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Oxidative stress in granul.sa cel.s contributes to p.or oocytequal.ty and IVF-ET outcomes in women with p.l.cystic ovarysyndrome

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Frontiers of Medicine 2018年第5期12卷 518-524页

作者： Qiaohong l.i Wenp.i Xiang Qing l. Hanwang Zhang Yufeng l. Guijin Zhu Chengl.ang Xiong l.i Jin Rep.oductive Medicine Center Tongji Hospital Famil. p.anning Research Institute Tongji Medical College Huazhong University ofScience and Technology Wuhan 430030 China

The increased l.vel. of intracel.ul.r reactive oxygen sp.cies (ROS) in granul.sa cel.s (GCs) may affect the p.egnancy resul.s in women with p.l.cystic ovary syndrome (p.OS). In this study, we comp.red the in vitro fertil.zation and embryo transfer (IVF-ET) resul.s of 22 p.tients with p.OS and 25 p.tients with tubal.factor infertil.ty and detected the ROS l.vel. in the GCs of these two group.. Resul.s showed that the p.OS group.had significantl. l.rger fol.icl.s on the administration day for human chorionic gonadotrop.n than the tubal.factor group.(p.l. different between the two group. (p.> 0.05). p.OS group.had sl.ghtl. l.wer fertil.zation, cl.avage, grade I/II embryo, cl.nical.p.egnancy, and imp.antation rates and higher miscarriage rate than the tubal.factor group.(p.> 0.05). We further found a significantl. higher ROS l.vel.of GCs in the p.OS group.than in the tubal.factor group.(p.l.vel. in GCs caused GC ap.p.osis, whereas NADp. oxidase 2 (NOX2) sp.cific inhibitors (dip.enyl.neiodonium and ap.cynin) significantl. reduced the ROS p.oduction in the p.OS group. In concl.sion, the increased ROS exp.ession l.vel. in p.OS GCs greatl. induced cel. ap.p.osis, which further affected the oocyte qual.ty and reduced the p.sitive IVF-ET p.egnancy resul.s of women with p.OS. NADp. oxidase p.thway may be invol.ed in the mechanism of ROS p.oduction in GCs of women with p.OS.

关键词： IVF-ET NADp. oxidase p.OS ROS granul.sa cel.

Sel.ction against abdominal.fat p.rcentage may increase intramuscul.r fat content in broil.rs

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Selection against abdominal fat percentage may increase intr...

Transl.tional.sel.nium nanop.rticl.s boost Gp.1 activation to reverse HAdV-14 virus-induced oxidative damage

第七届中国畜牧科技论坛

作者： l.l.ng H.Zhang J.Q.Dong Z.p.Wang X.Y.Zhang S.Z.Wang Z.p.Cao Y.M.l. H.l. Key l.boratory of Chicken Genetics and Breeding Ministry of Agriculture

Excessive abdominal.fat content(AFC) has negative imp.cts on feed efficiency and carcass *** AFC,intramuscul.r fat content(IMFC) coul. be a favorabl. trait,which has a p.sitive imp.ct on meat *** meet consumers’ needs,a l.ng-term goal.of broil.r breeders is to decrease AFC and imp.ove the IMFC *** current study was designed to investigate the rel.tionship.between AFC and IMFC and to comp.re IMFC,incl.ding the p.ctoral.major muscl. fat content(p.MFC) and intramuscul.r fat content of l.g muscl.(l.MFC),between two broil.r l.nes divergentl. sel.cted for abdominal.fat p.rcentage over 17 *** resul.s showed that there was a significant difference in p.MFC and l.MFC between the two l.nes in al. five generation p.p.l.tions *** birds in the l.an l.ne had significantl. l.wer AFC but higher p.MFC and l.MFC than the birds in the fat *** al.o detected differences in the l.ver fat content(l.C) between the two l.nes and the resul.s showed that birds in the fat l.ne had significant higher l.C than birds in the l.an *** resul.s indicated that a desirabl. broil.r l.ne with higher IMFC but l.wer AFC coul. be obtained by genetic sel.ction.

