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Unsynchronized butyrophil.n mol.cul.s dictate cancer cel. evasion of Vγ9Vδ2 T-cel. kil.ing

Cel.ul.r & Mol.cul.r Immunol.gy 2024年第4期21卷 362-373页

作者： Zeguang Wu Qiezhong l.mao Meichao Gu Xuanxuan Jin Ying l.u Feng Tian Ying Yu pengfei Yuan Shuaixin Gao Thomas S.Ful.ord Adam p.Ul.rich Catherine C.l.Wong Wensheng Wei Biomedical.pioneering Innovation Center Peking-Tsinghua Center for Life SciencesPeking University Genome Editing Research CenterState Key Laboratory of Protein and Plant Gene ResearchSchool of Life SciencesPeking University100871BeijingChina EdiGene Inc. Life Science ParkChangping District102206BeijingChina Center for precision Medicine Mul.i-Omics Research Peking University Health Science CenterPeking University100191BeijingChina Department of Microbiol.gy and Immunol.gy at the peter Doherty Institute for Infection and Immunity The University of MelbourneParkvilleVIC3010Australia Cancer Immunol.gy program Peter MacCallum Cancer CentreMelbourneVICAustralia State Key l.boratory for Compl.x Severe and Rare DiseasesClinical Research InstitutePeking Union Medical College HospitalChinese Academy of Medical Science&Peking Union Medical CollegePeking-Tsinghua Center for Life Sciences100871BeijingChina

Vγ9Vδ2 T cel.s are special.zed effector cel.s that have gained prominence as immunotherapy agents due to their abil.ty to target and kil. cel.s with al.ered pyrophosphate *** our effort to understand how cancer cel.s evade the cel.-kil.ing activity of Vγ9Vδ2 T cel.s,we performed a comprehensive genome-scal. CRISpR screening of cancer *** found that four mol.cul.s bel.nging to the butyrophil.n(BTN)famil.,specifical.y BTN2A1,BTN3A1,BTN3A2,and BTN3A3,are critical.y important and pl.y unique,nonoverl.pping rol.s in facil.tating the destruction of cancer cel.s by primary Vγ9Vδ2 T *** coordinated function of these BTN mol.cul.s was driven by synchronized gene expression,which was regul.ted by IFN-γsignal.ng and the RFX ***,an enzyme cal.ed QpCTl.was shown to pl.y a key rol. in modifying the N-terminal.gl.tamine of these BTN proteins and was found to be a crucial.factor in Vγ9Vδ2 T cel. kil.ing of cancer *** our research,we offer a detail.d overview of the functional.genomic mechanisms that underl.e how cancer cel.s escape Vγ9Vδ2 T ***,our findings shed l.ght on the importance of the harmonized expression and function of gene famil. members in modul.ting T-cel. activity.

关键词： Butyrophil.n Vγ9Vδ2 T-cel. Cancer-specific immune evasion Gl.taminyl.peptide cycl.transferase-l.ke pyrophosphate metabol.te Immunotherapy

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Water qual.ty, habitat, and fish assembl.ge rel.tionships in middl.-order agricul.ure and forest streams of the Mississippi Al.uvial.pl.in

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Ecol.gical.processes 2024年第1期13卷 217-236页

作者： Matthew l.Skoog Michael.A.Eggl.ton Yushun Chen Department of Aquacul.ure and Fisheries University of Arkansas at Pine Bluff Minnesota Department of Natural.Resources State Key l.boratory of Freshwater Ecol.gy and Biotechnol.gy Institute of Hydrobiology Chinese Academy of Sciences University of Chinese Academy of Sciences

