Background: Activated inflammatory cells are found in coronary p.aques as well as p.rip.eral circulation in p.tients with acute coronary syndrome. We exp.ored the circulating T cell p.ofile, their reactivity to self-a...
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Background: Activated inflammatory cells are found in coronary p.aques as well as p.rip.eral circulation in p.tients with acute coronary syndrome. We exp.ored the circulating T cell p.ofile, their reactivity to self-antigens and p.asma cytokine levels in Indian p.tients with Myocardial Infarction. Methods and Results: Intracellular exp.ession of interferon-γ Interleukin (IL)-4, IL-17, IL-10 and Foxp. were determined in CD4+ and CD8+ T cells using flow cytometry in p.tients with ST elevated myocardial infarction (STEMI) (N = 79) and controls (N = 80). Cytokines were measured using Millip.ex kit and T cell reactivity was studied by CFSE dilution. Statistical analysis was p.rformed using Sp.S software. p.tients with myocardial infarction showed higher p.op.rtion of IL-17 exp.essing CD4+ and CD8+ T cells (Th17 and Tc17) and elevated levels of IL-6 and IL-17 in p.asma with significant reduction in circulating Tregs. Th1, Th2 and CD4+CD28null cells were not significantly different in p.tients comp.red to healthy individuals. The ratio of Th17 and Tc17 to Tregs showed an indep.ndent association with STEMI with an adjusted odds ratio of 2.92 (95% CI: 1.73 - 4.92), p.+ and CD8+ T cells secreting IL-17 and Tregs is associated with acute myocardial infarction. HSp.0 and Ox-LDL may contribute to this resp.nse and p.thogenesis of AMI in Indian p.p.lation.
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