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Neuropsychiatric Systemic Lupus Erythematosus

Open Journal of Rheumatology and Autoimmune Diseases 2013年第2期3卷 86-91页

作者： Zouhayr Souirti Mariam Lahlou ourda el ouali Naima Chtaou Chadia Aarab Fatima el Ghazouani Wafaa Bono Ismail Rammouz Faouzi Belahsen Ouafae Messouak Internal Medicine Department UH Hassan II Fez Morocco Neurology Department UH Hassan II Fez Morocco Psychiatric Department UH Hassan II Fez Morocco

Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by multisystemic involvement and diverse manifestations. Neuropsychiatric systemic lupus erythematosus (NPSLE) is a complex neurological disorder characterized by neuropsychological dysfunction. NPSLE is associated with increased morbidity and mortality. In 1999, the American College of Rheumatology developed 19 discrete neuropsychiatric syndromes that comprised NPSLE. Nervous system disease in systemic lupus erythematosus is manifested by a wide variety of clinical manifestations. The pathogenesis of NPSLE is due to autoantibodies, neuronal and non neuronal antigens and the generation of proinflammatory cytokines and mediators. Anatomopathological lesions are attributed to in situ thrombosis, edema, hemorrhage, vasculitis, atherosclerosis or atheroembolism. The diagnosis of NPSLE remains largely one of exclusion and is approached by clinical evaluation, and supported when necessary by autoantibody profiles, diagnostic imaging, electrophysiologic studies and objective assessment of cognitive performance. Brain MRI abnormalities in NPSLE might show small punctate focal lesions in white matter being the most common MRI finding, followed by cortical atrophy, ventricular dilation, cerebral edema, diffuse white matter abnormalities, focal atrophy, cerebral infarction, acute leukoencephalopathy and intracranial hemorrhage. The treatment is based on the use of symptomatic therapies, immunosuppressives and non-pharmacologic interventions. This review paper was designed to understand the pathophysiology for better management of NPSLE.

关键词： Central Nervous System Systemic Lupus Erythematosus MRI

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Macrophage Activation Syndrome as the Primary Presentation of Pediatric Systemic Lupus Erythematosus: A Case Report and Review of the Literature

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Open Journal of Pediatrics 2024年第1期14卷 132-138页

作者： Hanane Hajaj Hanae Bahari Aziza el ouali Ayyad Ghanam Maria Rkain Abdeladim Babakhouya Department of Pediatrics Mohammed VI University Hospital Oujda Morocco Mohammed VI University Hospital Medical School University Mohammed First Oujda Morocco

Macrophage activation syndrome (MAS), in its secondary form, often complicates rheumatic diseases but rarely constitutes a mode of revelation. Systemic lupus erythematosus (SLE) is a systemic autoimmune disease of unknown etiology that primarily affects women in adulthood. MAS is a serious condition that may be the first presentation of SLE. Here, we report the case of a 4-year-old female with MAS as the primary manifestation of Systemic Lupus Erythematosus (SLE). In this case, we outline the characteristics of a complex case of SLE that was initially accompanied with MAS, and also review the literature to discuss the clinical, biological, and therapeutic aspects of this condition.

关键词： Macrophage Activation Syndrome Systemic Lupus Erythematosus Child

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Juvenile Xanthogranuloma: A Case Report with Literature Review

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Open Journal of Pediatrics 2024年第3期14卷 531-535页

作者： Ayad Ghanam Manal Azizi Hind Zahiri Aziza el ouali Abdeladim Babakhouya Maria Rkain Department of Pediatrics Mohammed VI University Hospital Faculty of Medicine and Pharmacy Mohammed First University Oujda Morocco

Juvenile xanthogranuloma (XGJ) is the most common form of non-Langerhansian histiocytosis. We report a pediatric case of multiple XGJ without visceral involvement in a 6-month-old female infant who was hospitalized with disseminated congenital skin nodules, of firm consistency, of variable diameter ranging from a few millimetres to 1 cm, involving the face, scalp, trunk and limbs. There was no mucosal localization. The remainder of the somatic examination was unremarkable. The diagnosis of disseminated XGJ was confirmed by skin biopsy without visceral or systemic involvement. Therapeutic abstention was recommended. This observation underlines the fact that XGJ is a rare clinical entity that should not be overlooked when faced with congenital skin nodules.

