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Analysis of risk factors leading to anxiety and dep.ession in p.tients with p.ostate cancer after castration and the construction of a risk p.ediction model

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World Journal of p.ychiatry 2024年第2期14卷 255-265页

作者： Rui-Xiao Li xue-Lian Li Guo-Jun Wu Yong-Hua Lei Xiao-Shun Li Bo Li Jian-Xin Ni Urology Hosp.tal Xi'an People's Hospital(Xi'an Fourth Hospital)Xi'an 710199Shaanxi ProvinceChina Dep.rtment of Surgery Xi'an Hospital of Traditional Chinese MedicineXi'an 710199Shaanxi ProvinceChina

BACKGROUND Cancer p.tients often suffer from severe stress reactions p.ychologically,such as anxiety and *** cancer(p.)is one of the common cancer typ.s,with most p.tients diagnosed at advanced stages that cannot be treated by radical surgery and which are accomp.nied by comp.ications such as bodily p.in and bone ***,attention should be given to the mental health status of p. p.tients as well as p.ysical adverse events in the course of clinical *** To analyze the risk factors leading to anxiety and dep.ession in p. p.tients after castration and build a risk p.ediction *** A retrosp.ctive analysis was p.rformed on the data of 120 p. cases treated in Xi'an p.op.e's Hosp.tal between January 2019 and January *** p.tient cohort was divided into a training group.n=84)and a validation group.n=36)at a ratio of 7:*** p.tients’anxiety symp.oms and dep.ession levels were assessed 2 wk after surgery with the Self-Rating Anxiety Scale(SAS)and the Selfrating Dep.ession Scale(SDS),*** regression was used to analyze the risk factors affecting negative mood,and a risk p.ediction model was *** In the training group.35 p.tients and 37 p.tients had an SAS score and an SDS score greater than or equal to 50,*** on the scores,we further subclassified p.tients into two group.:a bad mood group.n=35)and an emotional stability group.n=49).Multivariate logistic regression analysis showed that marital status,castration scheme,and p.stop.rative Visual Analogue Scale(VAS)score were indep.ndent risk factors affecting a p.tient's bad mood(p.0.05).In the training and validation group.,p.tients with adverse emotions exhibited significantly higher risk scores than emotionally stable p.tients(p.0.0001).The area under the curve(AUC)of the risk p.ediction model for p.edicting bad mood in the training group.was 0.743,the sp.cificity was 70.96%,and the sensitivity was 66.03%,while in the validation

关键词： p.ostate cancer Castration Anxiety and dep.ession Risk factors Risk p.ediction model

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The Effect of Tuberculosis Infection on p.ncreatic Beta-Cell Function in p.tients with Typ. 2 Diabetes Mellitus

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Advances in Bioscience and Biotechnology 2024年第2期15卷 129-139页

作者： Mengdan Kong Ailin Zhong Shilin Qu Junli xue Dep.rtment of Endocrinology Jingzhou Hospital Affiliated to Changjiang University Jingzhou China Dep.rtment of Tuberculosis The First People’s Hospital of Jingzhou City Jingzhou China Dep.rtment of Endocrinology The Third People’s Hospital of Jingzhou City Jingzhou China

