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Is portal vein cavernous transformation a component of congenital hepatic fibrosis?

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World Journal of Gastroenterology 2007年第13期13卷 1928-1929页

Congenital hepatic fibrosis (CHF) is an autosomal recessive disorder that belongs to the family of fibropolycystic liver diseases. This family includes a spectrum of disorders which are usually found in combination with each other and are usually inherited. Clinically fibropolycystic diseases have three effects being present in different proportions, those of a space occupying lesion, of portal hypertension and of cholangitis. In most patients, the first manifestations of CHF are signs and symptoms related to portal hypertension such as splenomegaly and varices. Portal hypertension in these patients has been attributed to the hypoplasia or compression of the portal vein radicles in the fibrous bands. Cavernous transformation of the portal vein (CTPV) is a relatively rare condition resulting from extrahepatic portal vein obstruction with recanalization or collateral vein formation to bypass the obstruction. It has been found that patients with CHF having an accompanying CTPV have relatively large splenomegaly and suffers more frequent episodes of bleeding from esophageal *** believe that CTPV is a congenital component of CHF and also one of the important causative factors of portal hypertension in these patients.

关键词：门静脉海绵样变形阻塞性肝纤维化门脉高压相关性

Meta-Herpetic Keratitis and Therapeutic Approach: Case Report

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Open Journal of Ophthalmology 2014年第3期4卷 75-78页

作者： ozlem Sahin Department of Ophthalmology/Uveitis DunyaGoz Hospital Ltd. Ankara Turkey

The purpose of this study is to disclose the steps in the therapeutic approach for meta-herpetic corneal ulcer. Report of a case with anterior segment photography was used. The 6 months of follow-up results of the cas... 详细信息

关键词： Corneal Ulcer Corneal Neovascularization Herpes Simplex Virus-1 Meta-Herpetic Keratitis

Comparison of intraperitoneal and intratesticular ozone therapy for the treatment of testicular ischemia-reperfusion injury in rats

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Asian Journal of Andrology 2017年第1期19卷 43-46页

作者： Fatih Mete Huseyin Tarhan Orcun Celik Ilker Akarken Kamil Vural Rahmi Gokhan Ekin Isil Aydemir Yusuf ozlem Ilbey Kanuni Sultan Suleyman Education and Research Hospital Pediatric Clinic 34150 Istanbul Turkey Tepecik Education and Research Hospital Urology Clinic 35170 IzmirTurkey Celal Bayar University Faculty of Medicine Department of Pharmacology45180 Manisa Turkey Celal Bayar University Faculty of Medicine Department of Histology and Embryology 45180 Manisa Turkey.

We compare the efficacy of intratesticular ozone therapy with intraperitoneal ozone therapy in an experimental rat model. For this purpose, 24 rats were divided into four groups including sham-operated, torsion/detorsion, torsion/detorsion plus intraperitoneal ozone （O-IP）, and torsion/detorsion plus intratesticular ozone （O-IT）. The O-IP ozone group received a 4 mg kg-1 intraperitoneal injection of ozone, and the O-IT group received the same injection epididymally. At 4 h after detorsion, the rats were sacrificed and orchiectomy materials were assessed histopathologically. Spermatogenesis in the seminiferous tubules and damage to the Sertoli cells were histopathologically evaluated in the testes using the Johnsen scoring system, i-NOS and e-NOS activities in the testis tissue were also evaluated. Torsion-detorsion caused a decreased Johnsen score and increased apoptosis of spermatogonial and Sertoli cells. Ozone injection prevented increases in Johnsen score and i-NOS level, e-NOS level of the O-IP group was significantly lower than that of the O-IP group, and i-NOS level of the O-IT group was significantly lower than that of the O-IP group. Local ozone therapy is more effective than systemic ozone therapy at improving IRI-related testicular torsion. Our study is the first to show that the efficacy of intratesticular implementation of ozone therapy is higher than that of intraperitoneal ozone therapy.

关键词： local therapy ozone rat model testis torsion

Triorchidism： a rare genital abnormality

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Asian Journal of Andrology 2014年第6期16卷 923-924页

作者： Orcun Celik Salih Budak Ozgur Cakmak Huseyin Tarhan Okan Nabi Yalbuzdag Aziz Peker Yusuf ozlem Ilbey Department of Urology Tepecik Educational and Research Hospital Izmir Turkey.

