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Effect of liver regeneration after partial hepatectomy and ischemia-reperfusion on expression of growth factor receptors

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World Journal of Gastroenterology 2006年第24期12卷 3835-3840页

作者： p baier G Wolf-Vorbeck S Hempel UT Hopt E von Dobschuetz Department of General and Visceral Surgery Albert-Ludwigs-University FreiburgGermany

AIM： To investigate the effects of experimental partial hepatectomy and normothermic ischemia-reperfusion damage on the time course of the expression of four different growth factor receptors in liver regeneration. This is relevant due to the potential therapeutic use of growth factors in stimulating liver regeneration. METHODS： For partial hepatectomy （pH） 80% of the liver mass was resected in Sprague Dawley rats. Ischemia and reperfusion （I/R） were induced by occlusion of the portal vein and the hepatic artery for 15 min. The epidermal growth factor receptor, hepatic growth factor receptor, fibroblast growth factor receptor and tumour necrosis factor receptor-1 were analysed by immunohistochemistry up to 72 h after injury. Quantitative RT-pCR was performed at the time point of minimal receptor expression （24 h）. RESULTS： In immunohistochemistry, EGFR, HGFR, FGFR and TNFR1 showed biphasic kinetics after partial hepatectomy with a peak up to 12 h, a nadir after 24 h and another weak increase up to 72 h. During liver regeneration, after ischemia and reperfusion, the receptor expression was lower; the nadir at 24 h after reperfusion was the same. To evaluate whether this nadir was caused by a lack of mRNA transcription, or due to a posttranslational regulation, RT-pCR was performed at 24 h and compared to resting liver. In every probe there was specific mRNA for the receptors. EGFR, FGFR and TNFR1 mRNA expression was equal or lower than in resting liver, HGFR expression after I/R was stronger than in the control. CONCLUSION： At least partially due to a post-transcriptional process, there is a nadir in the expression of the analysed receptors 24 h after liver injury. Therefore, a therapeutic use of growth factors to stimulate liverregeneration 24 h after the damage might be not successful.

关键词： partial hepatectomy Liver ischemia Growthfactor receptors

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Water productivity of poplar and paulownia on Two Sites in Kyrgyzstan, Central Asia

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Journal of Water Resource and protection 2021年第4期13卷 293-308页

作者： Niels Thevs Clara baier Kumar Aliev World Agroforestry Central Asia Office Bishkek Kyrgyzstan Gesellschaft für Internationale Zusammenarbeit (GIZ) Bonn Germany Sachsen-Leinen e.V. Markkleeberg Germany

As Central Asia is a region with wide spread water scarcity as a result of excessive irrigation of agriculture, land use changes deserve research about potential impacts on the already strained water resources. poplars have a long tradition as agroforestry tree across Central Asia, while paulownia is new to the region, but has been gaining extreme attention as a potential plantation and/or agroforestry tree. Therefore, the water productivity of those two tree species is investigated here on 3-year-old trees, in order to provide insights in how far the newly introduced paulownia could put additional strain on water resources compared to paulownia. poplar (p. deltoides × nigra) increased the stem biomass by 5.4 kg at an average water consumption of 4.18 l/d (water productivity 6.79 g/l). paulownia’s (paulownia tomentosa × fortunei) stem biomass grew by 4.81 kg at 2.36 l/d in average (water productivity 11.9 g/l). Expanding paulownia would not exert more pressure on Central Asia’s water resources than an expansion of poplar.

关键词： Fast-Growing Trees Water Consumption Sap Flow Central Asia Semi-Arid Climate

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Short-and long-term health implications of surgical intensive care in the elderly

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Health 2010年第12期2卷 1405-1412页

作者： Stefan Utzolino philipp A Ober Magnus Kaffarnik Andreas Fischer Ulrich T Hopt peter K baier 不详

Background: Treatment of elderly patients on intensive care units is an increasing challenge all over the world. Objectives: To evaluate short- term survival and long-term quality of life im-plications of intensive care for the elderly. Methods: Retrospective analysis of 314 patients 75 years of age or more requiring over 48 hours of intensive care. Results: In multivariate analy-sis, significant risk factors for mortality were chronic renal impairment (OR for survival .30, p 24 h (OR 4.5), hemodialysis (OR 6.8), and vasopressor therapy (OR 2.5, p p to 60-month follow-up of 28 patients revealed considerably lower physi-cal subscores of our patients compared to the general elderly population. Conclusions: Elderly patients benefit from intensive care in terms of survival. Complications are frequent, as are severe consequences for long-term quality of life. Short-term mortality in elderly intensive care patients correlates most closely to pre- existing disease, not age.