关键词： Cutaneous Nodules Juvenile Xanthogranuloma Child

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Ecthyma Gangrenosum in Patient with Bone Marrow Aplasia: A Case Report and Review of the Literature

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Open Journal of Pediatrics 2024年第2期14卷 272-278页

作者： Hanane Hajaj Hanae Bahari Hind Zahiri Ayyad Ghanam Aziza el ouali Abdeladim Babakhouya Maria Rkain Department of Pediatrics Mohammed VI University Hospital Oujda Morocco Mohammed VI University Hospital Medical School Mohammed First University Oujda Morocco

Background: Ecthyma gangrenosum (EG) is an infrequent and discernible cutaneous disease caused by Pseudomonas aeruginosa. In situations where it is associated with septicemia in debilitated patients, the prognosis is usually unfavorable. Objective: In this case, we aim to verify risk factors, clinical, bacteriological and therapeutic characteristics of ecthyma gangrenosum and we review the literature to highlight the features of this rare condition and discuss the role of early diagnosis and treatment. Case Report: We describe the clinical case of a 4-year-old male with bone marrow aplasia who was presented with characteristic skin lesions of EG and developed sepsis later. Conclusion: EG is a cutaneous disease characterized by its aggressive nature. The presence of delayed diagnosis and therapy, along with sepsis, is closely linked to a high mortality rate. Treatment is empirically founded on an aggressive initial approach.

关键词： Ecthyma Gangrenosum Child Bone Marrow Aplasia

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Sacrococcygeal Teratoma a Rare Tumor in Children: Case Report

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Open Journal of Pediatrics 2024年第1期14卷 78-83页

作者： Hanae Bahari Hanane Hajaj Hind Zahiri Ayyad Ghanam Aziza el ouali Abdeladim Babakhouya Maria Rkain Department of Pediatrics Mohammed VI University Hospital Oujda Morocco Medical School University Mohammed First Oujda Morocco

Sacrococcygeal teratomas (SCTs) are uncommon congenital tumors that typically develop in newborns, they are rarely associated with chromosomal abnormalities or other congenital anomalies. The majority of pediatric teratomas are benign in the neonatal age group, but the risk of malignancy increases with age. Diagnosis is based on a combination of clinical, radiological, and hormonal findings, but confirmed by anatomopathological study. Treatment is primarily surgical, with the aim of achieving complete resection to prevent recurrence. We present the case of a 22-month-old child who was admitted for management of a sacrococcygeal mass and was diagnosed with an immature teratoma.

关键词： Sacrococcygeal Mass Alpha-Fetoprotein Surgery

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Extra Dural Hematoma of the Dorso-Lumbar Region in a Hemophiliac: A Rare Entity

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Open Journal of Pediatrics 2024年第1期14卷 84-88页

作者： Hanane Hajaj Hanae Bahari Ayyad Ghanam Aziza el ouali Abdeladim Babakhouya Maria Rkain Department of Pediatrics Mohammed VI University Hospital Oujda Morocco Faculty of Medicine and Pharmacy Mohammed Ist University Oujda Morocco

Introduction and objective: Hemophilia is a genetic bleeding disorder inherited as a recessive train linked to the male gender. Bleeding into the central nervous system in patients with hemophilia is an extremely dangerous condition that can be directly life-threatening, if left untreated. Extradural hematoma of the dorso-lumbar region is rare but potentially deadly disease in children. This condition can result in severe neurological deficits. We aim to discuss the clinical, radiological and progressive clinical aspects of this illness. Case report: We report the case of a 5-year-old child with severe hemophilia A treated for extradural hematoma of the dorso-lumbar region resulting from trauma. A spinal magnetic resonance imaging revealed an extradural hematoma. The patient was successfully treated with intensive replacement therapy and did not require surgical intervention. Conclusion: Extradural hematoma is a rare complication of hemophilia, that needs to be looked for in children who have bleeding disorders. For the best neurological outcome, early diagnosis is crucial.

关键词： Extradural Hematoma Children Hemophilia

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Rhabdomyosarcoma in Children: About 10 Cases

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Open Journal of Pediatrics 2024年第3期14卷 522-530页

作者： Ayad Ghanam Manal Azizi Hind Zahiri Houssain Benhaddou Imane Kamaoui Amal Bennani Aziza el ouali Abdeladim Babakhouya Maria Rkain Noufissa Benajiba Department of Pediatrics Mohammed VI University Hospital Faculty of Medicine and Pharmacy Mohammed First University Oujda Morocco Department of Pediatric Surgery Mohammed VI University Hospital Faculty of Medicine and Pharmacy Mohammed First University Oujda Morocco Department of Radiology Mohammed VI University Hospital Faculty of Medicine and Pharmacy Mohammed First University Oujda Morocco Department of Anatomopathology Mohammed VI University Hospital Faculty of Medicine and Pharmacy Mohammed First University Oujda Morocco

