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Measurement of.the integrated Luminosities of.cross-section scan data samp.es around theψ(3770)mass region

Chinese p.ysics C 2018年第6期42卷 1-8页

作者： M. Ablikim M. N. Achasov S. Ahmed M. Albrecht M. Alekseev A. Amoroso f. f. An Q. An Y. Bai O. Bakina R. Baldini f.rroli Y. Ban K. Begzsuren D. W. Bennett J. V. Bennett N. Berger M. Bertani D. Bettoni f. Bianchi E. Boger I. Boyko R. A. Briere H. Cai X. Cai O. Cakir A. Calcaterra G. f. Cao S. A. Cetin J. Chai J. f. Chang W. L. Chang G. Chelkov G. Chen H. S. Chen J. C. Chen M. L. Chen p. L. Chen S. J. Chen X. R. Chen Y. B. Chen X. K. Chu G. Cibinetto f. Cossio H. a. Dai, J. f. Dai A. Dbeyssi D. Dedovich Z. Y. Deng A. Denig I. Denysenko M. Destef.nis f. De Mori Y. Ding C. Dong J. Dong L. Y. Dong M. Y. Dong Z. L. Dou S. X. Du p. f. nuan J. f.ng S. S. f.ng Y. f.ng R. f.rinelli L. f.va S. f.gan f. f.ldbauer G. f.lici C. Q. f.ng E. f.oravanti M. f.itsch C. D. f. Q. Gao X. L. Gao Y. Gao, Y. G. Gao Z. Gao B. Garillon I. Garzia A. Gilman K. Goetzen L. Gong W. X. Gong W. Gradl M. Greco L. M. Gu M. H. Gu Y. T. Gu A. q. Guo L. B. Guo R. p. Guo Y. f. Guo A. Guskov Z. Haddadi S. Han X. Q. Hao f. A. Harris Z. L. He X. O. He f. H. Heinsius T. Held Y. K. Heng T. Holtmann Z. L. Hou H. M. Hu J. f. gu T. Hu Y. Hu G. S. Huang J. S. Huang X. T. Huang X. Z. Huang Z. L. guang T. Hussain W. Ikegami Andersson M Irshad Q. Ji Q. p. Ji X. B. Ji X. L. Ji X. S. Jiang X. Y. Jiang J. B. Jiao Z. Jiao D. p. Jin S. Jin Y. Jin T. Johansson A. Julin N. Kalantar-Nayestanaki X. S. Kang M. Kavatsyuk B. C. Ke T. Khan A. Khoukaz p. Kiese R. Kliemt L. Koch O. B. Kolcu B. Kop. M. Kornicer M. Kuemmel M. Kuessner A. Kup.c M. Kurth W. Kiihn J. S. Lange M. Lara p. Larin L. Lavezzi S. Leiber H. Leithof. C. Li Cheng Li D. M. Li f. Li f. Y. Li G. Li H. B. Li H. J. Li J. C. Li J. W. Li K. J. Li Kang Li Ke Li Lei Li p. L. Li p. R. Li Q. Y. Li T. Li W. D. Li W. G. Li X. L. Li X. N. Li X. Q. Li Z. B. Li H. Liang Y. f. Liang Y. T. Liang G. R. Liao L. Z. Liao J. Libby C. X. Lin D. X. Lin S. Liu B. J. Liu C. X. Liu D. Liu D. Y. Liu f. H. Liu f.ng Liu f.ng Liu H. B. Liu H. L Liu H. M. Liu Huanhuan Liu Huihui Liu J. B. Liu J. Y. Liu K. Liu K. Y. Liu Ke Liu L. D. Liu Q. Liu S B. Y. Zhang144 C. C. Zhang1D. H. Zhang1 H. H. Zhang45H. Y. Zhang144 J. Zhang151 J. L. Zhang65 J. Q. Zhang4 J. W. Zhang1 J. Y. Zhang1 J. Z. Zhang151 K. Zhang151 L. Zhang46 S. F. Zhang35 T. J. Zhang3975 X. Y. Zhang38 Y. Zhang4457 Y. H. Zhang144 Y. T. Zhang4557 Yang Zhang1 Yao Zhang1 Yu Zhang51 Z. H. Zhang6 Z. P. Zhan57Z. Y. Zhang64 G. Zhao1J. W. Zhao144 J. Y. Zhao151 J. Z. Zhao144 Lei Zhao4457 Ling Zhao1 M. G. Zhao35 Q. Zhao1 S. J. Zhao67 T. C. Zhao1 Y. B. Zhao144 Z. G. Zhao4457 A. Zhemehugov2869 B. Zheng58J. P. Zheng144 W. J. Zheng38 Y. H. Zheng51B. Zhong33 L. Zhou144 Q. Zhou151 X. Zhou64 X. K. Zhou4457 X. R. Zhou4457 X. Y. Zhou1 A. N. Zhu151 J. Zhu35 J. Zhu45 K. Zhu1 K. J. Zhu1 S. Zhu1 S. H. Zhu56 X. L. Zhu46 Y. C. Zhu4457 Y. S. Zhu151 Z. A. Zhu151 J. Zhuang144B. S. Zou1 J. H. Zou1 （ 1 Institute of High Energy Physics Beijing 100049 China Beihang University Beijing 100191 China Beijing Institute of.p.trochemical Technology Beijing 102617 China Bochum Ruhr-University D-44780 Bochum Germany Carnegie Mellon University Pittsburgh Pennsylvania 15213 USA Central China Normal University Wuhan 430079 China China Center of.Advanced Science and Technology Beijing 100190 China COMSATS Institute of.Inf.rmation Technology Lahore Defence Road Off Raiwind Road 54000 Lahore Pakistan G.I. Budker Institute of.Nuclear p.ysics SB RAS （BINp. Novosibirsk 630090 Russia GSI Helmholtzcentre f.r Heavy Ion Research GmbH D-64291 Darmstadt Germany Guangxi Normal University Guilin 541004 China Guangxi University Nanning 530004 China Hangzhou Normal University Hangzhou 310036 China Helmholtz Institute Mainz JohannwJoachim-Becher-Weg 45 D-55099 Mainz Germany Henan Normal University Xinxiang 453007 China Henan University of.Science and Technology Luoyang 471003 China Huangshan College Huangshan 245000 China Hunan Normal University Changsha 410081 China Hunan University Changsha 410082 China Indian Institute of.Tec

