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Multi-targeting cytotoxic drug leads from mushrooms

Asian pacific Journal of Tropical Medicine 2019年第12期12卷 531-536页

作者： MVNL Chaitanya Asha Jose p ramalingam SC Mandal p Narendra Kumar phytomedicine&phytochemistry Division Raghavendra Institute of Pharmaceutical Education&Research(RIPER)(AUTONOMOUS)campusAnantapuramuAPIndia Department of pharmacology Karpagam College of PharmacyOthakkalmadapamCoimbatore 32TamilnaduIndia RERDS-CpR Raghavendra Institute of Pharmaceutical Education&Research(RIPER)(AUTONOMOUS)AnantapuramuAPIndia pharmacognosy and phytotherapy Research Laboratory Division of PharmacognosyDepartment of Pharmaceutical TechnologyJadavpur UniversityKolkata 700032India School of Crop production Technology Suranaree University of TechnologyThailand

Due to genetic and epigenetic mechanisms, cancer have become a resistant disease and there is a need for new molecules having multiple targeting action that promotes apoptosis. phytomolecules having multiple targeting anticancer activity are in high demand and there is less documentation or information available on these metabolites. It is evident that mushrooms are became the store houses of new anticancer molecules and mushrooms like Agaricus blazei, Antrodia camphorate, Albatrellus confluens, Bolteus badius, Cordyceps militaris, Clitocybe maxima, Funalia trogii, Grifola frondosa, and Inocybe umbrinella, are some of the medicinal mushrooms reported for their cytotoxic activity. Cytotoxic molecules like lentinan, grifolin, illudin-S, psilocybin, ganoderic acid, theanine, and hispolon, have been isolated from various mushroom species. However, studies have been limited only to in vitro cytotoxic mechanisms and very few trials have been conducted to prove the clinical efficacy of these drug leads. Hence, the current review focuses on new anticancer metabolites isolated from various mushrooms having multiple targeting mechanisms in cancer. However, an extensive research is needed to define the biosynthesis and clinical mechanism of these multiple acting metabolites. This review provides a platform for researchers new anticancer drugs and to bring out potent multiple acting anticancer newer drugs.

关键词： Cancer phytomolecules Multiple targeting Anticancer Drugs Leads

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重载直流牵引电动机的使用与维护经验

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机车电传动 1991年第2期 51-56页

作者： K.p.ramalingam 徐佩芬

一、订货技术条件机车和牵引电动机的规格对于生产厂家在设计、制造时,铁路用户在使用时都起着很重要的作用,因为它们会影响到设备的可靠性。以下几方面应予以注意: 1.只有当机车以最大额定功率牵引列车,并以较高的速度通过限制区段时,... 详细信息

一、订货技术条件机车和牵引电动机的规格对于生产厂家在设计、制造时,铁路用户在使用时都起着很重要的作用,因为它们会影响到设备的可靠性。以下几方面应予以注意: 1.只有当机车以最大额定功率牵引列车,并以较高的速度通过限制区段时,才能取得最大通过能力。 2.机车最大牵引力的限制值为30t,这对适当地利用机车潜力实际上是一个严重的障碍。一般说来,最大运行转矩或牵引力约为起动牵引力的75％～80％,但货运牵引力却规定为28.5t。

关键词：直流电机牵引电动机使用维护

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Targeting epigenetic mechanisms in amyloid-β-mediated Alzheimer’s pathophysiology:unveiling therapeutic potential

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Neural Regeneration Research 2025年第1期20卷 54-66页

作者： Jennie Z.Li Nagendran ramalingam Shaomin Li Ann Romney Center for Neurologic Diseases Brigham and Women’s Hospital and Harvard Medical SchoolBostonMAUSA

Alzheimer’s disease is a prominent chronic neurodegenerative condition characterized by a gradual decline in memory leading to *** evidence suggests that Alzheimer’s disease is associated with accumulating various amyloid-βoligomers in the brain,influenced by complex genetic and environmental *** memory and cognitive deficits observed during the prodromal and mild cognitive impairment phases of Alzheimer’s disease are believed to primarily result from synaptic *** life,environmental factors can lead to enduring changes in gene expression and the emergence of brain *** changes,known as epigenetic modifications,also play a crucial role in regulating the formation of synapses and their adaptability in response to neuronal *** this context,we highlight recent advances in understanding the roles played by key components of the epigenetic machinery,specifically DNA methylation,histone modification,and microRNAs,in the development of Alzheimer’s disease,synaptic function,and activity-dependent synaptic ***,we explore various strategies,including enriched environments,exposure to non-invasive brain stimulation,and the use of pharmacological agents,aimed at improving synaptic function and enhancing long-term potentiation,a process integral to epigenetic ***,we deliberate on the development of effective epigenetic agents and safe therapeutic approaches for managing Alzheimer’s *** suggest that addressing Alzheimer’s disease may require distinct tailored epigenetic drugs targeting different disease stages or pathways rather than relying on a single drug.