关键词： abdominal.fat content intramuscul.r fat content l.ver fat content chicken

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Bioactive Material. 2024年第8期38卷 276-291页

作者： Yinghua l. Ting l.u Ruil.n Zheng Jia l.i Jingyao Su Jial. l. Bing Zhu Tianfeng Chen Dep.rtment of Chemistry Jinan UniversityChina Center l.boratory Guangzhou Women and Children’s Medical CenterGuangzhou Medical UniversityGuangzhouChina Key l.boratory of Viral.p.thogenesis&Infection p.evention and Control.Jinan University) Ministry of EducationChina

Human adenovirus(HAdV)can cause severe resp.ratory infections in immunocomp.omised p.tients,but its cl.nical.treatment is seriousl. l.mited by side effects of drugs such as p.or efficacy,l.w bioavail.bil.ty and severe *** el.ment sel.nium(Se)has been found wil. affect the disease p.ogression of p.eumonia,but its antivirus efficacy coul. be imp.oved by sp.ciation ***,herein we p.rformed anti-HAdV effects of different Se sp.ciation and found that l.ntinan(l.T)-decorated sel.nium nanop.rticl.s(SeNp.)exhibited l.w cytotoxicity and excel.ent anti-HAdV antiviral.***,SeNp.@l.T reduced the HAdV infection-induced mitochondrial.damage and excessive p.oduction of reactive oxygen sp.cies(ROS).It was al.o invol.ed in the rep.ir of host cel. DNA damage and inhibition of viral.DNA ***@l.T inhibited HAdV-induced ap.p.osis mainl. by modul.ting the p.3/Bcl.2 ap.p.osis signal.ng *** vivo,SeNp.@l.T rep.enished Se by targeting the infected site through the circul.tory system and was invol.ed in the synthesis of Gl.tathione p.roxidase 1(Gp.1).More imp.rtantl.,Gp.1 p.ayed an antioxidant and immunomodul.tory rol. in al.eviating HAdV-induced infl.mmatory cytokine storm and al.eviating adenovirus p.eumonia in Se-deficient ***,this study p.ovides a Se sp.ciation of SeNp.@l.T with anti-HAdV activity,and demonstrate that SeNp.@l.T is a p.omising p.armaceutical.candidate for the treatment of HAdV.

关键词： Sel.nium sp.ciation Sel.nium nanop.rticl.s HAdV-14 Ap.p.osis Gp.1

Synchronization and Control.of Hal.-Chaos in Beam Transp.rt Network with Smal. Worl. Top.l.gy

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Communications in Theoretical.p.ysics 2007年第4期47卷 752-758页

作者： l.U Qiang FANG Jin-Qing l. Yong China Institute of Atomic Energy P.O. Box 275-81 Beijing 102413 China

The synchronous conditions of two kinds of the smal.-worl. （SW） network are studied. The smal. worl. top.l.gy can affect on dynamical.behaviors of the beam transp.rt network （BTN） l.rgel., if the BTN is constructed with the SW top.l.gy, the gl.bal.l.near coup.ing and sp.cial.l.near feedback can real.ze the synchronization control.of beam hal.-chaos as wel. as p.riodic state in the BTN with the SW top.l.gy, resp.ctivel.. This imp.rtant resul. can p.ovide an effective way for the exp.rimental.study and the engineering design of the BTN in the high-current accel.rator driven radioactive cl.an nucl.ar p.wer systems, and may have p.tential.use in p.osp.ctive ap.l.cations for hal.-chaos secure communication.

关键词： beam hal.-chaos synchronization control smal.-worl. network beam transp.rt network gl.bal.l.near coup.ing sp.cial.l.near feedback

Some Refl.ctions on “l.vabl. City”

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China City p.anning Review 2007年第2期16卷 64-68页

作者： MA Wuding, Secretary General. Xiamen Urban p.anning Commission, Fujian p.ovince and p.ofessor, Tongji University, Shanghai, p. R. China. l. Caige

It can be said that "l.vabl. city" is a com-p.ehensive concep. which invol.es the rel.tionship.between man and city in the asp.cts of al. man’s needs for l.ving. In-vol.ing various activities such as dressing, eating... 详细信息

关键词： housing entertainment sp.rts dressing eating freed

以β-淀粉样蛋白为靶标的藏药对阿尔采末病Tg2576转基因鼠学习记忆的影响

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中国药理学通报 2009年第6期25卷 720-724页

作者：朱爱琴褚以德 l. Qiao-xin Col.n l.Masters 青海省人民医院老年病研究所青海西宁810007 澳大利亚墨尔本大学精神研究中心

目的探讨藏药七十味珍珠丸(RNSp.以β-淀粉样蛋白为靶标对阿尔采末病(AD)动物模型学习记忆作用的机制。方法25只13～14mon♀Tg2576转基因鼠和同龄♀C57Bl.6XDBA鼠为正常对照组给予七十味珍珠丸灌胃8wk。利用Y-迷宫明暗分辨学习和旷场实... 详细信息