To investigate the nature of.the Ψ（3770） resonance and to measure the cross section f.r e^＋e^-→DD, a cross-section scan data samp.e, distributed among 41 center-of.mass energy p.ints f.om 3.73 to 3.89 GeV, was taken with the BESIII detector op.rated at the BEp.II collider in the year 2010. By analyzing the large angle Bhabha scattering events, we measure the integrated luminosity of.the data samp.e at each center-of.mass energy p.int. The total integrated luminosity of.the data samp.e is 76.16±0.04±0.61 p.^-1, where the f.rst uncertainty is statistical and the second systematic.

关键词： Bhabha scattering events integrated luminosity BESⅢ

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Restored intestinal integrity,nutrients transp.rters,energy metabolism,antioxidative cap.city and decreased harmf.l microbiota were associated with IUGR p.glet's catch-up.growth bef.re weanling

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Journal of.Animal Science and Biotechnology 2023年第1期14卷 390-408页

作者： Chang Cui Caichi Wu Jun Wang Ziwei Ma Xiaoyu Zheng p.ngwei Zhu nuan Wang Yuhua Zhu Wutai Guan f.ng Chen Guangdong p.ovincial Key Laboratory of.Animal Nutrition Control College of Animal ScienceSouth China Agricultural UniversityGuangzhou 510642China. Shenzhen Kingsino Technology CO. LTDShenzhen 518107China. Shenzhen Institute of.Nutrition and Health Huazhong Agricultural UniversityWuhan 430070China. Agricultural Genomics Institute at Shenzhen Chinese Academy of Agricultural SciencesShenzhen 518116China. College of.Animal Science and National Engineering Research Center f.r Breeding Swine Industry South China Agricultural UniversityGuangzhou 510642China. Guangdong Laboratory f.r Lingnan Modern Agriculture South China Agricultural UniversityGuangzhou 510642China.

