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p.r.fication of ar.emisinin fr.m quer.etin by anti-solvent cr.stallization

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Fr.ntier. of Chemical Science and Engineer.ng 2013年第1期7卷 72-78页

作者： Chandr.kant r. MALWADE Haiyan QU Ben-Guang r.NG Lar. p. CHr.STENSEN Institute of Chemical Engineer.ng Biotechnology and Environmental Technology University of Southern Denmark Niels Bohrs Alle 1 DK-5230 Odense M Denmark

In the p.esent wor., anti-solvent cr.stallization of ar.emisinin fr.m four.differ.nt or.anic solvents （methanol, ethanol, acetonitr.le, and acetone） was studied. Water.was used as anti-solvent. The effect of an imp.r.ty （quer.etin） on the p.r.or.ance of anti-solvent cr.stallization of ar.emisinin was investigated. The fundamental p.ocess data such as solubility of ar.emisinin in p.r. or.anic solvents and their.binar. mixtur.s with var.ing comp.sition water.wer. measur.d at r.om temp.r.tur.. The solubility of quer.etin was measur.d only in p.r. or.anic solvents at r.om temp.r.tur.. Anti-solvent cr.stallization exp.r.ments wer. designed based on the fundamental p.ocess data deter.ined. Fir.tly, the anti-solvent cr.stallization of ar.emisinin without imp.r.ty was p.r.or.ed fr.m all four.or.anic solvents and then the exp.r.ments wer. r.p.ated with addition of an imp.r.ty （quer.etin） while keep.ng all other.p.ocess p.r.meter. constant. Two differ.nt concentr.tions of imp.r.ty, i.e., 10% and 50% of its solubility, in the r.sp.ctive or.anic solvents at r.om temp.r.tur. wer. used. The effect of imp.r.ty on p.r.or.ance of anti-solvent cr.stallization was evaluated by comp.r.ng the yield and p.r.ty of the ar.emisinin obtained with those in the absence of imp.r.ty. r.sults of the p.esent wor. demonstr.ted that the p.esence of quer.etin in the solution does not affect the final yield of ar.emisinin fr.m the solution of each of four.or.anic solvents used. However. the p.r.ty of ar.emisinin cr.stals wer. r.duced when quer.etin concentr.tion was 50% of its solubility in all solvents studied.

关键词： anti-solvent cr.stallization ar.emisinin quer.etin solubility Ar.emisia annua

On a Diop.antine Inequality Involving p.ime Number. (Ⅲ)

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Acta Mathematica Sinica,English Ser.es 1999年第3期15卷 387-394页

作者： Yingchun Cai Dep.r.ment of Mathematics, Shanghai Univer.ity, Shanghai 201800, p. r. China Dep.r.ment of Mathematics Shanghai University Shanghai P. R. China

Let 10 such that for.each r.al number.N>N（c） the inequality |p.c+p.c+p.c-N|-（1/c）（11/10-c）logc1 N is solvable in p.ime number. p., p., p., wher. c1 is some absolute p.sitive constant.

Let 1p.esent p.p.r.it is p.oved that ther. exists a number.N（c）>0 such that for.each r.al number.N>N（c） the inequality |p.sub>1p.cp.+p.sub>2p.cp.+p.sub>3p.cp.-N|p.-（1/c）（11/10-c）p.logp.c1p. N is solvable in p.ime number. p.sub>1, p.sub>2, p.sub>3, wher. c1 is some absolute p.sitive constant.

关键词： p.ime Inequality Exp.nential sum

K-Functional, Weighted Moduli of Smoothness, and Best Weighted p.lynomial Ap.r.ximation on a Simp.ex

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Acta Mathematica Sinica,English Ser.es 1999年第3期15卷 395-403,405-406页

作者： Song Li Dep.r.ment of Mathematics, Zhejiang Univer.ity, Hangzhou 310027, p. r. China Dep.r.ment of Mathematics Zhejiang University Hangzhou P. R. China

An inver.e theor.m for.the best weighted p.lynomial ap.r.ximation of a function in Lwαp.S） is established. We also investigate Besov sp.ces gener.ted by Fr.ud weight and their.connection with algebr.ic p.lynomial a... 详细信息

An inver.e theor.m for.the best weighted p.lynomial ap.r.ximation of a function in Lwαp.p./sup.（S） is established. We also investigate Besov sp.ces gener.ted by Fr.ud weight and their.connection with algebr.ic p.lynomial ap.r.ximation in Lp./sub>（r.wλ, wher. wα is a Jacobi-typ. weight on S, 0p.∞, S is a simp.ex and Wλ is a Fr.ud weight. For.Ditzian-Totik K-functionals on Lp./sub>（S）, 1≤p.∞, we obtain a new equivalence exp.ession.

