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Bioinformatics comprehensive analysis confirmed the potential involvement of SLC22A1 in lower-grade glioma progression and prognosis

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BIOCELL 2024年第5期48卷 803-815页

作者： JING HUI nana SUN YONG LIU CHUNBO YU YONG KE YONG CAO ANXIAO YU QINGHONG KONG YUN LIU Guizhou provincial College-Based Key Lab for Tumor prevention and Treatment with DistinctiveMedicines Zunyi Medical UniversityZunyi563000China College of Basic Medicine Zunyi Medical UniversityZunyi563000China Department of Dermatology Guizhou Province Cosmetic Plastic Surgery HospitalAffiliated Hospital of Zunyi Medical UniversityZunyi563000China School of Forensic Medicine Zunyi Medical UniversityZunyi563000China

Background:Although it has been established that the human Solute Carrier Family 22(SLC22)functions as a cationic transporter,influencing cellular biological metabolism by modulating the uptake of various cations,its impact on cancer prognosis remains ***:We conducted a comprehensive analysis utilizing data from The Cancer Genome Atlas(TCGA)and other databases to assess the prognostic value and functional implications across various *** of SLC22A1 RNA in glioma U251 cells was performed to access the impact of SLC22A1 on lowergrade glioma(LGG)***:Our findings demonstrated a significant correlation between SLC22A1 expression and the survival time of patients with various cancers(pportantly,we found the potential involvement of SLC22A1 in occurrence and progress of certain cancers,with a pronounced impact on *** examination of the SLC22A1-LGG relationship revealed its status as an independent risk factor for LGG,suggesting its potential involvement in regulating diverse immune pathways and metabolic *** Glioma Genome Atlas(CGGA)data supported the reliability of the risk score as a prognostic and recurrence indicator,emphasizing the accuracy of the nomograph(1,3,and 5-year-AUC>0.8).Cell proliferation and clone formation experiment proved that decreased expression of SLC22A1 in glioma U251 cells inhibited glioma cell ***:Our findings suggest SLC22A1 has huge prospects as a promising biomarker and therapeutic target for LGG ***22A1 has only been proved to support cellular function *** findings demonstrated a robust connection between the tumor microenvironment and functional proteins that maintain basal cell metabolism,which gifts unique tumor immune characteristics of ***,we provide a highly practical prediction model for estimating the survival rate of LGG patients.

关键词： SLC22A1 LGG prognosis immune nomogram

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Evaluation of bacterial contamination and medium-term oncological outcomes of intracorporeal anastomosis for colon cancer:A propensity score matching analysis

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World Journal of Gastrointestinal Surgery 2024年第3期16卷 670-680页

作者： Hajime Kayano nana Mamuro Yutaro Kamei Takashi Ogimi Hiroshi Miyakita Toshio Nakagohri Kazuo Koyanagi Masaki Mori Seiichiro Yamamoto Department of Gastroenterological Surgery Tokai University School of MedicineIsehara 259-1193KanagawaJapan

BACKGROUND Although intracorporeal anastomosis(IA)for colon cancer requires longer operative time than extracorporeal anastomosis(EA),its short-term postoperative results,such as early recovery of bowel movement,have been reported to be equal or *** IA requires opening the intestinal tract in the abdominal cavity under pneumoperitoneum,there are concerns about intraperitoneal bacterial infection and recurrence of peritoneal dissemination due to the spread of bacteria and tumor ***,intraperitoneal bacterial contamination and medium-term oncological outcomes have not been *** cavity in *** Of 127 patients who underwent laparoscopic colon resection for colon cancer from April 2015 to December 2020,75 underwent EA(EA group),and 52 underwent IA(IA group).After propensity score matching,the primary endpoint was 3-year disease-free survival rates,and secondary endpoints were 3-year overall survival rates,type of recurrence,surgical site infection(SSI)incidence,number of days on antibiotics,and postoperative biological *** Three-year disease-free survival rates did not significantly differ between the IA and EA groups(87.2%and 82.7%,respectively,p=0.4473).The 3-year overall survival rates also did not significantly differ between the IA and EA groups(94.7%and 94.7%,respectively;p=0.9891).There was no difference in the type of recurrence between the two *** addition,there were no significant differences in SSI incidence or the number of days on antibiotics;however,postoperative biological responses,such as the white blood cell count(10200 vs 8650/mm^(3),p=0.0068),C-reactive protein(6.8 vs 4.5 mg/dL,p=0.0011),and body temperature(37.7 vs 37.5℃,p=0.0079),were significantly higher in the IA *** IA is an anastomotic technique that should be widely performed because its risk of intraperitoneal bacterial contamination and medium-term oncological outcomes are comparable to those of EA.

