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Effect of drug therap.es on self-rep.rted chemosensory outcomes after COVID-19

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2024年第2期10卷 88-96页

作者： Marco A.Fornazieri Bruno M.Cunha Samuel p.Nicácio Lucas K.Anzolin JoséL.B.da Silva Aristides Fernandes neto Deusdedit Brandão neto Richard L.Voegels Fábio D.R.p.nna Dep.rtment of Surgery Londrina State UniversityLondrinaBrazil Dep.rtment of Medicine Pontifical Catholic University of ParanáLondrinaBrazil Dep.rtment of Otorhinolaryngology University of São PauloSao PauloBrazil Dep.rtment of Otorhinolaryngology:Head and Neck Surgery Perelman School of MedicineSmell and Taste CenterUniversity of PennsylvaniaPhiladelphiaPennsylvaniaUSA

Objective:The aim of this study was to assess the relative efficacy of medications used following severe acute resp.ratory syndrome coronavirus-2(SARS-CoV-2)infection on self-rep.rted alterations in taste and/or smell ***:Seven hundred and fourteen p.rsons with self-rep.rted p.stcoronavirus disease 2019(p.st-COVID-19)chemosensory disorders were p.rsonally interviewed regarding sp.cific medications they were administered following the acute p.ase of the *** dep.ndent measure—self-rep.rted total recovery of chemosensory symp.oms—was subjected to step.ise logistic *** p.edictors included demograp.ic and clinical variables,in addition to sp.cific medications used to mitigate disease symp.oms(i.e.,systemic corticosteroids,oseltamivir,vitamin C,ibup.ofen,hydroxychloroquine,azithromycin,ivermectin,nitazoxanide,anticoagulants,and zinc).Results:The median time between COVID-19 symp.om onset and the interviews was 81 days(interquartile range:60-104).Of the 714 subjects,249(34.9%)rep.rted total recovery of their chemosensory function;437(61.2%)had at least one treatment since the beginning of the *** and those with more comorbidities had undergone more *** recovery rates of the treated and nontreated group. did not differ ***,resp.ndents who had used nitazoxanide tended to have a higher rate of self-rep.rted taste or smell *** who took oral zinc were less likely to ***:No medication emp.oyed during the first months after SARS-CoV-2 infection had a clear p.sitive effect on returning self-rep.rted smell or taste function to normal,although nitrazoxide trended in a p.sitive *** zinc had a negative effect on the rep.rted recovery of these senses.

关键词： chemosensory disorder coronavirus infections COVID-19 drug therap. SARS-CoV-2 smell loss taste loss

Influence of biological maturation on cardiac autonomic recovery in female volleyball p.ayers during&after rep.ated sp.ints training:An exp.rimental trial

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Sp.rts Medicine and Health Science 2024年第3期6卷 279-286页

作者： p.ulo Francisco de Almeida-neto Fernanda Cristina Silva de Oliveira Jose Marcondes de Oliveira-Júnior Júlio Cesar Medeiros Alves Matheus de Lima Rocha Iago Medeiros da Silva Roberto Felip. C^amara Rocha p.ulo Moreira Silva Dantas Breno Guilherme de Araújo Tin^oco Cabral Health Sciences Center Federal University of Rio Grande do NorteCCS-UFRNNatal59012-570RNBrazil Dep.rtment of p.ysical Education Federal University of Rio Grande do NorteDEF-UFRNNatal59078-970RNBrazil

p.eviously,it was suggested that biological maturation(BM)could be linked to cardiac autonomic recovery(CAR)in the p.diatric ***,this influence hasn’t been confirmed *** aim was to investigate the imp.ct of BM on CAR in female volleyball *** study with a samp.e of 38 volleyball p.ayers,comp.ising 20 girls(age:[11.62.1]years)and 18 women(age:[24.55.5]years),we analyzed BM,comp.ring maturing subjects(girls)with mature subjects(women).Additionally,we assessed p.ak height velocity(p.V)in *** conducted a training session involving rep.ated sp.ints(3 rounds of 6 sp.ints intersp.rsed by 5 min[min]of p.ssive rest).Using short-range radio telemetry,we analyzed CAR during(at the end of the 1st and 2nd rounds)and after(following the 3rd round)the training session of rep.ated sp.ints by ap.lying the 60-s to 300-s heart rate recovery index(HRR-Index).Girls exhibited sup.rior CAR comp.red to women(round 2:60-s,120-s,240-s,and 300-s,p.0.005).Subgroup.analyses of BM indicated that individuals in the Late-p.V stage demonstrated sup.rior CAR comp.red to those in the Early-p.V and During-p.V group..(60-s to 300-s,η2p.0.4,p.0.05).Subjects in the During-p.V stage were sup.rior to those in the Early-p.V stage(240-sa 300-s,η2 p.0.4,p.0.05).We have concluded that biological maturation has a significant imp.ct on cardiac autonomic recovery.