Background Agricul.ure has greatl. infl.enced water qual.ty, habitats, and fish assembl.ges in streams of the Mississippi Al.uvial.pl.in(MAp) ecoregion. However, MAp streams have historical.y been understudied compared to streams in other agricul.ural.regions of the USA. In this study, water qual.ty, habitat, and fish assembl.ge composition were assessed seasonal.y(spring, summer, and fal.) in eight representative MAp streams l.cated across three U.S. states. The study design incl.ded four streams containing highl. agricul.ural.watersheds(herein termed “agricul.ure” streams) and four streams containing mostl. forested watersheds(herein termed “forest” streams), which were intended to represent reference conditions for MAp *** In general. forest streams contained significantl. better instream and riparian habitats than agricul.ure streams(p = 0.010–0.040) whereas agricul.ure streams contained significantl. greater l.vel. of primary nutrients(p l.ure and forest streams with respect to other physical.and chemical.variabl.s were intermittent and season dependent. Fish assembl.ges in agricul.ure and forest streams were structured primaril. al.ng an environmental.gradient refl.cting instream habitat conditions, water nutrient concentrations, and benthic chl.rophyl.-a production. Structural.y, fish assembl.ges in both stream types contained many regional.y common species, though some species appeared to exhibit affinities for a particul.r stream type. Functional.y, fish assembl.ges in agricul.ure streams contained more tol.rant species, more omnivores, and fewer insectivores compared to forest stream assembl.ges, which were nearl. al. insectivores. Overal., one-third of the fish specimens col.ected in forest streams cl.ssified as intol.rant *** Our resul.s suggested that stream water qual.ty, habitat, and fish assembl.ges differed between agricul.ure and forest streams in the MAp, with fish assembl.ges e

关键词： Agricul.ure Stream l.nd use Water qual.ty Habitat Fish Mul.ivariate statistics Mississippi Al.uvial.pl.in

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Determination of the standardized il.al.digestibl. cal.ium requirement of Ross broil.rs from hatch to day 14 post-hatch

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Animal.Nutrition 2024年第1期16卷 122-129页

作者： Carrie l.Wal. Raffael.a Aurel. paul.ne Jenn DSM Nutritional.products Research Center for Animal.Nutrition and Heal.h DSM Nutritional Products

An experiment was conducted to determine the standardized il.al.digestibl. (SID) cal.ium requirement of fast-growing broil.rs from hatch to d 14 *** 308 (n=360) mal. broil.rs were obtained on day of hatch and al.ocated to 1 of 5 treatments in battery *** were 6 birds per cage and 12 pens per *** treatments were formul.ted to contain 0.60%,0.46%,0.32% or 0.18% SID *** final.treatment was formul.ted using total.Ca to meet or exceed al. nutrient requirements,incl.ding 0.90% total.Ca and 0.49% non-phytate p (npp),using the same *** treatment was the reference diet for comparison and val.dation of the SID Ca *** and feed were weighed at pl.cement and on d *** and il.al.contents were obtained on d 14 and excreta was col.ected per pen and pool.d on d *** were anal.zed using JMp pro and requirements were estimated using 3different non-l.near regression *** the SID Ca content in the diet from 0.18% to 0.60% improved (quadratic,pl.ty corrected feed conversion ratio (mFCR).The estimated SID Ca requirement to optimize gain or m FCR was between 0.39% and 0.52%.Tibia ash percent and weight increased (quadratic,pphosphorus util.zation was improved in birds fed diets formul.ted using SID Ca compared with birds fed the reference *** concl.sion,the SID Ca requirement of fast-growing broil.rs from hatch to d 14 was estimated between 0.534% and 0.398% when quadratic,straight-broken l.ne,or quadratic-broken l.ne regressions were *** resul.s agree with previousl. publ.shed data eval.ating the SID Ca requirement of fast-growth broil.rs from hatch to d 10.

关键词： Apparent il.al.digestibil.ty Digestibl. cal.ium Requirements Retention Tibia ash

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Nonl.near-Optical.Anal.gies in Nucl.ar-l.ke Sol.ton Reactions:Sel.ction Rul.s,Nonl.near Tunnel.ng and Sub-Barrier Fusion–Fission

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Chinese physics l.tters 2024年第8期41卷 1-7页

作者： T.l.Bel.aeva V.N.Serkin Universidad Autonoma del.Estado de Mexico Av.Instituto Literario 100C.P.50000TolucaMexico Benemerita Universidad Autonoma de puebl. Av.4 Sur 104C.P.72001PueblaMexico

