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Desialylated Platelet Clearance in the Liver is a Novel Mechanism of Systemic Immunosuppression

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Research 2024年第3期2023卷 35-50页

作者： June Li Danielle Karakas Feng Xue Yingyu Chen Guangheng Zhu Yeni H.yucel Sonya A.MacParland Haibo Zhang John W.Semple John Freedman Qizhen Shi Heyu Ni Department of Laboratory Medicine and Pathobiology University of TorontoTorontoONCanada Toronto Platelet Immunobiology Group TorontoONCanada Keenan Research Centre for Biomedical Science of St.Michael's Hospital TorontoONCanada Canadian Blood Services Centre for Innovation TorontoONCanada Departments of Pediatrics Medical College of WisconsinMilwaukeeWIUSA Blood Research Institute Versiti WisconsinMilwaukeeWIUSA Departments of Ophthalmology and Vision Sciences Medicine University of TorontoTorontoONCanada Faculty of Engineering and Architectural Science Ryerson UniversityTorontoONCanada Multi-Organ Transplant Program Toronto General Hospital Research InstituteTorontoONCanada Department of Immunology University of TorontoTorontoONCanada Critical Care Medicine Department ofAnesthesiology and PainUniversity of TorontoTorontoONCanada Department of Physiology University of TorontoTorontoONCanada Department of Pharmacology University of TorontoTorontoONCanada. Division of Hematology and Transfusion Medicine Lund UniversityLundSweden clinical Immunology and Transfusion Medicine Ofice of Medical ServicesRegion SkaneLundSweden Department of Medicine University of TorontoTorontoONCanada Children's Research Institute Children's WisconsinWauwatosaWIUSA Midwest Athletes Against Childhood Cancer Fund Research Center MilwaukeeWIUSA.

Platelets are small, versatile blood cells that are critical for hemostasis/thrombosis. Local platelet accumulation is a known contributor to proinflammation in various disease states. However, the anti-inflammatory/immunosuppressive potential of platelets has been poorly explored. Here, we uncovered, unexpectedly, desialylated platelets (dPLTs) down-regulated immune responses against both platelet-associated and -independent antigen challenges. Utilizing multispectral photoacoustic tomography, we tracked dPLT trafficking to gut vasculature and an exclusive Kupffer cell-mediated dPLT clearance in the liver, a process that we identified to be synergistically dependent on platelet glycoprotein Ibα and hepatic Ashwell–Morell receptor. Mechanistically, Kupffer cell clearance of dPLT potentiated a systemic immunosuppressive state with increased anti-inflammatory cytokines and circulating CD4+ regulatory T cells, abolishable by Kupffer cell depletion. Last, in a clinically relevant model of hemophilia A, presensitization with dPLT attenuated anti-factor VIII antibody production after factor VIII ( infusion. As platelet desialylation commonly occurs in daily-aged and activated platelets, these findings open new avenues toward understanding immune homeostasis and potentiate the therapeutic potential of dPLT and engineered dPLT transfusions in controlling autoimmune and alloimmune diseases.

关键词： Platelet transfusion homeostasis

Exploration of the Townsend regime by discharge light emission in a gas discharge device

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Chinese Physics B 2014年第1期23卷 289-296页

作者： Kurt, Hilal yucel Gazi University Faculty of Sciences Department of Physics 06500 Ankara Turkey

The Townsend discharge mechanism has been explored in a planar microelectronic gas discharge device （MGDD） with different applied voltages U and interelectrode distance d under various pressures in air. The anode and the cathode of the MGDD are formed by a transparent SnO2 covered glass and a GaAs semiconductor, respectively. In the experiments, the discharge is found to be unstable just below the breakdown voltage Ub, whereas the discharge passes through a homo- geneous stable Townsend mode beyond the breakdown voltage. The measurements are made by an electrical circuit and a CCD camera by recording the currents and light emission （LE） intensities. The intensity profiles, which are converted from the 3D light emission images along the semiconductor diameter, have been analysed for different system parameters. Dif- ferent instantaneous conductivity ~t regimes are found below and beyond the Townsend region. These regimes govern the current and spatio-temporal LE stabilities in the plasma system. It has been proven that the stable LE region increases up to 550 Torr as a function of pressure for small d. If the active area of the semiconductor becomes larger and the interlectrode distance d becomes smaller, the stable LE region stays nearly constant with pressure.

