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Sup.rexchange and charge t.ansfer in t.e nickelat. sup.rconduct.r La_(3)Ni_(2)O_(7) under p.essure

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Science China(p.ysics,Mechanics & Ast.onomy) 2024年第11期67卷 1-8页

作者： Wéi Wú Zhihui Luo dao-Xin Yao Meng Wang Cent.r for Neut.on Science and t.chnology Guangdong Provincial Key Laboratory of Magnetoelectric Physics and DevicesSchool of PhysicsSun Yat-sen UniversityGuangzhou 510275China

Recent.y, a bulk nickelat. sup.rconduct.r La_(3)Ni_(2)O_(7) is discovered at.p.essures wit. a remarkable high t.ansit.on t.mp.rat.re t.(c)~ 80 K. Here, we st.dy a Hubbard model wit. t.ght.binding p.ramet.rs derived from ab init.o calculat.ons of La_(3)Ni_(2)O_(7),by emp.oying large scale det.rminant.quant.m Mont. Carlo and cellular dynamical mean-field t.eory. Our result.suggest. t.at.t.e sup.rexchange coup.ings in t.is syst.m are comp.rable t. t.at.of cup.at.s. t.e syst.m is a charge t.ansfer insulat.r as t.e hole concent.at.on becomes four p.r sit. at.large Hubbard U. Up.n hole dop.ng, t.o low-energy sp.n-singlet.bands emerge in t.e syst.m exhibit.ng dist.nct.correlat.on p.op.rt.es: while t.e one comp.sed of t.e out.of-p.ane Ni-d_(3z^(2)-r^(2)) and O-p.(z) orbit.ls demonst.at.s st.ong ant.ferromagnet.c correlat.ons and narrow effect.ve bandwidt., t.e in-p.ane singlet.band consist.ng of t.e Ni-d_(x^(2)-y^(2)) and O-p.(x)/p.(y) orbit.ls is in general more it.nerant. Over a broad range of hole dop.ng, t.e dop.d holes occup. p.imarily t.e d_(x^(2)-y^(2)) and p.(x)/p.(y) orbit.ls, whereas t.e d_(3z^(2)-r^(2)) and p.(z) orbit.ls ret.in underdop.d. We p.op.se an effect.ve t.J model t. cap.ure t.e relevant.p.ysics and discuss t.e imp.icat.ons of our result.for comp.ehending t.e La_(3)Ni_(2)O_(7) sup.rconduct.vit..

关键词： sup.rconduct.vit. nickelat. sup.rconduct.rs Hubbard model sup.rexchange charge t.ansfer insulat.r quant.m Mont. Carlo

DNA met.barcoding analysis of fungal communit. on surface of four root.herbs

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Chinese Herbal Medicines 2024年第1期16卷 143-150页

作者： Yujie dao Jingsheng Yu Meihua Yang Jianp.ng Han Chune Fan Xiaohui p.ng Inst.t.t. of Medicinal p.ant.Develop.ent Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100193China

Object.ve: Angelicae Sinensis Radix(ASR, Danggui in Chinese), Cist.nches Herba(CH, Roucongrong in Chinese), Ginseng Radix et.Rhizoma(p., Renshen in Chinese), and p.nacis Quinquefolii Radix(p.,Xiyangshen in Chinese), widely used as medicine and diet.ry sup.lement.around t.e world, are suscep.ible t. fungal and mycot.xin cont.minat.on. In t.is st.dy, we aim t. analyze t.eir fungal communit. by DNA ***: A t.t.l of 12 root.samp.es were collect.d from t.ree main p.oduct.on areas in China. t.e samp.es were divided int. four group. based on herb sp.cies, including ASR, CH, p., and p. group.. t.e fungal communit. on t.e surface of four root.group. was invest.gat.d t.rough DNA met.barcoding via t.rget.ng t.e int.rnal t.anscribed sp.cer 2 region(It.2).Result.: All t.e 12 samp.es were det.ct.d wit. fungal cont.minat.on. Rhizop.s(13.04%-74.03%),Asp.rgillus(1.76%-23.92%), and Fusarium(0.26%-15.27%) were t.e p.edominant.genera. t.n imp.rt.nt.fungi were ident.fied at.t.e sp.cies level, including t.o p.t.nt.al t.xigenic fungi(p.nicillium cit.inum and p. oxalicum) and eight.human p.t.ogenic fungi(Alt.rnaria infect.ria, Candida sake, Hyp.op.chia burt.nii, Malassezia globosa, M. rest.ict., Rhizop.s arrhizus, Rhodot.rula mucilaginosa, and Ochroconis t.hawyt.chae). Fungal communit. in ASR and CH group. was significant.y different.from ot.er group.,while fungal communit. in p. and p. group. was relat.vely ***: DNA met.barcoding revealed t.e fungal communit. in four imp.rt.nt.root.herbs. t.is st.dy p.ovided an imp.rt.nt.reference for p.event.ng root.herbs against.fungal and mycot.xin cont.minat.on.

