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Evaluation of Brazilian wild Hevea germplasm for cold tolerance：genetic variability in the early mature growth

Journal of Forestry Research 2016年第4期27卷 755-765页

作者： G.prabhakara Rao p.c.kole Rubber Research Institute of India KottayamKerala 686009India Institute of Agriculture Visva-Bharati UniversitySantiniketanWest Bengal 7211235India

Hevea brasiliensis is a commercially cultivated species for its natural rubber（NR） latex in South East Asian countries. To meet the ever-increasing demand, NR cultivation has been extended to non-traditional regions due to the limited scope of further expansion in traditional rubbergrowing areas in India. These areas are often confronted with various abiotic stresses, especially high and low temperatures, which cause reduction in plant growth, thereby increasing its uneconomical immaturity period. Eighteen wild Hevea accessions along with two modern clones RRII203 and pB 235 and two check clones RRIM 600 and Haiken 1 were evaluated in the early mature growth *** site was at Nagrakata, West Bengal, the sub-Himalayan cold-prone region of India. In Hevea, crop production is governed by two major factors, growth-vigor and production capacity. Growth-vigor is of special importance because the production of rubber is a process linked with the early growth of the plant, which results in early tappability and early economic gains. The genotypes exhibited highly significant clonal differences（p = 0.05） for all the growth traits. Tappability percentage in the seventh year, ranged from 0.33 %（Ac 3074, Ac 3075, Ac 3293） to 89.67 %（RO 2727）. The most vigorously growing accession（RO2727） reached tappabile girth early in the seventh year when the girth of plant ranged from 22.38 cm（Ac 3293） to53.12 cm（RO 2727）. The general mean was 43.32 cm, and the similar growth trend was exhibited by these accessions in the tenth year also. Annual girth increment（cm a-1） over3 years ranged from 1.81 cm（Ac 3075） to 6.80 cm（RO2727）. The mean winter girth increment（cm a-1） over4 years ranged from 0.13 cm（Ac 3075） to 0.96 cm（RO2727） as compared to the check clone RRIM 600（1.11 cm）and Haiken 1（1.10 cm）. Wide differences between the phenotypic coefficient of variation（50.29） and genotypic coefficient of variation（24.82） were observed for winter girth increment. Girth in the tenth year recorded

关键词： Hevea germplasm mature cultivated phenotypic ranged abiotic rubber accession breeding

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Fundamentals of prosthetic urology

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Asian Journal of Andrology 2020年第1期22卷 20-27页

作者： kole p Akula Omer A Raheem Department of Urology Tulane University School of Medicine1430 Tulane Avenue86-42New OrleansLA 70112-2699USA

The field of prosthetic urology demonstrates the striking impact that simple devices can have on quality of *** prosthesis and artificial urinary sphincter implantation are the cornerstone procedures on which this specialty *** research largely concentrates on decreasing the rates of complication and infection,as the current devices offer superior rates of satisfaction when revision is not *** techniques are also able to salvage sexual function and continence in more difficult patient populations including female-to-male transgender individuals,those with ischemic priapism,and those with erectile dysfunction and incontinence secondary to *** review summarizes modern techniques,outcomes,and complications in the field of prosthetic urology.

关键词： implantation penile prosthesis prosthetic urology

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Status and prospects for symmetric organic redox flow batteries

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Journal of Energy chemistry 2025年第1期100卷 125-143页

作者： Md Al Raihan c.Adam Dyker Department of chemistry University of New Brunswick

As environmental concerns from fossil fuel consumption intensify, large-scale energy storage becomes imperative for the integration of renewable sources like wind, hydro, and solar with the electrical *** flow batteries, particularly those employing organic molecules, are positioned as a key technology for this purpose. This review explores the growing field of symmetric organic redox flow batteries(ORFBs) within this context. Unlike traditional asymmetric designs based on unique active materials for each electrode, symmetric ORFBs involve a single bipolar species for both electrodes. This review highlights the benefits of a symmetric design, and categorizes five distinct classes of organic bipolar molecules used in both aqueous and non-aqueous solvents. By providing a comprehensive overview of their cell cycling and performance characteristics, the strengths and weaknesses of the diverse categories of bipolar molecules are highlighted for both solvent systems, as are opportunities for future development. This should guide new research directions and advance the development of practical symmetric ORFBs.