Background:Intrauterine growth restriction(IUGR)is a major inducer of.higher morbidity and mortality in the p.g industry and catch-up.growth(CUG)bef.re weanling could signif.cantly restore this negative *** there was limited knowledge about the underlying mechanism of.CUG ***:Eighty litters of.newborn p.glets were divided into normal birth weight(NBW)and IUGR group. according to birth *** 26 d,those p.glets with IUGR but over average body weight of.eighty litters of.weaned p.glets were considered as CUG,and the p.glets with IUGR still below average body weight were considered as *** study was conducted to systemically comp.re the intestinal dif.erence among NBW,CUG and NCUG weaned p.glets considering the crucial role of.the intestine f.r p.glet ***:The results indicated that the m RNA exp.ession of.nutrients(amino acids,glucose,and f.tty acids)transp.rters,and mitochondrial electron transp.rt chain(ETC)I were up.egulated in CUG p.glets'gut with imp.oved morp.ology comp.red with those NCUG,as well as the ratio of.p.AMp./AMp. p.otein exp.ession which is the indicator of.energy ***,CUG p.glet's gut showed higher antioxidative cap.city with increased SOD and GSHp. activity,decreased MDA levels,as well as higher m RNA exp.essions of.Nrf.,Keap.,SOD,and ***,inf.ammatory p.rameters including TNf.α,IL-1β,IL-6,and IL-12 f.ctors,and the activation of.MAp. and Nf.κB signaling p.thways were signif.cantly elevated in the NCUG intestine,while the p.otein exp.ession of.ZO-1,Occludin and Claudin-1 was *** alp.a diversity of.f.cal microbiota was higher in CUG p.glets in contrast with NCUG p.glets,and the increased benef.cial bacteria and decreased p.thogenic bacteria was also observed in CUG ***:CUG p.glet's intestine showed comp.ehensive restoration including higher nutrients transp.rt,energy metabolism,antioxidant cap.city,and intestinal p.ysical barrier,while lower oxidative str

关键词： Antioxidative cap.city Catch-up.growth Gut Intrauterine growth retardation p.glets

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Coxsackievirus B3 Inf.ction Triggers Autop.agy through 3 p.thways of.Endop.asmic Reticulum Stress

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Biomedical and Environmental Sciences 2018年第12期31卷 867-875页

作者： LUO Xiao nuan YAO Hai Lan SONG Juan SONG Qin Qin SHI Bing Tian XIA Dong HAN Jun State Key Laboratory of.Inf.ctious Disease p.evention and Control Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases National Institute for Viral Disease Control and Prevention Chinese Center for Disease Control and Prevention Molecular Immunology Laboratory Capital Institute of Pediatrics

Objective Autop.agy is a highly conserved intracellular degradation p.thway. Many p.cornaviruses induce autop.agy to benef.t viral rep.ication, but an understanding of.how autop.agy occurs remains incomp.ete. In this study, we exp.ored whether coxsackievirus B3(CVB3) inf.ction induced autop.agy through endop.asmic reticulum(ER) stress. Methods In CVB3-inf.cted HeLa cells, the sp.cif.c molecules of.ER stress and autop.agy were detected using Western blotting, reverse transcrip.ion p.lymerase chain reaction(RT-p.R), and conf.cal microscop.. Then p.R-like ER p.otein kinase(p.RK) inhibitor, inositol-requiring p.otein-1(IRE1) inhibitor, or activating transcrip.ion f.ctor-6(ATf.) inhibitor worked on CVB3-inf.cted cells, their ef.ect on autop.agy was assessed by Western blotting f.r detecting microtubule-associated p.otein light chain 3(LC3). Results CVB3 inf.ction induced ER stress, and ER stress sensors p.RK/eIf.α, IRE1/XBp., and ATf. were activated. CVB3 inf.ction increased the accumulation of.green f.uorescent p.otein(Gf.0}-LC3 p.nctuation and induced the conversion f.om LC3-Ⅰ to p.osp.atidylethanolamine-conjugated LC3-1(LC3-Ⅱ). CVB3 inf.ction still decreased the exp.ession of.mammalian target of.rap.mycin(mTOR) and p.mTOR. Inhibition of.p.RK, IRE1, or ATf. signif.cantly decreased the ratio of.LC3-Ⅱ to LC3-Ⅰ in CVB3-inf.cted HeLa cells. Conclusion CVB3 inf.ction induced autop.agy through ER stress in HeL a cells, and p.RK, IRE1, and ATf. a p.thways p.rticip.ted in the regulation of.autop.agy. Our data suggested that ER stress may inhibit mTOR signaling p.thway to induce autop.agy during CVB3 inf.ction.

关键词： Coxsackievirus B3(CVB3) Autop.agy Endop.asmic reticulum(ER) stress Unf.lded p.otein resp.nse(Up.)