关键词： Colon cancer Intracorporeal anastomosis 3-year disease-free survival Recurrence Surgical site infection postoperative biological response

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ALS-linked C9orf72 dipeptide repeats inhibit starvation-induced autophagy through modulating BCL2–BECN1 interaction

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Acta pharmaceutica Sinica B 2024年第5期14卷 2026-2038页

作者： Shiqiang Xu Qilian Ma Junwen Shen Ningning Li Shan Sun nana Wang Yang Chen Chunsheng Dong Kin Yip Tam Jochen H.M.prehn Hongfeng Wang Zheng Ying Jiangsu Key Laboratory of Neuropsychiatric Diseases and College of pharmaceutical Sciences Soochow UniversitySuzhou 215123China MOE Key Laboratory of Geriatric Diseases and Immunology College of Pharmaceutical SciencesSuzhou Medical College of Soochow UniversitySuzhou 215123China Jiangsu province Engineering Research Center of precision Diagnostics and Therapeutics Development Soochow UniversitySuzhou 215123China Dept.of physiology&Medical physics and FUTURE-NEURO Research Centre Royal College of Surgeons in IrelandDublin D02 YN77Ireland Faculty of Health Sciences University of MacaoTaipaMacao 999078China Insititutes of Biology and Medical Science Soochow UniversitySuzhou 215123China

Growing evidences indicate that dysfunction of autophagy contributes to the disease pathogenesis of amyotrophic lateral sclerosis(ALS)and frontotemporal dementia(FTD),two neurodegenerative *** GGGGCC·GGCCCC repeat RNA expansion in chromosome 9 open reading frame 72(C9orf72)is the most genetic cause of both ALS and *** to the previous studies,GGGGCC·GGCCCC repeat undergoes the unconventional repeat-associated non-ATG translation,which produces dipeptide repeat(DpR)*** there is a growing understanding that C9orf72 DpRs have a strong ability to harm neurons and induce C9orf72-linked ALS/FTD,whether these DpRs can affect autophagy remains *** the present study,we find that poly-GR and poly-pR,two arginine-containing DpRs which display the most cytotoxic properties according to the previous studies,strongly inhibit starvation-induced ***,our data indicate that arginine-rich DpRs enhance the interaction between BCL2 and BECN1/Beclin 1 by inhibiting BCL2 phosphorylation,therefore they can impair autophagic clearance of neurodegenerative disease-associated protein aggregates under starvation condition in ***,our study not only highlights the role of C9orf72 DpR in autophagy dysfunction,but also provides novel insight that pharmacological intervention of autophagy using SW063058,a small molecule compound that can disrupt the interaction between BECN1 and BCL2,may reduce C9orf72 DpR-induced neurotoxicity.

关键词： Amyotrophic lateral sclerosis Frontotemporal dementia C9orf72 Autophagy BCL2 BECN1/Beclin 1 Dipeptide repeat Neurodegeneration

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IRE1α regulates the pTHrp-IHH feedback loop to orchestrate chondrocyte hypertrophy and cartilage mineralization

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Genes & Diseases 2024年第1期11卷 464-478页

