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Developing a coordinate-based strategy to support cognitive targeted prostate biopsies and correlative spatial-histopathological outcome analysis

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Asian Journal of Andrology 2021年第3期23卷 231-235页

作者： Keiran D Clement Lizzy Day Helen Rooney Matt Neilson Fiona Birrell Mark Salji Elizabeth Norm an Ross Clark Amit Patel John Morrison Hing y Leung Departm ent of Urology Queen Elizabeth University Hospital1345 Govan RdGlasgow G514TFUK Department of Urology Ayr University HospitalDalmellington RdAyr KA66DXUK CRUK Beatson Institute for Cancer Research Garscube EstateBearsdenGlasgow G611BDUK lnstitute of Cancer Sciences University of GlasgowBearsdenGlasgow G611BDUK Department of Radiology NHS Greater Glasgow and ClydeGlasgow G514TFUK.

Lack of investment for magnetic resonance(MR)fusion systems is an obstacle to deliver targeted prostate biopsies within the prostate cancer diagnostic *** developed a coordinate-based method to support cognitive targeted prostate biopsies and then performed an audit on cancer detection and the location of *** each patient,the prostate is considered as two separate hemiprostates,and each hemiprostate is divided into 4×4×4 *** unit is therefore defined by a three-dimensional *** prospectively applied our coordinates approach to target 106 prostatic lesions in 93 *** 45(of 106;42.5%)lesions positive for cancer,27 lesions(60.0%)harbored clinically significant *** density was significantly higher in patients with proven cancer(median:0.264 ng ml^(-2))when compared to the noncancer group(median:0.145 ng ml-2;P=0.003,Wilcoxon ranksum test).Lesions with Prostate Imaging-Reporting and Data System(PIRADS)score of 5 were found to have a cancer incidence of 65.2%,while PI RADS 4 and 3 lesions have a lower risk of cancer detection,as expected,at 37.3%and 31.3%,*** probability of a lesion being cancerous in our series significantly decreases as we go from the“apex-to-base”dimension(odds ratio[OR]:2.62,95%confidence interval[Cl]:1.55-4.44,P=0.00034).Our analysis also indicates that the probability of cancer decreases as the prostate volume increases(OR:1.03,95%Cl:1.01-1.05,P=0.00327).Based on this feasibility study,the use of coordinates to guide cognitive targeted prostate biopsies warrants future validation study in additional centers.

关键词： cognitive targeted prostate biopsies coordinates magnetic resonance imaging prostate cancer

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Ni-ySZ阳极支撑SOFC阴极LSM-ySZ的LSM同源离子渗透改性

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稀有金属 2006年第6期30卷 761-765页

作者：张全生 Takeda.y Department of Chemistry Faculty of EngineeringMie UniversityKurimamachiya-choTsu514-8507Japan

通过丝网印刷的方法在市场可获得的ySZ/NiO-ySZ半电池上印刷LSM-ySZ浆料,烧结后构成Ni-ySZ阳极支撑的SOFC试验电池。通过溶液渗透的方法,研究了La(NO3)3和La(NO3)3-Mn(NO3)2复合渗透电池性能的影响。以水分含量3%的纯氢气为燃料,未渗透... 详细信息

通过丝网印刷的方法在市场可获得的ySZ/NiO-ySZ半电池上印刷LSM-ySZ浆料,烧结后构成Ni-ySZ阳极支撑的SOFC试验电池。通过溶液渗透的方法,研究了La(NO3)3和La(NO3)3-Mn(NO3)2复合渗透电池性能的影响。以水分含量3%的纯氢气为燃料,未渗透电池800℃的峰值功率为0.202 ***-2,La(NO3)3溶液渗透后电池800℃的峰值功率为0.428 ***-2;在渗透La(NO3)3后的电池上再用Mn(NO3)2复合渗透,电池800℃的峰值功率为0.92 ***-2,电池在800℃保持38 h,峰值功率可以保持在0.46 ***-2。

关键词： SOFC LSM-ySZ阴极渗透方法峰值功率

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长周期变星的脉冲

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紫金山天文台台刊 1994年第2期13卷 168-173页

作者： Gong,ZG Li,y

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Severe Sepsis Caused by Listeria monocytogenes in A Patient Given Monoclonal Antibodies Against CD38 and Proteosome Inhibitor