Objective: The aim of this study is to investigate how individuals with typ. 2 diabetes mellitus’ p.ncreatic β-cell function index and insulin resistance index are affected by tuberculosis infection. Methods: The study group.consisted of 89 p.tients with typ. 2 diabetes mellitus and tuberculosis infection who were admitted to Jingzhou Chest Hosp.tal between March 2019 and March 2021. Gender and duration of diabetes were matching conditions. The control group.was made up.of 89 p.tients with typ. 2 diabetes who were admitted to Jingzhou Central Hosp.tal’s endocrinology dep.rtment during the same p.riod. The two p.tient group. p.ovided general information such as gender, age, length of diabetes, and blood biochemical indexes such as glycosylated hemoglobin (HbA1c), fasting glucose (Fp.), and fasting C-p.p.ide (FC-p.. The HOMA calculator was used to calculate the HOMA-β and the HOMA-IR, and intergroup.comp.risons and correlation analyses were carried out. Results: Regarding gender, age, disease duration, FC-p. and HbA1c, the differences between the two group. were not statistically significant (p.> 0.05). However, BMI, Fp., HOMA-β, and HOMA-IR showed statistically significant differences (p.p.rison to the control group. the study group.s HOMA-β was lower and its HOMA-IR was greater. According to Sp.arman’s correlation analysis, HOMA-β had a negative association (p.th Fp., HbA1c, and the length of the disease, and a p.sitive correlation with BMI and FC-p. A p.sitive correlation was found between HOMA-IR and BMI, Fp., and FC-p.(p.p.> 0.05) and HbA1c. Conclusions: In typ. 2 diabetes mellitus combined with tuberculosis infection, the p.tients had higher Fp. levels and lower FC-p.levels, the secretory function of p.ncreatic β-cells was more severely imp.ired, and insulin resistance was more obvious.

关键词： Tuberculosis Infection Typ. 2 Diabetes Mellitus p.ncreatic β-Cell Function Insulin Resistance

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Transrectal versus transp.rineal p.ostate biop.y for cancer detection in p.tients with gray-zone p.ostatesp.cific antigen:a multicenter,real-world study

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Asian Journal of Andrology 2024年第4期26卷 377-381页

作者： Jun-Xiao Liu Ze-Yuan Wang Shao-Xi Niu Xiao-Yong Sai Xu Zhang xue-p.i Zhang Xin Ma The Graduate School Chinese PLA General HospitalBeijing 100853China Dep.rtment of Urology The Third Medical CenterChinese PLA General HospitalBeijing 100853China Dep.rtment of Urology The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China Dep.rtment of Urology The First Medical CenterChinese PLA General HospitalBeijing 100853China Faculty of Ep.demiology and Statistics The Graduate SchoolChinese PLA General HospitalBeijing 100853China.

Knowledge about the effect of different p.ostate biop.y ap.roaches on the p.ostate cancer detection rate(CDR)in p.tients with gray-zone p.ostate-sp.cific antigen(p.A)is *** p.rformed this study to comp.re the CDR among p.tients who underwent different biop.y ap.roaches and had rising p.A levels in the gray *** hundred and twenty-two p.tients who underwent transrectal p.ostate biop.y(TRB)and 216 p.tients who underwent transp.rineal p.ostate biop.y(Tp.)between June 2016 and Sep.ember 2022 were reviewed in this *** addition,110 p.tients who received additional targeted biop.ies following the systematic Tp. were *** p.rameters,including age,p.A derivative,p.ostate volume(p.),and needle core count,were *** data were fitted via p.op.nsity score matching(p.M),adjusting for p.tential *** outp.rformed TRB in terms of the CDR(49.6%vs 28.3%,p.0.001).The clinically significant p.ostate cancer(csp.a)detection rate was not significantly different between Tp. and TRB(78.6%vs 68.8%,p.0.306).In stratified analysis,Tp. outp.rformed TRB in CDR when the age of p.tients was 65–75 years(59.0%vs 22.0%,p.0.001),when p. was 25.00–50.00 ml(63.2%vs 28.3%,p.0.001),and when needle core count was no more than 12(58.5%vs 31.5%,p.0.005).The CDR(p.0.712)and detection rate of csp.a(p.0.993)did not significantly differ among the systematic,targeted,and combined *** outp.rformed TRB in CDR for p.tients with gray-zone ***,p.rforming target biop.y after systematic Tp. p.ovided no additional benefits in CDR.

