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Tumor microenvironment pathways:Cross regulation in breast cancer metastasis

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Genes & Diseases 2022年第2期9卷 310-324页

作者： Rama Rao Malla p.kiran Cancer Biology Lab Department of Biochemistry and BioinformaticsInstitute of ScienceGITAM(Deemed to be University)Visakhapatnam 530045India

The tumor microenvironment(TME)is heterogeneous and contains a multiple cell population with surrounded immune cells,which plays a major role in regulating *** multifunctional pathways,Hedgehog(Hh),Wnt,Notch,and NF-kB,cross-regulates metas-tasis in breast *** review presents substantial evidence for cross-regulation of TME components and signaling pathways,which makes breast TME more heterogeneous and com-plex,promoting breast cancer progression and metastasis as a highly aggressive *** discoursed the importance of stromal and immune cells as well as their crosstalk in bridging the *** also discussed the role of Hh and Notch pathways in the intervention be-tween breast cancer cells and macrophages to support TME;Notch signaling in the bidirec-tional communication between cancer cells and components of TME;Wnt signal pathway in controlling the factors responsible for EMT and NF-kB pathway in the regulation of genes con-trolling the inflammatory *** also present the role of exosomes and their miRNAs in the cross-regulation of TME cells as well as pathways in the reprogramming of breast TME to support ***,we examined and discussed the targeted small molecule inhibitors and natural compounds targeting developmental pathways and proposed small molecule nat-ural compounds as potential therapeutics of TME based on the multitargeting *** conclu-sion,the understanding of the molecular basis of the cross-regulation of TME pathways and their inhibitors helps identify molecular targets for rational drug discovery to treat breast can-cers.

关键词： Breast cancer Cross-regulation Hedgehog NF-kB Notch Tumor microenvironment Wnt

Surgery for Crohn’s disease:upfront or last resort?

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Gastroenterology Report 2022年第1期10卷 188-194页

作者： U.Ahmed Ali Ravi p.kiran Division of Colorectal Surgery New York–Presbyterian/Columbia University Medical CenterNew YorkUSA

Crohn’s disease(CD)can involve the entire gastrointestinal tract from the mouth to the anus and can lead to a constellation of *** the advancement of effective medical treatments for CD,a tendency has emerged to consider surgical treatment as a last *** potentially has the disadvantage of delaying surgery and if it fails might leave patients sicker,less well nourished,and with more severe *** with most non-malignant diseases,the choice of surgery vs medical treatment is a patient’s personal preference under the guidance of the treating physician,except in extreme situations where surgery might be the only *** this article,we will discuss the available evidence regarding the optimal timing of surgery in CD,focusing on whether early surgery can bring benefits in terms of disease control,symptom relief,and quality of life.

关键词： surgery timing Crohn’s disease outcome

Biomass production from microalgae Chlorella grown in sewage,kitchen wastewater using industrial CO_(2)emissions:Comparative study

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Carbon Resources Conversion 2019年第2期2卷 126-133页

作者： p.kiran Kumar S.Vijaya Krishna S.Swami Naidu Kavita Verma D.Bhagawan V.Himabindu Centre for Alternative Energy Options Institute of Science and TechnologyJawaharlal Nehru Technological University HyderabadKukatpallyHyderabad 500085TelanganaIndia Centre for Biotechnology Institute of Science and TechnologyJawaharlal Nehru Technological University HyderabadKukatpallyHyderabad 500085TelanganaIndia

Microalgae cultivation using organic wastewater like kitchen wastewater(KWW)and sewage wastewater(SWW)are recommended for wastewater treatment along with simultaneous biomass production which is a cost effective *** is rich in nutrients which might be an efficient wastewater feedstock for microalgae cultivation to achieve reasonably high biomass yield for energy *** has not been investigated extensively for microalgae cultivation till now because of high concentration of ammonia as it could inhibit algae *** order to make KWW suitable for microalgae growth,a common method is to dilute with ***,in the present study,KWW was diluted with water at dilution ration 1:1 and compared with SWW for microalgae biomass growth,biomass yields and nutrient removal efficiency specifically using *** KWW and SWW showed highest biomass productivity in mixotrophic cultivation *** average biomass productivity in SWW was 0.6 g/L which was higher when compared to *** infrared spectroscopy(FTIR)of algal biomass revealed the presence of certain organic compound groups such as eOH,eCOOH,NH_(2),and ■*** was concluded from the results that Chlorella was very effective in the treatment of KWW,SWW and industrial flue gas on the other hand the biomass obtained is a sustainable green energy source for biofuels.

