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Assessment of CareStart G6PD rapid diagnostic test and CareStart G6PD biosensor in Mauritania

Infectious Diseases of Poverty 2021年第4期10卷 33-45页

作者： oum kelthoum mamadou djigo Yacoub Ould Khalef Mohamed Salem Ould Ahmedou Salem Nicolas Gomez Leonardo Basco Sebastien Briolant Ali Ould Mohamed Salem Boukhary Unite de Recherche"Genomes et Milieux"(Jeune Equipe Associee a I'lnstitut de Recherche pour le Developpement) Faculte des Sciences et lechniquesUniversite de Nouakchott Al-AasriyaNouakchottMauritania Service de Pediatrie Centre Hospitalier Mere et EnfantNouakchottMauritania IHU Mediterrande InfectionMarseilleFrance Aix Marseille Univ IRDAP-HMSSAVITROMEMarseilleFrance Unite de Parasitologie Entomologie Departement de Microbiologie et Maladies InfectieusesInstitut de Recherche Biomedicale des Armees(IRBA)MarseilleFrance

Background::The elimination of Plasmodium vivax malaria requires 8-aminoquinolines,which are contraindicated in patients with glucose-6-phosphate dehydrogenase(G6PD)deficiency due to the risk of acute haemolytic *** point-of-care devices have been developed to detect G6PD *** objective of the present study was to evaluate the performance of two of these devices against G6PD genotypes in ***::Outpatients were screened for G6PD deficiency using CareStart?rapid diagnostic test(RDT)and CareStart?G6PD biosensor in Nouakchott,Mauritania,in ***-type and Mediterranean-type G6PD genotypes commonly observed in Africa were determined by polymerase chain reaction-restriction fragment length polymorphism and *** variables were compared using Fisher’s exact ***::Of 323 patients(74 males and 249 females),5 males and 2 homozygous females had the African-type A-genotype:A-(202)in 3 males and 2 females and G6PD A-(968)in 2 *** heterozygous females,13 carried G6PD A-(202),12 G6PD A-(968),and 3 G6PD A-(542)*** had the Mediterranean-type G6PD *** had a positive G6PD RDT result,including all 7 hemizygous males and homozygous females with A-or A-A-(0.12 to 2.34 IU/g haemoglobin,according to G6PD biosensor),but RDT performed poorly(sensitivity,11.1%at the cutoff level of<30%)and yielded many false negative ***-seven(50.0%)males and 141(56.6%)females were *** adjusted median values of G6PD activity were 5.72 and 5.34 IU/g haemoglobin in non-anaemic males(n=35)and non-anaemic males and females(n=130)with normal G6PD genotypes using G6PD biosensor,*** on the adjusted median of 5.34 IU/g haemoglobin,the performance of G6PD biosensor against genotyping was as follows:at 30%cut-off,the sensitivity and specificity were 85.7%and 91.7%,respectively,and at 80%cut-off,the sensitivity was 100%while the specificity was 64.9%.Conclusions::Although this pilot study

关键词： Glucose-6-phosphate dehydrogenase Malaria Plasmodium vivax Primaquine Tafenoquine

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