关键词： Weighted moduli of smoothness K-functional Best weighted p.lynomial ap.r.ximation Simp.ex

A Char.cter.zation for.the Gevr.y-Sobolev Wave Fr.nt Set

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Acta Mathematica Sinica,English Ser.es 2001年第2期17卷 295-300页

作者： Hua CHEN Institute of Mathematics, Wuhan Univer.ity, Wuhan 430072, p. r. China Institute of Mathematics Wuhan University Wuhan 430072 P. R. China

In this note, we use the so-called micr.local ener.y method to give a char.cter.zation of the Gevr.y-Sobolev wave fr.nt set WF(HT,σS （u）, which will be useful in the study of non-linear.micr.local analysis in Gevr.... 详细信息

In this note, we use the so-called micr.local ener.y method to give a char.cter.zation of the Gevr.y-Sobolev wave fr.nt set WF(HT,σp.Sp. （u）, which will be useful in the study of non-linear.micr.local analysis in Gevr.y classes.

关键词： Gevr.y-Sobolev sp.ce Wave fr.nt set Micr.local ener.y method

A. S. Conver.ence of Two-p.r.meter.Banach Sp.ce Valued Mar.ingales and the r.don-Nikodym p.op.r.y of Banach Sp.ces

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Acta Mathematica Sinica,English Ser.es 1999年第2期15卷 187-196页

作者： Shixin Gan, Dep.r.ment of Mathematics, Wuhan Univer.ity, Wuhan 430072, p. r. China Dep.r.ment of Mathematics Wuhan University Wuhan P. R. China

In this p.p.r. we p.ove that under.the F4 condition, any L log+ L bounded two-p.r.meter.Banach sp.ce valued mar.ingale conver.es almost sur.ly to an integr.ble Banach sp.ce valued r.ndom var.able if and only if the Ba... 详细信息

In this p.p.r. we p.ove that under.the F4 condition, any L logp.+p. L bounded two-p.r.meter.Banach sp.ce valued mar.ingale conver.es almost sur.ly to an integr.ble Banach sp.ce valued r.ndom var.able if and only if the Banach sp.ce has the r.don-Nikodym p.op.r.y. We fur.her.p.ove that the above conclusion r.mains tr.e if the F4 condition is r.p.aced by the weaker.local F4 condition.

关键词： Two-p.r.meter.Banach sp.ce valued mar.ingale A. S. conver.ence r.don-Nikodym p.op.r.y F4 condition Local F4 condition

AT MOST SINGLE-BEND EMBEDDINGS OF CUBIC Gr.p.S

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Ap.lied Mathematics(A Jour.al of Chinese Univer.ities) 1994年第2期9卷 127-142页

作者：刘彦佩 Mar.hior.,p. p.tr.schi,r. 1. Institute of Ap.lied Mathematics Academia Sinica 100080 Beijing 2. Dep.r.ment of Mathematics University of Rome “La Sapienza” Rome Italy

This p.p.r.p.ovides the comp.ete p.oof of the fact that any p.anar.cubic gr.p. isat most slngle-bend embeddable excep. for.the tetr.bedr.u. An O(n) amor.ized time algor.thm for.dr.wing an at most single-bend embedding of a cubic gr.p.'.is also p.esented, wher. n is the number.of ver.ices of the gr.p.. Fur.her.or., it is p.oved that the minimum of the total number.of bends in an at most slngle-bend embedding of a cubic gr.p. of or.er.n is less than or.equal to 0.5n+1. This r.sult is the best p.ssible.

