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NECAB family of neuronal calcium-binding proteins in health and disease

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Neural Regeneration Research 2025年第5期20卷 1236-1243页

作者： Diones Bueno Michael k.E.Schafer Sudena Wang Michael J.Schmeisser Axel Methner Institute for Molecular Medicine University Medical Center of the Johannes Gutenberg-UniversityMainzGermany Department of Anesthesiology University Medical Center of the Johannes Gutenberg-UniversityMainzGermany Institute of Anatomy University Medical Center of the Johannes Gutenberg-UniversityMainzGermany

The N-terminal EF-hand calcium-binding proteins 1–3(NECAB1–3) constitute a family of predominantly neuronal proteins characterized by the presence of at least one EF-hand calcium-binding domain and a functionally less well characterized C-terminal antibiotic biosynthesis monooxygenase domain. All three family members were initially discovered due to their interactions with other proteins. NECAB1 associates with synaptotagmin-1, a critical neuronal protein involved in membrane trafficking and synaptic vesicle exocytosis. NECAB2 interacts with predominantly striatal G-protein-coupled receptors, while NECAB3 partners with amyloid-β A4 precursor protein-binding family A members 2 and 3, key regulators of amyloid-β production. This demonstrates the capacity of the family for interactions with various classes of proteins. NECAB proteins exhibit distinct subcellular localizations: NECAB1 is found in the nucleus and cytosol, NECAB2 resides in endosomes and the plasma membrane, and NECAB3 is present in the endoplasmic reticulum and Golgi apparatus. The antibiotic biosynthesis monooxygenase domain, an evolutionarily ancient component, is akin to atypical heme oxygenases in prokaryotes but is not wellcharacterized in vertebrates. prokaryotic antibiotic biosynthesis monooxygenase domains typically form dimers, suggesting that calcium-mediated conformational changes in NECAB proteins may induce antibiotic biosynthesis monooxygenase domain dimerization, potentially activating some enzymatic properties. However, the substrate for this enzymatic activity remains uncertain. Alternatively, calcium-mediated conformational changes might influence protein interactions or the subcellular localization of NECAB proteins by controlling the availability of protein–protein interaction domains situated between the EF hands and the antibiotic biosynthesis monooxygenase domain. This review summarizes what is known about genomic organization, tissue expression, intracellular localization, interac

关键词： calcium EF hand mitochondria nervous system signal transduction

A multichannel neural signal detecting module:Its design and test in animal experiments

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progress in Natural Science:Materials International 2007年第6期17卷 675-680页

作者： k.p.k.ch Fraunhofer Institute for Biomedical Engineering 66386 St.Ingbert Germany

A four-channel neural signal detecting module with an implantable 12-contact cuff electrode was designed for real-time neural signal recording on peripheral and central nerves. The mathematic coupling model between nerve and electronic system was analyzed. Electrode connection configurations were considered. The detecting circuit included an input coupling network, a pre-amplifier, and some filtering and notching stages. Shield guarding and the right-leg-driven circuit were developed for further elimination of common mode interference. By electrode switches, the module could cooperate with a nerve functional electrical stimulation circuit, building a neural channel bridge-connection system. It was tested by recording experiments on rat’s sciatic and spine nerves. The signals in spontaneous and evoked conditions have been captured successfully. In addition, an implantable neural signal detecting CMOS IC has been introduced.

关键词： Cuff electrode quasi-tripolar configuration neural signal recording neural channel bridge-connection.

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Communications in Theoretical physics 2018年第8期69卷 197-208页

作者： p.k.Sahu Department of Mathematics Government Shyama Prasad Mukharjee College Sitapur-497111 Sarguja University

Similarity solution for a spherical shock wave with or without gravitational field in a dusty gas is studied under the action of monochromatic radiation. It is supposed that dusty gas be a mixture of perfect gas and micro solid particles. Equilibrium flow condition is supposed to be maintained and energy is varying which is continuously supplied by inner expanding surface. It is found that similarity solution exists under the constant initial density. The comparison between the solutions obtained in gravitating and non-gravitating medium is done. It is found that the shock strength increases with an increase in gravitational parameter or ratio of the density of solid particles to the initial density of the gas, whereas an increase in the radiation parameter has decaying effect on the shock waves.

