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Asian pacific Journal of Reproduction 2024年第2期13卷 60-67页

作者： yasmin sabina sa’diah Agung Dewanto Lukman A Chandra Department of Obstetrics and Gynecology Faculty of MedicinePublic Health and NursingUniversitas Gadjah MadaYogyakartaIndonesia Department of pharmacology and Therapy Faculty of MedicinePublic Health and NursingUniversitas Gadjah MadaYogyakartaIndonesia

Objective:To conduct a systematic examination and meta-analysis of the most reliable data from experimental studies evaluating the efficacy of autologous platelet-rich plasma(pRp)on low ovarian ***:A comprehensive search was performed utilizing pertinent search terms across electronic databases,including pubMed,Cochrane,and Google *** included studies that assigned infertile women with low ovarian reserve in experimental *** reserve parameters were measured before and after pRp injection into *** data of each study was retrieved and subsequently ***:Of 301 articles collected and reviewed,six studies were finally included in the *** pRp injection,infertile women showed a non-significant increase in anti-Mullerian hormone(AMH)level(MD=0.10;95%CI-0.04,0.23),a significant increase in antral follicular count(AFC)(MD=1.88;95%CI 0.47,3.29),and a non-significant reduction in follicle-stimulating hormone(FSH)level(MD=-0.22;95%CI-8.32,7.87).Conclusions:Autologous pRp may increase AFC,but not *** it is found beneficial in enhancing ovarian reserve(AFC),further research with strong evidence is still required.

关键词： platelet-rich plasma Low ovarian reserve Ovarian rejuvenation

Application of pDCA in improving hand hygiene compliance and nosocomial infection quality in orthopedics

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Frontiers of Nursing 2024年第3期11卷 327-336页

作者： ya-ping Su Rui-Ling Li Yuan-Yuan Wang Yu-Rui Zhang ya-Jie Ji Nursing Teaching and Research Department School of Nursing and HealthHenan UniversityKaifengHenan 475004China Department of Continuing Education The First Affiliated Hospital of Henan UniversityKaifengHenan 475000China

Objective:To explore the effect of the plan-Do-Check-Action(pDCA)cycle on hand hygiene and nosocomial infection quality of or thopedic medical ***:The whole year of 2021 was selected to monitor the quality of hand hygiene and ***-up monitoring and real-time recording during the period of morning shift and medical operation concentration time,and compare the compliance of hand hygiene before and after implementation,and evaluate the quality of nosocomial ***:The hand hygiene compliance of doctors and nurses in stage p was 82%.The compliance of medical staff in stage D was 93%.The compliance of stage C was 94%and that of stage A was 95%.The quality score of hospital self-examination nosocomial infection was also significantly ***:The pDCA management cycle can effectively improve the compliance of hand hygiene and the nosocomial infection quality,which is wor thy of circulatory application in or thopedic nosocomial infection quality control,especially improving the quality of hand hygiene.

关键词： hand hygiene quality improvement pDCA nosocomial infection infection control nursing management

Viscosity and structure of CaO-BaO-SiO_(2)-Al_(2)O_(3)-based mold slags for continuous casting of high titanium steel with different Tio2 absorption

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Journal of Iron and Steel Research International 2024年第8期31卷 1936-1946页

作者： ya-tao Cui Xue-you Wang Xu-bin Zhang Qiang-qiang Wang Sheng-ping He College of Materials Science and Engineering Chongqing UniversityChongqing 400044China

The effect of TiO_(2) absorption into two different CaO-BaO-SiO_(2)-Al_(2)O_(3)-based mold slags from the steel plant on the viscosity,melting performance and microstructure of slags was investigated through the measurement of the viscosity-temperature relationship,melting temperature and raman *** parameter of the number of non-bridging oxygen per tetrahedrally-coordinated atom(NBO/T)was also calculated to explain the microstructure variation of molten slags with different TiO_(2) *** variation of the actual slag consumption and the depth of the liquid slag in mold was explained through the comparison of the viscosity and the melting temperature of two different *** viscosity of mold slags(basicity=0.6)decreased from 1.1 to 0.68 pa s with the increase in the Ti0_(2) absorption from 0 to 10%,while that of slags(basicity=0.7)decreased from 0.76 to 0.56 pa s with the Ti0_(2) absorption from 0 to 6%.The activation energy of both two groups of slags had the tendency to decrease with the increasing TiO_(2) *** network structure of both two groups of slags measured by the raman spectra showed that the fraction of complex structure units(Q^(1),Q^(2),Q^(3) and A1-O-Al)decreased and simple structure units(Al-O-and Q^(0))increased with the increase in TiO_(2) ***/T also increased with the increase in the TiO2 absorption,indicating that the absorption of TiO_(2) into slags resulted in the destruction of silicate/aluminate ***,the absorption of TiO_(2) into the current CaO-BaO-SiO_(2)-Al_(2)O_(3) mold slags decreased the degree of polymerization of these slags and then led to the decrease of viscosity.