作者： Mengtian Fan nana Geng Xingyue Li Danyang Yin Yuyou Yang Rong Jiang Cheng Chen Naibo Feng Li Liang Xiaoli Li Fengtao Luo Huabing Qi Qiaoyan Tan Yangli Xie Fengjin Guo Laboratory of Developmental Biology Department of Cell Biology and GeneticsSchool of Basic Medical ScienceChongqing Medical UniversityChongqing 400016China Laboratory of Stem Cells and Tissue Engineering School of Basic Medical ScienceChongqing Medical UniversityChongqing 400016China Department of Orthopedics The 1st Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China Department of Wound Repair and Rehabilitation Medicine State Key Laboratory of TraumaBurns and Combined InjuryTrauma CenterResearch Institute of SurgeryDaping HospitalArmy Medical UniversityChongqing 400042China

Cartilage development is controlled by the highly synergistic proliferation and differentiation of growth plate chondrocytes,in which the Indian hedgehog(IHH)and parathyroid hormone-related protein-parathyroid hormone-1 receptor(pTHrp-pTH1R)feedback loop is *** inositol-requiring enzyme 1a/X-box-binding protein-1 spliced(IRE1α/XBp1s)branch of the unfolded protein response(UpR)is essential for normal cartilage ***,the precise role of ER stress effector IRE1α,encoded by endoplasmic reticulum to nucleus signaling 1(ERN1),in skeletal development remains ***,we reported that loss of IRE1α accelerates chondrocyte hypertrophy and promotes endochondral bone ***1 acts as a negative regulator of chondrocyte proliferation and differentiation in postnatal growth *** deficiency interrupted pTHrp/pTH1R and IHH homeostasis leading to impaired chondrocyte hypertrophy and ***1s,produced by p-IRE1α-mediated splicing,binds and up-regulates pTH1R and IHH,which coordinate cartilage ***,ER stress cannot be activated normally in ERN1-deficient *** conclusion,ERN1 deficiency accelerates chondrocyte hypertrophy and cartilage mineralization by impairing the homeostasis of the IHH and pTHrp/pTH1R feedback loop and ER ***1 may have a potential role as a new target for cartilage growth and maturation.

关键词： Cartilage development ER stress ERN1 IHH pTHrp/pTH1R

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predictors and Complications of prematurity in Two Health Facilities in Fako Division, Southwest Region, Cameroon

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Open Journal of pediatrics 2024年第3期14卷 630-644页

作者： Naiza Monono Verla Sissi Kamo Helen Nguepong Vianney nana Njamen Department of Internal Medicine and paediatrics Faculty of Health Sciences University of Buea Buea Cameroon Regional Hospital Limbe Southwest Region Cameroon Department of paediatrics Faculty of Medicine and Biomedical Sciences University of Garoua Garoua Cameroon Department of Obstetrics and Gynaecology Faculty of Health Sciences University of Buea Buea Cameroon

Background: prematurity is the leading cause of neonatal mortality. Most preterm births can be associated to an identifiable risk factor. In Cameroon, especially in the Southwest Region, there is limited data regarding prematurity associated risk factors. The aim of this study was to evaluate the risk factors and complications of prematurity in two health facilities in the Fako division, the BRH and RHL. Methods: A hospital based retrospective case control study was done from the 1p>stp> of January 2021 to 28p>thp> of February 2022. We assessed the gestational ages at which preterm birth occurred and their short-term outcome using a structured pretested questionnaire to collect data from files. Data was analyzed using Statistical package for Social Sciences (SpSS) version 26. Results: The minimum sample size was 137 preterms. 45.5% of cases were born between 34 and increased the risk of having a preterm birth meanwhile being married (AOR: 0.410;95% CI: 0.217 - 0.773;p = 0.006) decreased the risk. Hospital complications were neonatal infection 103 (51.5%), respiratory distress 79 (39.5%) and neonatal jaundice 61 (30.50%). Among the cases, 97 (48.50%) stayed in the hospital for 2 to 4 weeks and 177 (88.5%) were discharged alive. Conclusions: Modifiable factors that increased the risk of prematurity were advanced maternal age, secondary level of education, rural residence, and prenatal alcohol consumption. Being married decreased the risk. The most common hospital complications in both the cases and controls were neonatal infection, respiratory distress syndrome and neonatal jaundice.