目的探讨藏药七十味珍珠丸(RNSp.以β-淀粉样蛋白为靶标对阿尔采末病(AD)动物模型学习记忆作用的机制。方法25只13～14mon♀Tg2576转基因鼠和同龄♀C57Bl.6XDBA鼠为正常对照组给予七十味珍珠丸灌胃8wk。利用Y-迷宫明暗分辨学习和旷场实验观察转基因鼠学习、记忆和行为学变化。蛋白免疫印迹法测定鼠血清β淀粉样蛋白(Aβ)和β位点Ap.内切酶(BACE-1)含量,免疫组织化学法观察Aβ在脑的表达。结果通过Y-迷宫测试,藏药Tg2576治疗组达标所需要的训练时间明显低于Tg2576对照组(p.0.01)。旷场实验测定发现Tg2576治疗组在中央格停留时间明显减低,跨格和站立次数增加,粪便颗粒数也明显减少。蛋白印迹法定量分析,经RNSp.疗的转基因鼠血清Aβ和BACE-1含量较对照组明显减低。RNSp.够明显减少大脑皮层和海马周围老年淀粉样斑块的数目和面积。结论藏药七十味珍珠丸改善Tg2576转基因鼠学习和空间记忆以及探索运动能力,减少焦虑状态等认知行为可能通过抑制BACE-1(即β-分泌酶)的表达来减少老年斑和Aβ的生成而起作用的。

关键词：藏药七十味珍珠丸阿尔采末病 Tg2576转基因鼠 β-淀粉样蛋白 β位点Ap.内切酶 Y-迷宫明暗分辨学习和旷场实验

Mul.ivariate statistical.anal.sis of cl.nicop.thol.gic factors infl.encing survival.of p.tients with bil. duct carcinoma

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Worl. Journal.of Gastroenterol.gy 2002年第5期8卷 943-946页

作者： He, p.Shi, JS Chen, WK Wang, ZR Ren, H l., H Xian Jiaotong Univ Hosp 1 Hepatobiliary Res Lab Xian 710061 Shanxi Province Peoples R China

AIM: To eval.ate the infl.ence of various cl.nicop.thol.gicfactors on survival.of p.tients with bil. duct carcinoma aftercurative ***: A retrosp.ctive anal.sis was made for 86 casesof bil. duct carcinoma treated from January 1981 toSep.ember 1995. Fifteen cl.nicop.thol.gic factors p.ssibl.infl.encing survival.were sel.cted. Indep.ndent variabl.swere first anal.zed by univariate methods. Survival.forvariabl. was estimated by the method of Kap.an and *** variabl.s that were statistical.y significant by univarl.teanal.sis were incl.ded in a mul.ivariate anal.sis, which wereconfirmed using the Cox step.ise p.op.rtion hazard model.ith the hel.0}of Sp.S 10.0 for Windows ***: The overal. cumul.tive survival.rate was 72.6 %at 1 year, 32.4 % at 3 years, and 18.7 % at 5 years. Theresul.s of univariate anal.sis showed that the majorsignificant p.ognostic factors infl.encing survival.of thesep.tients were histol.gical.typ. of l.sion, l.mp. nodemetastasis, p.ncreatic invasion, duodenal.invasion, p.dneural.nvasion, macroscop.c vessel.invol.ement, resected surgical.argin and dep.h of cancer invasion (p.0.02, 0.02, 0.004,0.005, 0.01, 0.43, 0.03 and 0.04). Age, sex, l.cation of tumor,size of tumor, macroscop.c typ. of l.sions, hep.ticmetastasis, and hep.tic invasion were not significantl.associated with p.ognosis (p.0.05). p.ncreatic invasion,p.rineural.invasion and l.mp. node metastases were thethree most imp.rtant p.ognostic factors by mul.ivariateanal.sis using the Cox p.op.rtional.hazards ***: p.ncreatic invasion, p.dneural.invasion andl.mp. node metastases are the most imp.rtant p.ognosticfactors for bil. duct carcinoma after curative resection.

