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Effectiveness of high intensity interval training on cardiorespiratory fitness and endothelial function in type 2 diabetes:A systematic review

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World Journal of Cardiology 2023年第4期15卷 184-199页

作者： Christos Kourek Eleftherios Karatzanos Vasiliki Raidou ourania papazachou Anastassios Philippou Serafim Nanas Stavros Dimopoulos Clinical Ergospirometry Exercise and Rehabilitation Laboratory1st Critical Care Medicine DepartmentEvangelismos HospitalAthens 10676Greece Department of Cardiology 417 Army Share Fund Hospital of AthensAthens 11521Greece Clinical Ergospirometry Exercise and Rehabilitation LaboratoryNational and Kapodistrian University of AthensAthens 10676Greece Department of Cardiology "Helena Venizelou"HospitalAthens 10676Greece Department of Physiology School of MedicineNational and Kapodistrian University of AthensAthens 11527Greece Cardiac Surgery Intensive Care Unit Onassis Cardiac Surgery CenterAthens 17674Greece

BACKGROUND Type 2 diabetes mellitus(T2DM)is a chronic metabolic syndrome characterized by insulin resistance and hyperglycemia that may lead to endothelial dysfunction,reduced functional capacity and exercise *** aerobic exercise has been promoted as the most beneficial non-pharmacological treatment of cardiovascular *** intensity interval training(HIIT)seems to be superior than moderate-intensity continuous training(MICT)in cardiovascular diseases by improving brachial artery flow-mediated dilation(FMD)and cardiorespiratory fitness to a greater ***,the beneficial effects of HIIT in patients with T2DM still remain under investigation and number of studies is *** To evaluate the effectiveness of high intensity interval training on cardiorespiratory fitness and endothelial function in patients with *** We performed a search on PubMed,PEDro and CINAHL databases,selecting papers published between December 2012 and December 2022 and identified published randomized controlled trials(RCTs)in the English language that included community or outpatient exercise training programs in patients with *** were assessed for methodological rigor and risk of bias via the Physiotherapy Evidence Database(PEDro).The primary outcome was peak VO_(2 ) and the secondary outcome was endothelial function assessed either by FMD or other indices of *** Twelve studies were included in our systematic *** 12 RCTs resulted in 661 participants in *** was performed in 310 patients(46.8%),MICT to 271 and the rest 80 belonged to the control *** VO_(2 ) increased in 10 out of 12 studies after *** studies compared HIIT with other exercise regimens(MICT or strength endurance)and 4 of them demonstrated additional beneficial effects of HIIT over MICT or other exercise ***,4 studies explored the effects of HIIT on endothelial function and FMD in T2DM *** 2 of them,HIIT further impro

关键词： Type 2 diabetes mellitus Exercise High intensity interval training Cardiorespiratory fitness Peak VO_(2) Endothelial function

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Effects of exercise training on diastolic and systolic dysfunction in patients with chronic heart failure

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World Journal of Cardiology 2021年第9期13卷 514-525页

作者： Ioannis Chaveles ourania papazachou Manal al Shamari Dimitrios Delis Argirios Ntalianis Niki Panagopoulou Serafim Nanas Eleftherios Karatzanos 1st Department of Cardiology-Clinical Ergospirometry Exercise and Rehabilitation Laboratory“Evaggelismos”HospitalAthens 10676Greece Department of Cardiology ”Helena Venizelou”HospitalAthens 10676Greece Clinical Ergospirometry Exercise and Rehabilitation Laboratory”Evaggelismos”HospitalSchool of MedicineNational and Kapodistrian University of AthensAthens 10676Greece Heart Failure Unit Department of Clinical Therapeutics”Alexandra”HospitalNational and Kapodistrian University of AthensAthens 11528Greece

BACKGROUND Chronic heart failure(CHF)is a complex syndrome characterized by a progressive reduction of the left ventricular(LV)contractility,low exercise tolerance,and increased mortality and *** dysfunction(DD)of the LV,is a keystone in the pathophysiology of CHF and plays a major role in the progression of most cardiac ***,it is well estimated that exercise training induces several beneficial effects on patients with *** To evaluate the impact of a cardiac rehabilitation program on the DD and LV ejection fraction(EF)in patients with *** Thirty-two stable patients with CHF(age:56±10 years,EF:32%±8%,88%men)participated in an exercise rehabilitation *** were randomly assigned to aerobic exercise(AER)or combined aerobic and strength training(COM),based on age and peak oxygen uptake,as stratified randomization *** and after the program,they underwent a symptom-limited maximal cardiopulmonary exercise testing(CPET)and serial echocardiography evaluation to evaluate peak oxygen uptake(VO2peak),peak workload(Wpeak),DD grade,right ventricular systolic pressure(RVSP),and *** The whole cohort improved VO2peak,and Wpeak,as well as DD grade(P0.05).CONCLUSION Exercise rehabilitation improves indices of diastolic and systolic *** protocol was not observed to affect *** results need to be further investigated in larger samples.

关键词： Chronic heart failure Cardiovascular effects Cardiac rehabilitation Aerobic exercise Strength training Diastolic dysfunction

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