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Insight into the liver dysfunction in COVID-19 patients: Molecular mechanisms and possible therapeutic strategies

World Journal of Gastroenterology 2023年第14期29卷 2064-2077页

作者： Naina Khullar Jasvinder Singh Bhatti Satwinder Singh Bhawana Thukral p hemachandra reddy Gurjit Kaur Bhatti Department of Zoology Mata Gujri CollegeFatehgarh Sahib 140407PunjabIndia Laboratory of Translational Medicine and Nanotherapeutics Department of Human Genetics and Molecular MedicineSchool of Health SciencesCentral University of PunjabBathinda 151401PunjabIndia Department of Computer Science and Technology Central University of PunjabBathinda 151401PunjabIndia Department of Nutrition and Dietetics University Institute of Applied Health SciencesChandigarh UniversityMohali 140413PunjabIndia Department of Internal Medicine Texas Tech University Health Sciences CenterLubbockTX 79430United States Department of Medical Lab Technology University Institute of Applied Health SciencesChandigarh UniversityMohali 140413PunjabIndia

As of June 2022,more than 530 million people worldwide have become ill with coronavirus disease 2019(COVID-19).Although COVID-19 is most commonly associated with respiratory distress(severe acute respiratory syndrome),metaanalysis have indicated that liver dysfunction also occurs in patients with severe *** studies revealed distinctive patterning in the receptors on the hepatic cells that helps in viral invasion through the expression of angiotensinconverting enzyme *** has also been reported that in some patients with COVID-19,therapeutic strategies,including repurposed drugs(mitifovir,lopinavir/ritonavir,tocilizumab,etc.)triggered liver injury and cholestatic *** proven indicators support cytokine storm-induced hepatic *** there are 1.5 billion patients with chronic liver disease worldwide,it becomes imperative to critically evaluate the molecular mechanisms concerning hepatotropism of COVID-19 and identify new potential *** review also designated a comprehensive outlook of comorbidities and the impact of lifestyle and genetics in managing patients with COVID-19.

关键词： COVID-19 Liver damage pharmacotherapy Cytokine storm Molecular mechanisms

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