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Clinical outcomes of influenza-like illness treated with Chinese herb- al medicine： an observational study

Journal of Traditional Chinese Medicine 2018年第1期38卷 107-116页

作者： Li Xiaoyan Cecilia Stalsby Lundborg Ding Banghan Chen Bojun Zhou Hong Li Jiqiang Ou Aihua ouyangwenwei Wen Zehuai Lu Chuanjian Gaetano Marrone Key Unit of Methodology in Clinical Research Second Affiliated Hospital of Guangzhou University of Chinese Medicine Guangzhou 510120 China Department of Public Health Sciences Karolinska Institutet Stockholm 17177 Sweden Department of Emergency Second Affiliated Hospital of Guangzhou University of Chinese Medicine Guangzhou 510120 China National Center for Design Measurement and Evaluation in Clinical Research Guangzhou University of Chinese Medicine Guangzhou 510405 China medical Department Second Affiliated Hospital of Guangzhou University of Chinese Medicine Guangzhou 510120 China Guangdong Provincial Key Laboratory of Clinical Research on Traditional Chinese Medicine Syndrome Guangzhou 510120 China

OBJECTIVE: To present and analyze treatmentsand clinical outcomes of Chinese patients with influenza-like ***: We conducted a multi-site observational study from December 2009 to April 2010. Patients with influenza-like illness from 45 hospitals were enrolled. Patients received Chinese herbal medicine(CHM), conventional treatments, or CHM plus conventional treatments(combination treatment) according to the guidelines for influenza A/H1 N1 2009 in China. The primary outcomes were the time to alleviation of symptoms and the incidence of complications. The secondary outcomes were the time until becoming afebrile, incidence of severe illness, testing negative on an influenza A viral test, and total medical ***: In total, 5967 patients were enrolled. The percentages of patients prescribed CHM alone, conventional treatment, and combination treatment were 27.8%, 5.1%, and 67.7%, respectively. There were no significant differences in the time to alleviation of symptoms, incidence of complications,time to becoming afebrile, or rate of severe illness among the CHM, conventional, and combination treatment groups. The rates of testing negative on the influenza virus A rapid test and H1 N1 virus test were 90.3% and 76.3%, respectively. However,significant differences were found in the total medical fees among the three groups: CHM treatments were more economical than the other two ***: The efficacy of CHM for influenza-like illness was not different from that of conventional treatments, but it was more economical.

关键词： Influenza A virus, H1N1 subtype Drugs, Chinese Herbal Observational study Cost-benefit analysis

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