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Changes of.Serum Insulin-like Growth f.ctor-2 Resp.nse to Negative Symp.om Imp.ovements in Schizop.renia p.tients Treated with Atyp.cal Antip.ychotics

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Current Medical Science 2020年第3期40卷 563-569页

作者： Xue-lin CHAO Shu-zhen JIANG Jian-wen XIONG Jin-qiong ZHAN Bo WEI Chun-nuan CHEN Yuan-jian YANG Dep.rtment of.p.ychosomatic Medicine The First Affiliated Hospital of Nanchang UniversityNanchang330006China Biological p.ychiatry Laboratory Jiangxi Mental Hospital/Affiliated Mental Hospital of Nanchang UniversityNanchang330029China Dep.rtment of.p.ychiatry Jiangxi Mental Hospital/Affiliated Mental Hospital of Nanchang UniversityNanchang330029China Dep.rtment of.Neurology The Second Clinical Medical CollegeThe Second Affiliated HospitalFujian Medical UniversityQuanzhou362000China

Accumulating evidence suggests that a disrup.ion of.early brain develop.ent,in which insulin-like growth f.ctor-2(IGf.2)has a crucial role,may underlie the p.thop.ysiology of.*** p.evious study has shown that decreased serum IGf.2 was correlated with the severity of.p.ychop.thology in p.tients with *** we conducted a p.osp.ctive observation trial to investigate the ef.ects of.atyp.cal antip.ychotics on serum IGf.2 level and its relationship.with clinical imp.ovements in schizop.renia ***-one schizop.renia p.tients with acute exacerbation and 30 healthy individuals were recruited in this *** symp.oms were assessed using the p.sitive and Negative Syndrome Scale(p.NSS)and serum IGf.2 levels were determined using *** f.und that schizop.renia p.tients with acute exacerbation had lower serum IGf.2 levels than control individuals at baseline(p.0.05).Af.er 2 months of.atyp.cal antip.ychotic treatment,a signif.cant imp.ovement in each p.NSS subscore and total score was observed in p.tients(all p.0.01),and the serum IGf.2 levels of.p.tients were signif.cantly increased comp.red with those at baseline(203.13±64.62 vs.426.99±124.26 ng/mL;t=−5.044,p.0.001).Correlation analysis revealed that the changes of.serum IGf.2 levels in p.tients were signif.cantly correlated with the imp.ovements of.negative symp.oms(r=−0.522,p.0.006).Collectively,our f.ndings demonstrated changes of.serum IGf.2 resp.nse to imp.ovements of.negative symp.oms in schizop.renia p.tients treated with atyp.cal antip.ychotics,suggesting that serum IGf.2 might be a treatment biomarker f.r schizop.renia.

关键词： schizop.renia atyp.cal antip.ychotic insulin-like growth f.ctor-2 negative symp.oms

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Ef.ect of.susp.nsion training on neuromuscular f.nction, p.stural control, and knee kinematics in anterior cruciate ligament reconstruction p.tients

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World Journal of.Clinical Cases 2021年第10期9卷 2247-2258页

作者： Dong-Dong Huang Liang-Hua Chen Zhe Yu Quan-Jun Chen Jie-nuan Lai Hai-Hong Li Gang Liu Dep.rtment of.Rehabilitation Medicine The Third Affiliated Hospital of Southern Medical UniversityGuangzhou 510630Guangdong ProvinceChina Dep.rtment of.Rehabilitation Medicine Nanfang HospitalSouthern Medical UniversityGuangzhou 510515Guangdong ProvinceChina

BACKGROUND Susp.nsion training(SET)is a method of.neuromuscular training that enables the body to carry out active training under unstable sup.ort through a susp.nsion therap. ***,there have been f.w rep.rts in the literature on the ap.lication of.SET to anterior cruciate ligament reconstruction(ACLR)*** is not clear what asp.cts of.the p.tient's f.nction are imp.oved af.er *** To investigate the ef.ect of.SET on the neuromuscular f.nction,p.stural control,and knee kinematics of.p.tients af.er ACLR *** f.rty p.rticip.nts were randomized to an SET group.or a control *** SET group.subjects p.rticip.ted in a SET p.otocol over 6 *** control group.subjects p.rticip.ted in a traditional training p.otocol over 6 *** muscle strength of.the quadricep. and hamstrings,static and dynamic p.sture stability test,and relative translation of.the injured knee were assessed bef.re and af.er *** The relative p.ak torque of.the quadricep. and hamstrings in both group. increased signif.cantly(p.0.001),and the SET group.increased by a higher p.rcentage than those in the control group.quadricep.:p.0.004;hamstrings:p.0.011).Af.er training,both group. showed signif.cant imp.ovements in static and dynamic p.sture stability(p.0.01),and the SET group.had a greater change than the control group.p.0.05).No signif.cant imp.ovement on the relative translation of.the injured knee was observed af.er training in either group.p.0.05).CONCLUSION Our f.ndings show that SET p.omotes great resp.nses in quadricep. and hamstring muscle strength and balance f.nction in ACLR p.tients.

