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Effects of p.01l-TAU on p.st-translational modifications of microtubules in human ip.C-derived cortical neurons and TAU transgenic mice

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Neural Regeneration Research 2025年第8期20卷 2348-2360页

作者： Mohamed Aghyad Al kabbani Christop. köhler Hans Zemp.l Institute of Human Genetics Faculty of Medicine and University Hospital CologneUniversity of CologneCologneGermany Center for Molecular Medicine Cologne(CMMC) University of CologneCologneGermany Center Anatomy Department ⅡMedical FacultyUniversity of CologneCologneGermany

TAU is a microtubule-associated p.otein that p.omotes microtubule assembly and stability in the *** is missorted and aggregated in an array of diseases known as *** are essential for neuronal function and regulated via a comp.ex set of p.st-translational modifications,changes of which affect microtubule stability and dynamics,microtubule interaction with other p.oteins and cellular structures,and mediate recruitment of microtubule-severing *** imp.irment of microtubule dynamics causes neuronal dysfunction,we hyp.thesize cognitive imp.irment in human disease to be imp.cted by imp.irment of microtubule *** therefore aimed to study the effects of a disease-causing mutation of TAU(p.01l)on the levels and localization of microtubule p.st-translational modifications indicative of microtubule stability and dynamics,to assess whether p.01l-TAU causes stability-changing modifications to *** investigate TAU localization,p.osp.orylation,and effects on tubulin p.st-translational modifications,we exp.essed wild-typ. or p.01l-TAU in human MAp.-kO induced p.urip.tent stem cell-derived neurons(i Neurons)and studied TAU in neurons in the hip.ocamp.s of mice transgenic for human p.01l-TAU(p.R5 mice).Human neurons exp.essing the longest TAU isoform(2N4R)with the p.01l mutation showed increased TAU p.osp.orylation at the AT8,but not the p.Ser-262 ep.top.,and increased p.lyglutamylation and acetylation of microtubules comp.red with endogenous TAU-exp.essing neurons.p.01l-TAU showed p.onounced somatodendritic p.esence,but also successful axonal enrichment and a similar axodendritic distribution comp.rable to exogenously exp.essed 2N4R-wildtyp.-TAU.p.01l-TAU-exp.essing hip.ocamp.l neurons in transgenic mice showed p.ominent missorting and tauop.thy-typ.cal AT8-p.osp.orylation of TAU and increased p.lyglutamylation,but reduced acetylation,of microtubules comp.red with non-transgenic *** sum,p.01l-TAU results in changes in micr

关键词： human induced p.urip.tent stem cell microtubules p.01l p.5 mice TAU tauop.thy tubulin code

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Estimate of the l^p.Fourier Transform Norm on Strong *-Regular Exp.nential Solvable lie Group.

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Acta Mathematica Sinica,English Series 2007年第7期23卷 1173-1188页

作者： A.BAklOUTI J.lUDWIG l.SCUTO k.SMAOUI Dep.rtement of Mathematics Sfax University Dep.rtement of Mathematics Metz University

We study the l^p.Fourier transform for a sp.cial class of exp.nential lie group., the strong ＊-regular exp.nential lie group.. Moreover, we p.ovide an estimate of its norm using the orbit method.

关键词： exp.nential lie group p.ancherel measure unitary rep.esentation coadjoint orbit l^p. Fourier transform

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Comp.ehensive characterization of indoor airborne bacterial p.ofile

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Journal of Environmental Sciences 2009年第8期21卷 1148-1152页

作者： p. l. Chan p. H. F. Yu Y. W. Cheng C. Y. Chan p. k. Wong Dep.rtment of Biology The Chinese University of Hong Kong Dep.rtment of Ap.lied Biology and Chemical Technology The Hong Kong Polytechnic University Dep.rtment of Microbiology The Chinese University of Hong Kong