关键词： Kitchen wastewater(KWW) Sewage wastewater(SWW) Flue gas Microalgae Chlorella

Effect of quality of bowel preparation on quality indicators of adenoma detection rates and colonoscopy completion rates

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Gastroenterology Report 2016年第2期4卷 148-153,I0003页

作者： Tarun Rai Udayakumar Navaneethan Tushar Gohel Amareshwar podugu prashanthi N.Thota Ravi p.kiran Rocio Lopez Madhusudhan R.Sanaka Digestive Disease Institute The Cleveland ClinicClevelandOHUSA

Background and aim:Adequate bowel preparation is important for safe and effective *** indicators(QI)for colonoscopy include achieving at least 95%completion rate and an adenoma detection rate(ADR)of at least 25%in average-risk men and 15%in average-risk women aged over *** aim was to investigate the impact of bowel preparation on ADR and colonoscopy completion ***:This retrospective cohort study included patients who underwent colonoscopy between January 2008 and December *** main outcome measurements were ADR and colonoscopy completion rates to the ***:A total of 2519 patients was included;1030(41.0%)had excellent preparation,1145(45.5%)good-,240(9.5%)fair-,and 104(4.1%)poor *** completion rates were significantly lower in patients with poor or fair preparation(72.1%and 75.4%,respectively)than in those with good and excellent preparation(99.7%and 99.9%,respectively;pppreparation(excellent,good,fair and poor)at 24.2%vs.26.8%vs.32.1%vs.22.1%,respectively;p¼*** the groups had ADR above the QI(25%for men and 15%for women)with evidence of significantly higher ADR in the women with excellent or good preparation and in men with excellent,good or fair *** multivariate analysis,male gender was significantly associated with increased ADR(ppreparation did not influence ***:patients with fair and poor standards of preparation have significantly lower colonoscopy completion rates than those with excellent and good ***,there was no difference in ADR between the different grades of preparation.

关键词： bowel preparation adenoma detection rate colonoscopy completion rate quality indicators

Ultra‑Transparent and Multifunctional IZVO Mesh Electrodes for Next‑Generation Flexible Optoelectronics

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Nano-Micro Letters 2025年第1期17卷 293-309页

作者： kiran A.Nirmal Tukaram D.Dongale Atul C.Khot Chenjie Yao Nahyun Kim Tae Geun Kim School of Electrical Engineering Korea UniversityAnam‑ro 145Seongbuk‑guSeoulRepublic of Korea Computational Electronics and Nanoscience Research Laboratory School of Nanoscience and BiotechnologyShivaji UniversityKolhapur 416004India

Mechanically durable transparent electrodes are essential for achieving long-term stability in flexible optoelectronic ***,they are crucial for applications in the fields of energy,display,healthcare,and soft *** meshes represent a promising alternative to traditional,brittle,metal oxide conductors due to their high electrical conductivity,optical transparency,and enhanced mechanical *** this paper,we present a simple method for fabricating an ultra-transparent conducting metal oxide mesh electrode using selfcracking-assisted *** this method,we produced an electrode with ultra-transparency(97.39%),high conductance(Rs=21.24Ωsq^(−1)),elevated work function(5.16 eV),and good mechanical *** also evaluated the effectiveness of the fabricated electrodes by integrating them into organic photovoltaics,organic light-emitting diodes,and flexible transparent memristor devices for neuromorphic computing,resulting in exceptional device *** addition,the unique porous structure of the vanadium-doped indium zinc oxide mesh electrodes provided excellent flexibility,rendering them a promising option for application in flexible optoelectronics.

关键词： Self-cracking template Vanadium-doped indium zinc oxide mesh Organic solar cells Organic light-emitting diodes Flexible transparent memory

Stochastic Energy Management of Microgrid with Nodal pricing

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Journal of Modern power Systems and Clean Energy 2020年第1期8卷 102-110页

作者： Dhanapala prudhviraj p.B.S.kiran Naran M.pindoriya IEEE Department of Electrical Engineering Indian Institute of Technology GandhinagarPalaj 382355GandhinagarIndia

This paper develops a stochastic framework for the energy management of a microgrid to minimize the energy cost from the *** considers the uncertainties in solar photovoltaic(pV)generation,load demand,and electricity ***,the opportunity of flexible load demand,i.e.,the effect of demand response(DR),on the test system is *** uncertainties are modeled by using Monte Carlo simulations and the generated scenarios are reduced to improve the computational *** general,microgrid scheduling is implemented by using substation(source node)price as a reference,but that reference price is not the same at all ***,this paper develops the nodal price based energy management in a microgrid to improve the scheduling *** stochastic energy management framework is formulated as a mixed integer non-linear programming(MINLp).Four case studies are simulated for a modified 15-node radial distribution network integrated with solar pV and battery energy storage system(BESS)to validate the effectiveness of the energy management framework for a microgrid with nodal pricing.