Introduction: Rhabdomyosarcoma (RMS) is a malignant soft-tissue tumor arising from striated muscle cells. It accounts for 60% - 70% of malignant mesenchymal tumors and 5% of pediatric cancers. Two-thirds of these cancers are diagnosed in children under 6 years of age, with a slight male predominance. Materials and Methods: This is a retrospective descriptive study of 10 cases of RMS collected in the pediatric hematology and oncology department of the Oujda university hospital, over a 5-year period, running from January 2018 to December 2022. Results: The median age at diagnosis was 3 years, with a sex ratio of 1. The mean time to diagnosis was 2 months. The most common site was the head and neck (50%), followed by the genitourinary tract (20%), the extremities (20%) and finally the abdomen (10%). The most frequent mode of discovery was a mass or swelling found in 90% of patients (all sites included), followed by exophthalmos in 30% of cases. At the diagnostic stage, CT scans were performed in 70% of cases and MRI in 5 patients (50%). Histological diagnosis was determined by immunohistochemical pathology in all our patients, with a predominance of embryonal (70%) versus alveolar (20%) and spindle cell types (10%). All patients underwent an extension workup, and a cervico-thoraco-abdominopelvic CT was performed in all patients (100%);MRI was performed in 2 patients (20%);lymph node involvement was present in 5 patients (50%). Metastases at the time of diagnosis were noted in only 1 patient (10%), who simultaneously presented with two metastatic sites;testicular and abdominal wall. Sixty percent of patients presented with advanced disease (high risk) and 40% with standard risk. Chemotherapy was used in all patients (100%), with upfront tumor resection performed in 40%. Fifty percent of patients received radiotherapy at a mean dose of 43 Gy, with the orbit the most frequently irradiated area (30%). All patients underwent CTscan and/or MRI and/or ultrasound surveillance.

关键词： Rhabdomyosarcoma Child Chemotherapy Surgery Radiotherapy

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Interpolation in the Automorphism Group of a Polynomial Ring

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Algebra Colloquium 2020年第3期27卷 587-598页

作者： M'hammed el Kahoui Najoua Essamaoui Mustapha ouali Department of Mathematics Faculty of Sciences Semlalia Cadi Ayyad UniversityP.O.Box 2390MarrakeshMorocco

Let R be a commutative ring with unity and SA_(n)(R)be the group of volumepreserving automorphisms of the polynomial R-algebra R^([n]).Given a proper ideal a of R,we address in this paper the question of whether the canonical group homomorphism SA_(n)(R)→SA_(n)(R/α)is *** an application,we retrieve and generalize,in a unified way,several known results on residual coordinates in polynomial rings.

关键词： polynomial automorphism coordinate residual coordinate

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Robust Sliding Mode Control Using Adaptive Switching Gain for Induction Motors

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International Journal of Automation and computing 2013年第4期10卷 303-311页

作者： K. Jamoussi L. Chrifi-Alaoui H. Benderradji A. el Hajjaji M. ouali Laboratory Computer and Embedded Systems National Engineering School University of Sfax Laboratory of Innovative Technology University of Picardie Jules Verne University of M'sila Electrical Engineering Department Laboratory of Modeling Information and Systems University of Picardie Jules Verne France

A robust sliding mode approach combined with a field oriented control （FOC） for induction motor （IM） speed control is presented. The proposed sliding mode control （SMC） design uses an adaptive switching gain and an integrator. This approach guarantees the same robustness and dynamic performance of traditional SMC algorithms. And at the same time, it attenuates the chattering phenomenon, which is the main drawback in actual implementation of this technique. This approach is insensitive to uncertainties and permits to decrease the requirement for the bound of these uncertainties. The stability and robustness of the closed- loop system are proven analytically using the Lyapunov synthesis approach. The proposed method attenuates the effect of both uncertainties and external disturbances. Experimental results are presented to validate the effectiveness and the good performance of the developed method.

关键词： Sliding mode control field oriented control (FOC) practical validation switching gain induction motor.

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Chemical composition and larvicidal activity of essential oil of Origanum majorana(Lamiaceae) cultivated in Morocco against Culex pipiens(Diptera:Culicidae)

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Asian Pacific Journal of Tropical Biomedicine 2014年第9期4卷 746-750页

作者： Fouad el-Akhal Abdelhakim el ouali Lalami Yassine Ez Zoubi Hassane Greche Raja Guemmouh Regional Diagnostic Laboratory Epidemiological and Environmental Hygiene Regional Health DirectorateEL Ghassani HospitalFezMorocco Sidi Mohamed Ben Abdellah University Faculty of Sciences Dhar El MahrazLaboratory Analysis and Modelling of Ecosystems ContinentalsFezMorocco National Institute of Medicinal and Aromatic Plants Sidi Mohamed Ben Ahdellah University.FezMorocco

Objective:To evaluate the larvicidal activity of essential oil of Origanum mtijoruna(Lamiaceae)cultivated in Morocco against Culex pipiens(Diptera:Culicidae).Methods:The analysis and the identification of the various constituents of essential oil were carried out by gas chromatography coupled with mass *** test was performed according to a standard methodology inspired by the World Health Organization protocol with slight ***:This oil mainly consisted of monoterpene and *** majority compounds are 4-terpinene(28.96%),y-terpinene(18.57%),α-terpinene(12.72%) and sabinene(8.02%).The lethal concentrations(LC_(50) and LC_(90)) measured for the essential oil Origanum majorana,were respectively of the order of 258.71 mg/L and 580.49 mg/***:The results could be useful in search for newer,safer,and more effective natural larvicidal agents.

关键词： Essential oil Origanum majorana Culex pipiens Larvicidal activity Morocco Fez

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