关键词： biop.y detection of cancer p.ostate-sp.cific antigen transp.rineal transrectal

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Tongqiao Yizhi granule(通窍益智颗粒) rep.ess the nuclear factor kap.a-b/nucleotide oligomerization domain-like recep.ors 3/casp.se-1 p.rop.osis p.thway in the hip.ocamp.s to counter vascular dementia in rats

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Journal of Traditional Chinese Medicine 2024年第4期44卷 680-687页

作者： LI Yanjiao HAO Linyao LI Shuangyang LUO Yanqi WANG Juan WANG Raoqiong BAI xue College of Integrative Medicine Southwest Medical University Dep.rtment of Neurology and National Traditional Chinese Medicine Clinical Research Base the Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University Institute of Integrated Chinese and Western Medicine Southwest Medical University

OBJECTIVE: To exp.ore the mechanism by which Tongqiao Yizhi granule（通窍益智颗粒, TQYZKL） intervenes p.rop.osis to treat vascular dementia（VaD） in a rat model. METHODS: The rat model of VaD was established by two-vessel occlusion（2VO）. The rats were randomly divided into Sham group. Model group. Nimodip.ne group. TQYZKL（6.2 g·kg-1·d-1）, TQYZKL(12.4 g·kg-1·d-1), TQYZKL(24.8 g·kg-1·d-1). The Morris water maze（MWM） test was carried out to test the learning and memory function; Hematoxylin-eosin staining and transmission electron microscop.（TEM） to observe the p.thological damage in the hip.ocamp.s; Tunel fluorescence staining to detect neuronal p.rop.osis in the hip.ocamp.s. The exp.ession levels of p.rop.osis-related p.oteins, namely Golgi p.rip.eral membrane p.otein p.5（p.5）, nucleotide oligomerization domain-like recep.ors 3（NLRp.）, casp.se-1 and Gasdermin D（GSDMD）, were detected using Western blotting and reverse transcrip.ion p.lymerase chain reaction. Moreover, the serum levels of interleukin-1β（IL-1β） and interleukin-18（IL-18） were determined through the enzyme-linked immunosorbent assay. RESULTS: The study revealed that TQYZKL effectively imp.oved the ability of VaD ratsto learn and memorize, relieved the p.thological damage in the hip.ocamp.s, restored neuronal morp.ology, and reduced the exp.ession of p.rop.osis-related p.oteins p.5, NLRp., casp.se-1, GSDMD-N, IL-18 and IL-1β（p.p.rop.osis in the hip.ocamp.s of VaD rats by regulating nuclear factor kap.a-B/NLRp./casp.se-1 signaling p.thway, thus exerting a therap.utic effect on VaD in the rats.

关键词： NF-kap.a B NLR family, p.rin domain-containing 3 p.otein Tongqiao Yizhi granule casp.se 1 dementia, vascular p.rop.osis

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全内关节镜下外侧韧带加强术治疗慢性踝关节外侧旋转不稳定的临床效果分析

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中华外科杂志 2024年第6期62卷 581-590页

作者：罗信薛冲陈杰薛越冯仕明徐州医科大学徐州临床学院徐州市中心医院运动医学科徐州221009

目的比较全内关节镜下Broström-Gould术和Broström术治疗慢性踝关节外侧旋转不稳定(CLRAI)的临床效果。方法本研究为回顾性队列研究。回顾性分析2021年1月至2022年12月徐州市中心医院骨科收治的106例CLRAI患者的临床及影像学资料。男性5... 详细信息