关键词： Mold slag Viscosity Melting temperature Slag consumption Liquid slag depth Structure

Advances in targeted therapy for human epidermal growth factor receptor 2 positive in advanced gastric cancer

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World Journal of Gastrointestinal Oncology 2024年第6期16卷 2318-2334页

作者： ya-Kun Jiang Wei Li Ying-yang Qiu Meng Yue Department of Gastroenterology Central Hospital Affiliated to Shandong First Medical UniversityJinan 250013Shandong ProvinceChina Health Management Center Central Hospital Affiliated to Shandong First Medical UniversityJinan 250013Shandong ProvinceChina Yong Loo Lin School of Medicine National University of SingaporeSingapore 119077Singapore

Emerging therapeutic methods represented by targeted therapy are effective supplements to traditional first-line chemoradiotherapy *** epidermal growth factor receptor 2(HER2)is one of the most important targets in targeted therapy for gastric *** combined with chemotherapy has been used as the first-line treatment for advanced gastric *** safety and efficacy of pertuzumab and margetuximab in the treatment of gastric cancer have been ***,monoclonal antibodies,due to their large molecular weight,inability to penetrate the blood-brain barrier,and drug resistance,lead to decreased therapeutic efficacy,so it is necessary to explore the efficacy of other HER2-targeting therapies in gastric ***-molecule tyrosine kinase inhibitors,such as lapatinib and pyrrotinib,have the advantages of small molecular weight,penetrating the blood-brain barrier and high oral bioavailability,and are expected to become the drugs of choice for perioperative treatment and neoadjuvant therapy of gastric cancer after validation by large-scale clinical trials in the ***-drug conjugate,such as T-DM1 and T-DXd,can overcome the resistance of monoclonal antibodies despite their different mechanisms of tumor killing,and are a supplement for the treatment of patients who have failed the treatment of monoclonal antibodies such as ***,after more detailed stratification of gastric cancer patients,various gastric cancer drugs targeting HER2 are expected to play a more significant role.

关键词： Human epidermal growth factor receptor 2 Gastric cancer Targeted therapy Review

Acupuncture for obesity and related diseases:Insight for regulating neural circuit

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Journal of Integrative Medicine 2024年第2期22卷 93-101页

作者： Lin-yan Jiang Jun Tian ya-nan yang Shao-hui Jia Qing Shu Department of Rehabilitation Medicine Zhongnan HospitalWuhan UniversityWuhan 430071Hubei ProvinceChina School of Sports Medicine Wuhan Sports UniversityWuhan 430079Hubei ProvinceChina Department of Traditional Chinese Medicine China Resources&Wu Gang General HospitalWuhan 430080Hubei ProvinceChina

Obesity is defined as abnormal or excessive fat accumulation that may impair *** is associated with numerous pathological changes including insulin resistance,fatty liver,hyperlipidemias,and other obesity-related *** comorbidities comprise a significant public health *** anti-obesity drugs have been limited by side effects that include depression,suicidal thoughts,cardiovascular complications and *** treatment has been shown to be effective for treating obesity and obesity-related conditions,while avoiding side ***,the mechanisms of acupuncture in treating obesity-related diseases,especially its effect on neural circuits,are not well understood.A growing body of research has studied acupuncture’s effects on the endocrine system and other mechanisms related to the regulation of neural *** this article,recent research that was relevant to the use of acupuncture to treat obesity and obesity-related diseases through the neuroendocrine system,as well as some neural circuits involved,was *** on this,acupuncture’s potential ability to regulate neural circuits and its mechanisms of action in the endocrine system were reviewed,leading to a deeper mechanistic understanding of acupuncture’s effects and providing insight and direction for future research about obesity.

关键词： Obesity Acupuncture Neural circuit Appetite Energy metabolism

Clinical features and prognostic factors of duodenal neuroendocrine tumours:A comparative study of ampullary and nonampullary regions

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World Journal of Gastrointestinal Oncology 2024年第3期16卷 907-918页

作者： sa Fang Yu-peng Shi Lu Wang Shuang Han Yong-Quan Shi Department of Gastroenterology Honghui HospitalXi’an Jiaotong UniversityXi'an 710054Shanxi ProvinceChina Department of Gastroenterology The Second Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710032Shaanxi ProvinceChina Department of Gastroenterology Xijing Hospital Affiliated to Air Force Medical UniversityXi'an 710032Shaanxi ProvinceChina

