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pulmonary Tuberculosis in HIV-infected patients presenting with Normal Chest Radiograph and Negative Sputum Smear

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Journal of Health Science 2016年第3期4卷 125-130页

作者： Mounika Arrabelli Raghuram Reddy Adidala Chakrapani Chatla Sireesha Tanniru Suryaprakash Chakramahanty malathi Jojula Department of pharmacy Sri Shivani Collage of Pharmacy Warangal Telangana State 506009 India Worm Health Organization India Country Office New Delhi India State TB Cell DM&HS Campus Koti Hyderabad 500097 Telangana State India Department of pharmaceutical Biotechnology Sri Shivani Collage of Pharmacy Warangal Telangana State 506009 India

Deaths due to Tuberculosis （TB） are high among the TB-HIV co-infected patients. Among pLHIV most of the instances the sputum smear is found to be negative for MTb. Chest X-rays also don＇t yield much diagnostic value mainly due to the advanced immune suppressed condition. This study makes an attempt to find out the utility of alternate staining methods such as Light Emitting Diode （LED）, Fluorescent Microscopy （FM） and solid culture in resource limited settings for effective diagnosis of TB among pLHIV. 2 sputum samples were collected from 102 successive presumptive TB cases, whose smear microscopy and X-Ray were negative for MTb among pLHIVs visiting ICTC at MGM hospital, Warangal, Telangana State, India. All the 102 samples were repeated with ZN microscopy and X-ray. Additionally LED and FM microscopy procedures were conducted with the NALC-NAOH concentration method. All the samples were inoculated on LJ medium for solid culture and all the positive cultures were subjected for biochemical test to identify phenotypic appearance, nitrate reduction, niacin and pNB susceptibility test for all the first line anti TB drugs as per standard guidelines. Samples found positive on microscopy were cross checked with Line probe assay （LpA）. All the 102 samples collected showed negative for MTb on ZN technique and negative for pulmonary TB on chest X-rays. 15 samples were positive for MTb both on LED and FM. LpA reconfirmed the MTb in all the 15 samples tested with 11 sensitive for both INH and Rifampicin, 3 INH mono resistant and I Rifmono resistance patterns. Of the 102 inoculations in LJ medium, 25 culture inoculations were positive for MTb growth and also were confirmed as MTb strains based on morphological, biochemical test and growth was seen after 4th week of inoculation. Of the 25 culture positives 20 were sensitive for INH and Rif, 4 INH mono resistant and 1 resistant to all first line anti TB drugs. In smear negative and chest X-ray negative presumptive TB cases, espec

关键词： Tuberculosis drug sensitivity direct AFB vs concentrated smear microscopy LED microscopy and FM Line probe Assay culture DST.

Carcinoma cervix with fat attenuating skull metastases

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Journal of Cancer Metastasis and Treatment 2016年第1期2卷 228-230页

作者： Anuradha Kapali Atmakuri Sateesh Kumar Mukunda malathi S.D.Shamsundar Department of Radiology Kidwai Memorial Institute of OncologyBangalore 560029India Department of pathology Kidwai Memorial Institute of OncologyBangalore 560029India Department of Radiotherapy Kidwai Memorial Institute of OncologyBangalore 560029India

Skeletal metastasis in carcinoma cervix occurs in about 0.8-23%of *** lesions are usually radiographically *** few cases of metastases to the skull have been identified,about 5 cases to the best of our *** present a case of adenosquamous cell carcinoma of cervix with fat attenuating skull metastases in a 38-year-old lady that is not reported till *** lesion was lytic,expansile and with negative attenuation of-15 to-30 Hounsfield units corresponding to *** must be included in the differentials of scalp lesions.A history of recent onset of swelling and associated lytic areas in calvarium on contrast enhanced computed tomography with multiplicity can give a clue to metastatic nature of disease.

