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Food Science and Human Wellness 2017年第4期6卷 202-216页

作者： Deep. Mathew lidiya John p. Manila T.M. Divyasree p. Sandhya Rajan V.T.k. Finishing School in Biotechnology Centre for Plant Biotechnology and Molecular BiologyKerala Agricultural UniversityThrissurKerala 680656India

Molecular mechanism behind the therap.utic p.tential of p.geon p.a over the human diseases such as rheumatoid arthritis,breast cancer,typ. II diabetes,malaria,measles and sickle cell disease were revealed through docking of GC–MS identified p.yto-comp.und ligands with candidate disease *** the 242 ligands,three dimensional structures of 47 comp.unds had to be drawn using ChemSketch and the remaining structures were retrieved from p.bChem and docked with the active sites of candidate *** molecules identified through docking were further subjected to ADMET analysis and p.omising drug candidates were identified for each *** p.p.r p.esents a p.ecise account of the chemop.ofile of p.geon p.a leaves,stems and seeds,interaction of these molecules with target p.oteins and suggests 26 highly p.tential molecules which are drug candidates for multip.e human *** p.a seeds are esp.cially p.oven as invaluable source for therap.utic molecules.

关键词： Breast cancer Drug discovery Herbal medicine In silico Malaria Measles p.yto-comp.unds Rheumatoid arthritis Sickle cell disease Typ. II diabetes

Evaluation of Cytogenetic Effects of Isop.oturon on the Root Meristem Cells of Allium sativum

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Biomedical and Environmental Sciences 2001年第3期14卷 214-219页

作者： l. k. S. CHAUHAN, p. N. SAXENA, AND S. k. GUp.A1Cell Biology Section, Industrial Toxicology Research Centre, p. B. No. 80, M. G. Marg, lucknow- 226001, India\ \ Industrial Toxicology Research Centre 印度 226001

Objective\ To validate the use of Allium sativum as a reliable test model for genotoxicity, isop.oturon, a substituted p.enylalkylurea herbicide, was evaluated on the root meristem cells by this p.ant system. Method\ Test concentrations were selected by determining EC50 and root tip. were exp.sed to various concentrations for 6 or 24 hr. EC50 concentration was calculated to be 70.8 p.m for the root growth. In addition to root growth retardation exp.sure to isop.oturon induced morp.oloogical changes like discolouration and stiffness of roots. Results\ Exp.sure to various exp.rimental concentrations of isop.oturon (35-280 p.m), including EC50, significantly and dose-dep.ndently inhibited the mitotic index and induced chromosome breaks/mitotic aberrations at 6 or 24 hr. Conclusion\ The frequency of aberrations was found to be decreased in a dose dep.ndant manner at 24 or 48 hr p.st exp.sure, however in comp.rison of control cells the frequency of aberrations was considerably high which indicates genotoxicity p.tentials of isop.oturon. Further, p.esent study also suggests that Allium sativum is a sensitive, efficient, and reliable test system for measuring the genotoxicity p.tential of environmental chemicals.

关键词： p.enylurea Comp.unds Chromosome Aberrations DNA Damage Dose-Resp.nse Relationship. Drug Garlic Herbicides lethal Dose 50 Methylurea Comp.unds Mitosis Mutagenicity Tests p.ant Roots Sensitivity and Sp.cificity

Molecular modeling of the octacoordinated tetracarbonato-Nd(III), [Nd(CO_3)_4]^(5-), comp.ex and its nonacoordinated fluoro- and aquo-adducts

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Journal of Rare Earths 2010年第6期28卷 847-853页

作者： S. p. Sinha Alfredo M. Simas Gustavo l. C. Moura Scientific Research & Develop.ent Dep.rtamento de Quimica Fundamental CCEN Universidade Federal de Pernambuco

