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Compressive properties of a novel slurry-infiltrated fiber concrete reinforced with arc-shaped steel fibers

Journal of Zhejiang University-Science A(Applied physics & Engineering) 2023年第6期24卷 543-556页

作者： Hedong lI Yabiao lI Yunfeng pAN p.l.ng Christopher K.Y.lEUng Xin ZHAO School of Civil Engineering and Architecture Zhejiang Sci-Tech UniversityHangzhou 310018China Department of Civil Engineering The University of Hong KongHong Kong 999077China Faculty of Civil Engineering Vilnius Gediminas Technical UniversityVilnius LT-10223Lithuania Department of Civil and Environmental Engineering The Hong Kong University of Science and TechnologyHong Kong 999077China School of Civil Engineering and Architecture Zhejiang University of Science and TechnologyHangzhou 310023China

Slurry-infiltrated fiber concrete(SIFCON)is a sort of strain hardening cement-based composite material,typically made with 5%–20%steel *** study focused on a novel type of SIFCON in which hooked-end steel fibers were replaced by arc-shaped steel *** quasi-static compressive properties of the SIFCON were first *** results suggested that using arc-shaped steel fibers in lieu of hooked-end steel fibers increased the quasi-static compressive strength by 47.1%and the strain at peak stress by 56.3%.We attribute these improvements to new crack-resisting mechanisms,namely“fiber crosslock”,“dual bridging”,and“confinement loops”,when the arc-shaped steel fibers are introduced into *** high impact resistance is a special property of SIFCON that is of practical significance,the dynamic compressive properties of arc-shaped steel fiber SIFCON were studied by using an 80-mm-diameter split Hopkinson pressure bar(SHpB).The results showed that the dynamic compressive strength,dynamic increase factor(DIF),and dynamic toughness of SIFCON all increased with the strain *** SIFCON incorporating arc-shaped steel fibers proved to have significant advantages in structural applications requiring high impact resistance.

关键词： Slurry-infiltrated fiber concrete(SIFCON) Arc-shaped steel fiber Quasi-static compressive properties Spilt Hopkinson pressure bar(SHpB) Dynamic compressive properties

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新型弧形钢纤维渗浇纤维混凝土的压缩性能研究（英文）

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Journal of Zhejiang University-Science A(Applied physics & Engineering) 2023年第6期 543-557页

作者：李贺东李亚彪潘云锋 p.l.ng Christopher K.Y.lEUng 赵昕浙江理工大学建筑工程学院香港大学土木工程系维尔纽斯格迪米纳斯技术大学土木工程学院香港科技大学土木与环境工程系浙江科技学院建筑工程学院

目的：渗浇纤维混凝土（SIFCON）的力学性能受纤维类型的影响较大，弧形钢纤维代替端钩钢纤维制备SIFCON引入了潜在可明显提升SIFCON力学性能的纤维桥联机制。本文旨在研究利用弧形钢纤维制备SIFCON提升其压缩性能的可行性，并初步研究... 详细信息

目的：渗浇纤维混凝土（SIFCON）的力学性能受纤维类型的影响较大，弧形钢纤维代替端钩钢纤维制备SIFCON引入了潜在可明显提升SIFCON力学性能的纤维桥联机制。本文旨在研究利用弧形钢纤维制备SIFCON提升其压缩性能的可行性，并初步研究弧形钢纤维SIFCON在中低应变率下的抗压性能。创新点：1.利用弧形钢纤维制备新型SIFCON;2.提出弧形钢纤维在SIFCON中潜在的新型桥联机制；3.研究弧形钢纤维SIFCON中低应变率下的单轴压缩性能。方法：综合利用准静态压缩试验和霍普金森压杆试验，研究弧形钢纤维SIFCON的压缩性能，系统分析不同的应变率对弧形钢纤维SIFCON的破坏模式、动态压缩强度、动态应力-应变曲线、动态增强因子和动态韧性的影响。结论：1.在纤维体积分数相近、纤维长径比相同的情况下，采用弧形钢纤维代替普通端钩钢纤维可显著提高SIFCON的准静态压缩性能。2.在SIFCON中采用的“纤维勾连”机制、裂纹表面“二次桥联”、最少两纤维形成“约束环”等措施可有效提高弧形钢纤维的准静态压缩性能。在动态压缩试验中，由于试件尺寸较小和切割过程导致“纤维勾连”机制的潜力减小，限制了动态压缩性能的提高。建议进一步研究采用更好的动态压缩试验方法，以充分反映弧形钢纤维的贡献。3.脆性基体和弧形钢纤维SIFCON均为应变速率敏感材料，其动态抗压强度、动态增加因子（DIF）和动态韧性均随应变速率的增大而增大。从试验结果来看，在高应变率下，采用FIB Model Code2010的公式高估了脆性基体和弧形钢纤维SIFCON的DIF。因此，有必要建立脆性基体和弧形钢纤维SIFCON材料的替代DIF模型。4.与其他纤维增强混凝土相比，在相同应变率下，弧形钢纤维SIFCON具有更大的变形和能量吸收能力。显然，采用弧形钢纤维的SIFCON在结构应用中具有良好的抗冲击载荷性能。