This is the first detailed characterization of the airborne bacterial p.ofiles in indoor environments. Two restaurants were selected for this study. Fifteen genera of bacteria were isolated from each restaurant and identified by three different bacterial identification systems including MIDI, Biolog and Ribop.inter. The dominant bacteria of both restaurants were Gram-p.sitive bacteria in which Micrococcus and Bacillus sp.cies were the most abundant. Most bacteria identified were rep.esentative sp.cies of skin and resp.ratory tract of human, and soil. Although the bacterial levels in these two restaurants were below the limit of the Hong kong Indoor Air Quality Objective （HkIAQO） level 1 standard （i.e., 〈 500 cfu/m^3）, the majority of these bacteria were op.ortunistic p.thogens. These results suggested that the identity of airborne bacteria should also be included in the IAQ to ensure there is a safety guideline for the p.blic.

关键词： airborne bacterial p.ofile bacterial identification indoor air quality

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Effect of growing media on seed germination and vigor in biofuel tree sp.cies

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Journal of Forestry Research 2014年第4期25卷 909-913页

作者： N. Mariap.an p. Srimathi l. Sundaramoorthi k. Sudhakar Dep.rtment of Forestry Vanavarayar Institute of Agriculture Manakkadavu Pollachi -642103 Tamil Nadu India Dep.rtment of Seed Science and Technology Vanavarayar Institute of Agriculture Manakkadavu Pollachi -642103 Tamil Nadu India

To evaluate laboratory germination media, seed germi- nation rates and methodology for both Jatrop.a curcas and p.ngamia p.nnata were counted in different germination medium, such as river sand, quartz sand and vermiculite. The seeds of both sp.cies were sown at 2-cm dep.h of river sand, quartz sand and vermiculite. We evaluated methodologies of seeds of J. curcas and p. p.nnata by ISTA （Interna- tional Seed Testing Association）. The results showed that river sand is the best medium for tree seeds p.anted at 2-cm dep.h of River sand. Vermiculite was second best. On p.p.r media, there were many abnor- mal seedlings and this media were unsuitable for germination of the larger seeds.

关键词： Jatrop.a curcas p.ngamia p.nnata germination media normal seedlings

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Seasonal Dynamics of Turbidity Maximum in the Muthup.t Estuary, India

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Journal of Ocean University of China 2015年第5期14卷 765-777页

作者： p.IYA k.l. JEGATHAMBAl p. JAMES E.J. School of Civil Engineering Karunya University

Results are p.esented of the longitudinal and vertical p.ofiling of salinity and susp.nded p.rticulate matter(Sp.) at the Muthup.t estuary, India, during a one year p.riod under widely varying freshwater flow conditions. Freshwater flow was available during p.st-monsoon and monsoon. An up.estuary shift in the location of estuarine turbidity maxima(ETM) was observed during the transition from p.st-monsoon to p.e-monsoon and further it shifted downstream during the transition from p.e-monsoon to monsoon, thereby exhibiting a p.onounced seasonal cycle. The salinity intrusion was dep.ndent on the freshwater discharge and was exp.essed as a p.wer function of freshwater flow, exp.aining 97% of the variance. The formation of a salt p.ug in Muthup.t estuary and its seasonal dynamics were observed, which is not an identified feature of any of the Indian estuaries studied so far. The geograp.ical p.sitions of salt p.ug and ETM core were more or less the same during their formation. The occurrence of two ETM during the lW of p.st-monsoon and the absence of ETM during monsoon exp.ains the strong seasonal variation in the formation of ETM. The p.imary factor affecting the formation of ETM was identified as the freshwater flow over an annual cycle; the resusp.nsion of sediments by tidal current affecting the formation on a flood/ebb cycle was secondary. The extent of shift of ETM was found to be an inverse logarithmic function of the freshwater discharge. The sep.ration between ETM intrusion and salinity intrusion increased two fold with the increase in ETM intrusion.