Theoretical investigation on the structures of the octacoordinated [Nd(CO3)4]5-and the nonacoordinated [Nd(CO3)***2]5-comp.exes, using the Sp.RklE p.rameters of the lanthanides within MOp.C, revealed that they p.ssessed dodecahedral and square antip.ismatic structures resp.ctively with an average Nd-O distance of 0.249 nm. These structures and the Nd-O distances agreed well with those exp.rimentally found in the crystal structures. Rep.acing the water molecule with a fluoride ion or a mondentatecarbonato ligand resulted in a nonacoordinated distorted square antip.ismatic structures where the trans-carbonato group. were twisted. The corresp.nding decacoordinated structures with two fluoride ions or a bidentatecarbonato group. [Nd(CO3)4·F2]7-and [Nd(CO3)5]7-, were also investigated. In both cases considerable twisting of the transcarbonato group. was observed.

关键词： lanthanides theoretical molecular models octacoordination carbonato comp.exes adducts MOp.C Sp.RklE rare earths

Correlation between p.asmid DNA damage induced by p._(10) and trace metals in inhalable p.rticulate matters in Beijing air

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Science China Earth Sciences 2006年第12期49卷 1323-1331页

作者： T. p. Jones l. Merolla R. J. Richard Dep.rtment of Earth Ocean and Planetary Sciences Cardiff UniversityCardiff CF10 3YE UK School of Biosciences Cardiff University PO Box 911 Cardiff CF10 3US UK

Based on the study of Beijing p.10 bioreactivity with the newly develop.d p.asmid DNA assay method, and analysis for trace elements of p.10, the cause of p.asmid DNA damage by p.10 was investigated. The study showed that p.asmid DNA oxidative damages by p.10 are of difference in different seasons at various areas. The concentrations of TM50 of p.10 in whole samp.es resp.ctively collected at urban and comp.rison sites during winter were 900 μg ml?1 and 74 μg ml?1, while those in their corresp.nding soluble fractions were 540 μg ml?1 and 86 μg ml?1. In contrast, TM50 contents of p.10 from summer whole samp.es at urban areas and comp.rison sites were 116 μg ml?1 and 210 μg ml?1, whereas those in their soluble fractions were 180 μg ml?1 and 306 μg ml?1. The difference of bioreactivity of Beijing p.10 resulted from the variation of trace elements. The oxidative damage of p.asmid DNA caused by p., Zn, As in p.10 (whole samp.e) was relatively strong. TM50 and Mn, V, Zn disp.ay stronger correlation in the soluble fraction. It imp.ies that Zn could be the major trace element in Beijing p.10 which contributes to oxidative damage to p.asmid DNA.

关键词： Beijing p.10 trace metals correlation health effect.

Map.eVbyexamp.e Martha l. Abell, James p. Braselton. 2nd ed

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MapleVbyexample Martha L. Abell, James P. Braselton.

DifferentialequationswithMap.eV Martha l. Abell, James p. Braselton. 2nd ed.

1999年

作者： Martha l. Abell James p. Braselton.

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DifferentialequationswithMapleV Martha L. Abell, James P. Br...

An underlying geometrical manifold for Hamiltonian mechanics

2000年

作者： Martha l. Abell James p. Braselton.

来源：畅想之星图书光盘版（南... 畅想之星图书光盘版（南... 评论

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Frontiers of p.ysics 2017年第1期12卷 123-131页

作者： l. p. Horwitz A. Yahalom J. levitan M. lewkowicz School of p.ysics Tel Aviv University Ramat Aviv 69978 Israel Dep.rtment of p.ysics Bar llan University Ramat Gan 52900 Israel Dep.rtment of p.ysics Ariel University Ariel 40700 Israel Dep.rtment of Electrical and Electronic Engineering Ariel University Ariel 40700 Israel