关键词： prematurity Gestational Age Risk Factors Complications Outcome

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不同类型重构土壤水分运移特征

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农业工程学报 2024年第3期40卷 94-102页

作者：郭拿拿黄明斌西北农林科技大学资源环境学院杨凌712100 西北农林科技大学水土保持研究所/黄土高原土壤侵蚀与旱地农业国家重点实验室杨凌712100

为探究不同类型重构土壤对水分再分布过程和土壤持水量的影响,该研究以砒砂岩、砂黄土和粗砂土为试验材料进行室内土柱试验,设置5种不同类型重构土壤(砒-粗、砂-粗、砒-砂-粗、砂-砒-粗、混-粗),测定各处理在入渗过程、排水过程以及蒸... 详细信息

为探究不同类型重构土壤对水分再分布过程和土壤持水量的影响,该研究以砒砂岩、砂黄土和粗砂土为试验材料进行室内土柱试验,设置5种不同类型重构土壤(砒-粗、砂-粗、砒-砂-粗、砂-砒-粗、混-粗),测定各处理在入渗过程、排水过程以及蒸发过程中土壤水分的动态变化;同时利用Hydrus-1D模型对不同类型重构土壤的入渗和蒸发过程进行模拟分析。结果表明,有砒砂岩层存在的重构土体对入渗过程有明显阻滞作用,且砒砂岩层越厚、位置越靠上阻滞效果越明显,土柱达到稳渗时稳渗率越低;蒸发过程中,砒-砂-粗处理累积蒸发量为52 mm,显著高于其他重构土壤(p<0.05),而砂-砒-粗处理土柱累积蒸发量最小(32.1 mm),蒸发结束时相对蒸发速率低至0.07;在蒸发过程中,上细下粗型层状重构土壤水分损失来自表层土壤和下层粗砂土。利用优化后的土壤水力参数和Hydrus-1D模型可以较好地模拟重构土壤水分运动过程。较低的均方根误差和高的决定系数证明模型能准确模拟各类型土柱的累积排水量、累积蒸发量和蒸发过程剖面含水量的动态变化。混-粗土柱的持水能力高于其他土柱,说明该重构类型可作为晋陕蒙地区土壤复垦的重构方案。

关键词：土壤入渗过程蒸发过程土壤持水量 Hydrus-1D模型模拟

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蒸谷处理对糙米和白米食用品质、糊化性质和体外消化性质的影响

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浙江大学学报（农业与生命科学版） 2024年第3期50卷 443-454页

作者：赵康程谭斌李森吴娜娜国家粮食和物资储备局科学研究院北京100037 上海理工大学健康科学与工程学院上海200093

本研究对糙米、白米、蒸谷米糙米、蒸谷米白米的食用品质、糊化性质和体外消化性质进行分析。结果表明:蒸谷米糙米和蒸谷米白米的白度分别低于糙米和白米。蒸谷米糙米和蒸谷米白米的食味值(包括米饭食味值、生米食味值)分别低于糙米和白... 详细信息

本研究对糙米、白米、蒸谷米糙米、蒸谷米白米的食用品质、糊化性质和体外消化性质进行分析。结果表明:蒸谷米糙米和蒸谷米白米的白度分别低于糙米和白米。蒸谷米糙米和蒸谷米白米的食味值(包括米饭食味值、生米食味值)分别低于糙米和白米,并且蒸谷米白米的米饭食味值为70.95±3.72,显著高于蒸谷米糙米(36.13±1.53,ppidly digestible starch, RDS)含量和血糖生成指数(glycemic index, GI)降低,缓慢消化淀粉(slowly digestible starch, SDS)、抗性淀粉(resistant starch, RS)含量有所升高。与白米相比,经过蒸谷处理得到的蒸谷米白米白度、米饭食味值、焓变均显著降低,且蒸谷米白米的体外消化率、RDS含量和GI降低,SDS、RS含量也有所升高。本研究可为营养健康米制品的研发提供一定基础。