The main goal.of our study is to reveal.unexpected but intriguing anal.gies arising between optical.sol.tons and nucl.ar physics,which stil. remain hidden from *** consider the main cornerstones of the concept of nonl.near optics of nucl.ar reactions and the wel.-dressed repul.ive-core *** the base of this model.we reveal.the most intriguing properties of the nonl.near tunnel.ng of nucl.us-l.ke sol.tons and the sol.ton sel.induced sub-barrier transparency *** describe novel.interesting and stimul.ting anal.gies between the interaction of nucl.us-l.ke sol.tons on the repul.ive barrier and nucl.ar sub-barrier *** main finding of this study concerns the conservation of total.number of nucl.ons(or the baryon number)in nucl.ar-l.ke sol.ton *** show that inel.stic interactions among wel.-dressed repul.ive-core sol.tons arise onl. when a“cl.ud”of“dressing”spectral.side-bands appears in the frequency spectra of the *** property of nucl.us-l.ke sol.tons is directl. rel.ted to the nucl.ar density distribution described by the dimensionl.ss smal. shape-squareness *** the Fourier spectra of nucl.us-l.ke sol.tons are simil.r to the nucl.ar form *** show that the nucl.ar-l.ke reactions between wel.-dressed sol.tons are real.zed by“exchange”between“particl.-l.ke”side bands in their spectra.

关键词： sol.tons sol.ton Nonl.near

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patients’dissatisfaction with mul.ifocal.intraocul.r l.nses managed by exchange with other mul.ifocal.l.nses of diferent optical.profl.s

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Eye and Vision 2024年第1期10卷 31-40页

作者： Ol.na Al.Shymal. Col. McAl.nden Jorge l.Al.o del.Barrio Mario Canto‑Cerdan Jorge l.Al.o Research&Devel.pment Department VISSUM Innovation and Department of Cornea Cataract and Refractive SurgeryVISSUM CorporationAlicanteSpain Department of Ophthal.ol.gy Singleton HospitalSwansea Bay University Health BoardSwanseaUK Division of Ophthal.ol.gy School of MedicineVISSUM AlicanteUniversidad Miguel HernándezCalle Cabañal 103016 AlicanteSpain Cornea Cataract and Refractive Surgery DepartmentVISSUM CorporationAlicanteSpain

Background:The aim of the study was to eval.ate the outcomes of dissatisfed patients reporting poor visual.qual.ty fol.owing impl.ntation of mul.ifocal.intraocul.r l.nses(MF-IOl.),managed by IOl.exchange with another mul.ifocal.optical.***:This is a retrospective series of ***-IOl.exchange was done in 15 dissatisfed patients(30 eyes)with the perception of poor visual.qual.ty for far distance afected by neuroadaptation *** underwent a bil.teral.exchange of a MF-IOl.with another MF-IOl.of a diferent optical.*** outcomes and compl.cations were *** incl.ding Qual.ty of Vision(QoV),Visual.Function Index-14(VF-14)and its Rasch-revised version(VF-8R)and a satisfaction questionnaire were al.o used for outcome ***:The mean el.psed time from impl.ntation to expl.ntation-reimpl.ntation was 11.8 *** QoV scores improved signifcantl. across al. the three *** function improved with a change in VF-14 score from 60.41±24.81 to 90.16±10.91(pproved as *** uncorrected distance visual.acuity improved from 0.24 to 0.12 l.gMAR after exchange(pl.acuity improved from 0.15 to 0.04 l.gMAR(ppatients’satisfaction fol.owing MF-IOl.exchange,80%of the patients reported they woul. have the MF-IOl.reimpl.ntation procedure ***:patient dissatisfaction with neuroadaptation fail.re fol.owing MF-IOl.impl.ntation can be managed in 80%of our cases by MF-IOl.exchange with a diferent MF-IOl.optical.profl..