关键词： Carcinoma cervix metastases skull fat attenuating

Hyperacute cEEG Attenuation in Aneurysmal Subarachnoid Hemorrhage

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Case Reports in Clinical Medicine 2016年第5期5卷 165-169页

作者： Tyson Burghardt Gautam Sachdeva malathi Rao Saqib Chaudhry Alex Schulte Mounzer Yassin-Kassab Department of Neurology Michigan State University East Lansing USA

We describe hyperacute generalized EEG slowing and then attenuation captured at the moment of subarachnoid hemorrhage in a monitored patient. This is the first reported cEEG capture of aneurysmal subarachnoid hemorrha... 详细信息

关键词： Aneurysmal Subarachnoid Hemorrhage EEG

In situ synthesis of gold nanostars within liposomes for controlled drug release and photoacoustic imaging

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Science China Materials 2016年第11期59卷 892-900页

作者： malathi Mathiyazhakan paul Kumar Upputuri Kathyayini Sivasubramanian Ashish Dhayani praveen Kumar Vemula 邹培超浦侃裔杨诚 Manojit pramanik 徐臣杰 School of Chemical&Biomedical Engineering Nanyang Technological University62 Nanyang DriveSingapore Institute for Stem Cell Biology and Regenerative Medicine(inStem) GKVK-CampusBellary RoadBangaloreIndia Ramalingaswami Re-Entry Fellow Department of BiotechnologyNew Delhi 110003India Division of Energy&Environment Graduate School at ShenzhenTsinghua UniversityShenzhen 518055China NTU-Northwestern Institute for Nanomedicine Nanyang Technological University50 Nanyang AvenueSingapore

This report describes the design and synthesis of gold nanostars(AuNSs) containing liposomes by the in situ reduction of gold precursor,HAuCU(pre-encapsulated within the liposomes) through HEpES diffusion and *** with the conventional process that encapsulates the pre-synthesized gold nanoparticles into liposomes during the thin-film hydration step,this facile and convenient method allows the formation and simultaneous encapsulation of AuNSs within *** absorption spectra of AuNSs can be tuned between visible and near infra-red(NIR) regions by controlling the size and morphology of AuNSs through varying the concentrations of HAuCU and *** a proof of concept,we demonstrate the synthesis of AuNSs with a maximum absorbance at 803 nm within the temperature-sensitive *** liposomes can produce stronger photoacoustic signals(1.5 fold) in the NIR region than ***,when there are drugs(i.e.,doxorubicin) within these liposomes,the irradiation with the NIR pulse laser will disrupt the liposomes and trigger the 100%release of these pre-encapsulated drugs within 10 *** comparison,there is neglectable contrast enhancement or minor release(10%) of drugs for the pure liposomes under the same ***,cell experiment shows the potential therapeutic application of this system.

关键词： gold nanostars light sensitive liposomes controlled drug release photoacoustic imaging

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临终关怀：以病人为中心的交流

中国全科医学 2008年第16期11卷 1464-1465页

作者： Quyen Ngo- Metzqer Kristin J August malathi Srinivasan Solomon Liao Frank L Meyskens Jr 周淑新(译) 不详中国天然气集团公司中心医院河北省廊坊市102800

病人一旦被诊断为癌症,常需要初级保健医生将诊断告诉病人,与其讨论预后或做适当的转诊。传递坏消息时,按优先次序使病人了解关键的问题。讨论预后时,医生应对病人想了解多少信息量反应灵敏。在不给予假希望的前提下准确地讨论预后是一... 详细信息

病人一旦被诊断为癌症,常需要初级保健医生将诊断告诉病人,与其讨论预后或做适当的转诊。传递坏消息时,按优先次序使病人了解关键的问题。讨论预后时,医生应对病人想了解多少信息量反应灵敏。在不给予假希望的前提下准确地讨论预后是一种挑战。所有为病人提供服务的医生对预后的观点要统一,避免给病人混淆不清的信息。根据病情进展,医生必须重新评价治疗的有效性。当治愈性治疗转为姑息性治疗时,医生应避免使用让病人感到治疗失败或被放弃的用语。医生要认识到文化因素会影响临终关怀的讨论。初级保健医生有机会与病人保持长期信赖关系,但在做临终关怀讨论时,他们还没有太多经验。采用系统方法有助于初级保健医生选择恰当方式讨论预后、提出现实性希望、提供治疗选项、协调疾病转换期、缓解病人痛苦(见表1)。

关键词：临终医护医生病人关系