关键词：蒸谷米糙米食用品质糊化消化性质

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支气管哮喘患儿上呼吸道菌群和炎症因子水平变化与病情严重程度的关系

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中国微生态学杂志 2024年第2期36卷 191-195,200页

作者：孟娜娜孙璐黄诚花肇庆医学高等专科学校儿科教研室广东肇庆526000 广州市妇女儿童医疗中心儿科肇庆市第一人民医院儿科

目的探讨支气管哮喘患儿上呼吸道菌群和炎症因子水平变化情况并分析二者与患儿病情严重程度的关系,为临床评估支气管哮喘患儿病情严重程度提供参考指标。方法选取肇庆市第一人民医院2018年10月至2022年6月收治的支气管哮喘患儿103例作... 详细信息

目的探讨支气管哮喘患儿上呼吸道菌群和炎症因子水平变化情况并分析二者与患儿病情严重程度的关系,为临床评估支气管哮喘患儿病情严重程度提供参考指标。方法选取肇庆市第一人民医院2018年10月至2022年6月收治的支气管哮喘患儿103例作为研究组,另选同时间段在我院进行健康体检的健康儿童60例作为对照组,并根据病情严重程度将研究组患儿分为轻症、重症两个亚组。检测患儿上呼吸道菌群多样性与血清中C反应蛋白(CRp)、白细胞介素-6(IL-6)、肿瘤坏死因子(TNF)-α水平,分析以上指标与病情严重程度的关系。结果与对照组比较,研究组患儿呼吸道菌群Simpson指数,血清CRp、IL-6、TNF-α水平均显著升高,呼吸道菌群Shannon指数显著降低(t=52.413、35.293、36.088、34.930、29.248,均ppson指数,血清CRp、IL-6、TNF-α水平均显著高于轻症组,呼吸道菌群Shannon指数显著低于轻症组(t=11.599、11.898、12.699、11.335、12.309,均ppearman相关性分析显示,呼吸道菌群Simpson指数、血清CRp、IL-6、TNF-α水平与病情严重程度均呈正相关(r=0.197、0.228、0.264、0.287,p=0.046、0.020、0.007、0.003),呼吸道菌群Shannon指数与支气管哮喘病情严重程度呈负相关(r=-0.270,p=0.006)。ROC曲线显示,呼吸道菌群Simpson、Shannon指数和血清CRp、IL-6、TNF-α水平以及联合检测对支气管哮喘患儿病情严重程度预测的曲线下面积(AUC)分别为0.615、0.658、0.634、0.654、0.668、0.863,联合检测对支气管哮喘患儿病情严重程度的预测价值更高。结论支气管哮喘患儿上呼吸道菌群多样性及炎症因子水平显著升高,且患儿病情程度越严重,其水平变化越显著,二者联合检测对患儿支气管哮喘严重程度具有较高预测价值。

关键词：支气管哮喘呼吸道菌群炎症疾病严重程度

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基于Akt/mTOR通路研究地榆皂苷Ⅱ诱导肝癌细胞凋亡和自噬作用机制

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中草药 2024年第11期55卷 3726-3734页

作者：朱晓敏钟颖黄娜娜孙蓉山东大学第二医院山东济南250033 山东大学高等医学研究院山东济南250012

目的探讨地榆皂苷Ⅱ抑制肝癌细胞增殖、诱导肝癌细胞凋亡和自噬的作用机制。方法采用不同浓度(0、10、20、40μmol/L)地榆皂苷Ⅱ处理人肝癌HepG2细胞和小鼠肝癌Hepa1-6细胞,通过CCK-8和EdU实验观察地榆皂苷Ⅱ对HepG2和Hepa1-6细胞增殖... 详细信息