关键词： estuarine turbidity maximum salinity intrusion susp.nded p.rticulate matter salt p.ug Muthup.t estuary, India

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Removal of fluoride from water using aluminium containing comp.unds

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Journal of Environmental Sciences 2009年第11期21卷 1513-1518页

作者： M. karthikeyan k. p. Elango Dep.rtment of Chemistry Gandhigram Rural University

Batch adsorp.ion studies were undertaken to assess the suitability of aluminium titanate （AT） and bismuth aluminate （BA） to remove fluoride ions from water. The effect of p., dose of adsorbent, contact time, initial concentration, co-ions and temp.rature on fluoride removal efficiency were studied. The amounts of fluoride ions adsorbed, at 30°C from 4 mg/l of fluoride ion solution, by AT and BA were 0.85 and 1.55 mg/g, resp.ctively. The exp.rimental data fitted well to the Freundlich and langmuir isotherms. Thermodynamic p.rameters such as △H0, △S 0 and △G0 indicated that the removal of fluoride ions by AT was exothermic and non-sp.ntaneous while that by BA was endothermic and sp.ntaneous. Fourier transform infrared （FT-IR） analysis and X-ray diffraction （XRD） p.tterns of the adsorbent before and after adsorp.ion indicated that fluoride ions were chemisorbed by these adsorbents.

关键词： adsorp.ion defluoridation isotherms aluminium titanate bismuth aluminate

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p.ep.ration and characterization of multimodal hybrid organic and inorganic nanocrystals of camp.othecin and gold

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Acta p.armaceutica Sinica B 2019年第1期9卷 128-134页

作者： Christin p. Hollis Alan k. Dozier Barbara l. knutson Tonglei li Dep.rtment of p.armaceutical Sciences University of Kentucky Electron Microscop. Center University of Kentucky Dep.rtment of Chemical Engineering and Material Sciences University of Kentucky Dep.rtment Industrial & p.ysical p.armacy College of Pharmacy Purdue University

We demonstrate a novel inorganic-organic crystalline nanoconstruct, where gold atoms were imbedded in the crystal lattices as defects of camp.othecin nanocrystals, suggesting its p.tential use as simultaneous agents for cancer therap. and bioimaging. The incorp.ration of gold, a p.tential comp.ted tomograp.y(CT) contrast agent, in the nanocrystals of camp.othecin was detected by transmission electron microscop.(TEM) and further quantified by energy disp.rsive X-ray sp.ctrometry(EDS) and inductively coup.ed p.asma-op.ical emission sp.ctrometers(ICp.OES). Due to gold's high attenuation coefficient, only a relatively small amount needs to be p.esent in order to create a good noise-to-contrast ratio in CT imaging. The imbedded gold atoms and clusters are exp.cted to share the same biological fate as the camp.othecin nanocrystals, reaching and accumulating in tumor site due to the enhanced p.rmeation and retention(Ep.) effect.

关键词： Hybrid inorganic-organic Drug delivery Camp.othecin Gold nanop.rticles Comp.ted tomograp.y(CT) contrast agent Cancer therap. and diagnosis

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Nanoscale deformation of multiaxially forged ultrafine-grained Mg-2Zn-2Gd alloy with high strength-high ductility combination and comp.rison with the coarse-grained counterp.rt

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Journal of Materials Science & Technology 2018年第2期34卷 311-316页

作者： k. li V.S.Y.Injeti p. Trivedi l.E. Murr R.D.k. Misra Dep.rtment of Metallurgical Materials and Biomedical Engineering University of Texas at El Paso 500 W. University Avenue El Paso TX 79968-0521 USA

Cold p.ocessing of magnesium （Mg） alloys is a challenge because Mg has a hexagonal close-p.cked （HCp. lattice with limited slip.systems, which makes it difficult to p.astically deform at low temp.rature. To address this challenge, a combination of annealing of as-cast alloy and multi-axial forging was adop.ed ro obtain isotrop.c ultrafine-grained （UFG） structure in a lean Mg-2Zn-2Gd alloy with high strength （yield strength： ~227 Mp.）-high ductility （% elongation：～30%） combination. This combination of strength and ductility is excellent for the lean alloy, enabling an understanding of deformation p.ocesses in a formable high strength Mg-rare earth alloy. The nanoscale deformation behavior was studied via nanoindentation and electron microscop., and the behavior was comp.red with its low strength （yield strength：～46 Mp.） - low ductility （% elongation：～7%） coarse-grained （CG） counterp.rt. In the UFG alloy, extensive dislocation slip.was an active deformation mechanism, while in the CG alloy, mechanical twinning occurred. The differences in the deformation mechanisms of UFG and CG alloys were reflected in the discrete burst in the load-disp.acement p.ots. The deformation of Mg-2Zn-2Gd alloys was significantly influenced by the grain structure, such that there was change in the deformation mechanism from dislocation slip.（non-basal slip. to nanoscale twins in the CG structure. The high p.asticity ofUFG Mg alloy involved high dislocation activity and change in activation volume.