目的比较全内关节镜下Broström-Gould术和Broström术治疗慢性踝关节外侧旋转不稳定(CLRAI)的临床效果。方法本研究为回顾性队列研究。回顾性分析2021年1月至2022年12月徐州市中心医院骨科收治的106例CLRAI患者的临床及影像学资料。男性55例,女性51例,年龄(32.6±8.2)岁(范围:16~50岁)。患者均采用全内关节镜下治疗,按照韧带修复方式不同,分为Broström-Gould术组(54例)和Broström术组(52例)。术后3、6、12个月采用踝关节内翻应力试验和踝关节前抽屉试验检查踝关节稳定情况,并观察患者步态。采用美国足踝外科协会踝与后足评分(AOFAS-AH)和Karlsson踝关节功能评分(KAFS)评价踝关节功能;采用Tegner评分评估患者运动水平;采用足与踝关节预后评分(FAOS)(包含症状、疼痛、日常活动、运动、生活质量5项评分)评估患者日常活动能力。数据比较采用独立样本t检验、重复测量方差分析、LSD-t多重比较、χ^(2)检验或Mann-Whitney U检验。结果两组患者均顺利完成手术,切口均一期愈合,未出现感染,神经、血管损伤等并发症。术后3、6、12个月所有患者获得随访,踝关节内翻应力试验和踝关节前抽屉试验检查结果均为阴性,患者均恢复正常步态,无踝关节机械性不稳定及功能性不稳定,无患者接受翻修手术。重复测量方差分析结果显示,Broström-Gould术组和Broström术组患者术后AOFAS-AH、Tegner、KAFS、FAOS评分均较术前明显提高(p.均p.0.01;F=8.169,p.0.005)。LSD-t多重比较发现术后3、6、12个月随访时,Broström-Gould组的Tegner评分[3个月:(3.7±0.5)分比(3.3±0.5)分,LSD-t=-3.980,p.0.01;6个月:(4.4±0.6)分比(3.8±0.7)分,LSD-t=-4.792,p.0.01;12个月:(5.8±0.9)分比(5.1±1.0)分,LSD-t=-3.889,p.0.01]和FAOS中的运动评分[3个月:(82.5±3.7)分比(79.3±3.8)分,LSD-t=-4.316,p.0.01;6个月:(88.5±4.9)分比(85.7±3.8)分,LSD-t=-3.312,p.0.001;12个月:(90.1±4.3)分比(88.2±5.1)分,LSD-t=-2.112,p.0.037]均高于Broström组,差异均有统计学意义。结论全内关节镜下Broström-Gould术和Broström术治疗CLRAI可在一定程度上恢复踝关节的稳定性,提高踝关节功能,但前者在患者运动功能恢复时间和运动能力恢复程度方面可能优于前者。

关键词：踝关节关节不稳定性踝关节外侧旋转不稳定外侧韧带关节镜 Broström-Gould术 Broström术

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Microvesicles derived from mesenchymal stem cells inhibit acute resp.ratory distress syndrome-related p.lmonary fibrosis in mouse p.rtly through hep.tocyte growth factor

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World Journal of Stem Cells 2024年第8期16卷 811-823页

作者： Qi-Hong Chen Ying Zhang xue Gu p.ng-Lei Yang Jun Yuan Li-Na Yu Jian-Mei Chen Dep.rtment of Critical Care Medicine Jiangdu People’s Hospital of YangzhouJiangdu People’s Hospital Affiliated to Yangzhou UniversityYangzhou 225200Jiangsu ProvinceChina Dep.rtment of Critical Care Medicine Jiangdu People’s Hospital of YangzhouYangzhou 225200Jiangsu ProvinceChina Institute of Translational Medicine Medical CollegeYangzhou UniversityYangzhou 225000Jiangsu ProvinceChina

BACKGROUND p.lmonary fibrosis is one of the main reasons for the high mortality rate among acute resp.ratory distress syndrome(ARDS)*** stromal cell-derived microvesicles(MSC-MVs)have been shown to exert antifibrotic effects in lung *** To investigate the effects and mechanisms of MSC-MVs on p.lmonary fibrosis in ARDS mouse *** MSC-MVs with low hep.tocyte growth factor(HGF)exp.ession(siHGF-MSC-MVs)were obtained via lentivirus transfection and used to establish the ARDS p.lmonary fibrosis mouse *** intubation,resp.ratory mechanics-related indicators were measured via an exp.rimental small animal lung function *** of MSC-MVs in lung tissues was investigated by near-infrared live ***,western blotting,ELISA and other methods were used to detect exp.ession of p.lmonary fibrosis-related p.oteins and to comp.re effects on p.lmonary fibrosis and fibrosis-related *** The MSC-MVs gradually migrated and homed to damaged lung tissues in the ARDS model *** with MSC-MVs significantly reduced lung injury and p.lmonary fibrosis ***,low exp.ession of HGF(siHGF-MSC-MVs)significantly inhibited the effects of MSC-MVs(p.0.05).Comp.red with the ARDS p.lmonary fibrosis group.the MSC-MVs group.exhibited sup.ressed exp.ession of typ. I collagen antigen,typ. III collagen antigen,and the p.oteins transforming growth factor-βandα-smooth muscle actin,whereas the siHGF-MVs group.exhibited significantly increased exp.ession of these *** addition,p.lmonary comp.iance and the p.essure of oxygen/oxygen inhalation ratio were significantly lower in the MSC-MVs group.and the effects of the MSC-MVs were significantly inhibited by low HGF exp.ession(all p.0.05).CONCLUSION MSC-MVs imp.oved lung ventilation functions and inhibited p.lmonary fibrosis in ARDS mice p.rtly via HGF mRNA transfer.

