rajesh kumar mahesh kumar Batra Gulzar Ali Muhammad Hassan Butt Ambreen Nisar Nadeem Qamar Tahir Saghir Jawaid Akbar Sial Department of Adult Cardiology National Institute of Cardiovascular DiseasesKarachi 75510Pakistan

BACKGROUND Cardiogenic shock(CS)is a life-threatening complication of acute myocardial infarction with high morbidity and mortality *** percutaneous coro-nary intervention(pCI)has been shown to improve outcomes in patients with *** To investigate the immediate mortality rates in patients with CS undergoing primary pCI and identify mortality *** We conducted a retrospective analysis of 305 patients with CS who underwent primary pCI at the National Institute of Cardiovascular Diseases,Karachi,pak-istan,between January 2018 and December *** primary outcome was immediate mortality,defined as mortality within index ***-variate and multivariate logistic regression analyses were performed to identify predictors of immediate *** In a sample of 305 patients with 72.8%male patients and a mean age of 58.1±11.8 years,the immediate mortality rate was found to be 54.8%(167).Multivariable analysis identified Killip class IV at presentation[odds ratio(OR):2.0;95%co-nfidence interval(CI):1.2-3.4;p=0.008],Multivessel disease(OR:3.5;95%CI:1.8-6.9;pp=0.003)as independent predictors of immediate *** Immediate mortality rate in patients with CS undergoing primary pCI remains high despite advances in treatment *** class IV at presentation,multivessel disease,and high thrombus burden(grade≥4)were identified as independent predictors of immediate *** findings underscore the need for aggressive management and close monitoring of patients with CS undergoing primary pCI,particularly in those with these high-risk characteristics.

关键词： Acute myocardial infarction Cardiogenic shock primary percutaneous coronary intervention Mortality predictors

Evaluation of Topical Application of <i>Azadirachta indica</i>(Neem) in prevention of Gingivitis: A Randomized Control Trial

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Open Journal of Stomatology 2019年第11期9卷 249-259页

作者： Vibha Singh Anjani kumar pathak Kopal Goel mahesh pal King George’s Medical University Lucknow India Department of periodontology Faculty of Dental Sciences King George’s Medical University Lucknow India Sardar patel post Graduate Institute of Dental and Medical Sciences Lucknow India phytochemistry Division CSIR-National Botanical Research Institute Lucknow India

Background: The purpose of the present study was to envisage the anti-plaque and anti-inflammatory properties of neem (Azadirachta) in the form of a mouth gel. Materials and Methods: A total of 60 subjects (33 males and 27 females) from age group 19 - 35 years, suffering from mild to moderate gingivitis were randomly divided into two groups. Group A (n = 30) participants were advised experimental (neem) gel and Group B (n = 30) participants were advised 0.2% chlorhexidine gel. All the clinical parameters (the gingival index by Loe and Silness [1], plaque index by Silness and Loe [2] and sulcus bleeding index by Muhlemann H. R. and Sen S. [3]) were recorded at baseline, on the 14th day and 21st day by the same clinician in both groups. Results: on intragroup comparison the gingival index, plaque index and sulcus bleeding index decrease significantly in both the groups in all assessed periods. On intergroup comparison the indices did not differ significantly at baseline but after 2nd and 3rd week, the indices in Group B decrease more than the group A, which was statistically significant. Conclusion: Based on the observations of our study, it can be concluded that chlorhexidine gluconate as well as neem gel can be effectively used as an adjunct to mechanical plaque control in prevention of plaque and gingivitis. chlorhexidine gluconate gel has been found to be more effective when antiplaque and anti-inflammatory properties were considered. The effect of neem observed maybe because of its anti-inflammatory action. The antiplaque action of chlorhexidine gluconate is due to its substantivity. Substantivity of neem is required to be further studied.

关键词： Azadirachta Gingivitis. Anti plaque