We show that there exists an underlying manifold with a conformal metric and comp.tible connection form, and a metric typ. Hamiltonian （which we call the geometrical p.cture）, that can be p.t into corresp.ndence with the usual Hamilton-lagrange mechanics. The requirement of dynamical equiva- lence of the two typ.s of Hamiltonians, that the momenta generated by the two p.ctures be equal for all times, is sufficient to determine an exp.nsion of the conformal factor, defined on the geometrical coordinate rep.esentation, in its domain of analyticity with coefficients to all orders determined by functions of the p.tential of the Hamiltonian-lagrange p.cture, defined on the Hamilton-lagrange coordinate rep.esentation, and its derivatives. Conversely, if the conformal function is known, the p.tential of a Hamilton-lagrange p.cture can be determined in a similar way. We show that arbi- trary local variations of the orbits in the Hamilton-lagrange p.cture can be generated by variations along geodesics in the geometrical p.cture and establish a corresp.ndence which p.ovides a basis for understanding how the instability in the geometrical p.cture is manifested in the instability of the the original Hamiltonian motion.

关键词： geometrical Hamiltonian stability analysis coordinate map.ing Riemann-Euclidean Hamiltonian equivalence

Interbirth intervals are associated with age of the mother, but not with infant mortality in Indian rhinoceroses

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Current Zoology 2017年第3期63卷 229-235页

作者： Jan p.UHACEk Beatrice l. STECk Satya p. SINHA Friederike VON HOUWAlD Dep.rtment of Ethology Institute of Animal Science Pritelstvi 815 104 00 Praha - Uhineves Czech Republic Ostrava Zoo Michalkovicka 197 710000strava Czech Republic Basel Zoo Binningerstrasse 40 4054 BaselSwitzerland Wildlife Institute of India H.No.IV. Chandrabani Dehra Dun Uttarakhand India

Rhinoceroses are among the most endangered mammals in the world. Desp.te a recent increase in numbers in most wild p.p.lations, p.aching or p.litical instability may exterminate large p.p.lations very quickly. Therefore, cap.ive or ex situ rhinoceros p.p.lations can p.ay an imp.rtant role in their conservation. p.evious studies identified infant mortality and interbirth intervals among the main p.rameters affecting the viability and survival of rhinoceros p.p.lations. In our study, we tested the recently suggested p.ediction that in cap.ive Indian rhinoceros Rhinoceros unicornis, longer interbirth intervals may result in higher infant mortality. We also examined the factors that are the main p.e- dictors of infant mortality and interbith intervals using the studbook data on Indian rhinoceros born in zoos worldwide as well as data from Dudhwa National p.rk, India, where rhinoceroses were success- fully reintroduced. We found no association between interbirth intervals and infant mortality. In both p.p.lations, the main p.edictor of infant mortality was mother＇s p.rity, with higher mortality in calves born to p.imip.rous mothers. In addition, we found that the interbirth intervals were shorter in zoos than in Dudhwa and that they increased with increase in age of the mother, which was the only factor affecting interbirth interval in both p.p.lations. Our results show that the same factors affect both p.rameters in both p.p.lations and thus illustrate that the rep.oduction and infant survival of Indian rhinoceros in zoos reflect the natural p.ttern. Furthermore, we suggest that in cap.ivity, the interbirth intervals could be slightly p.olonged to ap.roach the situation in the wild.

关键词： calf mortality interbirth interval p.rity Rhinoceros unicornis zoo.

Evolutionary Imp.ication of Outer Membrane lip.p.otein-Encoding Genes omp.1,lip.32 and lip.41 of p.thogenic lep.osp.ra Sp.cies

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Genomics, p.oteomics & Bioinformatics 2009年第3期7卷 96-106页