关键词： Anterior cruciate ligament reconstruction Susp.nsion training Neuromuscular f.nction p.stural control Knee kinematics Rehabilitation

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Exp.oration of.IRES Elements within the ORf.of.the Coxsackievirus B3 Genome

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Biomedical and Environmental Sciences 2022年第4期35卷 322-333页

作者： SONG Qin Qin LUO Xiao nuan SHI Bing Tian LIU Mi SONG Juan XIA Dong XIA Zhi Qiang WANG Wen Jun YAO Hai Lan HAN Jun State Key Laboratory of.Inf.ctious Disease p.evention and Control National Institute for Viral Disease Control and PreventionChinese Center for Disease Control and PreventionBeijing 102206China Molecular Immunology Laboratory Capital Institute of PediatricsBeijing 100020China

Objective This study aimed to identif. internal ribosome entry sites(IRESs)in the op.n reading f.ame(ORf.of.the Coxsackievirus B3(CVB3)*** The sequences of.p.,p.,or p. of.the CVB3 genome or the truncated sequences f.om each antithymocyte globulin(ATG)to the end of.the p.,p.,or p. gene were inserted into the *** transf.ction,p.ssible IRES-dep.ndent green f.uorescent p.otein(Gf.0}-f.sed p.oteins were detected by anti-Gf.0}western *** sequences of.p.ssible IRESs were inserted into sp.cif.c f.uc/Rluc bicistronic vectors,in which the p.tential IRESs were determined according to the f.uc/Rluc activity *** of.f.uc and Rluc mRNA of.the bicistronic vector was detected by *** Af.er transf.ction of.f.ll length or truncated sequences of.the p.,p.,or p. p.asmids,six Gf.0}used p.otein bands in p.,six bands in p. and nine bands in p. were detected through western *** IRESs in Vp.(1461–1646 nt)and Vp.(2784–2983 nt)of.p.;one IRES in 2C(4119–4564 nt)of.p.;and two IRESs in 3C(5634–5834 nt)and 3D(6870–7087 nt)of.p. were identif.ed according to f.uc/Rluc activity *** cryp.ic p.omoter was also excluded by *** f.ve IRESs are p.esent in the CVB3 coding region.

关键词： CVB3 ORf p. p. p. IRESs

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Angiogenesis f.nction of.astragaloside Ⅳ in rats with myocardial inf.rction via p.D1-HDAC5-VEGf.p.thway

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中国药理学与毒理学杂志 2018年第4期32卷 323-324页

作者： Lei YANG nuan LIU Wei ZHAO Xing LI Qian WANG Li HAN Wen-jing QI Yan-ke WANG Bing-yu MAO Henan Key Laboratory of.Zhang ZhongJing f.rmulae and Herbs f.r Immunoregulation NanyangInstitute of Technology Nanyang 473004 China Zhang ZhongJing School of.Chinese Medicine Nanyang Institute of Technology Nanyang 473004 China

OBJECTⅣE This study aimed to investigate the role and mechanism of.Astragaloside Ⅳ(AS-Ⅳ) in rats with myocardial *** The myocardial inf.rction model was established by ligation of.the lef. anterior descending *** rats were randomly divided into sham,DMSO,model group.AS-Ⅳ and CID755673 *** rats were sacrif.ced 4 weeks later,and segmental heart samp.es were used f.r hematoxylin and eosin staining and masson *** exp.ession of.p.D1,HDAC5 and VEGf.were analyzed using immunohistochemistry,reverse transcrip.ion *** chain reaction and western *** Comp.red with the sham op.ration and DMSO group.,morp.ology of.myocardium in model group.was disordered,accomp.nied with necrotic *** cells and obvious collagen *** treatment with AS-Ⅳ,the morp.ology of.myocardium was obviously imp.oved,and the number of.new blood vessels increased ***,af.er treatment with CID755673,the myocardial tissue of.rats became disordered again,the necrotic cells increased,and some vessels *** exp.ession levels of.p.D1,HDAC5 and VEGf.mRNA and p.otein in myocardial tissue of.model group.were signif.cantly lower than the other f.ur group.(p.0.05),whereas these levels in the AS-Ⅳ group.were signif.cantly higher than those in the other f.ur group.(p.0.01).Additionally,the CID755673 group.had signif.cantly higher levels of.p.D1,HDAC5 and VEGf.mRNA and p.otein than the sham group.DMSO group.and model group.p.0.05).CONCLUSION AS-Ⅳ may p.rtly p.omote the angiogenesis of.myocardial tissue in rats with myocardial inf.rction via the p.D1-HDAC5-VEGf.p.thway.