关键词：胆管癌生存率影响因素临床病理学

局部麻醉下机器人辅助经皮椎体后凸成形伤椎注入骨水泥的患者体验分析

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中国组织工程研究 2025年第22期29卷 4647-4652页

作者：李佳鸿林书唐六一胡豇俞阳张伟四川省医学科学院·四川省人民医院(电子科技大学附属医院)骨科四川省成都市610072

背景:局部麻醉下传统C臂辅助经皮椎体后凸成形手术需多次透视以调整穿刺方向,工作通道建立时间较长,患者术中疼痛刺激较大;而机器人辅助经皮椎体后凸成形手术可一次性精准穿刺成功,明显改善患者术中体验,同时减少骨水泥渗漏风险。目的:... 详细信息

背景:局部麻醉下传统C臂辅助经皮椎体后凸成形手术需多次透视以调整穿刺方向,工作通道建立时间较长,患者术中疼痛刺激较大;而机器人辅助经皮椎体后凸成形手术可一次性精准穿刺成功,明显改善患者术中体验,同时减少骨水泥渗漏风险。目的:比较局部麻醉下机器人辅助和传统C臂辅助经皮椎体后凸成形手术的患者体验和其他疗效。方法:选择四川省医学科学院·四川省人民医院(电子科技大学附属医院)收治的单节段骨质疏松性椎体压缩骨折患者241例,其中132例在局部麻醉下进行机器人辅助经皮椎体后凸成形手术治疗(机器人辅助组),109例在局部麻醉下进行传统C臂辅助经皮椎体后凸成形手术治疗(传统透视组),记录患者术中体验评价、骨水泥注射量、手术时间、工作通道建立时间、住院费用及并发症,术后1 d通过影像学评估穿刺偏差与骨水泥渗漏。结果与结论:(1)机器人组59例患者术中体验评价为“非常好”,43例为“好”,16例为“一般”,10例为“差”,4例为“非常差”;传统透视组30例患者术中体验评价为“非常好”,44例为“好”,21例为“一般”,9例为“差”,5例为“非常差”,两组间术中体验评价比较差异有显著性意义(Z=-2.546,p.0.011);机器人组患者术中目测类比评分低于传统透视组(t=-9.513,p.0.000);机器人组、传统透视组愿意在必要时再次接受经皮椎体后凸成形手术的患者分别为84例和47例,组间比较差异有显著性意义(Z=-2.730,p.0.006);(2)机器人组患者手术时间、住院费用均多于传统透视组(t=2.860,p.0.003;t=36.522,p.0.000),工作通道建立时间短于传统透视组(t=-27.066,p.0.000),穿刺精度优于传统透视组(Z=-3.656,p.0.000),骨水泥渗漏率低于传统透视组(χ^(2)=7.284,p.0.007);(3)结果表明,局部麻醉后在机器人辅助行经皮椎体后凸成形手术患者的手术体验较好,具有穿刺精确、工作通道建立时间短、骨水泥渗漏率低的优势。

关键词：机器人骨质疏松性椎体压缩骨折经皮椎体后凸成形患者体验局部麻醉

Greenhouse gas emissions from p.g and p.ul.ry p.oduction sectors in China from 1960 to 2010

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Journal.of Integrative Agricul.ure 2017年第1期16卷 221-228页

作者： WANG l.-zhi XUE Bai Tianhai Yan Animal.Nutrition Institute Sichuan Agricultural University Ya'an 625014 P.R. China Agri-Food and Biosciences Institute Co. Down BT26 6DR United Kingdom

p.g and p.ul.ry p.oduction in China had exp.rienced considerabl. changes from 1960 to 2010. The p.esent study aimed to eval.ate the effects of these changes on greenhouse gas emission inventeries （exp.essed as CO2 equival.nt） from these two sectors. The inventories incl.ded methane emissions from enteric fermentation, methane and nitrous oxide p.oduction from manure management. The greenhouse gas emissions from these sources in 2010 in p.g sector were 17, 62 and 21%, resp.ctivel., and that in p.ul.ry sector （incl.ding chicken, duck, goose and others） were 1, 18 and 81%, resp.ctivel.. Total.CO2 equival.nt increased from 1960 to 2010 in both p.g （11 582 to 55564 Gg yr-1） and p.ul.ry （1 497 to 14 873 Gg yr-1） sectors. Within p.ul.ry sector, emissions from chicken, duck, goose and others accounted for 74, 15, 11 and 0.01% in 2010, resp.ctivel.. However, during the l.st 50 years, these emissions continuousl. reduced when rel.ted to p.oduction of I kg of p.rk （8.01 to 1.14 kg kg-1）, p.ul.ry meat （1.19 to 0.37 kg kg-1） and egg （0.47 to 0.33 kg kg-1）, which is mainl. associated with the continuous imp.ovement in p.oduction efficiency in al. management systems. These resul.s p.ovide benchmark information for Chinese authorities to devel.p.ap.rop.iate p.l.cies and mitigation strategies to reduce greenhouse gas emissions from p.g and p.ul.ry sectors.

关键词： China greenhouse gas inventory p.g p.ul.ry