Dear Editor, We would like to present a rare case ofpolyorchidism. Polyorchidism is an unusual abnormality of the genital tract and until date, there are approximately 178 case reports of polyorchidism in the literature？ However, the most of patients are asymptomatic and usually diagnosed incidentally. Some may present as inguinal hernia （30%）, maldescended testis （15% to 30%）, testicular torsion （13%） and hydrocele （9%）, varicocele （1%）, hypospadias （〈1%）, anomalous urogenital union （〈1%）, and malignancy （〈1%）.2 Management of polyorchidism is still controversial. Important factors of polyorchidism management are testis location, size and anatomical organization of the testicular drainage system and the age of the patient.

关键词： POLYORCHIDISM

Neuropilins and liver

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World Journal of Gastroenterology 2015年第23期21卷 7065-7073页

作者： Gulsum ozlem Elpek Department of Pathology Medica School Akdeniz University Antalya 07070 Turkey

Neuropilins(NRPs) are highly conserved transmembrane glycoproteins that possess pleiotropic functions. Neuropilin-1(NRP1) and its homologue neuropilin-2 interact as coreceptors with both class 3 semaphorins and vascular endothelial growth factor and are involved in neuronal guidance and angiogenesis, respectively. The contribution of NRPs to tumor angiogenesis has been highlighted in previous studies, leading to the development of NRP antagonists as novel anti-angiogenesis therapies. However, more recent studies have demonstrated that NRPs have a much broader spectrum of activity in the integration of different pathways in physiological and pathological conditions. A few studies investigated the role of NRPs in both malignant and non-neoplastic liver diseases. In normal liver, NRP1 is expressed in hepatic stellate cells and liver sinusoidal endothelial cells. NRP1 expression in hepatocytes has been associated with malignant transformation and may play an important role in tumor behavior. A contribution of NRPs in sinusoidal remodeling during liver regeneration has been also noted. Studies in chronic liver diseases have indicated that, besides its influence on angiogenesis, NRP1 might contribute to the progression of liver fibrosis owing to its effects on other growth factors, including transforming growth factor β1. As a result, NRP1 has been identified as a promising therapeutic target for future antifibrotic therapies based on the simultaneous blockade of multiple growth factor signaling pathways. In this review, the structure of NRPs and their interactions with various ligands and associated cell surface receptors are described briefly. The current understanding of the roles of the NRPs in liver diseases including tumors, regeneration and fibrogenesis, are also summarized.

关键词： Neuropilins Neuropilin-1 Neuropilin-2 Angiogenesis Liver fibrosis Vascular endothelial growth factor Transforming growth factor β1

Optimum Arrival Routes for Flight Efficiency

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Journal of Power and Energy Engineering 2015年第4期3卷 449-452页

作者： ozlem Sahin Meric Faculty of Aeronautics and Astronautics Eskisehir Turkey

With the development of aircraft equipment, conventional navigation is the shift from performance based navigation (PBN). As is known, conventional navigation is based on ground-based navigation aids;however, PBN is based on aircraft avionics and performance. In this paper, a new method called Point Merge System (PMS) considered as one of PBN procedures will be introduced. PMS has many benefits related to fuel savings and emission reductions by implementing Continuous Descent Approaches (CDAs). A new PMS standard arrival route (STAR) model will be designed in radar simulation and it will be suggested.

关键词： Performance Based Navigation Area Navigation Required Navigation Performance Point Merge System Efficiency

Addiction to protein kinase Cɩdue to PRKCI gene amplification can be exploited for an aptamer-based targeted therapy in ovarian cancer

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Signal Transduction and Targeted Therapy 2020年第1期5卷 1080-1090页

作者： Hina Rehmani Yue Li Tao Li Ravi Padia ozlem Calbay Lingtao Jin Huijun Chen Shuang Huang Department of Biochemistry and Cancer Biology Medical College of GeorgiaAugusta UniversityAugustaGA 30912USA Department of Anatomy and Cell Biology University of Florida College of MedicineGainesvilleFL 32610USA Department of Gynecology and Obstetrics Zhongnan Hospital of Wuhan University430071 WuhanHubeiChina