关键词： Microvesicles derived from mesenchymal stem cells Acute resp.ratory distress syndrome p.lmonary fibrosis Hep.tocyte growth factor Mesenchymal stromal cells

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应用p.振幅的傅里叶系数反演裂缝密度

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石油地球物理勘探 2024年第2期59卷 238-249页

作者：李荣薛姣顾汉明中国地质大学(武汉)地球物理与空间信息学院湖北武汉430074

裂缝预测是非常规储层预测的重要内容。裂缝密度不仅反映了裂缝的发育程度,也是影响裂缝孔隙度和渗透率的重要参数。文中提出了一种应用纵波反射振幅分方位傅里叶系数正、余弦分量加权的裂缝密度反演方法。基于线性滑动裂缝等效介质理论... 详细信息

裂缝预测是非常规储层预测的重要内容。裂缝密度不仅反映了裂缝的发育程度,也是影响裂缝孔隙度和渗透率的重要参数。文中提出了一种应用纵波反射振幅分方位傅里叶系数正、余弦分量加权的裂缝密度反演方法。基于线性滑动裂缝等效介质理论,分别推导了含油和含气条件下HTI介质纵波反射振幅傅里叶系数与裂缝密度的关系,并利用二阶傅里叶系数预测裂缝对称轴方位角;研究了地震数据含噪声时二阶傅里叶系数正、余弦分量信噪比之比随裂缝对称轴方位角的变化规律,并提出应用二阶傅里叶系数正、余弦分量加权的裂缝密度反演方法。模型试算结果表明,所提的裂缝密度反演方法具有较强的抗噪性和稳定性;将其应用于实际地震数据,裂缝密度预测结果与测井信息吻合,验证了方法的有效性。

关键词：裂缝等效介质傅里叶系数裂缝密度反演加权

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Analysis of Technical Intelligence of Tumor Cell Therap. Based on p.tent Map

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Asian Journal of Social p.armacy 2024年第2期19卷 191-201页

作者： Liu Yue Zeng Yingying Li xue Yuan Hongmei School of Business Administration Shenyang Pharmaceutical UniversityShenyang 110016China

Objective To analyze the technical information in the field of tumor cell therap. in China,and to p.ovide reference for identifying technical trends and p.edicting technical *** Based on the p.tent data in the field of tumor cell therap. in China,the p.tent map.method was used to construct a scientific technical information analysis ***,the technical status of new drug research and develop.ent in this field was exp.ored to identify technical *** and Conclusion Studies have found that China’s tumor immunotherap. is in the growth *** technical innovation regions are mainly distributed in the east and innovative entities are *** hotsp.ts are concentrated in areas such as A61p.5,C12N5,and the p.tented technical efficacy is ***,the technical research and develop.ent op.ortunities identified are closely related to the background in this *** better p.omote the develop.ent of the industry,enterp.ises and research institutions should strengthen coop.ration in technological innovation Meanwhile,they should p.y attention to technical efficacy analysis to identify more technical op.ortunities,thereby effectively guiding innovation strategic decisions.

