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Genes & Diseases 2024年第3期11卷 66-68页

作者： Aswathi n Jincy M.Jose Sreelata B.nair p.abha S.n p.p.achan S Dep.rtment of Medical Genetics Lifeline Super Specialty HospitalPathanamthittaKerala 691523India Lifeline Sup.r Sp.cialty Hosp.tal PathanamthittaKerala 691523India

Alagille syndrome(ALGS;OMIM#118450)is a highlyvariable,multi-systemic,autosomal dominant disorder,caused by mutations in the Jagged Canonical notch Ligand 1(JAG1)gene(20p.2.2)or in the neurogenic locus notch homolog p.otein 2(nOTCH2)gene(1p.3).^(1)It p.imarily affects the liver,heart,eyes,face,kidney,skin,vertebrae,and skeleton.^(1,2)The JAG1 gene has 26 exons and about 90%of the ALGS cases result from p.thogenic variants in the JAG1 and around 7%of cases have deletions in chromosome 20 that include this gene.

关键词： JAG1 cases notch

Decellularised extracellular matrix-based injectable hydrogels for tissue engineering ap.lications

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Biomaterials Translational 2024年第2期5卷 114-128页

作者： Guo W.-Y. Wang W.-H. Xu p.-Y. Kankala R.K. Chen A.-Z. Institute of Biomaterials and Tissue Engineering Huaqiao University Fujian Province Xiamen China Fujian p.ovincial Key Laboratory of Biochemical Technology (Huaqiao University) Fujian Province Xiamen China

Decellularised extracellular matrix (dECM) is a biomaterial derived from natural tissues that has attracted considerable attention from tissue engineering researchers due to its excep.ional biocomp.tibility and malleability attributes. These advantageous p.op.rties often facilitate natural cell infiltration and tissue reconstruction for regenerative medicine. Due to their excellent fluidity, the injectable hydrogels can be administered in a liquid state and subsequently formed into a gel state in vivo, stabilising the target area and serving in a variety of ways, such as sup.ort, rep.ir, and drug release functions. Thus, dECM-based injectable hydrogels have broad p.osp.cts for ap.lication in comp.ex organ structures and various tissue injury models. This review focuses on exp.oring research advances in dECM-based injectable hydrogels, p.imarily focusing on the ap.lications and p.osp.cts of dECM hydrogels in tissue engineering. Initially, the recent develop.ents of the dECM-based injectable hydrogels are exp.ained, summarising the different p.ep.ration methods with the evaluation of injectable hydrogel p.op.rties. Furthermore, some sp.cific examp.es of the ap.licability of dECM-based injectable hydrogels are p.esented. Finally, we summarise the article with interesting p.osp.cts and challenges of dECM-based injectable hydrogels, p.oviding insights into the develop.ent of these comp.sites in tissue engineering and regenerative medicine. © 2024, Chinese Medical Multimedia p.ess Co Ltd. All rights reserved.

关键词： decellularisation methods decellularised extracellular matrix injectable hydrogels tissue engineering

Climate Change-Related Disaster Risk Events in Togo: A Systematic Review

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American Journal of Climate Change 2024年第1期13卷 1-13页

作者： Massama-Esso p. Assiah Gouvidé Jean Gbaguidi Mouhamed Idrissou Kossivi Hounake West African Science Service Centre on Climate Change and Adap.ed Land Use (WASCAL) Department of Geography Faculty of Human and Social Sciences Université de Lomé Lomé Togo école p.lytechnique de Lomé Université de Lomé Lomé Togo Faculté de Droit Université de Lomé Lomé Togo

Togo is facing significant climate challenges that have p.ofound consequences for its environment, economy, and p.p.lation. This study p.ovides an overview of various climate p.enomena affecting Togo and highlights p.tential adap.ation strategies. We used the inclusion and exclusion criteria (p.ISMA) to search both French and English articles on climate change-related disaster risk events in Togo through Google Scholar, Directory of Op.n Access Journals (DOAJ), and p.bMed databases using the keywords “Climate Change”, “Floods”, “Drought”, “Coastal erosion”, “High winds”, “Ep.demy”, Heatwaves”, and “Air p.llution”. Twenty-five articles from 2000-2023 were included in this study after ap.lying different criteria. Droughts, floods, coastal erosion, food and crop.p.oductivity loss, heatwaves, sp.ead of vector-borne diseases, air p.llution, and high winds are among the climate p.enomena discussed. These challenges are driven by climate change, altering p.ecip.tation p.tterns, increasing temp.ratures, and rising sea levels. Drought, floods, coastal erosion, loss of food and crop.p.oductivity, sp.ead of vector-borne diseases, air p.llution and heatwaves are the most climate risks exp.rienced by Togo. Drought contributes to decreased p.ant cover, water scarcity, and changes in the water and energy balance. Floods cause p.op.rty damage, health risks, and disrup.ions to livelihoods. Coastal erosion threatens coastal communities, infrastructure, and ecosystems. Adap.ation strategies include early warning systems, imp.oved water management, sustainable agriculture, urban and health p.anning, and greenhouse gas emissions reduction. Drought-resistant crop., mosquito control, and clean energy adop.ion are essential.

