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Prevalence of Adverse Drug Reactions to Second Line Anti Tuberculosis Drugs in Nigeria: A Cross-Sectional Study

Journal of Tuberculosis Research 2021年第2期9卷 90-102页

作者： Abideen Adedayo Ganiyu Yohanna Kambai Avong Akinwumi Akinyede Olusoji Mayowa Ige osman el tayeb Fatai Taleatu Ayobami Omayeka Victor Babawale Ibrahim Oreagba Department of Pharmacology Therapeutics and Toxicology College of Medicine University of Lagos Lagos Nigeria Government Chest Hospital Ibadan Nigeria Institute of Human Virology of Nigeria (IHVN) Abuja Nigeria University of Technology Sydney Ultimo Australia University College Hospital Ibadan Nigeria Damien Foundation Belgium Nigeria Office Ibadan Nigeria National Tuberculosis and Leprosy Control Programme (NTBLCP) Abuja Nigeria

Introduction: Multidrug resistant tuberculosis (MDR-TB) is treated with second line antituberculosis drugs. These drugs are notorious for inflicting serious adverse drug reactions (ADRs), which many studies have shown causes a wide range of economic and health problems including death. Aim: The study examined the prevalence of ADRs, associated risk factors, socio-demographic association and outcomes among patients treated for MDR-TB at a comprehensive tuberculosis treatment center in Nigeria. Method: The study was conducted at the Government Chest Hospital, Jericho, Ibadan. We applied a retrospective assessment of patient treatment data and ADRs reports stored at the study site from March 2013 and February 2016. Subsequently, a prospective study of ADRs was conducted on patients admitted into the same hospital. Causality relationship between the drugs and the reported ADRs was determined with a specially validated tool. The outcomes assessed include recovery from the ADRs, death and permanent deafness from the ADRs. Extracted data were analyzed using SPSS version 22.0. Risk Ratio was calculated for the influence of risk factors for adverse drug reactions. Logist

关键词： Multidrug Resistant Tuberculosis ADR Risk Factors Prevalence

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The Use of Sputum Dashboard and Dispatch Riders in Mitigating Delay in Sputum Samples’ Processing—Evidence from an Intervention in Lagos State, Nigeria

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Journal of Tuberculosis Research 2021年第3期9卷 146-159页

作者： Muse Olatunbosun Fadeyi Akinwumi Akindele Adebayo Bakare Bolaji Ahmed osman el-tayeb Taofeekat Ali Yasir Othman Obioha Udunze Gbolahan Dairo Aderonke Agbaje Damien Foundation Belgium (Nigeria Project) Ibadan Oyo State Nigeria Institute of Human Virology Nigeria (IHVN) Abuja Nigeria Hull University Teaching Hospitals NHS Trust Hull United Kingdom

The act of referring TB presumptive individuals after verbal screening to another health facility/diagnostic centres for testing often results in large loss to follow-up, owing to the many barriers people face in accessing care. The transportation of sputum samples is an efficient method of increasing access to tuberculosis (TB) diagnostics in areas where testing is not currently available. One of the major reasons for the low yield of TB cases in the field was delay in sputum sample transportation to diagnostic laboratories among other factors. Damien Foundation Belgium, carried out a unique sputum riders initiatives in 20 LGAs of Lagos state between Q3-2019 and Q4-2020. A total of 25 sputum dispatch riders across the 20 LGAs in the State who are monitored routinely on an electronic dashboard were engaged for sputum logistics. Therefore, this report highlights how the initiatives have contributed to increased TB case notification in a densely populated metropolitan city in Nigeria. Overall, 48,265 units of sputum samples were transported to the laboratory from the facilities 99.9% of results which were received from the laboratory by the dispatch riders. The contribution of sputum riders to the overall TB case detection by the project progressively increased from 9% when the intervention began to 57% as at Q4 2020. The transportation of sputum samples by motorcycle dispatch riders is an efficient method of increasing access to TB diagnostic services in communities where testing is not currently available.