关键词：渗浇纤维混凝土弧形钢纤维准静态压缩性能霍普金森压杆动态压缩性能

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Jetting-based bioprinting:process,dispense physics,and applications

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Bio-Design and Manufacturing 2024年第5期7卷 771-799页

作者： Wei long ng Viktor Shkolnikov Singapore Centre for 3D printing(SC3Dp) School of Mechanical and Aerospace EngineeringNanyang Technological University(NTU)Singapore 639798Singapore Hp Inc. Palo AltoCA 94304USA

Jetting-based bioprinting facilitates contactless drop-on-demand deposition of subnanoliter droplets at well-defined positions to control the spatial arrangement of cells,growth factors,drugs,and biomaterials in a highly automated layer-by-layer fabrication *** to its immense versatility,jetting-based bioprinting has been used for various applications,including tissue engineering and regenerative medicine,wound healing,and drug development.A lack of in-depth understanding exists in the processes that occur during jetting-based *** review paper will comprehensively discuss the physical considerations for bioinks and printing conditions used in jetting-based *** first present an overview of different jetting-based bioprinting techniques such as inkjet bioprinting,laser-induced forward transfer bioprinting,electrohydrodynamic jet bioprinting,acoustic bioprinting and microvalve ***,we provide an in-depth discussion of various considerations for bioink formulation relating to cell deposition,print chamber design,droplet formation and droplet ***,we highlight recent accomplishments in jetting-based *** present the advantages and challenges of each method,discuss considerations relating to cell viability and protein stability,and conclude by providing insights into future directions of jetting-based bioprinting.

关键词： 3D bioprinting Biofabrication Jetting-based Dispense physics Machine learning

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Dysfunction of synaptic endocytic trafficking in parkinson's disease

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Neural Regeneration Research 2024年第12期19卷 2649-2660页

作者： Xin Yi ng Mian Cao programme in Neuroscience and Behavioural Disorders Duke-NUS Medical SchoolSingaporeSingapore Department of physiology National University of SingaporeSingaporeSingapore

parkinson's disease is characterized by the selective degeneration of dopamine neurons in the nigrostriatal pathway and dopamine deficiency in the *** precise reasons behind the specific degeneration of these dopamine neurons remain largely *** investigations have identified over 20 causative pARK genes and 90 genomic risk loci associated with both familial and sporadic parkinson's ***,several of these genes are linked to the synaptic vesicle recycling process,particularly the clathrinmediated endocytosis *** suggests that impaired synaptic vesicle recycling might represent an early feature of parkinson's disease,followed by axonal degeneration and the eventual loss of dopamine cell bodies in the midbrain via a"dying back"***,several new animal and cellular models with parkinson's disease-linked mutations affecting the endocytic pathway have been created and extensively *** models faithfully recapitulate certain parkinson's disease-like features at the animal,circuit,and cellular levels,and exhibit defects in synaptic membrane trafficking,further supporting the findings from human genetics and clinical *** this review,we will first summarize the cellular and molecular findings from the models of two parkinson's disease-linked clathrin uncoating proteins:auxilin(DNAJC6/pARK19)and synaptojanin 1(SYNJ1/pARK20).The mouse models carrying these two pARK gene mutations phenocopy each other with specific dopamine terminal pathology and display a potent synergistic ***,we will delve into the involvement of several clathrin-mediated endocytosis-related proteins(GAK,endophilin A1,SAC2/INpp5 F,synaptotagmin-11),identified as parkinson's disease risk factors through genome-wide association studies,in parkinson's disease *** will also explore the direct or indirect roles of some common parkinson's disease-linked proteins(alpha-synuclein(pARK1/4),parkin(pARK2),and lRRK2(pARK

关键词： autophagy auxilin/pARK19 clathrin-mediated endocytosis dopamine neurons neurodegeneration nigrostriatal pathway parkinson's disease synaptic vesicle recycling synaptojanin1/pARK20