关键词： Exercise Sp.rt Volleyball Heart rate p.diatric

A web-based, comp.nent-oriented ap.lication for sp.tial modelling of habitat suitability of mosquito vectors

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International Journal of Digital Earth 2009年第4期2卷 327-342页

作者： p.Zeilhofer p.S.Arraes neto W.Y.Maja D.A.Vecchiato Dep.rtment of Geograp.y Universidade Federal de Mato GrossoBrazilAv.F.Correa da Costas/nCoxipo78.060-900 Cuiaba´-MTBrazil Dep.rtment of Comp.ter Science Universidade Federal de UberlandiaBrazil Universidade Federal de Mato Grosso Brazil

This p.p.r p.op.ses a web-enabled comp.tational environment for the sp.tial modelling of habitat suitability of mosquito *** a comp.nent-based architecture and imp.emented using an object-oriented data model,we integrate database interfaces,Web feature services(WFS)based on the op.n GIS consortium(OGC)p.otocols,and the data-mining tool WEKA,coup.ed through Java servlet scrip.s(JSp..The p.ototyp.,based exclusively on freely available libraries and software comp.nents,p.ovides basic dynamic sp.tial simulation cap.bilities using logistic regression to end-users engaged in local and regional health administration and p.anning but who lack access to sp.cific software and/or detailed knowledge of sp.tial modelling *** comp.nent-based ap.roach facilitates system maintenance and future exp.nsion of functionality,and guarantees the reusability of develop.d modules in new sp.tial modelling ap.lications of health and environmental-related *** of the WWW-ap.lication was validated in a study of habitat suitability map.ing of the Malaria vector Anop.eles darlingi,in an area surrounding the Manso River hydrop.wer p.ant,Central Brazil.

关键词： habitat map.ing comp.nent and service orientation WWW

Imp.ct of the biological definition of Alzheimer’s disease using amyloid, tau and neurodegeneration (ATN):what about the role of vascular changes,inflammation,Lewy body p.thology?

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Translational Neurodegeneration 2018年第1期7卷 111-117页

作者： S.Gauthier H.Zhang K.p.Ng T.A.p.scoal p.Rosa-neto McGill Center for Studies in Aging Douglas Mental Health Research InstituteMontrealCanada Dep.rtment of Neurology The First Affiliated Hospital of Chongqing Medical UniversityChongqingChina Dep.rtment of Neurology National Neuroscience InstituteSingaporeSingapore

Background:The NIA-AA research framework p.op.ses a biological definition of Alzheimer’s disease,where asymp.omatic p.rsons with amyloid dep.sition would be considered as having this disease p.ior to ***:Notwithstanding the fact that amyloid dep.sition in isolation is not associated with dementia,even the combined association of amyloid and tau p.thology does not inevitably need to dementia over age *** p.thological factors may p.ay a leading or an accelerating role in age-associated cognitive decline,including vascular small vessel disease,neuroinflammation and Lewy Body ***:Research should aim at understanding the interaction between all these factors,rather than focusing on them *** this will lead to a p.rsonalized ap.roach to the p.evention of brain aging,based on individual biological,genetic and cognitive p.ofiles.

关键词： Alzheimer’s disease Diagnosis Treatment Biomarkers p.ecision medicine Translational research Brain imaging Database analysis Human volunteer cohorts

Imp.ct of rainfed and irrigated agriculture systems on soil carbon stock under different climate scenarios in the semi-arid region of Brazil

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Journal of Arid Land 2022年第4期14卷 359-373页

作者： André L CARVALHO Renato A ARAúJO-neto Guilherme B LYRA Carlos E p.CERRI Stoécio M F MAIA Center for Agrarian Sciences Federal University of AlagoasRio Largo 57072-900Brazil Luiz de Queiroz College of Agriculture The University of Sao PauloPiracicaba 13418-900Brazil Federal Institute of Alagoas Marechal Deodoro 57160-000Brazil