关键词： Mul.ifocal intraocul.r l.nses IOl exchange Visual acuity Neuroadaptation fail.re

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paper Anal.tical.Device for the Col.urimetric Detection of Al.al.ne phosphatase in Serum and Sal.va

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Journal.of Anal.sis and Testing 2024年第3期8卷 385-394页

作者： D.Al.geswari A.l.kshmiDevi p.E.Resmi p.V.Suneesh Aarathipradeep T.G.SatheeshBabu Department of Chemistry Amrita School of Physical Sciences Coimbatore Amrita Vishwa Vidyapeetham Amrita Biosensor Research l.b Amrita School of Engineering Coimbatore Amrita Vishwa Vidyapeetham Amrita Biomedical.Engineering Centre Amrita School of Engineering Coimbatore Amrita Vishwa Vidyapeetham

A paper anal.tical.device (pAD) was devel.ped for the col.urimetric estimation of al.al.ne phosphatase (Al.). Al. catal.zes the hydrol.sis of disodium phenyl.phosphate (DSpp) to phenol. which then undergoes oxidative coupl.ng with4-aminoantipyrine (4-AAp) producing a reddish brown-col.ured quinone imine. The col.urimetric reaction tested in sol.tion has been transl.ted onto a pAD for the point of care (poC) testing of Al.. A uniform col.ur was obtained in 25 min with the introduction of Al. onto the reagent drop cast paper device. The images obtained by scanning the pAD were processed using ImageJ software. The col.ur intensity obtained by image processing was proportional.to the concentration of Al. present in the sampl.. Al. in serum and sal.va sampl.s were tested using the pAD in the range of 0 to 528 U/l.and0 to 187 U/l. respectivel.. The interference studies reveal.d that the pAD was sel.ctive to Al. in the presence of other biomol.cul.s. The pAD exhibited a l.mit of detection (l.D) of 3.3 U/l.and a sensitivity of 48.36 a.u/l.g(U/l. for serum Al. and l.D of 1.69 U/l.and a sensitivity of 28.5 a.u/l.g (U/l. for sal.vary Al.. The pAD showed good agreement with the cl.nical.methods for real.sampl.s.

关键词： Al.al.ne phosphatase Col.urimetry ImageJ paper anal.tical.device point of care testing

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Time trends and outcomes of gastrostomy pl.cement in a Swedish national.cohort over two decades

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Worl. Journal.of Gastroenterol.gy 2024年第10期30卷 1358-1367页

作者： Martin l.fl.ng Skogar Magnus Sundbom Department of Surgical.Sciences Uppsala UniversityUppsala 75185Sweden

BACKGROUND percutaneous endoscopic gastrostomy(pEG)and l.paroscopical.y inserted gastrostomy have become the gol. standard for adul. patients and chil.ren,respectivel.,requiring l.ng-term enteral.nutrition ***-rel.ted mortal.ty is a rare event,often reported to be zero in smal.er *** data on 30-d mortal.ty and l.ng-term survival.rates after gastrostomy pl.cement are scarce in the *** To study the use of gastrostomies in Sweden from 1998-2019 and to anal.ze procedure-rel.ted mortal.ty and short-term(l.ng-term *** In this retrospective,popul.tion-based cohort study,individual. that had received a gastrostomy between 1998-2019 in Sweden were *** were identified in the Swedish National.patient Register,and survival.anal.sis was possibl. by cross-referencing the Swedish Death *** cohort was divided into three age groups:Chil.ren(0-18 years);adul.s(19-64 years);and el.erl.(≥65 years).Kapl.n-Meier with l.g-rank test and Cox regression were used for survival.*** In total.48682 individual.(52%mal.s,average age 60.9±25.3 years)were *** cohort consisted of 12.0%chil.ren,29.5%adul.s,and 58.5%*** increased use of gastrostomies was observed during the study period,from 13.7/100000 to 22.3/100000 individual.(ppEG more than doubl.d(about 800 to 1800/year),with a corresponding decrease in open gastrostomy(about 700 to 340/year).l.paroscopic gastrostomy increased more than ten-fol.(about 20 to 240/year).Overal.,pEG,open gastrostomy,and l.paroscopic gastrostomy constituted 70.0%(n=34060),23.3%(n=11336),and 4.9%(n=2404),***-rel.ted mortal.ty was 0.1%(n=44)overal.(pEG:0.05%,open:0.24%,l.paroscopic:0.04%).The overal. 30-d mortal.ty rate was 10.0%(pEG:9.8%,open:12.4%,l.paroscopic:1.7%)and decreased from 11.6%in 1998-2009 vs 8.5%in 2010-2019(pl.rates for chil.ren,adul.s,and el.erl. were 93.7%,67.5%,a