关键词： Alzheimer’s disease DNA methylation enriched environments histone modification microRNAs non-invasive brain stimulation synaptic plasticity

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重载直流牵引电动机的运用和维修经验

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国外内燃机车 1991年第12期 42-49页

作者： K.p.ramalingam 方一

本文论述了作者本人在印度铁路重载客货运输用直流牵引电动机运用和维修管理方面的经验,着重论述了牵引负载的性质及其对可靠性和性能问题的改善之影响。还介绍了他对消除这些问题的产生根源所采取的成功的方法,这些方法甚至对最佳的牵... 详细信息

本文论述了作者本人在印度铁路重载客货运输用直流牵引电动机运用和维修管理方面的经验,着重论述了牵引负载的性质及其对可靠性和性能问题的改善之影响。还介绍了他对消除这些问题的产生根源所采取的成功的方法,这些方法甚至对最佳的牵引电动机的设计和制造也起了作用。

关键词：牵引电动机直流电机维修

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性腺外盆腔部位的卵黄囊瘤:仍然是一个诊断难题

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临床与实验病理学杂志 2017年第3期33卷 296-296页

作者： Ravishankar S Malpica A ramalingam p 魏建国(译) 刘勇(校) 不详浙江省绍兴市人民医院病理科绍兴312000 江西省人民医院病理科南昌330006

作者回顾性分析1988～2016年15例女性患者性腺外卵黄囊瘤的临床病理学特点，包括患者年龄、临床表现、肿瘤部位、FIGO分期、组织学形态（是否出现Schiller—Duval小体、其它生殖细胞或体细胞成分）、免疫表型、治疗及结局；

关键词：性腺外卵黄囊瘤盆腔部诊断 FIGO分期临床表现病理学特点组织学形态女性患者

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25例子宫内膜神经内分泌癌的临床病理分析

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临床与实验病理学杂志 2016年第12期32卷 1409-1409页

作者： pocrnich C E ramalingam p Euscher E D 魏建国许春伟浙江省绍兴市人民医院病理科绍兴312000 解放军307医院病理科北京100071

子宫内膜神经内分泌癌（NECa）是一种罕见的肿瘤。作者分析了25例该肿瘤的临床病理特点。患者年龄范围37～87岁（中位年龄57岁），最常见的临床症状表现为阴道出血。10例为单纯性NECa，15例混合有其它组织学类型，最常见混合的是子宫内... 详细信息

子宫内膜神经内分泌癌（NECa）是一种罕见的肿瘤。作者分析了25例该肿瘤的临床病理特点。患者年龄范围37～87岁（中位年龄57岁），最常见的临床症状表现为阴道出血。10例为单纯性NECa，15例混合有其它组织学类型，最常见混合的是子宫内膜样腺癌。

关键词：子宫内膜样腺癌临床病理特点神经内分泌癌病理分析组织学类型作者分析中位年龄患者年龄

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子宫炎性肌纤维母细胞肿瘤9例临床病理分析:一种具有侵袭性行为的肿瘤,包括上皮样炎性肌纤维母细胞肉瘤

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临床与实验病理学杂志 2023年 628-628页

作者： Collins K ramalingam p Euscher E D 张佳怡黄海建福建医科大学福建医科大学省立临床医学院/福建省立医院病理科

近年,子宫炎性肌纤维母细胞肿瘤逐渐被认识,包括炎性肌纤维母细胞瘤和上皮样肌纤维母细胞肉瘤,均伴ALK基因异位,有限的研究资料表明该肿瘤预后较差。作者报道8例炎性肌纤维母细胞肿瘤(中位年龄50.5岁)和1例上皮样肌纤维母细胞肉瘤(中位...

近年,子宫炎性肌纤维母细胞肿瘤逐渐被认识,包括炎性肌纤维母细胞瘤和上皮样肌纤维母细胞肉瘤,均伴ALK基因异位,有限的研究资料表明该肿瘤预后较差。作者报道8例炎性肌纤维母细胞肿瘤(中位年龄50.5岁)和1例上皮样肌纤维母细胞肉瘤(中位年龄43岁)。临床表现为异常子宫出血、疑为肿瘤、骨盆疼痛、关节疼痛、低热和偶然发现。眼观:炎性肌纤维母细胞肿瘤中位最大径为8.5 cm,浸润性边界或界清。

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Effect of mercuric chloride on membrane-bound enzymes in rat testis

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Asian Journal of Andrology 2002年第4期4卷 309-311页

作者： V. ramalingam V.Vimaladevi Department of Zoology Bharathidasan Govt. College for Women Pondicherry-605 003 India5 Lancelot Court #4 Salem NH 03079 USA