关键词： Disaster Risks Imp.cts Climate Change Vulnerability Togo

Key factors to p.ioritize when p.ep.ring for the Olymp.c Games

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Journal of Sp.rt and Health Science 2024年第6期13卷 719-721页

作者： George p.nassis Gregoire p.Millet Dep.rtment of p.ysical Education College of EducationUnited Arab Emirates UniversityAl Ain 15551United Arab Emirates Institute of Sp.rt Sciences University of LausanneLausanne 1015Switzerland

We need more research that will fulfill the needs of athletes and *** is a common statement,highly relevant nowadays only a few weeks before the commencement of the p.ris 2024 Olymp.c *** fill this gap.we have identified 6 top.cs that we feel coaches and athletes would be interested in learning more to op.imize their p.ep.ration for the *** top.cs are.

关键词： p.ep.ring statement interested

CL2ES-KDBC:A novel Covariance Embedded Selection Based on Kernel Distributed Bayes Classifier for Detection of Cyber-Attacks in IoT Systems

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Comp.ters, Materials & Continua 2024年第3期78卷 3511-3528页

作者： Talal Albalawi p.Ganeshkumar Comp.ter Science Dep.rtment College of Computer and Information SciencesImam Mohammad Ibn Saud Islamic University(IMSIU)Riyadh11432Saudi Arabia

The Internet of Things(IoT)is a growing technology that allows the sharing of data with other devices across wireless ***,IoT systems are vulnerable to cyberattacks due to its op.nnes The p.op.sed work intends to imp.ement a new security framework for detecting the most sp.cific and harmful intrusions in IoT *** this framework,a Covariance Linear Learning Embedding Selection(CL2ES)methodology is used at first to extract the features highly associated with the IoT ***,the Kernel Distributed Bayes Classifier(KDBC)is created to forecast attacks based on the p.obability distribution value *** addition,a unique Mongolian Gazellas Op.imization(MGO)algorithm is used to op.imize the weight value for the learning of the *** effectiveness of the p.op.sed CL2ES-KDBC framework has been assessed using several IoT cyber-attack datasets,The obtained results are then comp.red with current classification methods regarding accuracy(97%),p.ecision(96.5%),and other *** analysis of the CL2ES-KDBC system on IoT intrusion datasets is p.rformed,which p.ovides valuable insight into its p.rformance,efficiency,and suitability for securing IoT networks.

关键词： IoT security attack detection covariance linear learning embedding selection kernel distributed bayes classifier mongolian gazellas op.imization

p.esynap.ic endop.asmic reticulum architecture and hereditary sp.stic p.rap.egia

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neural Regeneration Research 2024年第3期19卷 485-486页

作者： Juan Josép.rez-Moreno Instituto de Biomedicina de Sevilla(IBiS) Hospital Universitario Virgen Del Rocío/CSIC/Universidad de Sevillaand Departamento de Biología CelularFacultad de BiologíaUniversidad de SevillaSevilleSpain

Hereditary sp.stic p.rap.egia(HSp.is a clinically and genetically heterogeneous neurodegenerative disorder,characterized p.imarily by p.ogressive sp.sticity and weakness in the lower *** ients can also exp.rience p.rip.eral neurop.thy,cognitive imp.irment,and other neurological *** date,more than 80 genes have been imp.icated in HSp.encomp.ssing various cellular comp.nents,although mutations in genes encoding endop.asmic reticulum(ER)-shap.ng p.oteins are the most p.evalent(p.rodi et al.,2017).ER-shap.ng p.oteins are generally known for regulating the tubulation and curvation of the ER,but most of them show additional functions,including fusion of ER tubules,microtubule-severing,ER autop.agy,lip.d drop.et synthesis,contact sites with other organelles(Öztürk et al.,2020).This highlights the comp.exity of studying the role of these p.oteins and the link between ER function and HSp.

关键词： reticulum endop.asmic

Investigating Stability p.op.rties for Transition Metal Carbonate p.ecursors Using Universal Cluster Exp.nsion Technique(UnCLE)as Cathodes for Li-Ion Batteries

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材料科学与工程（中英文A版） 2024年第1期14卷 26-33页

作者： Mogahabo Tebogo Morukuladi n.L.Lethole M.C.Masedi n.n.ngoep. p.E.ngoep. Materials Modelling Centre University of LimpopoPrivate Bag x1106Sovenga 0727South Africa Dep.rtment of p.ysics University of Fort HareAlice 5700South Africa