关键词： Sputum Samples Dispatch Rider electronic Dashboard Sputum Logistics Tuberculosis

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Assessment of the Contributions of Private Provider Engagement in Tuberculosis Case Finding and Notification in South West Nigeria

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Journal of Tuberculosis Research 2021年第3期9卷 160-171页

作者： Muse O. Fadeyi Bolaji Ahmed Akinwumi Akindele Adebayo Bakare Modupe Ariyo Olalekan Onitiju osman el-tayeb Taofeekat Ali Yasir Othman Aderonke Agbaje Damien Foundation Belgium (Nigeria Project) Ibadan Oyo State Nigeria Institute of Human Virology Nigeria (IHVN) Abuja Nigeria Hull University Teaching Hospitals NHS Trust Hull United Kingdom

Introduction: Tuberculosis is one of the leading causes of mortalities attributable to an infectious disease. In a private sector-driven health system such as Nigeria, the private health providers are very important stakeholders in tuberculosis diagnosis and management. Unfortunately, there are few data on the level of contribution of these private health providers to the case finding and notification of tuberculosis in Nigeria. Consequently, this study assessed the contribution of the private providers to the diagnosis and treatment of tuberculosis under the Global Fund Private Public Mix New Funding Model (2nd phase) grant (GF PPM NFM2) in the four implementing states of south west Nigeria. Materials and Methods: This is a retrospective, cross-sectional analysis of the NFM2 programme implementation data collected between January 1, 2019 and December 31, 2020. Data was extracted from the routine registers such as the presumptive TB registers;treatment register of the private health facilities engaged for PPM activities between 2019 and 2020. The data was entered and analyzed using Microsoft excel package. The variables were summarized using appropriate charts and table. Results: Concerning the percentage contribution of the Global Fund Private Public Mix (GF PPM) grant to the total sta

关键词： Private Provider Tuberculosis Diagnosis Notification

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Evidence supporting the relationship between maternal asthma and risk for autism spectrum disorders

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Neural Regeneration Research 2025年第4期20卷 1101-1102页

作者： Hadley osman Paul Ashwood Department of Medical Microbiology and Immunology and the M.I.N.D.InstituteUniversity of California at DavisSacramentoCAUSA

During pregnancy,maternal immune activation(MIA),due to infection,chronic inflammatory disorders,or toxic exposures,can result in lasting health impacts on the developing *** has been associated with an increased risk of neurodevelopmental disorders,such as autism spectrum disorder(ASD)in the *** is characterized by increased repetitive and stereotyped behaviors and decreased *** of 2020,1 in 36 children are diagnosed with ASD by the age of 8 years,with ASD rates continuing to increase in prevalence in USA(Tamayo et al.,2023).Post-mortem brain studies,biomarker and transcriptomic studies,and epidemiology studies have provided compelling evidence of immune dysregulation in the circulation and brain of individuals diagnosed with ***,the etiology of ASD is largely unknown,however,genetic components and environmental factors can contribute to increased *** allergic asthma(MAA),a form of MIA,has been identified as a potential risk factor for developing neurodevelopmental disorders(Patel et al.,2020).Asthma is a chronic inflammatory condition driven by a T-helper type(TH)2 immune response.

关键词： disorders epidemiology fetus

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A Synergistic Multi-Attribute Decision-Making Method for Educational Institutions Evaluation Using Similarity Measures of Possibility Pythagorean Fuzzy Hypersoft Sets

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Computer Modeling in Engineering & Sciences 2025年第1期142卷 501-530页

作者： Khuram Ali Khan Saba Mubeen Ishfaq Atiqe Ur Rahman Salwa el-Morsy Department of Mathematics University of SargodhaSargodha40100Pakistan Department of Mathematics University of Management and TechnologyLahore54000Pakistan Department of Mathematics College of ScienceQassim UniversityBuraydah51452Saudi Arabia

Due to the numerous variables to take into account as well as the inherent ambiguity and uncertainty,evaluating educational institutions can be *** concept of a possibility Pythagorean fuzzy hypersoft set(pPyFHSS)is more flexible in this regard than other theoretical fuzzy set-like models,even though some attempts have been made in the literature to address such *** study investigates the elementary notions of pPyFHSS including its set-theoretic operations union,intersection,complement,OR-and *** results related to these operations are also modified for ***,the similarity measures between pPyFHSSs are formulated with the assistance of numerical examples and ***,an intelligent decision-assisted mechanism is developed with the proposal of a robust algorithm based on similarity measures for solving multi-attribute decision-making(MADM)problems.A case study that helps the decision-makers assess the best educational institution is discussed to validate the suggested *** algorithmic results are compared with the most pertinent model to evaluate the adaptability of pPyFHSS,as it generalizes the classical possibility fuzzy set-like theoretical ***,while considering significant evaluating factors,the flexibility of pPyFHSS is observed through structural comparison.