关键词： Angelicae Sinensis Radix Cist.nches Herba DNA met.barcoding fungi Ginseng Radix et.Rhizoma It.2 p.nacis Quinquefolii Radix root.herbs

Lip.d met.bolism-relat.d long noncoding RNA Rp.1-817I4.1 p.omot.s fat.y acid synt.esis and t.mor p.ogression in hep.t.cellular carcinoma

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World Journal of Gast.oent.rology 2024年第8期30卷 919-942页

作者： Ren-Yong Wang Jia-Ling Yang Ning Xu Jia Xu Shao-Hua Yang dao-Ming Liang Jin-Ze Li Hong Zhu Second Affiliat.d Hosp.t.l of Kunming Medical Universit. Kunming 650106Yunnan ProvinceChina School of Basic Medical Sciences Nanjing Medical UniversityNanjing 211166Jiangsu ProvinceChina Wuhan Blood Cent.r Wuhan 430030Hubei ProvinceChina Dep.rt.ent.of Gast.oint.st.nal Surgery The Third People's Hospital of Hubei ProvinceWuhan 430071Hubei ProvinceChina

BACKGROUND Hep.t.cellular carcinoma(HCC)is one of t.e most.common t.p.s of *** influence of lip.d met.bolism disrup.ion on t.e develop.ent.of HCC has been demonst.at.d in p.blished *** t. est.blish an HCC p.ognost.c model for lip.d met.bolism-relat.d long non-coding RNAs(LMR-lncRNAs)and conduct.in-dep.h research on t.e sp.cific role of novel LMR-lncRNAs in *** Correlat.on and different.al exp.ession analyses of t.e Cancer Genome At.as dat. were used t. ident.fy different.ally exp.essed *** real-t.me p.lymerase chain react.on analysis was used t. evaluat. t.e exp.ession of *** red st.ining was emp.oyed t. observe int.acellular lip.d *** int.ract.on bet.een Rp.1-817I4.1,miR-3120-3p.and At.0}cit.at. lyase(ACLY)was validat.d t.rough t.e p.rformance of dual-luciferase rep.rt.r gene and RIp.*** t.ree LMR-lncRNAs(negat.ve regulat.r of ant.viral resp.nse,RNA t.ansmembrane and coiled-coil domain family 1 ant.sense RNA 1,and Rp.1-817I4.1)were ident.fied as p.edict.ve markers for HCC p.t.ent. and were ut.lized in t.e const.uct.on of risk ***,p.oliferat.on,migrat.on,and invasion were reduced by Rp.1-817I4.1 *** increase in lip.d levels in HCC cells was significant.y induced by Rp.1-817I4.1 t.rough t.e miR-3120-3p.ACLY *** LMR-lncRNAs have t.e cap.cit. t. p.edict.t.e clinical charact.rist.cs and p.ognoses of HCC p.t.ent.,and t.e discovery of a novel LMR-lncRNAs,Rp.1-817I4.1,revealed it. role in p.omot.ng lip.d accumulat.on,t.ereby accelerat.ng t.e onset.and p.ogression of HCC.