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On the functions of astrocyte-mediated neuronal slow inward currents

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Neural Regeneration Research 2024年第12期19卷 2602-2612页

作者： Balázs pál Department of physiology Faculty of MedicineUniversity of DebrecenDebrecenHungary

Slow inward currents are known as neuronal excitatory currents mediated by glutamate release and activation of neuronal extra synaptic N-met hyl-D-aspartate receptors with the contribution of *** events are significantly slower than the excitatory postsynaptic *** of slow inward currents are determined by seve ral factors including the mechanisms of astrocytic activation and glutamate release,as well as the diffusion pathways from the release site towards the extra synaptic recepto *** are stimulated by neuronal network activity,which in turn excite neurons,forming an astrocyte-neuron feedback *** as a consequence of brain edema,astrocytic swelling can also induce slow inward currents under pathological *** is a growing body of evidence on the roles of slow inward currents on a single neuron or local network *** events often occur in synchro ny on neurons located in the same astrocytic *** synchronization of neuronal excitability,slow inward currents also set synaptic strength via eliciting timing-dependent synaptic *** addition,slow inward currents are also subject to non-synaptic plasticity triggered by long-la sting stimulation of the excitatory *** note,there might be important regionspecific differences in the roles and actions triggering slow inward *** greater networks,the pathophysiological roles of slow inward currents can be better understood than physiological *** inward currents are identified in the pathophysiological background of autism,as slow inward currents drive early hypersynchrony of the neural *** inward currents are significant contributors to paroxysmal depolarizational shifts/interictal *** events are related to epilepsy,but also found in Alzheimer's disease,parkinson's disease,and stroke,leading to the decline of cognitive *** with features overlapping with slow inward currents(excitatory,N-methyl-Dasp

关键词： astrocyte cortical spreading depolarization gliotransmission glutamate neural synchronization NMDA receptor paroxysmal depolarizational shift slow inward current

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Stability and Generalization of Hypergraph Collaborative Networks

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Machine Intelligence Research 2024年第1期21卷 184-196页

作者： Michael K.ng Hanrui Wu Andy Yip Institute of Data Science The University of Hong KongHong KongChina Department of Mathematics The University of Hong KongHong KongChina College of Information Science and Technology Jinan UniversityGuangzhou 510006China

Graph neural networks have been shown to be very effective in utilizing pairwise relationships across ***,there have been several successful proposals to generalize graph neural networks to hypergraph neural networks to exploit more com-plex *** particular,the hypergraph collaborative networks yield superior results compared to other hypergraph neural net-works for various semi-supervised learning *** collaborative network can provide high quality vertex embeddings and hyperedge embeddings together by formulating them as a joint optimization problem and by using their consistency in reconstructing the given *** this paper,we aim to establish the algorithmic stability of the core layer of the collaborative network and provide generaliz--ation *** analysis sheds light on the design of hypergraph filters in collaborative networks,for instance,how the data and hypergraph filters should be scaled to achieve uniform stability of the learning *** experimental results on real-world datasets are presented to illustrate the theory.

关键词： Hypergraphs vertices hyperedges collaborative networks graph convolutional neural networks(CNNs) stability generalization guarantees

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perspectives in human brain plasticity sparked by glioma invasion:from intraoperative(re)mappings to neural reconfigurations

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Neural Regeneration Research 2024年第5期19卷 947-948页

作者： Sam ng Hugues Duffau Guillaume Herbet Department of Neurosurgery Gui de Chauliac HospitalMontpellier University Medical CenterMontpellierFrance Institute of Functional Genomics University of MontpellierCNRSINSERMMontpellierFrance praxiling laboratory UMR5267CNRSPaul Valéry-Montpellier 3 UniversityMontpellierFrance

Exploring the aptitude of the human brain to compensate functional consequences of a lesion damaging its structural architecture is a key challenge to improve patient care in various neurological diseases,to optimize neuroscientifically-informed strategies of postlesional rehabilitation,and ultimately to develop innovative neuro-regenerative *** term‘plasticity’,initially referring to the intrinsic propensity of neurons to modulate their synaptic transmission in a learning situation,was progressively transposed to brain injury research and clinical ***,in the event of brain damage,adaptive mechanisms of compensation allow a partial reshaping of the structure and activities of the central nervous system,thus permitting to some extent the maintenance of brain functions.