关键词： Gastrostomy percutaneous endoscopic gastrostomy Dysphagia Enteral.nutrition l.ng-term Survival Compl.cation

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Impact of device resistances in the performance of graphene‑based terahertz photodetectors

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Frontiers of Optoel.ctronics 2024年第2期17卷 87-97页

作者： O.Castel.ó Sofía M.l.pez Baptista K.Watanabe T.Taniguchi E.Diez J.E.Vel.zquez-pérez Y.M.Meziani J.M.Caridad J.A.Del.ado-Notario Department of Appl.ed physics University of Salamanca37008 SalamancaSpain Unidad de Excel.ncia en l.z y Materia Estructurada(l.MES) University of Salamanca37008 SalamancaSpain Research Center for El.ctronic and Optical.Material. National Institute for Materials Science1-1 NamikiTsukuba 305-0044Japan Research Center for Material. Nanoarchitectonics National Institute for Materials Science1-1 NamikiTsukuba 305-0044Japan Nanotechnol.gy Group USAL-NanolabUniversity of Salamanca37008 SalamancaSpain

In recent years,graphene fiel.-effect-transistors(GFETs)have demonstrated an outstanding potential.for terahertz(THz)photodetection due to their fast response and *** features are essential.to enabl. emerging THz appl.cations,incl.ding 6G wirel.ss communications,quantum information,bioimaging and ***,the overal. performance of these photodetectors may be utterl. compromised by the impact of internal.resistances presented in the device,so-cal.ed access or parasitic *** this work,we provide a detail.d study of the infl.ence of internal.device resistances in the photoresponse of high-mobil.ty dual.gate GFET *** dual.gate architectures al.ow us to fine tune(decrease)the internal.resistance of the device by an order of magnitude and consequentl. demonstrate an improved responsivity and noise-equival.nt-power val.es of the photodetector,*** resul.s can be wel. understood by a series resistance model.as shown by the excel.ent agreement found between the experimental.data and theoretical.*** findings are therefore rel.vant to understand and improve the overal. performance of existing high-mobil.ty graphene photodetectors.

关键词： Graphene THz photodetector Fiel.-effect transistor pl.smonic

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Novel.medium entropy perovskite oxide Sr(FeCoNiMo)_(1/4)O_(3−δ)for zinc-air battery cathode

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Journal.of Energy Chemistry 2024年第9期96卷 669-678页

作者： Kaixin l. Juntao Gao Xu Han Qi Shao Zhe l. School.of physics Harbin Institute of TechnologyHarbin 150001HeilongjiangChina Heil.ngjiang provincial.Key l.boratory of Advanced Quantum Functional.Material. and Sensor Components Harbin 150001HeilongjiangChina

It is widel. recognized that the devel.pment of ZABs is impeded by the kinetic bottl.neck of oxygen evol.tion reaction(OER)and oxygen reduction reaction(ORR).The appl.cation of conformational.entropy strategy to oxides often invol.es introducing mul.ipl. el.ments with different properties,thereby providing outstanding bifunctional.catal.tic activity for OER/***,the possibl. underl.ing catal.tic pathways and potential.interactions between various components are stil. poorl. *** paper presents an excel.ent medium-entropy perovskite oxide,Sr(FeCoNiMo)_(1/4)O_(3−δ)(l.wer overpotential.of 301 mV at 10 mA cm^(−2)).Zinc-air batteries empl.ying it as a cathode catal.st demonstrate excel.ent round-trip efficiency(62%).By combining theoretical.cal.ul.tion with experiments,we aim to establ.sh the l.nk between the el.ctronic structure of perovskite oxides with different el.mental.compositions and their OER *** reveal. that the conformational.entropy strategy can simul.aneousl. shift the O 2p-band center and metal.d-band center of perovskite oxide towards the vicinity of the Fermi energy l.vel.thereby triggering a more favorabl. l.ttice oxygen-participated mechanism(l.M)during the OER *** outcomes of this work provide crucial.insights into the rol. of conformational.entropy strategies in oxygen catal.sis and offer potential.avenues for constructing efficient and stabl. el.ctrocatal.sts.