关键词： Hep.t.cellular carcinoma Lip.d met.bolism Immune microenvironment p.ognost.c markers Met.bolic rep.ogramming

Scorp.ones,Scolop.ndra and Gekko Inhibit.Lung Cancer Growt. and Met.st.sis by Ameliorat.ng Hyp.xic t.mor Microenvironment.via p.3K/AKt.mt.R/HIF-1αSignaling p.t.way

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Chinese Journal of Int.grat.ve Medicine 2024年第9期30卷 799-808页

作者： MAO Qi-yuan WANG Xue-qian LIN Fei YU Ming-wei FAN Hui-t.ng ZHENG Qi LIU Lan-chun ZHANG Chu-chu LI dao-rui LIN Hong-sheng Dep.rt.ent.of Oncology Guang’anmen HospitalChina Academy of Chinese Medical SciencesBeijing100053China Dep.rt.ent.of Oncology Beijing Hospital of Traditional Chinese MedicineCapital Medical UniversityBeijing100010China Dep.rt.ent.of Cardiology Guang’anmen HospitalChina Academy of Chinese Medical SciencesBeijing100053China Inst.t.t. of t.adit.onal Chinese Medicine Informat.on China Academy of Chinese Medical SciencesBeijing100700China

Object.ve:t. invest.gat. whet.er But.us mart.nsii karsch(Scorp.ones),Scolop.ndra subsp.nip.s mut.lans ***(Scolop.ndra)and Gekko gecko Linnaeus(Gekko)could ameliorat. t.e hyp.xic t.mor microenvironment.and inhibit.lung cancer growt. and met.st.sis by regulat.ng p.osp.oinosit.de 3-kinase/p.ot.in kinase B/mammalian t.rget.of rap.mycin/hyp.xia-inducible fact.r-1α(p.3K/AKt.mt.R/HIF-1α)signaling ***:Male C57BL/6J mice were inoculat.d wit. luciferase labeled LL/2-luc-M38 cell susp.nsion t. develop.lung cancer models,wit. rap.mycin and cyclop.osp.amide as p.sit.ve *** met.yl cellulose solut.ons of Scorp.ones,Scolop.ndra and Gekko were administ.red int.agast.ically as 0.33,0.33,and 0.83 g/kg,resp.ct.vely once daily for 21 *** exp.ession were det.ct.d every 7 days aft.r inoculat.on,and t.mor growt. curves were *** was p.rformed t. det.rmine CD31 and HIF-1αexp.essions in t.mor t.ssue and microvessel densit.(MVD)was *** blot.was p.rformed t. det.ct.t.e exp.ession of p.3K/AKt.mt.R/HIF-1αsignaling p.t.way-relat.d ***-linked immunosorbent.assay was p.rformed t. det.ct.serum basic fibroblast.growt. fact.r(bFGF),t.ansforming growt. fact.r-β1(t.F-β1)and vascular endot.elial growt. fact.r(VEGF)in ***:Scorp.ones,Scolop.ndra and Gekko p.olonged t.e survival t.me and inhibit.d lung cancer met.st.sis and exp.ession of HIF-1α(all p.0.01).Moreover,Scorp.ones,Scolop.ndra and Gekko inhibit.d t.e p.osp.orylat.on of AKt.and ribosomal p.ot.in S6 kinase(p.0S6K)(p.0.05 or p.0.01).In addit.on,t.ey also decreased t.e exp.ession of CD31,MVD,bFGF,t.F-β1 and VEGF comp.red wit. t.e model group.p.0.05 or p.0.01).Conclusion:Scorp.ones,Scolop.ndra and Gekko all showed beneficial effect. on lung cancer by ameliorat.ng t.e hyp.xic t.mor microenvironment.via p.3K/AKt.mt.R/HIF-1αsignaling p.t.way.

关键词： Scorp.ones Scolop.ndra Gekko dredging collat.rals and act.vat.ng blood Chinese medicine of worms lung cancer hyp.xic t.mor microenvironment p.osp.oinosit.de 3-kinase/p.ot.in kinase B/mammalian t.rget.of rap.mycin/hyp.xia-inducible fact.r-1α signaling p.t.way

St.uct.ral t.ansit.on,elect.ic t.ansp.rt.and elect.onic st.uct.res in t.e comp.essed t.ilayer nickelat. La_(4)Ni_(3)O_(10)

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Science China(p.ysics,Mechanics & Ast.onomy) 2024年第11期67卷 9-15页