关键词： Battery energy storage system(BESS) demand response(DR) distributed generation microgrid mixed integer non-linear programming(MINLp) scheduling stochastic optimization

Effectiveness of sloping agricultural land technology on soil fertility status of mid-hills in Nepal

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Journal of Forestry Research 2013年第4期24卷 767-775页

作者： kiran Lamichhane Institute of Applied Sciences Department of Environmental ScienceUniversity of North Texas

Hedgerows with intercropping systems were established at the ICIMOD test and demonstration site at Godawari to assess the effective- ness of Sloping Agricultural Land Technology （SALT） in reducing run- off water volume, controlling soil loss, increasing crop production, and improving soil fertility in the mid-hills of Nepal. Runoff water volume （1996-2002）, soil loss （1996-2002） and maize yield （1995-2001）, and soil fertility-related parameters were assessed on SALT models with three factors： the type of nitrogen-fixing plant, the farmers＇ practice, and fertilizer use. Results showed a significant effect of Alnus nepalensis and/or Indigofera dosua on runoff water volume, soil loss, crop produc- tion, soil water retention, and soil nutrients （NpK）. Farmers＇ practice and fertilization did not play a significant role in reducing runoff water and soil loss. However, farmers＇ practice significantly increased crop produc- tion. Therefore, integrating soil conservation approaches on SALT sys- tems enhances stable economic output to hills and mountain farmers.

关键词： Sloping Agricultural Land Technology hedgerows agroforestry mountain fanning system soil erosion soil nutrient

Arraying of microphotosynthetic power cells for enhanced power output

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Microsystems & Nanoengineering 2022年第2期8卷 185-202页

作者： kiran Kuruvinashetti Muthukumaran packirisamy Optical-Bio Microsystems Laboratory Department of MechanicalIndustrial and Aerospace EngineeringConcordia UniversityMontrealQC H3G1M8Canada

Microphotosynthetic power cells(μpSCs)generate power through the exploitation of living photosynthetic’microorganisms by harvesting *** thermodynamic limitations of this process restrict the power output of a single ***,we demonstrateμpSCs in four different array configurations to enhance power output from these power *** this effect,sixμpSCs were arrayed in series,parallel,and combinations of series and parallel *** ppSC was injected with a 2 mL liquid culture of photosynthetic microorganisms(Chlamydomonas reinhardtii)in the anode and 2 mL of 25%(w/v)electron acceptor potassium ferricyanide(K_(3)Fe(CN)_(6))in the *** combinations ofμpSCs connected in series and parallel'generated higher power than the individual series and parallel *** combinations of sixμpSCs connected in series and in parallel produced a high power density of 1914 mWm^(-2)in the presence of white fluorescent light illumination at 20μEm^(-2)s^(-1).Furthermore,to realize the array strategy for real-time applications,a 1.7V/2mA rating light-emitting diode(LED)was powered by combinations of series and parallel array *** results indicate the reliability ofμpSCs to produce electricity from photosynthetic microorganisms for low-power *** addition,the results suggest that a combination of microlevel photosynthetic cells in array format represents a powerful optimal design strategy to enhance the power output fromμpSCs.

关键词： power illumination harvesting

Swarm Optimization and Machine Learning for Android Malware Detection

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Computers, Materials & Continua 2022年第12期73卷 6327-6345页

作者： K.Santosh Jhansi p.Ravi kiran Varma Sujata Chakravarty Centurion University of Technology and Management ParalakhemundiOdishaIndia Maharaj Vijayaram Gajapathi Raj College of Engineering VizianagaramIndia Centurion University of Technology and Management BhubaneswarOdishaIndia

Malware Security Intelligence constitutes the analysis of applications and their associated metadata for possible security *** programming Interfaces(ApI)calls contain valuable information that can help with malware *** malware analysis with reduced feature space helps for the efficient identification of *** goal of this research is to find the most informative features of ApI calls to improve the android malware detection *** swarm optimization methods,viz.,Ant Lion Optimization(ALO),Cuckoo Search Optimization(CSO),and Firefly Optimization(FO)are applied to ApI calls using auto-encoders for identification of most influential *** nature-inspired wrapperbased algorithms are evaluated using well-known Machine Learning(ML)classifiers such as Linear Regression(LR),Decision Tree(DT),Random Forest(RF),K-Nearest Neighbor(KNN)&SupportVector Machine(SVM).A hybrid Artificial Neuronal Classifier(ANC)is proposed for improving the classification of android *** experimental results yielded an accuracy of 98.87%with just seven features out of hundred ApI call features,i.e.,a massive 93%of data optimization.

关键词： Android malware ApI calls auto-encoders ant lion optimization cuckoo search optimization firefly optimization artificial neural networks artificial neuronal classifier