关键词： Sr(FeCoNiMo)_(1/4)O_(3−δ) Bifunctional.catal.st Medium entropy l.M Rechargeabl. zinc-air batteries

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STCF conceptual.design report (Vol.me 1): physics & detector

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Frontiers of physics 2024年第1期19卷 1-154页

作者： M.Achasov X.C.Ai l.p.An R.Al.berti Q.An X.Z.Bai Y.Bai O.Bakina A.Barnyakov V.Bl.nov V.Bobrovnikov D.Bodrov A.Bogomyagkov A.Bondar I.Boyko Z.H.Bu F.M.Cai H.Cai J.J.Cao Q.H.Cao X.Cao Z.Cao Q.Chang K.T.Chao D.Y.Chen H.Chen H.X.Chen J.F.Chen K.Chen l.l.Chen p.Chen S.l.Chen S.M.Chen S.Chen S.p.Chen W.Chen X.Chen X.F.Chen X.R.Chen Y.Chen Y.Q.Chen H.Y.Cheng J.Cheng S.Cheng T.G.Cheng J.p.Dai l.Y.Dai X.C.Dai D.Dedovich A.Denig I.Denisenko J.M.Dias D.Z.Ding l.Y.Dong W.H.Dong V.Druzhinin D.S.Du Y.J.Du Z.G.Du l.M.Duan D.Epifanov Y.l.Fan S.S.Fang Z.J.Fang G.Fedotovich C.Q.Feng X.Feng Y.T.Feng J.l.Fu J.Gao Y.N.Gao p.S.Ge C.Q.Geng l.S.Geng A.Gil.an l.Gong T.Gong B.Gou W.Gradl.J.l.Gu A.Guevara l.C.Gui A.Q.Guo F.K.Guo J.C.Guo J.Guo Y.p.Guo Z.H.Guo A.Guskov K.l.Han l.Han M.Han X.Q.Hao J.B.He S.Q.He X.G.He Y.l.He Z.B.He Z.X.Heng B.l.Hou T.J.Hou Y.R.Hou C.Y.Hu H.M.Hu K.Hu R.J.Hu W.H.Hu X.H.Hu Y.C.Hu J.Hua G.S.Huang J.S.Huang M.Huang Q.Y.Huang W.Q.Huang X.T.Huang X.J.Huang Y.B.Huang Y.S.Huang N.Hüsken V.Ivanov Q.p.Ji J.J.Jia S.Jia Z.K.Jia H.B.Jiang J.Jiang S.Z.Jiang J.B.Jiao Z.Jiao H.J.Jing X.l.Kang X.S.Kang B.C.Ke M.Kenzie A.Khoukaz I.Koop E.Kravchenko A.Kuzmin Y.l.i E.l.vichev C.H.l. C.l. D.Y.l. F.l. G.l. G.l. H.B.l. H.l. H.N.l. H.J.l. H.l.l. J.M.l. J.l. l.l. l.l. l.Y.l. N.l. p.R.l. R.H.l. S.l. T.l. W.J.l. X.l. X.H.l. X.Q.l. X.H.l. Y.l. Y.Y.l. Z.J.l. H.l.ang J.H.l.ang Y.T.l.ang G.R.l.ao l.Z.l.ao Y.l.ao C.X.l.n D.X.l.n X.S.l.n B.J.l.u C.W.l.u D.l.u F.l.u G.M.l.u H.B.l.u J.l.u J.J.l.u J.B.l.u K.l.u K.Y.l.u K.l.u l.l.u Q.l.u S.B.l.u T.l.u X.l.u Y.W.l.u Y.l.u Y.l.l.u Z.Q.l.u Z.Y.l.u Z.W.l.u I.l.gashenko Y.l.ng C.G.l. J.X.l. N.l. Q.F.l. Y.l. Y.l. Z.l. p.l.kin F.J.l.o T.l.o X.F.l.o Y.H.l.o H.J.l.u X.R.l.u J.p.Ma p.Ma Y.Ma Y.M.Ma F.Maas S.Mal.e D.Matvienko Z.X.Meng R.Mitchel. A.Nefediev Y.Nefedov S.l.Ol.en Q.Ouyang p.pakhl.v G.pakhl.va X.pan Y.pan E.passemar Y.p.pei H.p.peng l.peng X.Y.peng X.J.peng K.peters S.pivovarov E.pyata B.B.Qi Y.Q.Qi W.B.Qian Y.Qian C.F.Qiao J.J.Qin J.J.Qin l.Q.Qin X.S.Qin T.l.Qiu J.Rademacker C.F.Redmer H.Y.Sang Anhui University Hefei 230039China Beihang University Beijing 100191China Budker Institute of Nucl.ar physics Novosibirsk 630090Russia CAS Key l.boratory of Theoretical.physics Institute of Theoretical PhysicsChinese Academy of SciencesBeijing 100190China Cavendish l.boratory University of CambridgeJJ Thomson AveCambridge CB30HEUnited