关键词： Hypersoft set Pythagorean fuzzy hypersoft set computational complexity multi-attribute decision-making optimization similarity measures uncertainty

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Solid Waste Management:A MADM Approach Using Fuzzy Parameterized Possibility Single-Valued Neutrosophic Hypersoft Expert Settings

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Computer Modeling in Engineering & Sciences 2025年第1期142卷 531-553页

作者： Tmader Alballa Muhammad Ihsan Atiqe Ur Rahman Noorah Ayed Alsorayea Hamiden Abd el-Wahed Khalifa Department of Mathematics College of SciencesPrincess Nourah bint Abdulrahman UniversityRiyadh11671Saudi Arabia 2 Department of Mathematics University of Management and TechnologyLahore54000Pakistan Department of Mathematics College of ScienceQassim UniversityBuraydah51452Saudi Arabia

The dramatic rise in the number of people living in cities has made many environmental and social problems *** search for a productive method for disposing of solid waste is the most notable of these *** scholars have referred to it as a fuzzy multi-attribute or multi-criteria decision-making problem using various fuzzy set-like approaches because of the inclusion of criteria and anticipated *** goal of the current study is to use an innovative methodology to address the expected uncertainties in the problem of solid waste site *** characteristics(or sub-attributes)that decision-makers select and the degree of approximation they accept for various options can both be indicators of these *** tackle these problems,a novel mathematical structure known as the fuzzy parameterized possibility single valued neutrosophic hypersoft expert set(ρˆ-set),which is initially described,is integrated with a modified version of Sanchez’s *** this,an intelligent algorithm is *** steps of the suggested algorithm are explained with an example that explains *** compatibility of solid waste management sites and systems is discussed,and rankings are established along with detailed justifications for their *** study’s strengths lie in its application of fuzzy parameterization and possibility grading to effectively handle the uncertainties embodied in the parameters’nature and alternative approximations,*** uses specific mathematical formulations to compute the fuzzy parameterized degrees and possibility grades that are missing from the prior *** is simpler for the decisionmakers to look at each option separately because the decision is *** the computed results,it is discovered that they are consistent and dependable because of their preferred properties.

关键词： Hypersoft expert set Sanchez’s method decision making optimization solid waste management possibility grade fuzzy parameterization

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Herbal compounds as promising therapeutic agents in precision medicine strategies for cancer:A systematic review

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Journal of Integrative Medicine 2024年第2期22卷 137-162页

作者： Bizhar Ahmed tayeb Ikhwan Yuda Kusuma Alaa A.M.osman Renáta Minorics Institute of Pharmacodynamics and Biopharmacy Faculty of PharmacyUniversity of Szeged6720 SzegedHungary Institution of Clinical Pharmacy Faculty of PharmacyUniversity of Szeged6725 SzegedHungary Department of Clinical Pharmacy and Pharmacy Practice Faculty of PharmacyUniversity of Gezira20 Wad MadaniSudan Pharmacy Study Program Facuity of HealthUniversitas Harapan BangsaPurwokerto 53182Indonesia

Background:The field of personalized medicine has gained increasing attention in cancer care,with the aim of tailoring treatment strategies to individual patients for improved *** medicine,with its long-standing historical use and extensive bioactive compounds,offers a rich source of potential treatments for various diseases,including ***:To provide an overview of the current knowledge and evidence associated with incorporating herbal compounds into precision medicine strategies for cancer ***,to explore the general characteristics of the studies included in the analysis,focusing on their key features and *** strategy:A comprehensive literature search was conducted from multiple online databases,including Pub Med,Scopus,Web of Science,and *** search strategy was designed to identify studies related to personalized cancer medicine and herbal *** criteria:Publications pertaining to cancer research conducted through in vitro,in vivo,and clinical studies,employing natural products were included in this *** extraction and analysis:Two review authors independently applied inclusion and inclusion criteria,data extraction,and assessments of methodological *** quality assessment and biases of the studies were evaluated based on modified Jadad scales.A detailed quantitative summary of the included studies is presented,providing a comprehensive description of their key features and ***:A total of 121 studies were included in this review for *** of them were considered as comprehensive experimental investigations both in vitro and in *** majority(n=85)of the studies included in this review were conducted in vitro,with 44 of them specifically investigating the effects of herbal medicine on animal ***,7 articles with a combined sample size of 31,271 patients,examined the impact of herbal medicine in clinical ***:Personal

关键词： Cancer Herbal medicine Personalized medication Active phytochemicals Natural compound

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Hydrogen bonding: a mechanism for tuning electronic and optical properties of hybrid organic–inorganic frameworks

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npj Computational Materials 2016年第1期2卷 19-24页

作者： Fedwa el-Mellouhi el tayeb Bentria Asma Marzouk Sergey N Rashkeev Sabre Kais Fahhad H Alharbi Qatar Environment&Energy Research Institute(QEERI) Hamad Bin Khalifa UniversityDohaQatar College of Science and Engineering Hamad Bin Khalifa UniversityDohaQatar Department of Chemistry and Physics Birck Nanotechnology CenterPurdue UniversityWest LafayetteINUSA.