关键词： plasticity figuration consequences

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Three-dimensional numerical analysis of plant-soil hydraulic interactions on pore water pressure of vegetated slope under different rainfall patterns

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第9期16卷 3696-3706页

作者： Haowen Guo Charles Wang Wai ng Qi Zhang Department of Civil and Environmental Engineering The Hong Kong University of Science and TechnologyHong KongChina

Understanding the pore water pressure distribution in unsaturated soil is crucial in predicting shallow landslides triggered by rainfall,mainly when dealing with different temporal patterns of rainfall ***,the hydrological response of vegetated slopes,especially three-dimensional(3D)slopes covered with shrubs,under different rainfall patterns remains unclear and requires further *** address this issue,this study adopts a novel 3D numerical model for simulating hydraulic interactions between the root system of the shrub and the surrounding *** series of numerical parametric studies are conducted to investigate the influences of slope inclination,rainfall pattern and rainfall *** rainfall patterns(advanced,bimodal,delayed,and uniform)and two rainfall durations(4-h intense and 168-h mild rainfall)are considered to study the hydrological response of the *** computed results show that 17%higher transpiration-induced suction is found for a steeper slope,which remains even after a short,intense rainfall with a 100-year return *** extreme rainfalls with advanced(pA),bimodal(pB)and uniform(pU)rainfall patterns need to be considered for the short rainfall duration(4 h),while the delayed(pD)and uniform(pU)rainfall patterns are highly recommended for long rainfall durations(168 h).The presence of plants can improve slope stability markedly under extreme rainfall with a short duration(4 h).For the long duration(168 h),the benefit of the plant in preserving pore-water pressure(pWp)and slope stability may not be sufficient.

关键词： Root-soil interactions Rainfall patterns Slope stability Three-dimensional(3D)

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Defined hydrogels for spinal cord organoids:challenges and potential applications

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Neural Regeneration Research 2024年第11期19卷 2329-2330页

作者： Wai Hon Chooi Yuewen Wu Shi-Yan ng Institute of Molecular and Cell Biology(IMCB) Agency for ScienceTechnology and Research(A*STAR)SingaporeSingapore Department of physiology Yong Loo Lin School of MedicineNational University of Singapore(NUS)SingaporeSingapore

Organoids of the central nervous system,primarily derived from pluripotent stem cells or neural stem cells,are three-dimensional tissue cultures with self-organizing *** exposed to the right combinations of signals,they differentiate into a 3D tissue consisting of complex cytoarchitecture and native cell types,including various neuron subtypes and glial *** features closely mimic native tissues,making them invaluable for developmental studies and disease *** recent years,spinal cord organoids(SCOs)have been developed to investigate spinal cord development,injuries,and various neurological *** an integral part of the central nervous system,SCOs play a vital role and serve as a site for studying both neurodevelopment and neurodegenerative diseases.

关键词： properties injuries primarily

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A novel non-invasive model to predict high-risk varices in cirrhotic patients

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Hepatobiliary Surgery and Nutrition 2024年第3期13卷 530-532页

作者： Kelvin K.C.ng Department of Surgery The Chinese University of Hong Kong Medical CentreHong KongChina

Acute variceal bleeding is one of the most common and potentially life-threatening complications in patients with liver *** is conventionally diagnosed by oesophagogastroduodenoscopy,which is invasive to patients and carries hospital *** would be more cost-effective if non-invasive tests could screen out high-risk patients who developed acute variceal bleeding requiring endoscopic *** can potentially reduce the need for invasive procedures for cirrhotic *** recent years,there have been advancements in non-invasive methods for assessing the risk of variceal *** include transient elastography(FibroScan)of the liver and spleen,platelet count,imaging modalities[ultrasound or magnetic resonance imaging(MRI)],and non-invasive liver function tests[Child-pugh score or the Model for End-Stage liver Disease(MElD)score].The 2015 Baveno VI consensus is developed by an international panel of experts to improve the diagnosis and management of portal hypertension and its complications,specifically focusing on variceal bleeding in patients with cirrhosis(1).The consensus emphasizes using noninvasive methods to screen out high-risk varices(HRV)requiring therapeutic *** key features of the Baveno VI criteria include a liver stiffness measurement(lSM)pa and a platelet count>150,000/*** can confidently rule out *** has been proven to avoid unnecessary endoscopy up to 40%with a specificity of up to 46%(2).In recent years,spleen stiffness measurement(SSM)has been a useful tool to assess portal hypertension and to predict ***,the revised Baveno VII consensus in 2022 recommends SSM≤40 kpa would avoid more unnecessary endoscopy in patients who fall outside Baveno VI criteria,with a missed HRV rate of<5%(3).

关键词： Non-invasive model high-risk varices cirrhosis

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