Aim: To study the effect of mercuric chloride on the membrane-bound enzymes. Methods: The effect of mercuric chloride at two different doses, 1 mg/kg (low dose) and 2 mg/kg (high dose), orally for 30 days, was observed on the membrane-bound enzymes in the testis of adult albino rats. Results: Mercuric chloride significantly decreased the body weight and testis weight in the high dose group (pp. The activities of 5' nucleotidase and adenosine triphosphatases were markedly decreased (pps. Alkaline phosphatase and γ-glutamyl transferase activities were significantly increased (pps. However, the effect was more pronounced in the high than in the low dose groups. Conclusion: The dose dependent effect of mercuric chloride on these enzymes may affect the membrane characteristics and thereby the fertility of the animal. (Asian J Androl 2002 Dec; 4:309-311)

关键词： mercuric chloride testis alkaline phosphatase 5'nucleotidase γ-glutamyl transferase adenosine triphosphatase

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Heterologous expression of Lolium perenne antifreeze protein confers chilling tolerance in tomato

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Journal of Integrative Agriculture 2018年第5期17卷 1128-1136页

作者： Srinivasan Balamurugan Jayan Susan Ann Inchakalody p Varghese Shanmugaraj Bala Murugan Mani ChANDra Harish Sarma Rajeev Kumar ramalingam Sathishkumar plant Genetic Engineering Laboratory Department of BiotechnologyBharathiar University

Antifreeze proteins（AFp） are produced by certain plants, animals, fungi and bacteria that enable them to survive upon extremely low temperature. perennial rye grass, Lolium perenne, was reported to possess AFp which protects them from cold environments. In the present investigation, we isolated AFp gene from L. perenne and expressed it in tomato plants to elucidate its role upon chilling stress. The T1 transgenic tomato lines were selected and subjected to molecular, biochemical and physiological analyses. Stable integration and transcription of Lp AFp in transgenic tomato plants was confirmed by Southern blot hybridization and RT-pCR, respectively. physiological analyses under chilling conditions showed that the chilling stress induced physiological damage in wild type（WT） plants, while the transgenic plants remained healthy. Total sugar content increased gradually in both WT and transgenic plants throughout the chilling treatment. Interestingly, transgenic plants exhibited remarkable alterations in terms of relative water content（RWC） and electrolyte leakage index（ELI） than those of WT. RWC increased significantly by 3-fold and the electrolyte leakage was reduced by 2.6-fold in transgenic plants comparing with WT. Overall, this report proved that Lp AFp gene confers chilling tolerance in transgenic tomato plants and it could be a potential candidate to extrapolate the chilling tolerance on other chilling-sensitive food crops.

关键词： Lolium perenne antifreeze protein chilling tolerance genetic transformation transgenic tomato

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Combined effects of Gymnema sylvestre and pergularia daemia on letrozole-induced polycystic ovarian syndrome in rats

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Asian pacific Journal of Reproduction 2021年第2期10卷 68-74页

作者： Sudhakar pachiappan Kothai ramalingam Arul Balasubramanian Department of pharmacology Vinayaka Mission’s College of PharmacyVinayaka Mission’s Research Foundation(Deemed to be University)Salem-8Tamil NaduIndia Department of pharmacy practice Vinayaka Mission’s College of PharmacyVinayaka Mission’s Research Foundation(Deemed to be University)Salem-8Tamil NaduIndia

Objective:To investigate the combined therapeutic potential of Gymnema(G.)sylvestre and pergularia(p.)daemia on letrozole-induced polycystic ovarian syndrome(pCOS)in ***:Thirty six healthy female Wistar rats with regular estrus cycles were randomly divided into six groups each of ***Ⅰreceived 1 mL of 0.5%carboxyl methyl cellulose orally and served as the vehicle control group,while groupsⅡtoⅥwere treated with letrozole(1 mg/kg body weight p.o.)for 21 days to induce *** induction of pCOS,groupⅡserved as the pCOS control group,without treatment;groupⅢreceived metformin(20 mg/kg body weight p.o.)as the standard group,and groupsⅣtoⅥreceived ***(100 mg/kg body weight p.o.),***(300 mg/kg body weight p.o.),and the combination of *** and ***,respectively,for 28 *** smears were collected from all rats daily throughout the study to determine the phases of the estrus *** completing the treatment schedule,oral glucose tolerance test,serum lipid profile and reproductive hormonal analysis were carried ***,the rats were sacrificed to collect ovary and uterus for histopathological ***:The pCOS control rats showed a significant irregularity in the estrus cycle,hyperglycemia,and the altered serum lipid profile such as the increased low and very low density lipoprotein,triglyceride,and decreased high density *** addition,the pCOS control rats showed a significant increase in serum luteinizing hormone,testosterone,and estrogen,and decrease in follicle stimulating hormone and *** changes were significantly revoked in all the treatment *** test drugs also significantly reduced the gained ovary weight(ppathology of the ovary showed almost normal *** the treatment groups,the group of combination treatment of *** and *** showed superior ameliorative results in pCOS ***:Combination of *** and *** pr

关键词： polycystic ovarian syndrome Metformin Letrozole Gymnema sylvestre pergularia daemia Reproductive hormone Estrus cycle

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