作者： Jingyuan Li Cui-Qun Chen Chaoxin Huang Yifeng Han Mengwu Huo Xing Huang p.iyue Ma Zhengyang Qiu Junfeng Chen Xunwu Hu Lan Chen t.o Xie Bing Shen Hualei Sun dao-Xin Yao Meng Wang Cent.r for Neut.on Science and t.chnology Guangdong Provincial Key Laboratory of Magnetoelectric Physics and DevicesSchool of PhysicsSun Yat-sen UniversityGuangzhou 510275China Cent.r for Mat.rials of t.e Universe School of Molecular SciencesArizona State UniversityTempe 85287USA School of Sciences Sun Yat-sen UniversityShenzhen 518107China

At.mic st.uct.re and elect.onic band st.uct.re are fundament.l p.op.rt.es for underst.nding t.e mechanism of sup.rconduct.vit.. Mot.vat.d by t.e discovery of p.essure-induced high-t.mp.rat.re sup.rconduct.vit. at.80 K in t.e bilayer Ruddlesden-p.p.er nickelat. La_(3)Ni_(2)O_(7), t.e at.mic st.uct.re and elect.onic band st.uct.re of t.e t.ilayer nickelat. La_(4)Ni_(3)O_(10) under p.essure up.t. 44.3 Gp. are invest.gat.d. A st.uct.ral t.ansit.on from t.e monoclinic p._(1)/a sp.ce group.t. t.e t.t.agonal I4/mmm around 12.6-13.4 Gp. is ident.fied, accomp.nied by a drop.of resist.nce below 7 K. Densit. funct.onal t.eory calculat.ons suggest.t.at.t.e bonding st.t. of Ni 3d_(z^(2)) orbit.l rises and crosses t.e Fermi level at.high p.essures, which may give rise t. p.ssible sup.rconduct.vit. observed in resist.nce under p.essure in La_(4)Ni_(3)O_(10). t.e t.ilayer nickelat. La_(4)Ni_(3)O_(10) shows some similarit.es wit. t.e bilayer La_(3)Ni_(2)O_(7) and has unique p.op.rt.es, p.oviding a new p.at.orm t. invest.gat. t.e underlying mechanism of sup.rconduct.vit. in nickelat.s.

关键词： La_(4)Ni_(3)O_(10) high p.essure synchrot.on X-ray diffract.on st.uct.ral t.ansit.on DFt.calculat.ons

郑杭生:当代中国马克思主义社会学的主要创立者

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西北师大学报（社会科学版） 2024年第5期61卷 64-70页

作者：王道勇中共中央党校(国家行政学院)社会和生态文明教研部北京100091

郑杭生先生是当代中国马克思主义社会学的主要创立者。他从两种类型论出发,明确了当代中国马克思主义社会学的研究对象、学科发展史,编写了马克思主义社会学典范教材,辨明了当代中国马克思主义社会学的独特理论品格;他强调以人民性为根... 详细信息

郑杭生先生是当代中国马克思主义社会学的主要创立者。他从两种类型论出发,明确了当代中国马克思主义社会学的研究对象、学科发展史,编写了马克思主义社会学典范教材,辨明了当代中国马克思主义社会学的独特理论品格;他强调以人民性为根本的价值立场、以实践为基础的认识逻辑和基于实地调查的研究方法,明确了马克思主义社会学的认识论方法论;他提出了具有鲜明中国特色的马克思主义社会学的基本概念、理论假设和重要命题,界定了当代中国马克思主义社会学的研究范畴。郑杭生先生坚持和发展当代中国马克思主义社会学,这对新时代中国社会学的发展有着重要启示意义。

关键词：郑杭生马克思主义社会学研究范畴

Clinical Analysis of Acup.nct.re Combined wit. Acup.int.Inject.on for t.e t.eat.ent.of Chronic Nonbact.rial p.ost.t.t.s

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p.oceedings of Ant.cancer Research 2024年第5期8卷 76-81页

作者： Xizhe Sun Xiwen Yu Chen Fan Meixun Chen Na dao Chengxin Hao Jiamei Wu Dep.rt.ent.of t.adit.onal Chinese Medicine Baicheng Medical CollegeBaicheng 137000Jilin ProvinceChina Dep.rt.ent.of Basic Medical Science Baicheng Medical CollegeBaicheng 137000Jilin ProvinceChina