PRKCI,the gene for protein kinase Cι(PKCι),is frequently amplified in ovarian cancer and recent studies have shown that PKCιparticipates in ovary ***,it is unknown whether PKCιis differentially involved in the growth/survival between PRKCI-amplified and non-amplified ovarian cancer *** this study,we analyzed ovarian cancer patient dataset and revealed that PRKCI is the only PKC family member significantly amplified in ovarian cancer and PRKCI amplification is associated with higher PKCι*** a panel of ovarian cancer cell lines,we found that abundance of PKCιis generally associated with PRKCI ***,silencing PKCιled to apoptosis in PRKCI-amplified ovarian cancer cells but not in those without PRKCI amplification,thus indicating an oncogenic addiction to PKCɩin PRKCI-amplified *** small-molecule inhibitors characterized to selectively block atypical PKCs did not offer selectivity nor sensitivity in PRKCI-amplified ovarian cancer cells and were even cytotoxic to non-cancerous ovary surface or fallopian tube epithelial cells,we designed an EpCAM aptamer-PKCιsiRNA chimera(EpCAM-siPKCιaptamer).EpCAM-siPKCιaptamer not only effectively induced apoptosis of PRKCI-amplified ovarian cancer cells but also greatly deterred intraperitoneal tumor development in xenograft mouse *** study has demonstrated a precision medicine-based strategy to target a subset of ovarian cancer that contains PRKCI amplification and shown that the EpCAM aptamerdelivered PKCιsiRNA may be used to suppress such tumors.

关键词： expression cancer PRK

Epidemiologic Characteristics of Patients with Cerebral Palsy

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Open Journal of Therapy and Rehabilitation 2014年第3期2卷 126-132页

作者： Fatma Fidan ozlem Baysal Department of Physical Medicine and Rehabilitation Yildirim Beyazit University Faculty of MedicineAnkaraTurkey Department of Physical Medicine and Rehabilitation Inonu University Faculty of MedicineMalatyaTurkey

Aim: The aim of this study was to determine the demographical and clinical features of patients with cerebral palsy (CP) attending to our outpatient or inpatient clinics. Materials and Methods: Children admitted to Inonu University Faculty of Medicine Department of Physical Medicine and Rehabilitation outpatient or inpatient clinics, Malatya, Turkey with the diagnosis of CP during the study period were included in the study. Age, sex, etiological factors, clinical classifications, and epidemiological characteristics such as socio-economic status as well as the problems associated with CP were analyzed in all patients. Results: Of the total of 130 patients with mean ages 51.05 ± 36.06 months, 51 were girls and 79 were boys. The most common etiologic risk factors were bleeding and presence of threatened miscarriage in prenatal period;asphyxia, low birth weight and prematurity in perinatal period;and neonatal convulsions and hyperbilirubinemia in the postnatal period. Consanguineous marriage was present in 24.6% of families. In clinical classification it was seen that 45 subjects were spastic quadriplegic (34.6%), 41 were spastic diplegic (31.5%), 15 were dyskynetic (11.5%), 14 were spastic hemiplegic (10.8%), 10 were mixed type (7.7%) and 5 were hypotonic/ataxic (3.8%). Conclusion: Prenatal risk factors constitute the foremost risk factors in CP etiology. CP incidence can be lowered by close follow up of the newborns who has been considered as high risk newborns due to the presence of risk factors during pregnancies or deliveries, and by increasing the number of neonatal intensive care units. Besides, it is important to raise public awareness about consanguinity marriages in our country.

关键词： Cerebral Palsy Epidemiology Etiology

Echocardiographic Measurement of Pulmonary Arterial Pressure in Patients with Sarcoidosis

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Open Journal of Respiratory Diseases 2016年第1期6卷 7-13页

作者： Ipek Candemir ozlem Ozdemir Kumbasar Ataturk Chest Diseases and Surgery Education and Research Hospital Ankara Turkey Department of Chest Diseases Ankara University Faculty of Medicine Ankara Turkey

Introduction: Pulmonary hypertension (PH) is a significant complication and is poor prognostic factor for sarcoidosis. We evaluated various tests of diagnosis and treatment as well as the associations between PH and value of six-minute walk test (6 MWT) in sarcoidosis patients. Methods: This study was conducted with fifty patients with sarcoidosis. We grouped patients according to echocardiography. Results: PH prevalence in sarcoidosis was found to be 10%. In cases with likely PH, FEV1%, FVC%, MMF% was found to be lower. Although DLCO was less than 80% in the group of likely PH and over 80% in the other, there were no statistical differences between two groups. Mean value of FVC/DLCO ratio was 1.1 ± 0.38 in group of likely PH. There was no significant difference between groups. Mean distance of 6 MWT was 464 ± 105 m in all cases. There were no statistical differences between two groups in 6 MWT. Significant desaturation with exercise was observed in cases with PH (p = 0.007). Conclusion: In all stages, patients who have longer disease duration and abnormal pulmonary function tests, should be examined about PH. Patients should undergo 6 MWT and presence of desaturation after 6 MWT, even without hypoxemia, should be looked after and dealt with accordingly.

关键词： Sarcoidosis PH ECO PFT 6 MWT