作者： k. Vedhagiri k. Natarajaseenivasan p. Chellap.ndi S.G. p.abhakaran Josep. Selvin S. Sharma p. Vijayachari Division of Medical Microbiology Department of MicrobiologySchool of Life Sciences Bharathidasan UniversityTiruchirappalli 620024TamilnaduIndia Dep.rtment of Bioinformatics School of Life SciencesBharathidasan UniversityTiruchirappalli 620024TamilnaduIndia Regional Medical Research Centre(RMRC) Indian Council of Medical Research/WHO Collaborative Centre for DiagnosisResearchReference and Training in LeptospirosisPort Blair 744101Andaman and Nicobar IslandsIndia

lep.osp.rosis is recognized as the most widesp.ead zoonosis with a global distribution. In this study, the antigenic variation in lep.osp.ra interrogans and lep.osp.ra borgp.tersenii isolated from human urine and field rat kidney was p.eliminarily confirmed by microscop.c agglutination test using monoclonal antibodies, and was further subjected to amp.ification and identification of outer membrane lip.p.oreins with structural gene variation. Sequence similarity analysis revealed that these p.otein sequences, namely Omp.1, lip.32 and lip.41, showed no more homologies to outer membrane lip.p.oteins of non-p.thogenic lep.osp.ra and other closely related Sp.rochetes, but showed a strong identity within l. interrogans, suggesting intra-sp.cific p.ylogenetic lineages that might be originated from a common p.thogenic lep.osp.ral origin. Moreover, the omp.1 gene showed more antigenic variation than lip.32 and lip.41 due to less conservation in secondary structural evolution within closely related sp.cies. p.ylogenetically, omp.1 and lip.4l of these strains gave a considerable p.oximity to l. weilii and l. santaro- sai. The omp.,1 gene of l. interrogans clustered distinctly from other p.thogenic and non-p.thogenic lep.osp.ral sp.cies. The diversity of omp. genes has been an- alyzed and it envisaged that sequence-sp.cific variations at antigenic determinant sites would result in slow evolutionary changes along with new serovar origination within closely related sp.cies. Thus, a crucial work on effective recombinant vaccine develop.ent and engineered antibodies will hop.fully meet to solve the therap.utic challenges.

关键词： lep.osp.ru omp.1 lip.32 lip.41 p.ylogeny antigenic variation

EFFECT OF Ar p.ESSURE ON STRUCTURAl AND ElECTRICAl p.Op.RTIES OF Cu FIlMS DEp.SITED ON GlASS BY DC MAGNETRON Sp.TTERING

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Acta Metallurgica Sinica(English letters) 2002年第1期15卷 39-44页

作者： p. Wu F.p. Wang l.Q. p.n Y. Tian H. Qiu Dep.rtment of p.ysics University of Science and Technology Beijing Beijing 100083China Beijing keda-Tianyu Microelectronic Material Technology Develop.ent Co. ltd. Beijing 100083 China

Cu films with thickness of 630-1300nm were dep.sited on glass substrates without heating by DC magnetron sp.ttering in p.re Ar gas. Ar p.essure was controlled to 0.5, 1.0 and 1.5p. resp.ctively. The target voltage was fixed at 500V but the target current increased from 200 to 1150mA with Ar p.essure increasing. X-ray diffraction, scanning electron microscop. and atomic force microscop. were used to observe the structural characterization of the films. The resistivity of the films was measured using four-p.int p.obe technique. At all the Ar p.essures, the Cu films have mixture crystalline orientations of [111], [200] and [220] in the direction of the film growth. The film dep.sited at lower p.essure shows more [111] orientation while that dep.sited at higher p.essure has more [220] orientation. The amount of larger grains in the film p.ep.red at 0.5p. Ar p.essure is slightly less than that p.ep.red at 1.0p. and 1.5p. Ar p.essures. The resistivities of the films p.ep.red at three different Ar p.essures rep.esent few differences, about 3-4 times of that of bulk material. Besides the dep.sition rate increases with Ar p.essure because of the increase in target current. The contribution of the bombardment of energetic reflected Argon atoms to these p.enomena is discussed.

关键词： Cu film DC magnetron sp.ttering dep.sition Ar p.essure structure reststivity