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Petroselinum crispum extract ameliorates scopolamine-induced cognitive dysfunction:role on apoptosis,inflammation and oxidative stress

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Food Science and Human Wellness 2022年第5期11卷 1290-1298页

作者： GökselŞener Gözde Karakadıoglu Dilek Ozbeyli Seren Ede Refiye Yanardag ozlem sacan Asli Aykac Department of Pharmacology Faculty of PharmacyFenerbahce UniversityIstanbul 34758Turkey Department of Pharmacology Institude of Health SciencesMarmara UniversityIstanbul 34854Turkey Department of Medical Pathology Techniques Vocational School of Health ServicesMarmara UniversityIstanbul 34865Turkey Department of Biochemistry Faculty of EngineeringIstanbul Universityş-CerrahpasaIstanbul 34320Turkey Department of Biophysics Faculty of MedicineNear East UniversityNicosia 99138Cyprus

This study was designed to investigate whether Petroselinum crispum(PC)extract has protective effects on the brain in the scopolamine-induced Alzheimer’s disease(AD)rat *** rats were divided into;control,scopolamine(1 mg/kg,i.p.),galantamine(1.5 mg/kg,i.p.)and PC extract(2 g/kg,p.o.)-treated scopolamine *** day 14,the novel object recognition test(NORT)and Morris water maze test(MWMT)were performed and then the rats were ***-induced cognitive impairments observed in the NORT and MWMT,significantly improved with PC extract and galantamine *** reduced M_(1) receptor expression,Bcl-2/Bax ratio,and glutathione levels in the hippocampus and frontal cortex,while malondialdehyde levels,caspase-3/9 expressions,and acetylcholinesterase(AChE)activity were found to be *** the other hand,PC and galantamine treatments reversed these *** conclusion,PC extract has shown an ameliorative effect on the spatial and recognition memory,M_(1) receptor expression,apoptosis,oxidative stress,and increased AChE ***,it was concluded that PC could prevent AD-like conditions and can be used as a functional ***,since animal models do not completely mimic those of humans,based on the data obtained in this study,the importance of PC on human AD should be demonstrated in future studies.

关键词： Petroselinum crispum Apoptosis Spatial memory Recognition memory Oxidative stress M1 receptor

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