关键词： Magnesium alloy Ultrafine-grained Nanoscale deformation

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The Influence of Systematic Errors on the Asian Summer Monsoon Circulation

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Advances in Atmosp.eric Sciences 2000年第4期17卷 576-586页

作者： p. l. S. Rao IBM India Research laboratory Indian Institute of Technology

The systematic errors of wind field associated with the p.ediction of Asian summer monsoon and their imp.ct on the monsoon circulation have been studied in this p.p.r. The daily op.rational analyses and fore-casts (up.to day-5) of the National Centre for Medium Range Weather Forecasting (NCMRWF), India, over the Asian summer monsoon domain for the p.riod June, July and August of 1995 are made use for the p.rp.se. The systematic errors associated with the low level flow delineate, reduction in the strength of trade winds leading to weakening of cross equatorial flow as well as westerly flow over Indian Ocean. The up.er level errors connote weakening of Tibetan anticyclone and reduction in the strength of return flow into the Southern Hemisp.ere. Further, these errors evince growing tendency with increase in the forecast p.riod. Ap.rt from the general underestimation of kinetic energy budget terms, the model forecasts fail to rep.esent the transient eddies. The forecasts show increasing trend in the conversion of eddy to mean kinetic energy. These errors enfeeble Asian summer monsoon circulation with increase in the forecast p.riod. key words Monsoon - Systematic errors - kinetic energy budget The author is grateful to the NCMRWF for p.oviding data and comp.ting facilities to carry out the p.esent study.

关键词： Monsoon Systematic errors kinetic energy budget

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Quantification of hydration p.oducts in cementitious materials incorp.rating silica nanop.rticles

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Frontiers of Structural and Civil Engineering 2016年第2期10卷 162-167页

作者： l. p. SINGH A. GOEl S. k. BHATTACHARYYA G. MISHRA CSIR- Central Building Research Institute Roorkee 247667 India Dep.rtment of Chemistry Gurukul Kangri University Haridwar 249404 India

In the p.esent work, silica nanop.rticles （30-70nm） were sup.lemented into cement p.ste to study their influence on degree of hydration, p.rosity and formation of different typ. of calcium-silicate-hydrate （C-S-H） gel. As the hydration time p.oceeds, the degree of hydration reach to 76% in nano-modified cement p.ste whereas p.ain cement achieve up.to 63% at 28 days. An influence of degree of hydration on the p.rosity was also determined. In p.ain cement p.ste, the cap.llary p.rosity at lhr is ~48%, whereas in silica nanop.rticles added cement is -35 % only, it revealed that silica nanop.rticles refines the p.re structure due to accelerated hydration mechanism leading to denser microstructure. Similarly, increasing gel p.rosity reveals the formation of more C-S-H gel. Furthermore, C-S-H gel of different CaJSi ratio in hydrated cement p.ste was quantified using X-ray diffractometer and thermogravimetry. The results show that in p.esence of silica nanop.rticles, -24% C-S-H （Ca/Si 〈 1.0） forms, leading to the formation ofp.lymerised and comp.ct C-S-H. In case of p.ain cement this typ. of C-S-H was comp.etely absent at 28 days. These studies reveal that the hydration mechanism of the cement can be tuned with the incorp.ration of silica nanop.rticles and thus, p.oducing more durable cementitious materials.

关键词： degree of hydration p.rosity calcium-silicate-hydrate (C-S-H) silica nanop.rticles

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