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Superplasticity of a friction stir processed overaged WE54 magnesium alloy

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Journal of Magnesium and Alloys 2022年第11期10卷 3156-3166页

作者： oscar A.ruano Marta Alvarez-Leal Alberto Orozco-Caballero Fernando Carreño Physical Metallurgy Department CENIM-CSICAv.Gregorio del Amo 828040 MadridSpain Department of R&D and programmes Technology Centre of Metal-Mechanical and Transport(CETEMET).Avda.1°de Mayos/n.LinaresJaén2370Spain Department of Mechanical Engineering Chemistry and Industrial DesignPolytechnic University of MadridRonda de Valencia 328012MadridSpain

The coarse-grained WE54 magnesium alloy was heat treated in order to have minimum hardness minimizing the effects of precipitates and solid solution. Friction stir processing(FSP) was applied in severe conditions to obtain fine, equiaxed and highly misoriented grains, with grain sizes even less than 1 μm. The high severity of processing demonstrated to have a strong impact in the microstructure. Consequently,the processed materials exhibited excellent superplasticity at the high strain rate 10^(-2)s^(-1), and temperatures between 300 and 400 ℃. The maximum tensile superplastic elongation of 756% was achieved at 400 ℃ thanks to the operation of grain boundary sliding mechanism(GBS). Besides the new data obtained through tensile testing, the paper deals with a transcendental question regarding the large differences in strain rate values at a given stress in the superplastic regime at maximum elongation compared to other magnesium-based alloys. With this is mind, 19 magnesium alloys from 22 different investigations were analyzed to give some light to this behavior that never was treated before. It is proposed that this behavior has to be attributed to the accommodation process, necessary for GBS to occur, which is hindered by reinforcing solutes.

关键词： WE54 magnesium alloy Friction stir processing Processing severity Superplasticity Grain boundary sliding Solutes

Spinal cord injury-induced cognitive impairment: a narrative review

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Neural Regeneration Research 2022年第12期17卷 2649-2654页

作者： oscar V.Alcántar-Garibay Diego Incontri-Abraham antonio Ibarra Centro de Investigación en Ciencias de la Salud(CICSA) Facultad de Ciencias de la SaludUniversidad Anáhuac México Campus NorteHuixquilucanEstado de MéxicoMéxico

Spinal cord injury is a serious damage to the spinal cord that can lead to life-long *** on its etiology,spinal cord injury can be classified as traumatic or non-traumatic spinal cord ***,the pathology of spinal cord injury can be divided into two phases,a primary injury phase,and a secondary injury *** primary spinal cord injury phase involves the initial mechanical injury in which the physical force of impact is directly imparted to the spinal cord,disrupting blood vessels,axons,and neural cell *** the primary injury,a cascade of secondary events begins,expanding the zone of neural tissue damage,and exacerbating neurological *** injury is a progressive condition characterized by pro-inflammatory cytokines,reactive oxygen species,oxidative damage,excitatory amino acids such as glutamate,loss of ionic homeostasis,mitochondrial dysfunction,and cell *** secondary phase lasts for several weeks or months and can be further subdivided into acute,subacute,and *** of the most frequent and devastating complications developed among the spinal cord injury population is cognitive *** risk of cognitive decline after spinal cord injury has been reported to be 13 times higher than in healthy *** exact etiology of this neurological complication remains unclear,however,many factors have been proposed as potential contributors to the development of this disorder,such as concomitant traumatic brain injury,hypoxia,anoxia,autonomic dysfunction,sleep disorders such as obstructive sleep apnea,body temperature dysregulation,alcohol abuse,and certain *** review focuses on a deep understanding of the pathophysiology of spinal cord injury and its relationship to cognitive *** highlight the main mechanisms that lead to the development of this neurological complication in patients with spinal cord injury.