BACKGROUND Duodenal neuroendocrine tumours(DNETs)are rare ***,the incidence of DNETs has been increasing in recent years,especially as an incidental finding during endoscopic ***,there is no consensus regarding the ideal treatment of *** there are few studies on the clinical features and survival analysis of *** To analyze the clinical characteristics and prognostic factors of patients with duodenal neuroendocrine *** The clinical data of DNETs diagnosed in the First Affiliated Hospital of Air Force Military Medical University from June 2011 to July 2022 were ***-docrine tumours located in the ampulla area of the duodenum were divided into the ampullary region group;neuroendocrine tumours in any part of the duo-denum outside the ampullary area were divided into the nonampullary region *** a retrospective study,the clinical characteristics of the two groups and risk factors affecting the survival of DNET patients were *** Twenty-nine DNET patients were *** male to female ratio was 1:1.9,and females comprised the *** ampullary region group accounted for 24.1%(7/29),while the nonampullary region group accounted for 75.9%(22/29).When diagnosed,the clinical symptoms of the ampullary region group were mainly abdominal pain(85.7%),while those of the nonampullary region groups were mainly abdominal distension(59.1%).There were differences in the composition of staging of tumours between the two groups(Fisher's exact probability method,p=0.001),with nonampullary stage II tumours(68.2%)being the main stage(prate of the ampullary region group was 14.3%(1/7),which was lower than that of 72.7%(16/22)in the nonampullary region group(Fisher's exact probability method,p=0.011).The survival time of the ampullary region group was shorter than that of the nonampullary region group(ppullary

关键词： Duodenum Neuroendocrine Tumour Ampullary Nonampullary Clinical features prognostic

Honokiol prevents Intestinal Barrier Dysfunction in Mice with Severe Acute pancreatitis and Inhibits JAK/STAT1 pathway and Acetylation of HMGB1

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Chinese Journal of Integrative Medicine 2024年第6期30卷 534-542页

作者： LI Jie CHEN ya-feng GAO Lei LI Yi-jie FENG Dian-xu Department of General Surgery Putuo HospitalShanghai University of Traditional Chinese MedicineShanghai200062China

Objective To investigate the effect of honokiol(HON)and the role of high-mobility group protein B1(HMGB1)on the pathogenesis of severe acute pancreatitis(sap).Methods Thirty mice were numbered according to weight,and randomly divided into 5 groups using a random number table,including control,sap,sap and normal saline(sap+NS),sap and ethyl pyruvate(sap+Ep),or sap+HON groups,6 mice in each *** of pancreas,intestine,and blood were collected 12 h after sap model induction for examination of pathologic changes,immune function alterations by enzyme linked immunosorbent assay(ELIsa),and Western *** vitro experiments,macrophages were divided into 5 groups,the control,lipopolysaccharide(LpS),LpS+DMSO(DMSO),LpS+anti-HMGB1 monoclonal antibody(mAb),and LpS+HON *** tight connection level was determined by transmission electron microscopy and fluorescein *** location and acetylation of HMGB1 were measured by Western ***,pyridone 6 and silencing signal transducer and activator of the transcription 1(siSTAT1)combined with honokiol were added to determine whether the Janus kinase(JAK)/STAT1 participated in the regulation of honokiol on *** protein expression levels of HMGB1,JAK,and STAT1 were detected using Western *** Mice with sap had inflammatory injury in the pancreas,bleeding of intestinal tissues,and cells with disrupted *** in the sap+HON group had significantly fewer pathological *** with sap also had significant increases in the serum levels of amylase,lipase,HMGB1,tumor necrosis factor-α,interleukin-6,diamine oxidase,endotoxin-1,and *** in the sap+HON group did not show these abnormalities(ppS increased the levels of occludin and claudin-1 as well as tight junction permeability,decreased the levels of junctional adhesion molecule C,and elevated intercellular permeability(p<0.01).HON treatment blocked these *** of

关键词： severe acute pancreatitis intestinal barrier dysfunction honokiol high-mobility group protein B1 Januskinase signal transducerand activatorof transcription1

More Catastrophic Flow Events may Follow the Chamoli Rock and Ice Avalanche under Climate Change

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Journal of Earth Science 2024年第4期35卷 1382-1384页

作者： Haijun Qiu ya Liu Bingzhe Tang Ninglian Wang Jiading Wang Shaanxi Key Laboratory of Earth Surface System and Environmental Carrying Capacity College of Urban and Environmental SciencesNorthwest UniversityXi’an 710127China Institute of Earth Surface System and Hazards Northwest UniversityXi’an 710127China State Key Laboratory of Continental Dynamics Department of GeologyNorthwest UniversityXi’an 710069China

0 INTRODUCTION Global warming not only exacerbates the instability of the climate system,causing more weather extremes but also has far-reaching impacts on surface systems,changing disaster environments(Qiu et al.,2024;Ye et al.,2024).The key medium between climate warming and the mountain environment is the cryosphere,whose recession increases the occurrence of chain disasters such as rock-ice avalanches and other flow events(yang et al.,2023).