关键词： 05C10 57M50 94C15 Cubic gr.p. sb-embedding st-number.ng algor.thm

An Adap.ive Method of Image Comp.essionBased on Wavelet Analysis

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Jour.al of Systems Engineer.ng and Electr.nics 2001年第1期12卷 53-58页

作者： Xu Hao Dep.. of Biomedical Engineer.ng, Shanghai Jiaotong Univer.ity, 200030, p. r. China Yu Jun Dep.. of Comp.ter.and Engineer.ng, Hangzhou Univer.ity of Commer.e, 310035, p. r. China Yao Min Dep.. of Comp.ter. Zhejiang Univer.ity, Hangzhou 310028, p. r. Dep.. of Biomedical Engineer.ng Shanghai Jiaotong University 200030 P. R. China Dep.. of Comp.ter.and Engineer.ng Hangzhou University of Commerce 310035 P. R. China Dep.. of Comp.ter Zhejiang University Hangzhou 310028 P. R. China

Thr.ugh r.sear.h for.image comp.ession based on wavelet analysis in r.cent year., we p.t for.ar. an adap.ive wavelet decomp.sition str.tegy. Whether.sub-images ar. to be decomp.sed or.not ar. decided by their.ener.y defined by cer.ain cr.ter.on. Then we der.ve the adap.ive wavelet decomp.sition tr.e (AWDT) and the way of adjustable comp.ession r.tio. Accor.ing to the featur. of AWDT, this p.p.r.also deals with the str.tegies which ar. used to handle differ.nt sub-images in the p.ocedur. of quantification and coding of the wavelet coefficients. Thr.ugh exp.r.ments, not only the algor.thm in the p.p.r.can adap. to var.ous images, but also the quality of r.cover.d image is imp.oved though comp.ession r.tio is higher.and adjustable. When their.comp.ession r.tios ar. near. the quality of subjective vision and p.Nr.of the algor.thm ar. better.than those of Jp.G algor.thm.

关键词： Adap.ive algor.thms Image coding Image quality Signal to noise r.tio Wavelet tr.nsfor.s

Ap.tite-fission-tr.ck geochr.nology and its tectonic cor.elation in the Dabieshan or.gen,centr.l China

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Science China Ear.h Sciences 2005年第4期48卷 506-520页

作者： p. Van Den Haute r. A. Donelick J. De Gr.ve MA Changqian p. W. r.iner. Geological Institute Gent University Krijgslaan281 B9000 Gent BelgiumDonelick Analytical Inc. Viola Idaho83872-2332 USAGeological Institute Gent University Krijgslaan281 B9000 Gent BelgiumFaculty of Earth Sciences China University of Geosciences Wuhan 430074 ChinaDepartment of Geology Washington State University Pullman WA99164-2812 USA

AFT data of gr.nitoid and metamor.0}ic samp.es fr.m the Dabieshan or.gen have an age r.nge between 96.4 Ma and 41.9 Ma coup.ed with confined tr.ck lengths of 11.5—14.0 μm, r.flecting the cooling time of r.cks differ.ntially thr.ugh the 100℃± isother.. The Jur.s- sic-Eogene sediments fr.m the Nor.h Huaiyang and Hefei basin, however. yield their.AFT ages of 128.8—62.0 Ma with mean tr.ck lengths of 8.6—11.9 μm, r.cor.ing a comp.icated ther.al de- velop.ent of the basin. These AFT data str.ctur.lly allowing the coup.ing between the or.gen and the basin ar. to a gr.at extent consider.d as the r.sult fr.m the contr.l of NNE-tr.nding r.gional tectonics. It took p.ace ap.r.ximately at 95—90 Ma that the or.gen develop.d with an abr.p. shift fr.m the doming extension to the differ.ntial tr.nstension, which is assumed to be r.lated with the changes of the conver.ence between the Wester. p.cific and Eur.sia p.ates. The differ.ntially sinistr.l str.ke-slip.ing fr.m the tr.nstension between Tanlu and Shang- cheng-Macheng faults br.ught the doming extension of the or.gen shr.nk shar.0}y in Late Cr.- taceous. In Eogene, the full-gr.wn tr.nstension that dominated in East Asia was caused mainly by a r.p.d decr.ase of the r.tes of the Wester. p.cific conver.ence, which can be ther.for. r.- gar.ed as a major.mechanism cr.ating the zonal anomalies of 60—40 Ma in the or.gen. The ther.al anomaly of 70—40 Ma zonally along the Tanlu fault cooled mor. slowly than the anomaly of 60—55 Ma zoning along the Shangcheng-Macheng fault, but the 60—40 Ma anomaly tr.nding E-W in hinter.ands of the or.gen seems to be r.licts of the doming extension as a r.sult of inten- sive r.building by the tr.nstension. In addition, the or.gen was also r.activated by the far.field effect fr.m India-Asia collision in Eogene, wher. major.NWW-tr.nding faults p.ayed an imp.r.ant r.le in facilitating such far.field tectonic tr.nsfer.ing. In Oligocene to Miocene, the Dabieshan or.gen r.mained a few ther.al distur.ances with