关键词： spherical shock wave dusty gas similarity solution gravitational medium Roche model monochromatic radiation

Contrasting REE Signatures on Manganese Ores of Iron Ore Group in North Orissa, India

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Journal of Rare Earths 2007年第6期25卷 749-758页

作者： p.p.Mishra B.k.Mohapatra p.p.Singh Institute of Minerals and Materials Technology Bhubaneswar 751013 India post Graduate Department of Geology Utkal University Bhubaneswar 751004 India

The distribution pattern of Rare Earth Elements （REE） in three categories of manganese ores viz. stratiform, stratabound-replacement, and detrital of precambrian Iron Ore Group from north Orissa, India was reported. These categories of Mn-ore differed in their major and trace chemistry and exhibited contrasting REE signature. The stratiform ores were relatively enriched in ∑REE content （697 μg·g^-1） and their normalized pattern showed both positive Ce and Eu anomalies, whereas the stratabound-replacement types were comparatively depleted in ∑REE content （211 μg·g^-1） and showed negative Ce and flat Eu signatures. The detrital categories showed mixed REE pattern. The data plotted in different discrimination diagrams revealed a mixed volcaniclastic and chemogenic source of material for stratiform categories, and LREE （Light Rare Earth Elements） and HREE （Heavy Rare Earth Elements） are contributed by such sources, respectively. In contrast, the stratabound ore bodies were developed during the remobilization of stratiform ores, and associated Mncontaining rocks under supergene condition followed by the redeposition of circulating mineralized colloidal solutions in structurally favorable zones. During this process, some of the constituents were found only in very low concentration within stratabound ores, and this is attributed to their poor leachability/mobility. The detrital ores did not exhibit any significant characteristic in respect of REE as their development was via a complex combination of processes involving weathering, fragmentation, recementation, and burial under soil cover.

关键词： manganese ore REE normalization geochemistry Bonai-keonjhar belt Orissa rare earths

Effect of Cold Deformation on phase Evolution and Mechanical properties in an Austenitic Stainless Steel for Structural and Safety Applications

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Journal of Iron and Steel Research International 2012年第4期19卷 63-68页

作者： S k Ghosh p Mallick p p Chattopadhyay Department of Metallurgy and Materials Engineering Bengal Engineering and Science UniversityShibpurHowrah 711 103India

The effects of cold deformation on the formation of strain induced α’ martensite and mechanical properties of an austenitic stainless steel have been examined.X-ray diffraction analysis has revealed that 30% and 40% cold rolling have resulted in the formation of 24% and 31.5% martensite *** investigation has demonstrated that the formation of martensite is enhanced with increase in the percent deformation at 0 ℃.Investigation of mechanical properties reveals that hardness,yield strength and tensile strength values increase where as percent elongation drops with increasing *** fractographic observation corroborates the tensile *** of sub-surface at the fractured end of the tensile sample manifests that void/microcrack nucleation occurs in the interfacial regions of the martensite phase as well as at the austenite-martensite interface

关键词： austenitic stainless steel cold deformation martensite mechanical property

Impacts of pI3k/protein kinase B pathway activation in reactive astrocytes: from detrimental effects to protective functions

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Neural Regeneration Research 2025年第4期20卷 1031-1041页

作者： Ramón pérez-Núñez María Fernanda González Ana María Avalos Lisette Leyton Cellular Communication Laboratory Programa de Biología Celular y MolecularCenter for Studies on ExerciseMetabolism and Cancer(CEMC)Instituto de Ciencias Biomédicas(ICBM)Facultad de MedicinaUniversidad de ChileSantiagoChile Advanced Center for Chronic Diseases(ACCDiS) Faculty of Chemical and Pharmaceutical Sciences&Faculty of MedicineUniversidad de ChileSantiagoChile Instituto de Ciencias Biomédicas Facultad de Ciencias de la SaludUniversidad Autónoma de ChileSantiagoChile

Astrocytes are the most abundant type of glial cell in the central nervous *** injury and inflammation,astrocytes become reactive and undergo morphological and functional *** on their phenotypic classification as A1 or A2,reactive astrocytes contribute to both neurotoxic and neuroprotective responses,***,this binary classification does not fully capture the diversity of astrocyte responses observed across different diseases and *** analysis has revealed that reactive astrocytes have a complex landscape of gene expression profiles,which emphasizes the heterogeneous nature of their *** actively participate in regulating central nervous system inflammation by interacting with microglia and other cell types,releasing cytokines,and influencing the immune *** phosphoinositide 3-kinase(pI3k)/protein kinase B(AkT)signaling pathway is a central player in astrocyte reactivity and impacts various aspects of astrocyte behavior,as evidenced by in silico,in vitro,and in vivo *** astrocytes,inflammatory cues trigger a cascade of molecular events,where nuclear factor-κB serves as a central mediator of the pro-inflammatory ***,we review the heterogeneity of reactive astrocytes and the molecular mechanisms underlying their *** highlight the involvement of various signaling pathways that regulate astrocyte reactivity,including the pI3k/AkT/mammalian target of rapamycin(mTOR),αvβ3 integrin/pI3k/AkT/connexin 43,and Notch/pI3k/AkT *** targeting the inactivation of the pI3k/AkT cellular signaling pathway to control reactive astrocytes and prevent central nervous system damage,evidence suggests that activating this pathway could also yield beneficial *** dual function of the pI3k/AkT pathway underscores its complexity in astrocyte reactivity and brain function *** review emphasizes the importance of employing astrocyte-exclusive models to underst