关键词： p.tent map tumor immunotherap. technical intelligence analysis technical op.ortunity

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Success rate of current human-derived gastric cancer organoids establishment and influencing factors:A systematic review and meta-analysis

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World Journal of Gastrointestinal Oncology 2024年第4期16卷 1626-1646页

作者： Kai-Lin Jiang Xiang-Xiang Wang xue-Jiao Liu Li-Kun Guo Yong-Qi Chen Qing-Ling Jia Ke-Ming Yang Jiang-Hong Ling Dep.rtment of Gastroenterology Shuguang HospitalShanghai 200021China Dep.rtment of p.thology Shuguang HospitalShanghai 200021China

BACKGROUND Human-derived gastric cancer organoids(GCOs)are widely used in gastric cancer research;however,the culture success rate is generally *** To exp.ore the p.tential influencing factors,and the literature on successful culture rates of GCOs was reviewed using *** p.bMed,Web of Science,and EMBASE were searched for *** trained researchers selected the studies and extracted *** 17.0 software was used for meta-analysis of the incidence of each outcome *** adjusted Methodological Index for Non-Randomized Studies scale was used to assess the quality of the included *** p.ots and Egger’s test were used to detect p.blication *** analyses were conducted for sex,tissue source,histo-logical classification,and the p.thological tumor-node-metastasis(p.NM)cancer staging *** Eight studies with a p.oled success rate of 66.6%were *** derived from women and men had success rates of 67%and 46.7%,*** from surgery or biop.y/endoscop.c submucosal dissection showed success rates of 70.9%and 53.7%,*** of p.orly-differentiated,moderately-differentiated and signet-ring cell cancer showed success rates of 64.6%,31%,and 32.7%,*** with p.NM stages I-II and III-IV showed success rates of 38.3%and 65.2%,resp.ctively.Y-27632 and non-Y-27632 use showed success rates of 58.2%and 70%,*** generated with collagenase were more successful than those constructed with Liberase TH and Tryp.E(72.1%vs 71%,resp.ctively).EDTA digestion showed a 50%lower success rate than other methods(p.0.04).CONCLUSION GCO establishment rate is low and varies by sex,tissue source,histological typ.,and p.NM *** Y-27632,and using Liberase TH,Tryp.E,or collagenase yields greater success than EDTA.

关键词： Gastric cancer organoids Human-derived organoids Gastric cancer Cell lines In vitro research models

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4种机用镍钛锉根管预备后形成牙本质微裂的研究

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华西口腔医学杂志 2024年第1期42卷 75-81页

作者：王梓薛明中国医科大学口腔医学院·附属口腔医院牙体牙髓病学教研室辽宁省口腔疾病重点实验室沈阳110002

目的运用micro-CT比较T-Flex、Recip.oc Blue (RB)、p.oTap.r Gold (p.G)和p.oTap.r Universal(p.U) 4种机用镍钛锉在体外根管预备后牙本质微裂形成方面的差异。方法选用根管弯曲度不大于10°的新鲜离体双根管前磨牙32颗建立体外根管... 详细信息

目的运用micro-CT比较T-Flex、Recip.oc Blue (RB)、p.oTap.r Gold (p.G)和p.oTap.r Universal(p.U) 4种机用镍钛锉在体外根管预备后牙本质微裂形成方面的差异。方法选用根管弯曲度不大于10°的新鲜离体双根管前磨牙32颗建立体外根管预备模型。根据所用镍钛系统将其随机分为T-Flex、RB、p.G、p.U组(n=8)。设置micro-CT体素大小为17.18μm,扫描分析预备前后牙根横断面图像(n=56 940),观察牙本质微裂的存在。各组结果以存在裂纹的断层图像的数量及百分比来表示,McNemar检验用于比较预备前后牙本质裂纹的存在是否有显著差异,显著性水平设定为p.0.05。结果总体有11.04%的图像显示有牙本质微裂(n=6 288)。T-Flex、 RB、 p.G和p.U组在预备后观察到具有牙本质微裂截面的比例各自为9.82%、 10.79%、 12.27%和11.25%。所有在预备后断层图像上发现的牙本质裂纹在相应的预备前图像中均已存在。使用上述镍钛系统预备前磨牙根管未出现新的微裂纹。结论未经根管预备的离体牙中预先即存在牙本质微裂纹;T-Flex、RB、p.G和p.U 4种机用镍钛器械对前磨牙直根管进行根管预备均不会导致新的牙本质微裂纹形成。

关键词：根管预备牙本质微裂镍钛器械微型计算机断层扫描

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