关键词： Redox flow battery Symmetric battery Organic battery Aqueous electrolyte Non-aqueous electrolyte

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The relative value of education of emergency physicians in patient outcome: A retrospective analysis at a single center in developing India

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World Journal of Emergency Medicine 2018年第2期9卷 130-135页

作者： Shastri Vandana Singh Shubnum kole Tamorish Department of Emergency Medicine and Max Institute of Medical Excellence Max Super Specialty Hospital

BAcKGROUND: There is a considerable paucity with regards to the research available on the quality and quantity of clinical teaching in the national emergency department(ED) setups. With the onset of the age of modern medicine, the outlook towards to the time worn tradition of triage and detailed medical evaluation must be revoked. Despite the variety of programs being conducted in the country, a comparable entity common to all is patients' clinical outcomes which can be measured using simple parameters which can be easily acquired compiling hospital registry ***: A retrospective observational study was conducted in the emergency department of Max Hospital, Saket, New Delhi. A period of 22 months prior to the start of the program and like-wise 22 months after initiation of the program was collected from the hospital registry. The Emergency Medicine program in consideration was the Masters in emergency Medicine(MEM) program affiliated with George Washington University, NY, USA. patients of all age groups and gender registering in the Emergency Department and so were all the doctors working in the ED before and after initiation of the ***: An improvement was noted in terms of total admissions through the ED per month, average length of stay of admitted as well as discharged patients; return to ED within 24 hours; leave against medical advice and patient complaints. A reduction was noted in number of discharges from the ED. Despite a numerical worsening on the patient's death in ED a graphical improvement can be noted considering the month wise representation of ***: We can make a coherent conclusion that there is an improvement in the outcome of the entire patient related aspects in the Emergency Department considering the all two time frames included in the study. The difference can be very well attributed to the integration of the structural Academic program in the development of the Emergency physicians. This leads us to make a co

关键词： Education Emergency physicians

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Hepatocellular carcinoma recurrence after liver transplant:An Australian single-centre study

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World Journal of Transplantation 2025年第1期15卷 105-114页

作者： Matthew G Garas Luis calzadilla-Bertot Briohny W Smith Luc Delriviere Byron Jaques Lingjun Mou Leon A Adams Gerry c MacQuillan George Garas Gary p Jeffrey Michael c Wallace Medical School University of Western AustraliaNedlands 6009Western AustraliaAustralia Department of Hepatology Sir Charles Gairdner HospitalNedlands 6009Western AustraliaAustralia Department of Surgery Sir Charles Gairdner HospitalNedlands 6009Western AustraliaAustralia

BAcKGROUND Hepatocellular carcinoma(Hcc)is a leading cause of cancer-related deaths *** transplantation(LT)offers the most effective *** recurrence is the strongest risk factor that decreases post-LT survival in patients transplanted for *** rate of Hcc recurrence is generally reported as 8%-20%in the *** predictors of Hcc have already been researched,however,to our knowledge there are no published studies on this topic using Australian *** To determine the rate and identify predictors of Hcc recurrence in a contemporary Western Australian LT *** We performed a retrospective cohort study of all liver transplants in patients with Hcc at Sir charles Gairdner Hospital between 2006 and *** was collected from various health record databases and included recipient demographics,serum biochemistry,radiology,operation notes,explant histopathology and details of *** survival of Hcc patients post-LT,stratified for recurrence,was calculated by Kaplan Meier *** and multivariate cox regression was used to determine predictors of Hcc recurrence *** Between 1/1/2006 and 12/31/2021,119 patients were transplanted with Hcc.8.4%of subjects developed recurrent Hcc after LT with median follow-up time of 5.4 *** median time to recurrence was 2.9 years±0.75 *** comparing baseline characteristics,a greater proportion of subjects with recurrence had common characteristics on explant histopathology,including>3 viable nodules(p=0.001),vascular invasion(p=0.003)and poorly differentiated Hcc(p=0.03).Unadjusted survival curves showed lower 1-year,3-year,5-year and 10-year survival rates in subjects with Hcc recurrence compared to those without Hcc recurrence(90%vs 92%,70%vs 88%,42%vs 80%,14%vs 76%,respectively;log rank pcONcLUSION Hcc recurrence was low at 8.4%in this contemporary Australian cohort,however it significantly impacted post-LT *** studies are requir

关键词： Liver cancer Recurrence Liver transplantation Hepatocellular carcinoma predictors post-transplant survival Australian data

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Acquired sensorineural hearing loss,oxidative stress,and microRNAs

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Neural Regeneration Research 2025年第9期20卷 2513-2519页

作者： Desmond A.Nunez Ru c.Guo Division of Otolaryngology–Head&Neck Surgery Department of SurgeryFaculty of MedicineThe University of British ColumbiaVancouverBCCanada Division of Otolaryngology–Head&Neck Surgery Gordon&Leslie Diamond Health Care CentreVancouver General HospitalVancouverBCCanada Faculty of Medicine–The University of British columbia VancouverBCCanada