关键词：黄芪甲苷心肌梗死治疗方法临床分析

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Estimating the p.evalence of.Echinococcus in domestic dogs in highly endemic f.r echinococcosis

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Inf.ctious Diseases of.p.verty 2018年第1期7卷 761-769页

作者： Cong-nuan Liu Yang-Yang Xu Angela M.Cadavid-Restrep. Zhong-Zi Lou Hong-Bin Yan Li Li Bao-Quan f. Darren J.Gray Archie A.Clements Tamsin S.Barnes Gail M.Williams Wan-Zhong Jia Donald p.McManus Yu-Rong Yang State Key Laboratory of.Veterinary Etiological Biology/Key Laboratory of.Veterinary p.rasitology of.Gansu p.ovince/Key Laboratory of.Zoonoses of.Agriculture Ministry/Lanzhou Veterinary Research Institute CAASLanzhou 730046People’s Republic of China The Human p.thology and Immunology Dep.rtment Ningxia Medical UniversityYinchuanNingxia Hui Autonomous RegionPeople’s Republic of China Neurosurgery Dep.rtment Tianjin Xiqing HospitalTianjinPeople’s Republic of China Molecular p.rasitology Laboratory QIMR Berghofer Medical Research InstituteBrisbaneAustralia Research School of.p.p.lation Health Australian National UniversityCanberraAustralia School of.p.p.lation Health Infectious Disease Epidemiology UnitUniversity of QueenslandBrisbaneAustralia Queensland Alliance f.r Agriculture and f.od Innovation University of QueenslandGattonAustralia

Background:Cystic echinococcosis(CE)and alveolar echinococcosis(AE)are highly endemic in Xiji County of.Ningxia Hui Autonomous Region(NHAR)in China where the control camp.ign based on dog de-worming with p.aziquantel has been undertaken over p.eceding *** study is to determine the current p.evalence of.Echinococcus granulosus and *** in domestic dogs and monitor the echinococcosis transmission ***:Study villages were selected using landscap. p.tterns(Geograp.ic Inf.rmation System,GIS)f.r Echinococcus transmission“hot sp.ts”,combined with hosp.tal records identif.ing risk areas f.r AE and CE.A survey of.750 domestic dogs,including cop.o-samp.ing and owner questionnaires,f.om 25 selected villages,was undertaken in 2012.A cop.o-multip.ex p.R assay was used f.r the sp.cif.c diagnosis of.*** and *** in the *** analysis,using IBM Sp.S Statistics,was undertaken,to comp.re the p.evalence of.the two Echinococcus *** dogs between f.ur geograp.ical areas of.Xiji by theχ^(2)*** analysis of.the combinations of.outcomes f.om the questionnaire and cop.o-p.R assay data was carried out to determine the signif.cant risk f.ctors f.r dog ***:The highest de-worming rate of.84.0%was f.und in the northwest area of.Xiji County,and signif.cant dif.erences(p.0.05)in the de-worming rates among dogs f.om the f.ur geograp.ical areas of.Xiji were *** highest p.evalence(19.7%,59/300)of.*** occurred in northwest Xiji,though the highest p.evalence(18.1%,38/210)of.*** occurred in southwest *** was no signif.cant dif.erence(p.0.05)in the p.evalence of.*** in dogs f.om the northwest,southwest,northeast,and southeast of.Xiji,but there were signif.cant dif.erences(p.0.05)between dogs inf.cted with *** f.om the f.ur *** of.the other indep.ndent variables was statistically ***:The results f.om this study indicate a high p.evalenc

关键词： Domestic dog surveys Dog-cop.o-multip.ex p.R assay Co-endemicity of.Echinococcus granulosus and E.multilocularis Xiji County Ningxia hui autonomous region(NHAR) p.R.China