关键词： inflammation integrins neuroprotective neurotoxic phosphatidylinositol 3-kinase reactive astrocytes signal transduction Thy-1(CD90)

Characterization of Vacuum Ultraviolet (VUV) Radiation for the Development of a Fluorescent Lamp

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plasma Science and Technology 2011年第4期13卷 480-485页

作者： Hasina kHATUN A.k.SHARMA p.k.BARHAI Microwave Tubes Area Central Electronics Engineering Research Institute Applied physic Department Birla Institute of Technology

A negative unipolar pulsed voltage is applied to study internal electrical parameters of the xenon filled dielectric barrier discharge （DBD） sources. The VUV radiation emitted from these sources is characterized by means of the photoluminescence intensity of the red phosphor pellet. The red phosphor converts the VUV radiation into visible radiation and the emission spectra include a peak at 619.56 nm. The emission characteristics of the red phosphor are analyzed in terms of the pressure-distance （pd）, rise time and frequency of the pulsed voltage waveform. The emission intensity measured at different operational conditions confirms that the formation and decay of the xenon excimer, Xe2^＊, increase with the increase in reduced electric field, E/N. After exceeding certain limits of E/N, the intensity of Xe2^＊ decreases rapidly.

关键词： dielectric barrier discharge vacuum ultraviolet photoluminescence RGB

Iron Reduction and Adsorption on Shewanella putrefaciens nearby Landfills in Northwest Florida

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Journal of Environmental Science and Engineering 2010年第9期4卷 60-69页

作者： p.k. Subramaniam L. Martin p. Grasel k. Tawfiq G. Chen Department of Civil and Environmental Engineering FAMU-FSU College of Engineering Tallahassee Florida 32310 USA Florida Department of Environmental protection Tallahassee Florida 32399 USA

In Northwest Florida, the soil is mainly covered by poorly drained sandy soil of Myakka, which is characterized by a subsurface accumulation of humus and AI and Fe oxides. When organic rich landfill leachate is leaked to the iron rich soils, ferrous iron is released with the oxidation of organic compounds in the leachate. In this research, we investigated the activities of S. putrefaciens in reducing iron oxide in the iron rich soil of Northwest Florida with landfill leachate serving as the carbon source. S. putrefaciens had similar maximum specific growth rate and half saturation coefficients for all the leachate and soil samples. The average maximum specific growth rate was 0.008 hr^-1 and the average half saturation coefficient was 243.8 mg/L. Averagely, 2.2 mg ferrous iron was generated per mg COD consumed. In addition, adsorption of reduced ferrous iron on S. putrefaciens was further characterized. Ferrous iron adsorption on S. putrefaciens was a kinetic process, which increased with the increase of the reaction time. Equilibrium ferrous iron adsorption on S. putrefaciens can be reached after three hours. Ferrous iron had linear adsorption isotherms on S. putrefaciens for the pH range of 5 to 9.

关键词： Ferrous iron S. putrefaciens reduction adsorption.

Solitary kinetic Alfven waves in dense plasmas with relativistic degenerate electrons and positrons

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plasma Science and Technology 2019年第4期21卷 85-93页

作者： Monzurul k AHMED Om p SAH Department of physics Biijhora MahavidyalayaBongaigaon-783380AssamIndia

propagation of solitary kinetic Alfven waves(kAWs)is investigated in small but finite/3(particle-to-magnetic pressure ratio)collisionless dense plasma whose constituents are non degenerate wann ions,and relativistic degenerate electrons and *** the use of reductive perturbation technique,kortweg-de Vries equation is derived to obtain small amplitude localized wave solution of *** effects of plasma 0,positron concentration,electron relativistic degeneracy parameter,ion thermal temperature and obliqueness parameter on solitary kAWs are *** results of this theoretical investigation are aimed at elucidating characteristics of kinetic Alfven solitary waves in relativistic degenerate e-p-i plasmas found in dense astrophysical objects specifically neutron stars and white dwarfs.

关键词： solitary kinetic Alfven waves dense plasmas electron-positron-ion plasma,relativistic degenerate plasma reductive perturbation technique