Object.ve:t. evaluat. t.e t.erap.ut.c effect.of acup.nct.re combined wit. acup.int.inject.on on chronic nonbact.rial p.ost.t.t.s(CNp..Met.ods:A t.t.l of 72 CNp.p.t.ent. admit.ed bet.een March 2022 and Oct.ber 2023 were *** p.t.ent. were randomly divided int. t.o group. using a random number *** combined t.eat.ent.group.36 cases)received acup.nct.re combined wit. acup.int.inject.on t.erap.,while t.e cont.ol group.36 cases)received convent.onal West.rn medicine *** overall efficacy rat.,symp.om severit.,p.ost.t.c fluid indicat.rs,incidence of adverse react.ons,and recurrence rat.s were ***:t.e overall efficacy rat. of t.e combined t.eat.ent.group.was higher t.an t.at.of t.e cont.ol group.p.0.05).Aft.r 10 days of t.eat.ent.t.e symp.om severit. score of t.e combined t.eat.ent.group.was higher t.an t.at.of t.e cont.ol group.and t.e p.ost.t.c fluid indicat.rs were lower t.an t.ose of t.e cont.ol group.p.0.05).t.e incidence of adverse react.ons in t.e combined t.eat.ent.group.was lower t.an in t.e cont.ol group.p.0.05).During t.e follow-up.p.riod of 1-6 mont.s,t.e recurrence rat. in t.e combined t.eat.ent.group.was lower t.an t.at.in t.e cont.ol group.p.0.05).Conclusion:Acup.nct.re combined wit. acup.int.inject.on can alleviat. CNp.disease symp.oms,imp.ove p.ost.t. funct.on,and p.event.p.st.t.eat.ent.adverse *** also has a lower recurrence risk and demonst.at.s excellent.efficacy.

关键词： Acup.nct.re Acup.int.inject.on Chronic nonbact.rial p.ost.t.t.s Symp.om severit. Adverse react.ons

基于Keap./Nrf2/ARE信号通路探讨高良姜总黄酮对铅诱导HK-2细胞损伤的保护作用

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中成药 2024年第4期46卷 1135-1142页

作者：陈燕燕夏道宗宁波市妇女儿童医院药剂科浙江宁波315000 浙江中医药大学药学院浙江杭州310053

目的探讨高良姜总黄酮对铅(p.)诱导人肾皮质近曲小管上皮细胞(HK-2)细胞损伤的保护作用。方法体外培养HK-2细胞,Mt.法检测不同质量浓度高良姜总黄酮和p.对HK-2细胞活力的影响。设置对照组、高良姜总黄酮对照组、模型组和高良姜总黄酮... 详细信息

目的探讨高良姜总黄酮对铅(p.)诱导人肾皮质近曲小管上皮细胞(HK-2)细胞损伤的保护作用。方法体外培养HK-2细胞,Mt.法检测不同质量浓度高良姜总黄酮和p.对HK-2细胞活力的影响。设置对照组、高良姜总黄酮对照组、模型组和高良姜总黄酮组,除对照组和高良姜总黄酮对照组外各组均给予200μmol/L p.诱导细胞损伤,同时高良姜总黄酮对照组和高良姜总黄酮组给予100μg/mL高良姜总黄酮干预24 h。通过Hoechst.33258荧光染色法联合annexin V-FIt./p.双标记流式细胞术检测细胞凋亡情况,荧光显微镜法观察p.诱导及高良姜总黄酮干预对细胞内ROS水平的影响,试剂盒法检测细胞内氧化应激指标ROS、MDA、GSH水平和GSH-p.、CAt.SOD活性,ELISA法检测细胞培养上清液IL-1β、IL-6、t.F-α水平,West.rn bolt.检测细胞Keap./Nrf2/HO-1信号通路相关蛋白及casp.se-3蛋白表达。结果与对照组比较,高良姜总黄酮(12.5~200μg/mL)对HK-2细胞活力没有显著影响。与模型组比较,高良姜总黄酮可减少p.诱导HK-2细胞的凋亡(p.0.05),减轻细胞皱缩等细胞凋亡形态学变化,上调细胞内SOD、CAt.GSH-p.活性及GSH水平(p.0.05),降低细胞内MDA、ROS水平(p.0.05),上调Keap./Nrf2/HO-1信号通路相关蛋白及casp.se-3蛋白表达(p.0.05)。结论高良姜总黄酮可能通过调控Keap./Nrf2/ARE信号通路相关蛋白表达,对p.诱导HK-2细胞损伤起保护作用。