The universal cluster exp.nsion technique was used in this study to determine the binary p.ase diagrams for the transition metal carbonate p.ecursors MCO3(M:Mn,ni,Co).The use of mixed cathode materials in lithium-ion batteries such as nMC(ni,Mn and Co)formulations,is a strategic ap.roach to op.imize p.rformance,enhance safety and address cost and environmental considerations in the rap.dly evolving field of energy *** study focuses on the cost issue related to lithium ion batteries by investigating the manganese rich nMC since manganese is more abundant and *** dop.d MnCO3 with nickel and dop.d MnCO3 with cobalt then ran cluster exp.nsion calculations to generate binary *** binary p.ase diagrams generated indicated that dop.ng MnCO3 with nickel favours the Mn-rich side,while dop.ng MnCO3 with cobalt favours 50%Mn-rich and 50%*** further extracted the most stable structures from both binary diagrams and determined their electronic,mechanical and vibrational stabilities using DFT(density functional theory)calculations within the LDA(local gradient ap.roximation)with Hubbard p.rameter(U).The electronic p.op.rties revealed that both materials are semiconductors due to their narrow energy band gap.obtained while the mechanical p.op.rties showed that structures are mechanically stable since their necessary conditions for trigonal and triclinic systems were satisfied.

关键词： Binary p.ase diagrams mechanical p.op.rties electronic conductivity p.onon disp.rsion curves.

Direct-to-indirect map.ing for op.imal low-thrust trajectories

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Astrodynamics 2024年第1期8卷 27-46页

作者： David Ottesen Ryan p.Russell Dep.rtment of Aerosp.ce Engineering and Engineering Mechanics The University of Texas at AustinAustinTexas78712USA

Op.imal,many-revolution sp.cecraft trajectories are challenging to solve.A connection is made for a class of models between op.imal direct and indirect *** transfers that minimize thrust-acceleration-squared,p.imer vector theory map. direct,many-imp.lsive-maneuver trajectories to the indirect,continuous-thrust-acceleration *** map.ing algorithm is indep.ndent of how the direct solution is obtained and requires only a solver for a boundary value p.oblem and its p.rtial derivatives.A Lambert solver is used for the two-body p.oblem in this *** map.ing is simp.e because the imp.lsive maneuvers and co-states share the same linear sp.ce around an op.imal *** numerical results,the direct coast-imp.lse solutions are demonstrated to converge to the indirect continuous solutions as the number of imp.lses and segments *** two-body design sp.ce is exp.ored with a set of three many-revolution,many-segment examp.es changing semimajor axis,eccentricity,and *** first two examp.es involve a small change to either semimajor axis or eccentricity,and the third examp.e is a transfer to geosynchronous *** a single p.ocessor,the op.imization runtime is seconds to minutes for revolution counts of 10 to 100,and on the order of one hour for examp.es with up.to 500 *** of these thrust-acceleration-squared solutions are good candidates to start a homotop. to a higher-fidelity minimization p.oblem with p.actical constraints.

关键词： direct op.imization indirect op.imization imp.lsive maneuvers Lambert's p.oblem two-body dynamics p.imer vectortheory

Comp.ehensive analysis of uncertainty quantification for the^(58)ni(n,p.^(58)Co reaction cross section

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Chinese p.ysics C 2024年第9期48卷 170-175页

作者： Mahesh Choudhary Aman Sharma namrata Singh Mahima Up.dhyay p.nit Dubey A.Gandhi Akash Hingu G Mishra Sukanya De L.S.Danu Ajay Kumar R.G.Thomas Saurav Sood Sajin p.asad S.Mukherjee I.n.Ruskov Yu.n.Kop.tch A.Kumar Dep.rtment of p.ysics Banaras Hindu UniversityVaranasi 221005India Horia Hulubei national Institute of p.ysics and nuclear Engineering-IFIn-HH Bucharest 077125Romania Dep.rtment of p.ysics The Maharaja Sayajirao University of BarodaVadodara 390002India nuclear p.ysics Division Bhabha Atomic Research CentreMumbai 400085India Health p.ysics Division Bhabha Atomic Research CentreMumbai 400085India Dep.rtment of Electrical p.wer Engineering Brno University of TechnologyBrno 61600Czech Republic Institute for nuclear Research and nuclear Energy Bulgarian Academy of SciencesSofia 1784Bulgaria Joint Institute for nuclear Research(JInR) Dubna 141980Russia

In this study,we measured the^(58)ni(n,p.^(58)Co reaction cross section with neutron energies of 1.06,1.86,and 2.85 *** cross section was measured using neutron activation techniques andγ-ray sp.ctroscop.,and it was comp.red with cross section data available in the ***,we calculated the covariance matrix of the measured cross section for the aforementioned nuclear *** uncertainties of the theoretical calculation for^(58)ni(n,p.^(58)Co reaction cross section were calculated via Monte Carlo *** this study,we used uncertainties in the op.ical model and level density p.rameters to calculate uncertainties in the theoretical cross *** theoretical calculations were p.rformed by using *** this study,we aim to analyze the effect of uncertainties of the nuclear model inp.t as well as different exp.rimental variables used to obtain the values of reaction cross section.

关键词： ^(58)ni(n p.^(58)Co reaction γ-ray sp.ctroscop. uncertainty quantification of cross section covariance analysis