关键词： Surgical Intensive Care Aged Frail Elderly Quality of Life General Surgery Concomitant Disease

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Diminished fracture initiation sites in ceramic layers bonded to glow-discharge treated substructure

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Open Journal of Stomatology 2013年第6期3卷 307-313页

作者： Hyeongil Kim Edward A. Monaco Jr. Frederick McIntyre Elaine L. Davis Robert E. baier Department of Oral Diagnostic Sciences University at Buffalo New York USA Department of Restorative Dentistry University at Buffalo New York USA VA Western New York Healthcare System at Buffalo New York USA

A mechanically retentive structure and meticulous surface cleanliness are critical factors in providing fracture resistance and clinical success of metal ceramic restorations. This investigation compared the porcelain/metal interfaces of deliberate compressive fractures of ceramic crowns between conventional preparation and application of the Radio Frequency Glow Discharge Treatment (RFGDT) before each bonding step. It evaluated RFGDT’s capacity to improve wetting effectiveness and minimize porosity. Twelve metal ceramic crowns were fabricated identically. RFGDT was applied to the metal substructures of half the specimens before the ceramic layering process. All specimens were fractured in the same manner by an applied compressive force to simulate dental occlusive failure. Fracture surfaces were inspected by light and scanning electron microscopy. Quantitative analyses of images were performed to identify numbers, locations of cracks, porosity patterns, and other morphological correlates of the fracture zones. There were significantly fewer voids per millimeter at the interfaces in the RFGDT group than in the non-RFGDT group (t = 2.377, df = 9, p = 0.021). There was a significant difference in the number of horizontal cracks per millimeter between the groups (t = 2.132, df = 7, p = 0.035), with more cracks occurring in the non-RFGDT group. RFGDT can improve the integrity of metal ceramic crowns by increasing the substratum surface energy, improving porcelain wetting and spreading and thereby diminishing the numbers of interfacial voids available for initiation of fracture. Routine application of RFGDT should result in fewer cracks along metal/ceramic interfaces in all restorative preparations.

关键词： porcelain Fracture Glow Discharge Treatment Metal Ceramic Crown porosity Surface Energy

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低对比度字母视力测试发现多发性硬化症患者的视觉障碍

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世界核心医学期刊文摘（神经病学分册） 2005年第9期1卷 45-46页

作者： baier M.L. Cutter G.R. Rudick R.A. 周永 Ctr. for Res. Methodol. and Biometr. Cooper Institute 14023 Denver West Parkway 100 Golden CO 80401 United StatesDr.

Objective: To evaluate concurrent and predictive validity for low-contrast le tter acuity (L-CLA) testing as a candidate visual component for the Multiple Sc lerosis Functional Composite (MSFC). Methods: L-CLA testing was conducted in tw o MS patient cohorts. In the MSFC Validation Study, 137 participants from a phas e III trial of inteferon beta-1a (Avonex) for relapsing-remitting MS were foll owed. A second cohort included 65 patients with secondary progressive MS who par ticipated in a substudy of the International MS Secondary progressive Avonex Con trolled Trial (IMpACT). The total number of letters read correctly at four contr ast levels (100, 5, 1.25, and 0.6%)was correlated with Expanded Disability Stat us Scale (EDSS), MSFC, Sickness Impact profile, Multiple Sclerosis Quality of Li fe Inventory, and brain parenchymal fraction (BpF), as determined by MRI. Result s: Low-and high-contrast letter acuity scores correlated with BpF at follow-u p in the MSFC Validation Study (5%: r=0.40, p p=0.0002 ). L-CLA also correlated with EDSS (5%: r=-0.35, p p=0.0003) and MSFC(5%: r=0.47, p p pACT Substudy, change in L-CLA scores from baseline to year 1 predicted sub sequent change in the EDSS from year 1 to 2 at the 5%(p=0.0142) and the 1.25%( p=0.0038) contrast levels, after adjusting for change in MSFC scores from baseli ne to year 1. Conclusions: Low-contrast letter acuity (L-CLA) scores demonstra te concurrent and predictive validity in patients with relapsing-remitting and secondary progressive multiple sclerosis (MS). L-CLA testing provides additiona l information relevant to the MS disease process that is not entirely captured b y the Multiple Sclerosis Functional Composite.

关键词：多发性硬化症视觉障碍 EDSS 效能研究生活质量问卷疾病影响对照试验失能临床试验 pACT

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应用低对比度字母分辨力检查测试多发性硬化患者的视功能障碍

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世界核心医学期刊文摘（眼科学分册） 2005年第8期1卷 6-7页

作者： baier M.L. Cutter G.R. Rudick R.A. 陈立军 Ctr. for Res. Methodol. and Biometr. Cooper Institute 14023 Denver West Parkway 100 Golden CO 80401 United States Dr.