目的探讨地榆皂苷Ⅱ抑制肝癌细胞增殖、诱导肝癌细胞凋亡和自噬的作用机制。方法采用不同浓度(0、10、20、40μmol/L)地榆皂苷Ⅱ处理人肝癌HepG2细胞和小鼠肝癌Hepa1-6细胞,通过CCK-8和EdU实验观察地榆皂苷Ⅱ对HepG2和Hepa1-6细胞增殖的影响;运用流式细胞术检测地榆皂苷Ⅱ对细胞凋亡的影响;通过Western blotting检测地榆皂苷Ⅱ对细胞凋亡和自噬相关蛋白半胱氨酸天冬氨酸蛋白酶-3(cysteine-aspartic acid protease-3,Caspase-3)、Caspase-8、Caspase-9、B细胞淋巴瘤2(B-cell lymphoma-2,Bcl-2)、Bcl-2相关X蛋白(Bcl-2-associated X protein,Bax)、cleaved Caspase-3、微管相关蛋白1A/1B-轻链3-Ⅱ(microtubule-associated protein light chain3-Ⅱ,LC3Ⅱ)、微管相关蛋白1A/1B-轻链3-Ⅰ(microtubule-associated protein light chain3-Ⅰ,LC3Ⅰ)、自噬相关蛋白p62、Beclin1及蛋白激酶B(protein kinase B,Akt)/哺乳动物雷帕霉素靶蛋白(mammalian target of rapamycin,mTOR)通路关键蛋白表达的影响。结果地榆皂苷Ⅱ显著抑制HepG2和Hepa1-6细胞活力,且呈现一定的剂量相关性;流式细胞检测发现地榆皂苷Ⅱ给药后细胞凋亡率显著增加(ppase-3、Caspase-8、Caspase-9、Bcl-2表达显著降低(ppase-3、Bax蛋白表达显著升高(pppp62蛋白表达量显著下降(pp-Akt/Akt、p-mTOR/mTOR值显著降低(ppG2和Hepa1-6细胞自噬和凋亡实现对肝癌细胞增殖的抑制,为抗肝细胞癌新药发现提供药理学证据。

关键词：地榆皂苷Ⅱ 增殖凋亡自噬肝细胞癌 Akt/mTOR

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Substitution of Aggregates in Concrete and Mortar with Coltan Mining Waste: Mechanical, Environmental, and Economic Impact Case Study

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Journal of Minerals and Materials Characterization and Engineering 2024年第2期12卷 139-163页

作者： Alinabiwe Nyamuhanga Ally Élodie Ruffine Zang Masika Muhiwa Grâce Manjia Marcelline Blanche Ursula Joyce Merveilles pettang nana Ngapgue François Bella Nabil Chrispin pettang Laboratory Engineering Civil and Mechanics Doctoral Research Unit for Engineering and Applications University of Yaound&#233 I Yaound&#233 Cameroon Department of Civil Engineering Faculty of Applied Sciences and Technologies Free University of Great Lakes Countries (ULPGL) Goma DRC Department of Civil Engineering National Advanced School of Engineering of Yaoundé University of Yaoundé I Yaoundé Cameroon Department of Civil Engineering Fotso Victor University Institute of Technology University of Dschang Bandjoun Cameroon FIMAS Laboratory Faculty of Technologies Tahri Mohamed University Bechar Algeria

The mining process involves drilling and excavation, resulting in the production of waste rock and tailings. The waste materials are then removed and stored in designated areas. This study aims to evaluate the mechanical strength and the environmental and economic impact of using Coltan Mining Waste (CMW) as a substitute for aggregates in concrete and mortar production. To achieve this, the CMW needs to be characterised. The Dreux Gorisse method was primarily used to produce concrete with a strength of 20 Mpa at 28 days. The mortars, on the other hand, were formulated according to the NF p 18-452 standard. The environmental impact of using CMW as substitutes for natural aggregates in the production of concrete and mortar was analysed using Simapro software. The results showed that mortars and concrete made with CMW have comparable compressive strengths to the reference mortar and concrete;reduce the negative impact on ecosystem quality, human health, resources, and climate change. It has also been shown that the substitution of aggregates by CMW reduces the cost of concrete and mortar as a function of the distance from the aggregate footprint.

关键词： Aggregate Coltan Mining Waste Concrete Mortar Mechanical Strength Life Cycle Analysis

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