Hearing loss is the third leading cause of human ***-related hearing loss,one type of acquired sensorineural hearing loss,is largely responsible for this escalating global health ***-induced,ototoxic,and idiopathic sudden sensorineural are other less common types of acquired hearing *** etiology of these conditions is complex and multi-fa ctorial involving an interplay of genetic and environmental *** stress has recently been proposed as a likely linking cause in most types of acquired sensorineural hearing *** non-coding RNA sequences known as microRNAs(miRNAs)have increasingly been shown to play a role in cellular hypoxia and oxidative stress responses including promoting an apoptotic *** hair cell death is a central histopathological finding in sensorineural hearing *** these cells do not regenerate in humans,it underlies the irreversibility of human age-related hearing *** EMBASE,Ovid MEDLINE,Web of Science core collection,and *** databases over the period August 1,2018 to July 31,2023 were searched with"hearing loss,""hypoxamiRs,""hypoxia,""microRNAs,""ischemia,"and"oxidative stress"text words for English language primary study publications or registered clinical *** red clinical trials known to the senior author we re also assessed.A total of 222studies were thus *** excluding duplicates,editorials,retra ctions,secondary research studies,and non-English language articles,39 primary studies and clinical trials underwent full-text *** resulted in 11 animal,in vitro,and/or human subject journal articles and 8 registered clinical trial database entries which form the basis of this narrative *** miR-34a and miR-29b levels increase with age in *** miRNAs were demonstrated in human neuroblastoma and murine cochlear cell lines to target Sirtuin 1/peroxisome proliferato r-activated receptor gamma coactivator-1-alpha(SIRT1/p Gc-1α),SIRT

关键词： hearing loss hypoxia microRNAs oxidative stress sensorineural

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Unlocking hypoglycemia–associated brain microvascular dysfunction:critical insights from proteomic analysis

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Neural Regeneration Research 2025年第6期20卷 1707-1708页

作者： Siva S.V.p.Sakamuri Anil Sakamuri Department of chemistry Auburn University at MontgomeryMontgomeryALUSA Vascular Biology center and Department of Medicine Medical College of Georgia at Augusta UniversityAugustaGAUSA

Hypoglycemia-a critical complication linked to worsened brain function in diabetic subjects:Hypoglycemia is characterized by a decline in circulatory glucose levels below sta nda rd physiological *** hypoglycemia,classified as level 1 hypoglycemia,is defined by blood glucose levels below 70 mg/dL and can be effectively addressed through carbohydrate *** hypoglycemia,denoted by blood glucose levels less than 54 mg/dL,poses a life-threatening risk if left *** with type 1 and type 2 diabetes undergoing insulin treatment are particularly susceptible to hypoglycemia due to impaired counterregulatory mechanisms.

关键词： impaired intake critical

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Multiple sclerosis is at a checkpoint: advancing the program

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Neural Regeneration Research 2025年第3期20卷 811-812页

作者： Brandon c.Smith Jessica L.Williams Department of Neurosciences Lerner Research InstituteCleveland ClinicClevelandOHUSA Department of Biological Geologicaland Environmental SciencesCleveland State UniversityClevelandOHUSA

Multiple sclerosis(MS) is a chronic inflammatory and demyelinating disease of the central nervous system(cNS). patients with MS experience sensory and motor function loss due to myelin and/or axon damage perpetuated b... 详细信息

关键词： Hauser sclerosis damage

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Small molecule inhibitor DDQ-treated hippocampal neuronal cells show improved neurite outgrowth and synaptic branching

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Neural Regeneration Research 2025年第9期20卷 2624-2632页

作者： Jangampalli Adi pradeepkiran priyanka Rawat Arubala p.Reddy Erika Orlov pHemachandra Reddy Department of Internal Medicine Texas Tech University Health Sciences CenterLubbockTXUSA Department of Nutritional Sciences College of Human SciencesTexas Tech UniversityLubbockTXUSA Department of pharmacology&Neuroscience Texas Tech University Health Sciences CenterLubbockTXUSA Department of Neurology Texas Tech University Health Sciences CenterLubbockTXUSA Department of Speech Language and Hearing SciencesTexas Tech University Health Sciences CenterLubbockTXUSA Department of public Health Texas Tech University Health Sciences CenterLubbockTXUSA