关键词： Townsend discharge breakdown microelectronic gas discharge device semiconductor cathode

Epilepsy Radiology Reports Classification Using Deep Learning Networks

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Computers, Materials & Continua 2022年第2期70卷 3589-3607页

作者： Sengul Bayrak Eylem yucel Hidayet Takci Department of Computer Engineering Halic UniversityIstanbul34445Turkey Department of Computer Engineering Istanbul University–CerrahpasaIstanbul34320Turkey Department of Computer Engineering Sivas Cumhuriyet UniversitySivas58140Turkey

The automatic and accurate classification of Magnetic Resonance Imaging(MRI)radiology report is essential for the analysis and interpretation epilepsy and *** the majority of MRI radiology reports are unstructured,the manual information extraction is time-consuming and requires specific *** this paper,a comprehensive method is proposed to classify epilepsy and non-epilepsy real brain MRI radiology text reports *** method combines the Natural Language Processing technique and statisticalMachine Learning methods.122 realMRI radiology text reports(97 epilepsy,25 non-epilepsy)are studied by our proposed method which consists of the following steps:(i)for a given text report our systems first cleans HTML/XML tags,tokenize,erase punctuation,normalize text,(ii)then it converts into MRI text reports numeric sequences by using indexbased word encoding,(iii)then we applied the deep learning models that are uni-directional long short-term memory(LSTM)network,bidirectional long short-term memory(BiLSTM)network and convolutional neural network(CNN)for the classifying comparison of the data,(iv)finally,we used 70%of used for training,15%for validation,and 15%for test *** previous methods,this study encompasses the following objectives:(a)to extract significant text features from radiologic reports of epilepsy disease;(b)to ensure successful classifying accuracy performance to enhance epilepsy data ***,our study is a comprehensive comparative study with the epilepsy dataset obtained from numeric sequences by using index-based word encoding method applied for the deep learning *** traditionalmethod is numeric sequences by using index-based word encoding which has been made for the first time in the literature,is successful feature descriptor in the epilepsy data *** BiLSTM network has shown a promising performance regarding the accuracy *** show that the larger sizedmedical text reports can be a

关键词： Epilepsy radiology text report analysis natural language processing feature engineering index-based word encoding deep learning networks-based text classification

Classification of Epileptic Electroencephalograms Using Time-Frequency and Back Propagation Methods

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Computers, Materials & Continua 2021年第11期69卷 1427-1446页

作者： Sengul Bayrak Eylem yucel Hidayet Takci Ruya Samli Department of Computer Engineering Halic UniversityIstanbul34445Turkey Department of Computer Engineering Istanbul University—CerrahpasaIstanbul34320Turkey Department of Computer Engineering Sivas Cumhuriyet UniversitySivas58140Turkey

Today,electroencephalography is used to measure brain activity by creating signals that are viewed on a *** signals are frequently used to obtain information about brain neurons and may detect disorders that affect the brain,such as ***(EEG)signals are however prone to *** artefacts must be removed to obtain accurate and meaningful ***,computer-aided systems have been used for this *** systems provide high computing power,problem-specific development,and other *** this study,a new clinical decision support system was developed for individuals to detect epileptic seizures using EEG *** classification results were obtained for the extracted filtered features from the time-frequency *** classification accuracies of the time-frequency features obtained from discrete continuous transform(DCT),fractional Fourier transform(FrFT),and Hilbert transform(HT)are *** neural networks(ANN)were applied,and back propagation(BP)was used as a learning *** studies in the literature describe a single BP *** contrast,we looked at several BP algorithms including gradient descent with momentum(GDM),scaled conjugate gradient(SCG),and gradient descent with adaptive learning rate(GDA).The most successful algorithm was tested using simulations made on three separate datasets(DCT_EEG,FrFT_EEG,and HT_EEG)that make up the input *** HT algorithm was the most successful EEG feature extractor in terms of classification accuracy rates in each EEG dataset and had the highest referred accuracy rates of the *** a result,HT_EEG gives the highest accuracy for all algorithms,and the highest accuracy of 87.38%was produced by the SCG algorithm.

关键词： Extracranial and intracranial electroencephalogram signal classification back propagation finite impulse response filter discrete cosine transform fractional Fourier transform Hilbert transform

Analysis of risk factors associated with complications of colonic stenting for malignant obstruction

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World Journal of Gastroenterology 2014年第27期20卷 9215-9216页

作者： Gokhan Dindar yucel Ustundag Tarkan Karakan Department of Gastroenterology Bulent Ecevit University School of Medicine Department of Gastroenterology Gazi University School of Medicine

Self expanding metalic stent(SEMS) application can cause serious problems up to one third of the patients and some studies reported negative effect of SEMSs on survival in patients with malignancy. The SEMS type especially the rigid one like Wall-stent rather than more flexible type Ultraflex was also reported to have bad impact on the risk of perforation we believe that stent based management protocol for patients with non-perforating left sided obstructing colorectal cancer is a complex method that needs qualified medical and technical team.