Objective: To evaluate concurrent and predictive validity for low-contrast le tter acuity (L-CLA) testing as a candidate visual component for the Multiple Sc lerosis Functional Composite (MSFC). Methods: L-CLA testing was conducted in tw o MS patient cohorts. In the MSFC Validation Study, 137 participants from a phas e III trial of inteferon beta-1a (Avonex) for relapsing-remitting MS were foll owed. A second cohort included 65 patients with secondary progressive MS who par ticipated in a substudy of the International MS Secondary progressive Avonex Con trolled Trial (IMpACT). The total number of letters read correctly at four contr ast levels (100, 5, 1.25, and 0.6%) was correlated with Expanded Disability Sta tus Scale (EDSS), MSFC, Sickness Impact profile, Multiple Sclerosis Quality of L ife Inventory, and brain parenchymal fraction (BpF), as determined by MRI. Resul ts: Low-and high-contrast letter acuity scores correlated with BpF at follow- up in the MSFC Validation Study (5%: r=0.40, p p=0.000 2). L-CLA also correlated with EDSS (5%: r=-0.35, p p=0.0003) and MSFC (5%: r=0.47, p p pACT Substudy, change in L-CLA scores from baseline to year 1 predicted s ubsequent change in the EDSS from year 1 to 2 at the 5%(p=0.0142) and the 1.25 %(p=0.0038) contrast levels, after adjusting for change in MSFC scores from bas eline to year 1. Conclusions: Low-contrast letter acuity (L-CLA) scores demons trate concurrent and predictive validity in patients with relapsing-remitting a nd secondary progressive multiple sclerosis (MS). L-CLA testing provides additi onal information relevant to the MS disease process that is not entirely capture d by the Multiple Sclerosis Functional Composite.

关键词：多发性硬化视功能障碍分辨力检查测试 EDSS 复发率疾病预测疾病影响分辩力 pACT

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miR-124-3p调控的LAD1作为肺腺癌潜在治疗靶点的生物信息学分析

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南通大学学报（医学版） 2023年第5期43卷 406-411页

作者：孙百尔钱佳燕南通大学附属医院呼吸与危重症医学科南通226001 江苏省南通市第一老年病医院呼吸与危重症医学科

目的:应用生物信息学探索非小细胞肺癌(non-small cell lung cancer,NSCLC)发病机制,筛选目标基因。方法:使用R语言limma包对基因表达综合数据库(gene expression omnibus,GEO)中NSCLC数据集进行差异表达基因鉴定,并对差异表达基因进行... 详细信息

目的:应用生物信息学探索非小细胞肺癌(non-small cell lung cancer,NSCLC)发病机制,筛选目标基因。方法:使用R语言limma包对基因表达综合数据库(gene expression omnibus,GEO)中NSCLC数据集进行差异表达基因鉴定,并对差异表达基因进行基因本体论(gene ontology,GO)分析和京都基因和基因组百科全书(Kyoto encyclopedia of genes and genomes,KEGG)通路富集分析,然后通过STRING数据库和Cytoscape进行关键基因筛选,在Kaplan-Meier plotter数据库对核心基因进行生存曲线分析,并对感兴趣的核心基因进行表达差异的验证,使用TargetScan数据库预测调控靶基因的微小RNA(microRNA,miRNA)。结果:共筛选出289个差异表达基因,蛋白质-蛋白质相互作用网络筛选出10个核心基因,其中ladinin-1(LAD1)在蛋白印迹分析中表达差异明显,Kaplan-Meier plotter数据库显示LAD1在肺腺癌组织中高表达与不良预后有关。TargetScan数据库预测调控靶基因的miR-124-3p与LAD1的mRNA的3′UTR结合。miR-124-3p在NSCLC组织中表达明显下调,且与女性肺腺癌患者的预后具有一定相关性。结论:miR-124-3p调控的LAD1可能是女性肺腺癌潜在的治疗靶点。

关键词：非小细胞肺癌差异表达基因 ladinin-1 微小RNA-124-3p 生物信息学分析

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评估98个已确定的体质量指数基因位点在美洲印第安人中的作用

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中华高血压杂志 2019年第5期27卷 419-419页

作者：刘青(译) 叶鹏(摘、审校) Muller YL Hanson RL piaggi p Chen p Wiessner G Okani C Skelton G Kobes S Hsueh WC Knowler WC Bogardus C baier LJ 不详

欧洲人全基因组关联研究的荟萃分析已经确定了>98个体质量指数(body mass index,BMI)基因位点。该研究分析了在pima印第安人中,这些已建立的相关性是否也适用。方法:在98个单核苷酸多态性(single nucleotide polymorphisms,SNps)中,82个... 详细信息