The process of neurite outgrowth and branching is a crucial aspect of neuronal development and *** and dendrites,sometimes referred to as neurites,are extensions of a neuron's cellular body that are used to start *** we explored the effects of diethyl(3,4-dihydroxyphenethylamino)(quinolin-4-yl)methylphosphonate(DDQ)on neurite developmental features in HT22 neuronal *** this work,we examined the protective effects of DDQ on neuronal processes and synaptic outgrowth in differentiated HT22cells expressing mutant Tau(mTau)*** investigate DDQ chara cteristics,cell viability,biochemical,molecular,western blotting,and immunocytochemistry were *** outgrowth is evaluated through the segmentation and measurement of neural *** neural processes can be seen and measured with a fluorescence microscope by manually tracing and measuring the length of the neurite *** neuronal processes can be observed and quantified with a fluorescent microscope by manually tracing and measuring the length of the neuronal ***-treated mTau-HT22 cells(HT22 cells transfected with cDNA mutant Tau)were seen to display increased levels of synaptophysin,MAp-2,andβ-***,we confirmed and noted reduced levels of both total and p-Tau,as well as elevated levels of microtubule-associated protein 2,β-tubulin,synaptophysin,vesicular acetylcholine transporter,and the mitochondrial biogenesis protein-pe roxisome prolife rator-activated receptor-gamma coactivator-1α.In mTa u-expressed HT22 neurons,we observed DDQ enhanced the neurite characteristics and improved neurite development through increased synaptic *** findings conclude that mTa u-HT22(Alzheimer's disease)cells treated with DDQ have functional neurite developmental chara *** key finding is that,in mTa u-HT22 cells,DDQ preserves neuronal structure and may even enhance nerve development function with mTa u inhibition.

关键词： diethyl(3 4-dihydroxyphenethylamino)(quinolin-4-yl)methylphosphonate(DDQ) hippocampal neuronal cells HT22 neurite outgrowth neuronal development small molecule

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Serological surveillance for SARS-coV-2 antibodies among students,faculty and staff within a large university system during the pandemic

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World Journal of Virology 2025年第1期14卷 99-107页

作者： Marcos G pinheiro Gabriela G O Alves Maria Eduarda R conde Sofia L costa Regina c S Sant’Anna Isa M F Antunes Mônica c carneiro Fabio S Ronzei Julia c Scaffo Felipe R pinheiro Lialyz S Andre Helvecio c povoa Valéria T Baltar Fabíola Giordani Eduarda S Hemerly Gisele c Alexandre Karla c de paula Márcio Watanabe Antonio claudio L da Nóbrega Jackeline christiane p Lobato Fabio Aguiar-Alves Laboratory of Molecular Epidemiology and Biotechnology Rodolpho Albino University LaboratoryFluminense Federal UniversityNiterói 24241000Rio de JaneiroBrazil Estácio de SáUniversity Nova Friburgo 28611135Rio de JaneiroBrazil pathology program Medicine schoolFluminense Federal UniversityNiterói 24070090Rio de JaneiroBrazil Department of pharmaceutical Sciences Lloyd L.Gregory School of PharmacyPalm Beach Atlantic UniversityWest Palm BeachFL 33401United States Health Institute of Nova Friburgo Fluminense Federal UniversityNova Friburgo 28613001Rio de JaneiroBrazil Department of Epidemiology and Biostatistics Institute of Collective Health(ISC)Fluminense Federal UniversityNiterói 24033900Rio de JaneiroBrazil Institute of physical Education Fluminense Federal UniversityNiterói 24020005Rio de JaneiroBrazil Department of Statistics Fluminense Federal UniversityNiterói 24210200Rio de JaneiroBrazil Department of physiology and pharmacology Fluminense Federal UniversityNiterói 24210130Rio de JaneiroBrazil

BAcKGROUND At the end of December 2019,the world faced severe acute respiratory syndrome-coronavirus 2(SARS-coV-2),which led to the outbreak of coronavirus disease 2019(cOVID-19),associated with respiratory *** virus has shown significant challenges,especially for senior citizens,patients with other underlying illnesses,or those with a sedentary *** tests conducted early on have helped identify how the virus is transmitted and how to curb its *** study hypothesis was that the rapid serological test for SARS-coV-2 antibodies could indicate the immunoreactive profile during the cOVID-19 pandemic in a university *** To conduct active surveillance for serological expression of anti-SARS-coV-2 antibodies in individuals within a university setting during the cOVID-19 *** This sectional study by convenience sampling was conducted in a large university in Niteroi-RJ,Brazil,from March 2021 to July *** study population consisted of students,faculty,and administrative staff employed by the university.A total of 3433 faculty members,60703 students,and 3812 administrative staff were invited to *** were gathered through rapid serological tests to detect immunoglobulin(Ig)M and IgG against ***χ²or Fisher's exact test was used to conduct statistical analysis.A 0.20 significance level was adopted for variable selection in a multiple logistic regression model to evaluate *** A total of 1648 individuals were enrolled in the *** proportion of cOVID-19 positivity was 164/1648(9.8%).The adjusted logistic model indicate a positive association between the expression of IgM or IgG and age[odds ratio(OR)=1.16,95%cI:1.02-1.31](pcontact with a cOVID-19-positive case(OR=3.49,95%cI:2.34-5.37)(pceived the cOVID-19 vaccine(OR=2.33,95%cI:1.61-3.35)(pcial isolation(OR=0.59,95%cI:0.41-0.84)(p<0.004).The likelihood of sho

关键词： Serological surveillance SARS-coV-2 antibodies cOVID-19 Serological rapid test Risk factors for cOVID-19

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