Understanding the dynamics of soil organic carbon(SOC) is of fundamental imp.rtance in land use and management, whether in the current researches or in future scenarios of agriculture systems considering climate change. In order to evaluate SOC stock of the three districts(Delmiro Gouveia, p.riconha, and Inhap. districts) in the semi-arid region of Brazil in rainfed and irrigated agriculture systems under different climate scenarios using the Century model, we obtained RCp..5 and RCp..5 climate scenarios derived from the Eta Regional Climate Model(Eta-Had GEM2-ES and Eta-MIROC5) from the National Institute for Sp.ce Research, and then inp.t the data of bulk density, p.H, soil texture, maximum temp.rature, minimum temp.rature, and rainfall into the soil and climate files of the Century model. The results of this study showed that the Eta-Had GEM2-ES model was effective in estimating air temp.rature in the future p.riod. In rainfed agriculture system, SOC stock under the baseline scenario was lower than that under RCp..5 and RCp..5 climate scenarios, while in irrigated agriculture system, SOC stock in the almost all climate scenarios(RCp..5 and RCp..5) and models(Eta-Had GEM2-ES and Eta-MIROC5) will increase by 2100. The results of this study will help.p.oducers in the semi-arid region of Brazil adop. sp.cific agriculture systems aimed at mitigating greenhouse gas emissions.

关键词： soil carbon stock agriculture systems climate scenarios Century model semi-arid region

Can the Intersp.nous Distance p.edict Kyp.osis in Conservative Treatment in Thoracolumbar Burst Fracture? A Retrosp.ctive, Diagnostic Study

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Op.n Journal of Orthop.dics 2016年第1期6卷 10-15页

作者： Robert Meves osmar Avanzi Orthop.dics Dep.rtment Faculty of Medical Sciences Santa Casa Spine Center Sao Paulo Brazil

Study Design: Retrosp.ctive, diagnostic study. Objective: To verify if the intersp.nous distance is able to p.edict the risk for kyp.otic collap.e in thoracolumbar burst fractures treated conservatively without neurological deficit. Summary of Background Data: In p.tients with thoracolumbar burst fractures, the association between the amount of comminution, by using load-sharing classification (LSC), and kyp.otic collap.e is p.esented in the literature. However, LSC does not include the intersp.nous distance as an indirect sign to suggest biomechanical instability due to p.sterior ligamentous disrup.ion in these p.tients in order to p.edict kyp.otic collap.e. Methods: We added the intersp.nous distance to the load-sharing classification (MLSC) in 50 consecutive p.tients with thoracolumbar burst fractures (according to Denis criteria) treated conservatively. Results: The LSC score was correlated to kyp.otic collap.e in the p.tients treated with TLSO (r = 0.312, p.= 0.027;Sp.arman test;A = 0.668). The MLSC was similarly correlated to kyp.otic collap.e among TLSO-treated p.tients (r = 0.295, p.= 0.038;Sp.arman test;A = 0.652). Conclusions: The intersp.nous distance did not contribute to the identification of worse radiograp.ic outcomes, rep.esented by the kyp.otic collap.e. This may suggest that the amount of comminution p.inted out by the LSC is enough and more imp.rtant than the intersp.nous op.ning in order to p.edict kyp.otic collap.e in thoracolumbar burst fractures. p.ssibly, the intersp.nous distance is much too heterogenous and multifactorial to be useful, since it reflects vertebral body height, p.einjury anatomy, as well as p.sterior element disrup.ion.

关键词： Sp.ne Sp.nal Fractures Trauma Severity Indices

Correlative CD4 and CD8 T-cell immunodominance in humans and mice:Imp.ications for p.eclinical testing

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Cellular & Molecular Immunology 2023年第11期20卷 1328-1338页

作者： Tertuliano Alves p.reira neto John Sidney Alba Grifoni Alessandro Sette Center for Infectious Disease and Vaccine Research La Jolla Institute for Immunology(LJI)La JollaCA92037USA Dep.rtment of Medicine Division of Infectious Diseases and Global Public HealthUniversity of CaliforniaSan DiegoLa JollaCA92037USA

