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Pharmacological properties and related constituents of stem bark of Pterocarpus erinaceus Poir.(Fabaceae)

Asian Pacific Journal of Tropical Medicine 2012年第1期5卷 46-51页

作者： ouedraogo noufou Sawadogo Richard Wamtinga Tibiri Andre Bayet Christine Lompo Marius Hay A Emmanuelle Koudou Jean Dijoux Marie-Genevieve Guissou Innocent Pierre Departement de medecine-pharmacopee traditionnelle/pharmacie(IRSS/CNRST) 03 BP 7192 Ouagadougou 03 Burkina Faso Laboratoire de pharmacologie et toxicologie UFR/SDSUniversite de Ouagadougou 03 BP 7021 Ouagadougou 03Burkina Faso Universite de Lyon F-69622LyonFrance Universite Lyon I Villeurbanne CNRS UMR 5557Ecologie MicrobienneISPB69373 LyonFrance Laboratoire de chimie des substances naturelles Faculte des SciencesUniversite de Bangui.BP908Bangui.Republique Centrafricaine Departement de medecine-pharmacopee traditionnelle/pharmacie(IRSS/CNRST) 03 BP 7192 Ouagadougou 03 Burkina Faso Laboratoire de pharmacologie et toxicologieUFR/SDSUniversite de Ouagadougou 03 BP 7021 Ouagadougou 03Burkina Faso

Objective:To sereen methanol and dichloromethane extracts of stem bark of Pterocarpus erinaceus for anti-inflammatory,*** vitro antioxidant activities and phytochemical ***:Anti-inflammatory activity was detcrmined by using carrageenan inducededema of mice paw and croton oil-induced edema of mice ear:analgesic effect was evaluated using acetic acid-induced *** screening of extracts was performed by thin layer *** chromatographic fractionation led to the isolation of main active components as *** and *** structures were established hy TLC and nuclear magnetic resonance ***:Both methanol and dichloromethane extracts, *** and epicatechin showed a significant anti—inflammatory effect using croton oil induced—ear ***,the action of dichloroinethane extract was more important. At the doses of 100 and 200 mg/*** methanol extract was able to reduce the carrageeuan induced-hind paw edema,while al the doses of 100.200 and 400 mg/*** showed an important analgesic effect against writhing induced by acetic acid injection of 38.8%.68.0%and 74.3%, *** properties of methanol extract and its dichloromethane and ethyl acetate fractions were assessed by using the 1,1—diphenyl—2—picrylhydrazyl *** methanol extract showed the stronger radical scavenging activity than dichloromethane and ethyl acetate fractions,with an antiradical power of 5.3.5 and 2 *** main components isolated from these extracts as friedelin,lupeol and epicathechin were responsible of these ***:The results suggest that the stem hark extracts of Pterocarpus erinaceus possessed important *** activities and strong antioxidant properties, therefore,they could he used as natural potential ingredients for pharma ceutical industry.

关键词： Pterocarpus erinaceus Phytochemical Anti-inflammatory Analgesic Antioxidant

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HPTLC Phytochemical Screening and Hydrophilic Antioxidant Activities of Apium graveolensL., Cleome gynandraL., and Hibiscus sabdariffaL. Used for Diabetes Management

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American Journal of Analytical Chemistry 2021年第1期12卷 15-28页

作者： Moumouni Koala Alphonsine Ramde-Tiendrebeogo noufou ouedraogo Sylvain Ilboudo Boukaré Kaboré Félix B. Kini Sylvin ouedraogo Institut de Recherche en Sciences de la Santé Centre National de la Recherche Scientifique et Technologique (IRSS/CNRST) Ouagadougou Burkina Faso Laboratoire de Chimie Organique et Physique Appliquées (L.C.O.P.A.) Université Joseph KI-ZERBO UFR/SEA Département de Chimie Ouagadougou Burkina Faso Unité Mixte Internationale Environnement-Santé-Société (UMI 3189 ESS) CNRST/CNRS/UCAD/UGB/USTTB-P&ocirc le Burkina Ouagadougou Burkina Faso

Diabetes mellitus is a socially significant disease characterized by chronic hyperglycemia and metabolic disorders of proteins, carbohydrates, and lipids due to reduced function of insulin. Medicinal plants, rich in bioactive components that promote prevention and treatment, are inexpensive and no side effects. Apium graveolens, Cleome gynandra, and Hibiscus sabdariffa from Burkina Faso were investigated for their phytochemical profile and antioxidant activities. The high-performance thin-layer chromatography profile revealed flavonoids, tannins, and sterols in these herbaceous. The Hibiscus sabdariffa methanolic extract exhibited the highest total phenolic (138.4 ± 0.5 mg GAE/g DW) and flavonoid (52.8 ± 0.6 mg RuE/g DW) contents comparatively to Cleome gynandra and Apium graveolens. Hibiscus sabdariffa methanolic extract also presented the highest antioxidant activity (IC50 = 0.31 ± 0.002 mg/mL) using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging capacity assay. A high correlation between flavonoid contents and hydrophilic antioxidant activities (r = 0.99) was observed, indicating that flavonoids contribute significatively to these herbaceous antioxidant properties. Apium graveolens, Cleome gynandra, and Hibiscus sabdariffa constitute a natural source of phenolic compounds that could be exploited in diabetes mellitus management.