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Infectious Microbes & Diseases 2019年第1期1卷 30-31页

作者： Derek L.L.Hung Susanna K.P.Lau Patrick C.y.Woo Department of Microbiology The University of Hong KongHong KongChina State Key Laboratory of Emerging Infectious Diseases The University of Hong KongHong KongChina Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases The University of Hong KongHong KongChina

Introduction Target therapies are widely used for treatment of various kinds of hematological *** the cancer cells that are targeted,share the same markers with the non-cancerous cells of the immunological system,these therapies are often associated with infectious diseases that require the particular type of immune response for *** this article,we report a case of Listeria monocytogenes bacteraemia complicating carfilzomib and daratumumab treatment for multiple *** the best of our knowledge,this is the first case report of listeriosis as a complication of monoclonal antibodies against CD38 and/or proteosome inhibitor therapy.

关键词： listeria multiple myeloma daratumumab carfilzomib

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The Synthesis of Solvent-Free TiO<sub>2</sub>Nanofluids through Surface Modification

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Soft Nanoscience Letters 2011年第2期1卷 46-50页

作者： P. y. yu y. P. Zheng L. Lan Northwestern Polytechnical University

TiO2 nanoparticles with surface hydroxyl groups are treated by trimethoxysilane (CH3O)3Si(CH2)3O(CH2CH2O)6-9CH3 and a inorganic core/organic shell hybridmaterials, which shows itself a yellow viscous fluid, is obtained. We call it solvent-free TiO2 nanofliuds. Transmission electron microscopy (TEM), Fourier transform infrared spectrum (FTIR), differential scanning calorimetry (DSC), thermogravimetric analysis (TGA) and rheometer are adopted to characterize the product. As a result, the content of TiO2 nanoparticles in the nanofliuds is about 5.5wt%, the functionalized TiO2 nanoparticles possess better dispersion, very low viscosity and an obvious liquid-like behavior at room temperature in absence of solvent.

关键词： Solvent-Free Nanofulids TiO2 Nanoparticles Liquid-Like Behave

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Orientation control of REBa2Cu3Oz (RE=rare earth) Superconductor thick film grown by liquid phase epitaxy

Orientation control of REBa2Cu3Oz (RE=rare earth) Supercondu...

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第15届全国晶体生长与材料学术会议

作者： X. yao, y.Q. Cai, C. y. Tang, y. y. Chen, W. Li Department of Physics, Shanghai Jiao Tong University, Shanghai 200240, China

Single crystalline thick films of REBCO were grown by liquid-phase epitaxy (LPE). The growth conditions were changed by employing different oxygen partial pressures, liquid compositions and growth temperatures. It was found that oxygen partial pressure plays a predominant role in controlling out-of-plane and in-plane alignments. Under pure oxygen atmosphere, the growth window of a-axis yBCO films on NGO was obviously enlarged. On the other hand, growing in oxygen atmosphere, we firstly reported to gain an yBCO c-oriented film with a pure 45° in-plane alignment on MgO substrates. The systematic work includes studies on the relation of the formation of oriented film and the thermodynamic parameter, growth modes and properties of different oriented films.

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奇异吸引子和最早的混沌

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数学译林 1995年第2期14卷 117-136页

作者： Ueda,y 纪林

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IL-1 Receptor Type II Production Is Upregulated by IL-4 and IL-13, and Downregulated by IFN-<i>γ</i>in Mouse Gingival Epithelial Cells

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Modern Research in Inflammation 2014年第2期3卷 37-47页

作者： y. Kamiya y. Ishihara H. Kamei y. Ozawa H. Mizutani K. Kubo H. Maeda T. Noguchi Department of Pathology School of Dentistry Aichi-Gakuin University Nagoya Japan Department of Periodontology School of Dentistry Aichi-Gakuin University Nagoya Japan