欧洲人全基因组关联研究的荟萃分析已经确定了>98个体质量指数(body mass index,BMI)基因位点。该研究分析了在pima印第安人中,这些已建立的相关性是否也适用。方法:在98个单核苷酸多态性(single nucleotide polymorphisms,SNps)中,82个在pima印第安人中存在次要等位基因频率≥0.01,研究人员分析了它们与成年期最大BMI(n=3491)和儿童时期BMI z评分(n=1958)的相关性。对98个基因位点的普通标记SNps的附加信号也进行了分析。

关键词：体质量指数印第安人基因位点单核苷酸多态性美洲等位基因频率荟萃分析全基因组

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NSCLC组织中FOXp1和FOXQ1的表达及相关性研究

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南通大学学报（医学版） 2017年第5期37卷 419-424页

作者：孙百尔冯健黄剑飞倪松石南通大学附属医院呼吸内科南通226001

目的:探讨叉头框蛋白p1(forkhead box p1,FOXp1)和叉头框蛋白Q1(forkhead box Q1,FOXQ1)在非小细胞肺癌(non-small cell lung cancer,NSCLC)组织中的表达与临床病理特点、预后的相关性,以及二者是否存在相互关系、二者联合检测在NSCLC... 详细信息

目的:探讨叉头框蛋白p1(forkhead box p1,FOXp1)和叉头框蛋白Q1(forkhead box Q1,FOXQ1)在非小细胞肺癌(non-small cell lung cancer,NSCLC)组织中的表达与临床病理特点、预后的相关性,以及二者是否存在相互关系、二者联合检测在NSCLC中的意义。方法:采用免疫组化En Vision两步法检测207例NSCLC组织及相对应的癌周正常肺组织中FOXp1和FOXQ1蛋白的表达。使用卡方检验和Spearman's rank检验分析二者在NSCLC中表达的相关性。为了评估联合检测FOXp1和FOXQ1对预后的意义,将207例NSCLC组织再分为A组(FOXp1低表达/FOXQ1高表达)(100例)和B组(非FOXp1低表达/FOXQ1高表达)(107例)。结果:FOXp1表达率与性别、淋巴结转移、临床分期、病理类型有关(pp1低表达组的患者在NSCLC中生存时间较短,即预后差。FOXQ1表达率与淋巴结转移、临床分期有关(ppp1、高表达的FOXQ1、FOXp1低表达/FOXQ1高表达、淋巴结转移分期、临床分期是NSCLC的独立预后因素。结论:FOXp1和FOXQ1参与了NSCLC的发生发展及转移,且与预后有关。二者具有负相关性,联合检测FOXp1和FOXQ1能更好地判断NSCLC患者的预后,可作为NSCLC诊断及判断预后的联合指标之一。

关键词：非小细胞肺癌免疫组化叉头框蛋白p1 叉头框蛋白Q1 FOXp1低表达/FOXQ1高表达预后

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多层螺旋CT和MRI扩散加权成像对四肢软组织肿瘤的诊断效果评价

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中国医学装备 2019年第7期16卷 99-102页

作者：迪丽拜尔·玉奴司曹勇阿克班新疆哈密第十三师红星医院影像科

目的:分析多层螺旋CT(MSCT)和磁共振成像(MRI)弥散加权成像(DWI)对四肢软组织肿瘤的诊断效果。方法:回顾性选取医院收治的81例四肢软组织肿瘤患者,入院后均进行MSCT及MRI检查,且所有患者在进行手术治疗时均获得病理证实。对比不同诊断... 详细信息

目的:分析多层螺旋CT(MSCT)和磁共振成像(MRI)弥散加权成像(DWI)对四肢软组织肿瘤的诊断效果。方法:回顾性选取医院收治的81例四肢软组织肿瘤患者,入院后均进行MSCT及MRI检查,且所有患者在进行手术治疗时均获得病理证实。对比不同诊断方式下患者良性、恶性肿瘤和肌肉组织的表观扩散系数的差异情况。结果:MRI检查针对四肢软组织肿瘤的诊断符合率为80.25%,MSCT检查的诊断符合率为45.68%,MRI明显高于MSCT检查结果,差异有统计学意义(x2=25.625,pp<0.05)。结论:采用MSCT和MRI DWI对四肢软组织肿瘤检查均具有一定优势,但MSCT准确性及稳定程度较差,MRI DWI对良恶性肿瘤的鉴别性较好,具有临床应用价值。

关键词：多层螺旋CT 磁共振成像扩散加权成像四肢软组织肿瘤表观扩散系数

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