关键词： Diabetes Mellitus Medicinal Plants Flavonoids Contents Hydrophilic Antioxidant Activity HPTLC Screening

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Phytochemical Screening by High-Performance Thin-Layer Chromatography, Antioxidant Activities and Acute Toxicity of Trunk Barks Extracts of Lannea velutina A. Rich

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American Journal of Analytical Chemistry 2022年第10期13卷 365-381页

作者： Boukaré Kaboré Moumouni Koala Mathieu Nitiema Windingoudi Rimwagna Christian ouedraogo Souleymane Compaoré Lazare Belemnaba Salfo ouedraogo Sylvain Ilboudo noufou ouedraogo Constantin M. Dabiré Félix B. Kini Sylvin ouedraogo Eloi Palé Laboratoire de Chimie Organique et de Physique Appliquée (LCOPA) école Doctorale Sciences et Technologie UniversitéJoseph KI-ZERBO Ouagadougou Burkina Faso Département Médecine-Pharmacopée Traditionnelles/Pharmacie (MEPHATRA/Ph) Institut de Recherche en Sciences de la Santé (IRSS/CNRST) Ouagadougou Burkina Faso International ResearchLoboratory-Environnement Santé Sociétés (IRL 3189 ESS) CNRST/CNRS/UCAD/UGB/USTTB Burkina Faso Laboratoire de Chimie et énergies Renouvelables Université Nazi BONI Bobo Burkina Faso

Lannea velutina is a traditional herbal remedy used to treat various diseases, including hypertension (HBP). Herbal medicines are affordable, and some have minimal side effects;they are rich in bioactive components that encourage prevention and treatment. This work uses appropriate experimental paradigms to investigate the phytochemical composition, antioxidant activity, and acute oral toxicity of L. velutina trunk bark extracted in water, methanol, ethyl acetate, dichloromethane, and hexane. According to a high-performance thin-layer chromatography profile, this shrub’s bark contains sterols, saponosides, flavonoids, and tannins. Compared to ethyl acetate and aqueous extracts, the methanol extract had the highest total phenolic (607.06 ± 0.6 mg GAE/g DW), flavonoid (20.97 ± 0.23 mg QE/g DW), and condensed tannins (194.50 ± 0.75 CE/g DW) content. The methanol extract displayed the highest antioxidant activity using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging capability assay (IC50 = 8.59 g/mL;AAI = 4.66) compared to the other extracts. It exhibited antiradical action comparable to that of Trolox (IC50 = 15.16 g/mL), ascorbic acid (IC50 = 11.94 g/mL), and catechin (IC50 = 11.64 g/mL). The connection between flavonoid concentration and hydrophilic antioxidant activity was robust (r = 0.997). Mice were used to evaluate the acute oral toxicity of ethyl acetate, methanol, and aqueous extracts using guidelines 425 of the Organization for Economic Cooperation and Development. All tested extracts have an estimated LD50 greater than 2000 mg/kg body weight. The truncal bark of L. velutina could be an alternative source for HTA management.

关键词： Lannea velutina Phytochemicals Proanthocyanidins Antioxidants LD50

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Uterine Fibroids Operated in the Obstetric Gynecology Department of the Mother-Child Department at the University Hospital of Tengandogo: About 109 Cases

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Open Journal of Obstetrics and Gynecology 2023年第2期13卷 175-182页

作者： Dieudonné Hien Paul Kain noufou Sankara Raïssom Zongo Batababon Adjahourabou Ali ouedraogo Obstetrics and Gynaecology Department of the University Hospital of Tengandogo Ouagadougou Burkina Faso

Background: Uterine fibroid is the most common benign gynecological tumor in women of childbearing age and is common in our context. It can be discovered incidentally or by metrorrhagia. Objective: To study the epidemiological, clinical, therapeutic and prognostic aspects of uterine fibroids operated in the gynaecology and obstetrics department of the CHU-T. Patients and Method: This was a descriptive cross-sectional study including all patients operated on for uterine fibromyoma in the gynaecology-obstetrics department. The collection mode was retrospective, over a 5-year period from January 1, 2017 to December 31, 2021 in the mother-child department of the CHU-T. Data entry and analysis were carried out on a microcomputer using Epi info 7.2.5 software. Results: We collected 109 cases of uterine fibroids which represented 42.5% of the surgical activities of the gynaecology department. The average age of the patients was 38.9 years ± 7.8. Married women represented 77.1%. Salaried women accounted for 65.1%. The main reasons for consultation were uterine haemorrhage (53.1%), pelvic pain (40.4%) and hypofertility (31.2%). Ultrasound was performed in all patients to help map the fibroid nuclei. The main indication for surgery was haemorrhagic myoma (43.1%). The surgical treatment was conservative (myomectomy) in 58.7% of cases and radical (hysterectomy) in 27.4% of cases. The most frequent postoperative complication was vulvar haemorrhage and the average hospital stay was 4 days ± 1.4. Anatomical pathological examination of the surgical excision specimen carried out on 30 operated patients concluded that uterine leiomyoma was diagnosed in 100% of cases. Conclusion: Patient education for early detection, universal health insurance and cost subsidies could improve the management of this condition.

关键词： Uterine Fibromyoma Surgical Treatment CHU-Tengandogo Burkina Faso

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