Background and Objective: Interleukin-1 (IL-1) binds to 2 distinct and separate receptors, types I and II (IL-1RI and IL-1RII, respectively). The binding of IL-1 to IL-1RI induces cellular signaling and biological effects, whereas binding to IL-1RII does not induce cellular signaling and indirectly inhibits IL-1 biological activities such as that of the decoy receptor. Recently, Suzukiet *** that soluble IL-1RII (sIL-1RII) was detected in gingival crevicular fluid from a periodontitis patient. However, it remains unclear which cells produce sIL-1RII detected in periodontal tissues. We examined the localization of IL-1RII producing cells in gingival tissues as well as related production control mechanisms. Material and Methods: IL-1RII mRNA expression in gingival epithelial cells (GE1) was performed by real-time PCR analysis, while the amount of sIL-1RII production in supernatant from GE1 cells was examined by dot-blot analysis. Involvement of the phosphorylation of STAT6 in the signaling pathway was determined by western blot analysis. Statistical analysis was performed with Student’st-test. Results: Culturing with IL-4 and IL-13 significantly increased IL-1RII mRNA to levels 10.5-and 8.89-fold, respectively, above that of the control (py suppressed IL-1RII mRNA by 0.22-fold as compared to the control (py IL-4 and IL-13, and decreased by IFN-γ, while western blotting determines the suppression of IL-1RII production by IFN-γ. Without the addition of IL-4 or IL-13 with or without IFN-γ, P-Tyr-STAT6 was not detected. Conclusion: IL-1RII mRNA expression and sIL-1RII production were increased by IL-4 and IL-13, and decreased by IFN-γ. Finally, IL-4 signaling was regulated by IFN-γ through phosphorylation of STAT6 and IL-13 signaling blockage by IFN-γ downstream of STAT6 translocation.

关键词： IL-1RII IL-4 IL-13 IFN-γ STAT-6

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Do specific ultrasonography features identified at the time of early pregnancy loss predict fetal chromosomal abnormality? e A systematic review and meta-analysis

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Genes & Diseases 2019年第2期6卷 129-137页

作者： J.Huang W.Zhu J.Tang S.H.Saravelos L.C.y.Poon T.C.Li Department of Obstetrics and Gynaecology The First Affiliated Hospital of Chongqing Medical UniversityChongqing400016China Department of Obstetrics and Gynaecology The Chinese University of Hong KongHong Kong SARChina IVF Unit Hammersmith HospitalImperial College Healthcare NHS TrustLondonUK

To investigate the association of specific ultrasonography features identified during the diagnosis of early pregnancy loss(EPL)and abnormal *** was a systematic review and meta-analysis conducted in accordance with PRISMA *** searched PubMed,Cochrane and Ovid MEDLINE from 1977 to Jan 2017 to identify the articles that described EPL with karyotype and ultrasonography *** differences were pooled to estimate the chromosomal abnormality rates in ultrasonography features,including pre-embryonic,enlarged yolk sac(yS),short crown rump length(CRL),small gestational sac(GS),symmetrical arrested growth embryo,or gestational sac with only a *** assessment of included studies was performed using Strengthening the Reporting of Observational Studies in Epidemiology(STROBE)checklists for Observational Studies(2007 version).Thirteen studies were included in the *** abnormality was more likely to occur in embryonic EPL and enlarged *** the other hand,short CRL,small GS,symmetrical arrested growth embryo,or gestational sac with only a yS,were not associated with an increased risk of fetal chromosomal *** features at the time of diagnosis of EPL have limited predictive value of fetal chromosomal abnormality.

关键词： Ultrasonography Early pregnancy loss Chromosomal abnormality Predictive value

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Preparation and optimization of tocotrienol rich fraction(TRF)-loaded niosomes

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Asian Journal of Pharmaceutical Sciences 2016年第1期11卷 56-57页

作者： L.H.Chuah L.De Silva M.Saravanan J.y.Fu School of Pharmacy Monash University MalaysiaBandar Sunway47500 SelangorMalaysia Malaysian Palm Oil Board Bandar Baru Bangi43000 SelangorMalaysia

Vesicular delivery systems have gainedmuch attention as pharmaceutical entities since their *** occupy the general structure of bilayer vesicles,having a hydrophilic core shielded from one or multiple hydrophobic lipid *** unique structure enables them to both accommodate oilsoluble compounds as well as to encapsulate water-soluble drugs[1].The anticancer effects of tocotrienol were first discovered in the early 1990s when Nesaretnam et *** that palm oil stripped of vitamin E-promoted tumorigenesis in rats[2].

关键词： Niosomes Tocotrienol Drug delivery Breast cancer

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