关键词： Self expanding metalic stent Colon tumor Colonic obstruction Complications Perforation

Evolution of globular microstructures during processing of aluminium slurries

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Transactions of Nonferrous Metals Society of China 2013年第1期23卷 1-6页

作者： yucel BIROL Materials Institute Marmara Research CenterTUBITAK GebzeKocaeliTurkey

Slurry processing experiments were performed with AlSi7Mg0.6 to identify the globularization *** melt sample water quenched slightly above the liquidus point is predominantly dendritic while that cooled into the semi-solid temperature range internally via stirring the melt with a rotating cylindrical block of the alloy itself becomes fully *** globules are much smaller when internal cooling and stirring are employed longer to achieve higher solid fractions before *** dendrite fragments of various sizes are revealed,in the case of stirring after an initial fraction of solid is first formed without the benefit of additional internal cooling.

关键词： Al alloys AlSi7Mg0.6 alloy solidification microstructure internal cooling stirring solid fraction

Precut sphincterotomy:A reliable salvage for difficult biliary cannulation

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World Journal of Gastroenterology 2013年第1期19卷 1-7页

作者： Ulku Saritas yucel Ustundag Ferda Harmandar Department of Internal Medicine Gastroenteorology ClinicsZonguldak Karaelmeas University Hospital67600 ZonguldakTurkey

Even experienced endoscopists have 90% success in achieving deep biliary cannulation with standard methods. Biliary cannulation may become difficult in 10%-15% of patients with biliary obstruction and pre- cut (access) sphincterotomy is frequently chosen as a rescue treatment in these cases. Generally, precut sphincterotomy ensures a rate of 90%-100% success- ful deep biliary cannulation. The precut technique has been performed as either a fistulotomy with a needle knife sphincterotome or as a transpapillary septotomy with a standard sphincterotome. Both methods have similar efficacy and complication rates when adminis- tered to the proper patient. Although precut sphincter- otomy ensures over 90% success of biliary cannula- tion, it has been characterized as an independent risk factor for pancreatitis. The complications of the precut technique are not limited to pancreatitis. Two more important ones, bleeding and perforation, are also re- ported in some publications as being observed more commonly than during standard sphincterotomy. It is also reported that precut sphincterotomy increases morbidity when performed in patients without dilata- tion of their biliary tract. Nevertheless, precut sphinc- terotomy is a good alternative as a rescue method in the setting of a failed standard cannulation method. This paper discusses the technical details, timing, ef- ficacy and potential complications of precut sphincter- otomy.

关键词： Biliary cannulation Salvage Precut sphincterotomy Needle knife Transpancreatic septotomy

Synthesis of Al-SrB_6 composite via powder metallurgy processing

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Transactions of Nonferrous Metals Society of China 2015年第3期25卷 677-682页

作者： yucel BIROL Department of Metallurgical and Materials Engineering Dokuz Eylul University

The potential of powder metallurgy processing for the manufacture of Al?SrB6 composites was explored. Al4Sr particles fractured extensively during the ball milling of Al?15Sr/Al?4B powder mixtures. There was no interaction between the Al4Sr and AlB2 compounds across the section of the aluminium grains in the as-milled state. SrB6 formed, when the ball milled powder blends were subsequently annealed at sufficiently high temperatures. Ball milling for 1 h was sufficient for SrB6 to become the major constituent in powder blends annealed at 700 °C while it took 2 h of ball milling for powder blends annealed at 600 °C. Higher annealing temperatures and longer ball milling time encouraged the formation of the SrB6 compound while the latter made a great impact on the microstructural features of the Al?SrB6 composite. The SrB6 compound particles were much smaller and more uniformly distributed across the aluminium matrix grains in powder grains ball milled for 2 h before the annealing treatments at 600 °C and 700 °C.

关键词： Al-SrB6 composites strontium hexaboride ball milling powder metallurgy processing

Precipitation during homogenization cooling in AlMgSi alloys

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Transactions of Nonferrous Metals Society of China 2013年第7期23卷 1875-1881页

作者： yucel BIROL Materials Institute Marmara Research CentreTUBITAKKocaeli 41470Turkey

Precipitation during the industrial cool down takes place predominantly above 300 °C in the EN AW 6082 and 6005 alloys. The phase precipitation throughout cooling is equilibrium phase. A considerable capacity is retained after the cool down for further precipitation during a subsequent heating cycle. The β-Mg 2 Si is once again the predominant phase that forms during a scan heating cycle employed in exactly the same manner with the industrial billet preheating operation. The precipitation in the 6060 alloy, on the other hand, occurs predominantly below 300 °C with additionally ′-Mg 2 Si particles formed below 200 °C.

关键词： aluminium alloys extrusion precipitation homogenization