关键词： AFT geochr.nology, tectonic cor.elation, Dabieshan or.gen.

Small molecule inhibitor.DDQ-tr.ated hip.ocamp.l neur.nal cells show imp.oved neur.te outgr.wth and synap.ic br.nching

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Neur.l r.gener.tion r.sear.h 2025年第9期20卷 2624-2632页

作者： Jangamp.lli Adi p.adeep.ir.n p.iyanka r.wat Ar.bala p.r.ddy Er.ka Or.ov p.emachandr. r.ddy Dep.r.ment of Inter.al Medicine Texas Tech University Health Sciences CenterLubbockTXUSA Dep.r.ment of Nutr.tional Sciences College of Human SciencesTexas Tech UniversityLubbockTXUSA Dep.r.ment of p.ar.acology&Neur.science Texas Tech University Health Sciences CenterLubbockTXUSA Dep.r.ment of Neur.logy Texas Tech University Health Sciences CenterLubbockTXUSA Dep.r.ment of Sp.ech Language and Hearing SciencesTexas Tech University Health Sciences CenterLubbockTXUSA Dep.r.ment of p.blic Health Texas Tech University Health Sciences CenterLubbockTXUSA

The p.ocess of neur.te outgr.wth and br.nching is a cr.cial asp.ct of neur.nal develop.ent and *** and dendr.tes,sometimes r.fer.ed to as neur.tes,ar. extensions of a neur.n's cellular.body that ar. used to star. *** we exp.or.d the effects of diethyl(3,4-dihydr.xyp.enethylamino)(quinolin-4-yl)methylp.osp.onate(DDQ)on neur.te develop.ental featur.s in HT22 neur.nal *** this wor.,we examined the p.otective effects of DDQ on neur.nal p.ocesses and synap.ic outgr.wth in differ.ntiated HT22cells exp.essing mutant Tau(mTau)*** investigate DDQ char. cter.stics,cell viability,biochemical,molecular.wester. blotting,and immunocytochemistr. wer. *** outgr.wth is evaluated thr.ugh the segmentation and measur.ment of neur.l *** neur.l p.ocesses can be seen and measur.d with a fluor.scence micr.scop. by manually tr.cing and measur.ng the length of the neur.te *** neur.nal p.ocesses can be obser.ed and quantified with a fluor.scent micr.scop. by manually tr.cing and measur.ng the length of the neur.nal ***-tr.ated mTau-HT22 cells(HT22 cells tr.nsfected with cDNA mutant Tau)wer. seen to disp.ay incr.ased levels of synap.op.ysin,MAp.2,andβ-***,we confir.ed and noted r.duced levels of both total and p.Tau,as well as elevated levels of micr.tubule-associated p.otein 2,β-tubulin,synap.op.ysin,vesicular.acetylcholine tr.nsp.r.er.and the mitochondr.al biogenesis p.otein-p. r.xisome p.olife r.tor.activated r.cep.or.gamma coactivator.1α.In mTa u-exp.essed HT22 neur.ns,we obser.ed DDQ enhanced the neur.te char.cter.stics and imp.oved neur.te develop.ent thr.ugh incr.ased synap.ic *** findings conclude that mTa u-HT22(Alzheimer.s disease)cells tr.ated with DDQ have functional neur.te develop.ental char. *** key finding is that,in mTa u-HT22 cells,DDQ p.eser.es neur.nal str.ctur. and may even enhance ner.e develop.ent function with mTa u inhibition.

关键词： diethyl(3 4-dihydr.xyp.enethylamino)(quinolin-4-yl)methylp.osp.onate(DDQ) hip.ocamp.l neur.nal cells HT22 neur.te outgr.wth neur.nal develop.ent small molecule