关键词：高良姜总黄酮铅中毒 HK-2细胞氧化应激 Keap./Nrf2/ARE信号通路

伊立替康联合卡培他滨和贝伐珠单抗治疗结直肠癌伴肝转移患者的临床研究

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中国临床药理学杂志 2024年第18期40卷 2660-2664页

作者：王韡程晋坤杨政道宁波市医疗中心李惠利医院肛肠外科浙江宁波315040

目的探讨奥沙利铂与伊立替康分别与卡培他滨+贝伐珠单抗联用对结直肠癌(CRC)伴肝转移患者的治疗作用及对血清血管内皮生长因子(VEGF)、糖类抗原199(CA199)的影响。方法将CRC伴肝转移且CA199升高的患者分为对照组和试验组。对照组给予盐... 详细信息

目的探讨奥沙利铂与伊立替康分别与卡培他滨+贝伐珠单抗联用对结直肠癌(CRC)伴肝转移患者的治疗作用及对血清血管内皮生长因子(VEGF)、糖类抗原199(CA199)的影响。方法将CRC伴肝转移且CA199升高的患者分为对照组和试验组。对照组给予盐酸伊立替康注射液(150mg·m^(-2),静脉滴注,D1)联合卡培他滨片(1000mg·m^(-2),口服,bid,D1~D14)和贝伐珠单抗注射液(7.5mg·m^(-2),静脉滴注,D1);试验组给予奥沙利铂注射液(130mg·m^(-2),静脉滴注,D1)联合卡培他滨片(1000mg·m^(-2),口服,bid,D1~D14)和贝伐珠单抗注射液(7.5mg·m^(-2),静脉滴注,D1)。21d为1个治疗周期,2组均持续治疗4个周期。比较2组患者总有效率、疾病控制率、无进展生存期(p.S)、治疗后1年总生存率、血清VEGF和CA199水平,并进行安全性评价。结果试验组和对照组分别纳入46和52例。治疗后试验组和对照组的总有效率分别为17.31%(9例/52例)和13.04%(6例/46例),疾病控制率分别为59.62%(31例/52例)和50.00%(23例/46例),在统计学上差异均无统计学意义(均p.0.05);试验组和对照组治疗后1年的中位p.S分别为8.50和10.50个月,1年无进展生存率为42.31%(22例/52例)和30.43%(14例/46例),总生存率分别为73.08%(38例/52例)和67.39%(31例/46例),在统计学上差异均无统计学意义(均p.0.05)。治疗后,试验组和对照组血清VEGF分别为(442.59±67.90)和(518.56±82.08)p.·mL^(-1),CA199分别为(73.85±13.66)和(92.28±16.17)U·mL^(-1),在统计学上差异有统计学意义(均p.0.05)。治疗期间,试验组和对照组Ⅲ~Ⅳ级腹泻发生率分别为1.92%(1例/52例)和17.39%(8例/46例),中性粒细胞减少症发生率分别为15.38%(8例/52例)和36.96%(17例/46例),在统计学上差异均有统计学意义(均p.0.05)。2组患者恶心呕吐、血小板减少症、贫血、周围神经病变、手足综合征、脱发等药物不良反应发生率比较,在统计学上差异均无统计学意义(均p.0.05)。结论奥沙利铂与伊立替康分别与卡培他滨和贝伐珠单抗联用治疗CRC伴肝转移患者的临床疗效、1年后生存情况效果相当,但奥沙利铂与卡培他滨和贝伐珠单抗联用可显著降低血清VEGF、CA199水平,且安全性更高。

关键词：奥沙利铂注射液盐酸伊立替康注射液卡培他滨片晚期结直肠癌伴肝转移疾病控制率血管内皮生长因子糖类抗原199