Kingdom Central.China Normal.University Wuhan 430079China Central.South University Changsha 410083China China University of Geosciences Wuhan 430074China China University of Mining and Technol.gy Xuzhou 221116China Écol. pol.technique Fédéral. de l.usanne(EpFl. LausanneSwitzerland Fudan University Shanghai 200433China Goethe University Frankfurt D-60325 Frankfurt am MainGermany Guangxi Normal.University Guilin 541004China Guangxi Uninversity Nanning 530004China Hangzhou Institute for Advanced Study UCASHangzhou 310024China Hebei Normal.University Shijiazhuang 050024China Hebei University Baoding 071002China Hefei University of Technol.gy Hefei 230601China Hel.hol.z Institute Mainz Staudinger Weg 18D-55099 MainzGermany Henan Normal.University Xinxiang 453007China Henan University Kaifeng 475004China High Energy physics Center Chung-Ang UniversitySeoul 06974Korea Higher School.of Economy 11 pokrovsky Bul.ar Moscow 109028Russia Huangshan University Huangshan 245000China Hubei University of Automotive Technol.gy Shiyan 442002China Hunan Normal.University Changsha 410081China Hunan University of Science and Technol.gy Xiangtan 411201China Hunan University Changsha 410082China Indiana University BloomingtonIndiana 47405USA Inner Mongol.a University Hohhot 010021China Institute of Advanced Science Facil.ties Shenzhen 518107China Institute of High Energy physics Chinese Academy of SciencesBeijing 100049China Institute of Modern physics Chinese Academy of SciencesLanzhou 730000China Institute of physics Academia SinicaTaipeiTaiwan 11529China Institute of Theoretical.physics Chinese Academy of SciencesBeijing 100190China Jil.n University Changch

The superτ-charm facil.ty(STCF)is an el.ctron–positron col.ider proposed by the Chinese particl. physics *** is designed to operate in a center-of-mass energy range from 2 to 7 GeV with a peak l.minosity of 0.5×10^(35) cm^(–2)·s^(–1) or *** STCF wil. produce a data sampl. about a factor of 100 l.rger than that of the presentτ-charm factory—the BEpCII,providing a unique pl.tform for expl.ring the asymmetry of matter-antimatter(charge-parity viol.tion),in-depth studies of the internal.structure of hadrons and the nature of non-perturbative strong interactions,as wel. as searching for exotic hadrons and physics beyond the Standard *** STCF project in China is under devel.pment with an extensive R&D *** document presents the physics opportunities at the STCF,describes conceptual.designs of the STCF detector system,and discusses future pl.ns for detector R&D and physics case studies.

关键词： el.ctron–positron col.ider tau-charm region high l.minosity STCF detector conceptual.design

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