关键词： warming disaster climate

Stomatal dynamics are regulated by leaf hydraulic traits and guard cell anatomy in nine true mangrove species

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plant Diversity 2024年第3期46卷 395-405页

作者： ya-Dong Qie Qi-Wei Zhang Scott A.M.McAdam Kun-Fang Cao State Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresources College of ForestryGuangxi UniversityNanning 530004China Guangxi Key Laboratory of Forest Ecology and Conservation College of ForestryGuangxi UniversityNanning 530004China Key Laboratory of Ecology of rare and Endangered Species and Environmental protection Ministry of EducationGuangxi Normal UniversityGuilin 541001China Guangxi Key Laboratory of Landscape Resources Conservation and Sustainable Utilization in Lijiang River Basin Guangxi Normal UniversityGuilin 541001China purdue Center for plant Biology Department of Botany and Plant PathologyPurdue UniversityWest LafayetteIN 47907USA

Stomatal regulation is critical for mangroves to survive in the hyper-saline intertidal zone where water stress is severe and water availability is highly ***,very little is known about the stomatal sensitivity to vapour pressure deficit(VpD)in mangroves,and its co-ordination with stomatal morphology and leaf hydraulic *** measured the stomatal response to a step increase in VpD in situ,stomatal anatomy,leaf hydraulic vulnerability and pressure-volume traits in nine true mangrove species of five families and collected the data of genome *** aimed to answer two questions:(1)Does stomatal morphology influence stomatal dynamics in response to a high VpD in mangroves?with a consideration of possible influence of genome size on stomatal morphology;and(2)do leaf hydraulic traits influence stomatal sensitivity to VpD in mangroves?We found that the stomata of mangrove plants were highly sensitive to a step rise in VpD and the stomatal responses were directly affected by stomatal anatomy and hydraulic ***,denser stomata was correlated with faster stomatal closure at high VpD across the species of Rhizophoraceae,and stomata size negatively and vein density positively correlated with genome *** negative leaf osmotic pressure at the full turgor(πo)was related to higher operating steady-state stomatal conductance(gs);and a higher leaf capacitance(Cleaf)and more embolism resistant leaf xylem were associated with slower stomatal responses to an increase in *** addition,stomatal responsiveness to VpD was indirectly affected by leaf morphological traits,which were affected by site salinity and consequently leaf water *** results demonstrate that mangroves display a unique relationship between genome size,stomatal size and vein packing,and that stomatal responsiveness to VpD is regulated by leaf hydraulic traits and stomatal *** work provides a quantitative framework to better understand of stomatal regulation in mangroves

关键词： Stomatal temporal kinetics Vapour-pressure deficit(VpD) Leaf water relations Leaf hydraulic vulnerability Leaf osmotic potential Genome size

Toward a Learnable Climate Model in the Artificial Intelligence Era

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Advances in Atmospheric Sciences 2024年第7期41卷 1281-1288页

作者： Gang HUANG ya WANG Yoo-Geun HAM Bin MU Weichen TAO Chaoyang XIE State key Laboratory of Numerical Modeling for Atmospheric Sciences and Geophysical Fluid Dynamics Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China Laboratory for Regional Oceanography and Numerical Modeling Qingdao National Laboratory for Marine Science and TechnologyQingdao 266237China University of Chinese Academy of Sciences Beijing 100049China Department of Environmental planning Graduate School of Environmental StudiesSeoul National UniversitySeoul 08826South Korea School of Software Engineering Tongji UniversityShanghai 200092China

Artificial intelligence(AI)models have significantly impacted various areas of the atmospheric sciences,reshaping our approach to climate-related *** this AI-driven transformation,the foundational role of physics in climate science has occasionally been *** perspective suggests that the future of climate modeling involves a synergistic partnership between AI and physics,rather than an“either/or”*** controversies around current physical inconsistencies in large AI models,we stress the critical need for detailed dynamic diagnostics and physical ***,we provide illustrative examples to guide future assessments and constraints for AI *** AI integration with numerical models,we argue that offline AI parameterization schemes may fall short of achieving global optimality,emphasizing the importance of constructing online ***,we highlight the significance of fostering a community culture and propose the OCR(Open,Comparable,Reproducible)*** a better community culture and a deep integration of physics and AI,we contend that developing a learnable climate model,balancing AI and physics,is an achievable goal.

关键词： artificial intelligence deep learning learnable climate model