The field of hybrid inorganic–organic framework materials is one of the fastest growing fields in materials science because their enormous structural and chemical diversity presents great opportunities for creating many technologically relevant *** of the most important issues is controlling and tuning the structural,optical,thermal,mechanical and electronic properties of these complex materials by varying their chemistry,fabrication techniques and preparation *** we demonstrate that significant progress in this area may be achieved by introducing structural elements that form hydrogen bonds with the *** hybrid framework materials with different structural ordering containing protonated sulfonium cation H3S+and electronegative halogen anions(I^(−),Br^(−),Cl^(−)and F^(−)),we found that hydrogen bonding increases the structural stability of the material and may be used for tuning electronic states near the *** suggest that such a behaviour has a universal character and should be observed in hybrid inorganic–organic framework materials containing protonated *** effect may serve as a viable route for optoelectronic and photovoltaic applications.

关键词： inorganic bonding electronic

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A fractional-order chaotic Lorenz-based chemical system:Dynamic investigation,complexity analysis,chaos synchronization,and its application to secure communication

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Chinese Physics B 2024年第12期33卷 223-235页

作者： Haneche Nabil Hamaizia tayeb Mathematical Modeling&Simulation Laboratory Department of MathematicsUniversity of Mentouri BrothersConstantineAlgeria Department of Mathematics University of Mentouri BrothersConstantineAlgeria

Synchronization of fractional-order chaotic systems is receiving significant attention in the literature due to its applications in a variety of fields,including cryptography,optics,and secure *** this paper,a three-dimensional fractional-order chaotic Lorenz model of chemical reactions is *** basic dynamical properties,such as stability of equilibria,Lyapunov exponents,bifurcation diagrams,Poincarémap,and sensitivity to initial conditions,are *** adopting the Adomian decomposition algorithm(ADM),the numerical solution of the fractional-order system is *** is found that the lowest derivative order in which the proposed system exhibits chaos is q=0.694 by applying *** result has been validated by the existence of one positive Lyapunov exponent and by employing some phase *** addition,the richer dynamics of the system are confirmed by using powerful tools in nonlinear dynamic analysis,such as the 0-1 test and C_(0)***,modified projective synchronization has been implemented based on the stability theory of fractional-order *** paper presents the application of the modified projective synchronization in secure communication,where the information signal can be transmitted and recovered successfully through the *** simulations are provided to show the validity of the constructed secure communication scheme.

关键词： chaotic system Adomian decomposition method modified projective synchronization secure communication

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Hydrothermal Characteristics of Blended Cement Pastes Containing Silica Sand Using Cement Kiln Dust as an Activator

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Journal of Materials Science & Technology 2002年第5期18卷 474-478页

作者： S.A.Abo-el-Enein F.I.el-Hosiny E.el-Shimy T.A.osman Faculty of Sci. Ain Shams Univ. Abbassia-Cairo Egypt Building Res. Cent. Cairo P. O. Box 1770 Egypt

The hydrothermal reactivity of silica sand was studied using cement kiln dust (CKD) as an activator in addition to the Portland cement fraction of el-Karnak cement (a blend of ordinary Portland cement and ground sand). Autoclaved EI-Karnak cement pastes were studied at pressures of 0.507, 1.013 and 1.520 MPa of saturated steam with respect to their compressive strength, kinetics of hydrothermal reaction and the phase composition of the formed hydrates. The role of CKD in affecting the physicochemical and mechanical properties of EI-Karnak cement pastes was studied by autoclaving of several pastes containing 5, 7.5, 10 and 20% CKD at a pressure of 1.013 MPa of saturated steam. CKD was added either as a raw CKD (unwashed) or after washing with water (washed CKD). The results of these physicochemical studies obtained could be related as much as possible to the role of CKD (raw or washed) in affecting the hydrothermal reactivity of silica sand in EI-Karnak cement pastes.

关键词： Blended cement Silica Cement kiln dust Hydrothermal characteristics

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