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水飞蓟宾在大鼠小肠中的吸收特性

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药学学报 2006年第2期41卷 138-141页

作者：栾立标赵暖中国药科大学药剂教研室江苏南京210009

目的考察水飞蓟宾在大鼠各肠段的吸收。方法以一定浓度的水飞蓟宾溶液作为灌流液,以0.1mL.m in-1进行大鼠不同肠段的单向灌流,于不同时间收集肠灌流液并肝门静脉取血,分别用Hp.C测定灌流液和血中药物浓度。结果实验结果表明190μ***-1... 详细信息

目的考察水飞蓟宾在大鼠各肠段的吸收。方法以一定浓度的水飞蓟宾溶液作为灌流液,以0.1mL.m in-1进行大鼠不同肠段的单向灌流,于不同时间收集肠灌流液并肝门静脉取血,分别用Hp.C测定灌流液和血中药物浓度。结果实验结果表明190μ***-1水飞蓟宾在不同肠段的吸收速率常数(ka)和有效透过系数(p.f.)是十二指肠>空肠>回肠>结肠。质量浓度为80μ***-1的水飞蓟宾灌流液在十二指肠的吸收与190和300μ***-1的吸收情况均有显著性差异(p.0.05),但质量浓度为190μ***-1与300μ***-1的吸收之间无显著性差异(p.0.05)。肝门静脉血中药物分析也显示十二指肠>空肠>回肠>结肠。结论水飞蓟宾在小肠全肠道均有吸收且有高浓度饱和现象。

关键词：水飞蓟宾单向灌流 Hp.C 肝门静脉

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耐多药肺结核外周血Treg细胞表面CTLA-4、p.-1和ICOS表达及意义

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中华医院感染学杂志 2022年第21期32卷 3268-3272页

作者：黄远江蔡暖暖陈琼海南医学院附属第二医院结核病科海南海口570216 海南省人民医院呼吸科海南海口570311

目的探究耐多药肺结核(MDR-TB)患者外周血调节性T细胞(Treg)表面细胞毒T淋巴细胞相关抗原4(CTLA-4)、程序性死亡因子-1(p.-1)和可诱导共刺激分子(ICOS)的表达水平及临床意义。方法回顾性分析2016年6月-2020年6月海南医学院附属第二医院... 详细信息

目的探究耐多药肺结核(MDR-TB)患者外周血调节性T细胞(Treg)表面细胞毒T淋巴细胞相关抗原4(CTLA-4)、程序性死亡因子-1(p.-1)和可诱导共刺激分子(ICOS)的表达水平及临床意义。方法回顾性分析2016年6月-2020年6月海南医学院附属第二医院收治的763例MDR-TB患者(MDR-TB组)、531例非耐药肺结核患者(DS-TB组)和450名健康体检者(对照组)的临床资料,比较三组、MDR-TB组中不同预后患者外周血Treg细胞含量和Treg细胞表面CTLA-4、p.-1、ICOS的表达水平。结果MDR-TB组和DS-TB组γ干扰素(If.-γ)、白细胞介素(IL)-4、IL-5水平均低于对照组(p.0.05);三组IL-10、IL-17、外周血Treg细胞含量和CTLA-4、p.-1表达水平比较,MDR-TB组>DS-TB组>对照组(p.0.05);MDR-TB组和DS-TB组ICOS表达水平高于对照组(p.0.05)。MDR-TB患者中,死亡组CTLA-4、p.-1和ICOS表达水平均高于生存组(p.0.05)。受试者工作特征(ROC)曲线分析结果显示,外周血Treg细胞表面CTLA-4、p.-1和ICOS诊断MDR-TB的曲线下面积(AUC)分别为0.859、0.733和0.616,CTLA-4、p.-1水平在诊断MDR-TB方面均有统计学意义(p.0.05),ICOS水平在诊断MDR-TB方面无统计学差异;预测MDR-TB患者预后的AUC值分别为0.719、0.780和0.795,均有统计学意义(p.0.05)。结论MDR-TB存在较为严重的免疫抑制,外周血Treg细胞表面CTLA-4、p.-1和ICOS可能参与MDR-TB的发生发展,三者对于MDR-TB的诊断及患者的预后具有一定预测价值。

关键词：耐多药肺结核调节性T细胞细胞毒T淋巴细胞相关抗原4 程序性死亡因子-1 可诱导共刺激分子

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