Antigen-sp.cific T-cell recognition is restricted by Major Histocomp.tibility Comp.ex(MHC)molecules,and differences between CD4 and CD8 immunogenicity in humans and animal sp.cies used in p.eclinical vaccine testing are yet to be fully *** this study,we addressed this matter by analyzing exp.rimentally identified ep.top.s based on p.blished data curated in the Immune Ep.top.s DataBase(IEDB)*** first analyzed SARS-CoV-2 sp.ke(S)and nucleop.otein(N),which are two common targets of the immune resp.nse and well studied in both human and mouse *** observed a weak but statistically significant correlation between human and H-2^(b)mouse T-cell resp.nses(CD8 S sp.cific(r=0.206,p.1.37×10^(−13));CD4 S sp.cific(r=0.118,p.2.63×10^(−5))and N sp.cific(r=0.179,p.2.55×10^(−4))).Due to intrinsic differences in MHC molecules across sp.cies,we also investigated the association between the immunodominance of common Human Leukocyte Antigen(HLA)alleles for which HLA transgenic mice are available,namely,A*02:01,B*07:02,DRB1*01:01,and DRB1*04:01,and found higher significant correlations for both CD8 and CD4(maximum r=0.702,p.1.36×10^(−31)and r=0.594,p.3.04−122,resp.ctively).Our results further indicated that some regions are commonly immunogenic between humans and mice(either H-2^(b)or HLA transgenic)but that others are human ***,we noted a significant correlation between CD8 and CD4 S-(r=0.258,p.7.33×10^(21))and N-sp.cific(r=0.369,p.2.43×10^(14))resp.nses,suggesting that discrete p.otein subregions can be simultaneously recognized by T *** findings were confirmed in other viral systems,p.oviding general guidance for the use of murine models to test T-cell immunogenicity of viral antigens destined for human use.

关键词： T cells SARS-CoV-2 Vaccine Animal testing HLA

Revisiting the Evaluation of a Multidimensional Gaussian Integral

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Journal of Ap.lied Mathematics and p.ysics 2017年第2期5卷 449-452页

作者： R. p. Mondaini S. C. de Albuquerque neto Federal University of Rio de Janeiro Centre of Technology COPPE Rio de Janeiro Brazil

The evaluation of Gaussian functional integrals is essential on the ap.lication to statistical p.ysics and the general calculation of p.th integrals of stochastic p.ocesses. In this work, we p.esent an elementary exte... 详细信息

关键词： Gaussian Integral Determinants Sp.ctral Theorem Sylvester’s Criterion

Altitude as environmental filtering influencing p.ylogenetic diversity and sp.cies richness of p.ants in trop.cal mountains

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Journal of Mountain Science 2023年第2期20卷 285-298页

作者： GALVÁN-CISNEROS Carlos M. VILLA p.dro M. COELHO Alex J.p. CAMp.S p.ímula V. MEIRA-neto João A.A. Laboratory of Ecology and Evolution of p.ants Departamento de Biologia VegetalUniversidade Federal de ViçosaViçosaMG36570-900Brazil Botany Gradute p.ogram Universidade Federal de ViçosaViçosaMG36570-900Brazil

Elucidating how multip.e factors affect biodiversity and p.ant community assembly is a central issue in ecology,esp.cially in vulnerable ecosystems such as trop.cal *** studies are more relevant in global warming scenarios that induce the up.ard disp.acement of p.ant sp.cies towards reduced habitats and hostile environments in trop.cal *** study aimed to analyze how altitude affects taxonomic and p.ylogenetic diversity in p.ant communities of trop.cal ***,we tested if(i)increased altitude works as an environmental filtering p.omoting decreased sp.cies richness,decreased p.ylogenetic diversity,and increased p.ylogenetic clustering in these trop.cal mountains;and if(ii)p.ant communities of high altitude in trop.cal mountains are also result of recent diversification with p.ant sp.cies recently sp.it shortening p.ylogenetic distances between closest related *** tested effects of altitude on sp.cies richness and p.ylogenetic metrics using linear mixed-effects *** Haleakala p.esented 114 sp.cies,Mount Kilimanjaro p.esented 231 sp.cies and Mount p.race p.esented 280 *** found an environmental filtering effect with increasing altitude causing p.ylogenetic clustering,decreased p.ylogenetic diversity and decreased sp.cies *** decreasing p.ylogenetic distances between closest relatives are congruent with neo-endemics,suggesting recent p.ant diversification in high altitudes of trop.cal mountains,p.ssibly driven by geograp.ic isolation and environmental *** of global warming should be monitored in trop.cal mountains focusing on distribution shifts.

关键词： Trop.cal mountains Global warming Environmental filtering p.ylogenetic ecology Assembly rules Conservation Mountaintop.vegetation