关键词： autonomic dysfunction cognitive impairment spinal cord injury traumatic brain injury

Effects of a school-based karate intervention on academic achievement,psychosocial functioning,and physical fitness:A multi-country cluster randomized controlled trial

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Journal of Sport and Health Science 2024年第1期13卷 90-98页

作者： Tania Pinto-Escalona Erica Gobbi Pedro L.Valenzuela Simon J.Bennett Pierluigi Aschieri Manuel Martin-Loeches antonio Paoli oscar Martinez-de-Quel Faculty of Education Complutense University of MadridMadrid 28040Spain Department of Biomolecular Sciences University of Urbino“Carlo Bo”Urbino 61029Italy Department of Systems Biology University of AlcaláMadrid 28805Spain Research Institute for Sport and Exercise Sciences Faculty of ScienceLiverpool John Moores UniversityLiverpoolL33AFUK Italian Judo WrestlingKarate and Martial Arts FederationRome 00122Italy Psychobiology&Methods for the Behavioural Sciences Department Complutense University of MadridMadrid 28040Spain Department of Biomedical Sciences University of PaduaPadua 35122Italy

Purpose:To examine the effects of a school-based karate intervention on academic achievement,psychosocial functioning,and physical fitness in children aged 7-8 ***:Twenty schools in 5 different European countries(2 second-grade classrooms per school)participated in a cluster randomized controlled trial(Sport at School trial).Participants were assigned to either a control group,which continued with their habitual physical education lessons,or to an intervention group,which replaced these lessons with a 1-year karate intervention(Karate Mind and Movement program).A total of 721 children(344 girls and 377 boys,7.4±0.5 years old,mean±SD)completed the study,of which 333 and 388 were assigned to the control group and intervention group,*** included academic performance(average grade),psychosocial functioning(Strengths and Difficulties Questionnaire for parents),and different markers of physical fitness(cardiorespiratory fitness,balance,and flexibility).Results:The intervention provided small but significant benefits compared to the control group for academic achievement(d=0.16;p=0.003),conduct problems(d=-0.28;p=0.003),cardiorespiratory fitness(d=0.36;p0.05).Conclusion:A 1-year school-based karate intervention was effective in improving academic achievement,conduct problems,and physical fitness in primary school *** results support the inclusion of karate during physical education lessons.

关键词： Academic performance Cardiorespiratory fitness Conduct problems Karate Physical fitness

Clinicopathological alterations in wild mammals from the reservoir system of Trypanosoma cruzi:a scoping review

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Animal Diseases 2024年第1期4卷 48-58页

作者： Ricardo Sanchez Pérez JoséManuel Aranda-Coello Joséantonio De Fuentes Vicente oscar Rico Chavez Facultad de Estudios Superiores Cuautitlan Universidad Nacional Autonoma deMexicoCuautitlan lzcalliEstadodeMexicoMexico El Colegio de la Frontera Sur-Unidad Campeche CampecheCampecheMexico Instituto de Ciencias Biologicas-Universidad de Ciencias y Artes de Chiapas Tuxtla GutierrezChiapasMexico Facultad de Medicina Veterinaria y Zootecnia-Universidad Nacional Autonoma deMexico Ciudad deMexicoMexico

Trypanosoma cruzi is the etiologic agent of Chagas *** flagellated protozoan is transmitted to humans as well as different species of domestic and wild animals via vectors from the Reduviidae family(known as"kissing bugs").Despite the fact that hundreds of species of wild mammals are part of the reservoir system,the morphologi-cal changes and clinical manifestations resulting from the pathogenesis of the infection have been largely *** aim of this review is to systematically compile the available information regarding clinicopathological altera-tions in wild mammals due to natural infection by *** was obtained from six online bibliographic data search platforms,resulting in the identification of 29 publications that met the inclusion *** was the most common clinical manifestation,cardiac damage was the main finding at necropsy,and lymphoplas-macytic inflammation was the most frequent microscopic ***,regardless of its role as a reservoir,*** has the potential to affect the health status of wild mammals,a situation that highlights the need for further research to analyze,measure,and compare its effects at both the individual and population levels.

关键词： Trypanosoma cruzi Chagas disease American trypanosomiasis Clinicopathological alterations Natural infection Wild mammals

Portal hypertensive colopathy is associated with portal hypertension severity in cirrhotic patients

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World Journal of Gastroenterology 2009年第38期15卷 4781-4787页

作者： antonio Diaz-Sanchez oscar Nuez-Martinez Cecilia Gonzalez-Asanza Ana Matilla Beatriz Merino Diego Rincon Inmaculada Beceiro Maria Vega Catalina Magdalena Salcedo Rafael Baares Gerardo Clemente Liver Unit-CIBEREHD.Hospital General Universitario Gregorio Maraón Madrid 28007Spain Gastroenterology Unit Hospital Infanta Leonor Gastroenterology Unit Hospital Infanta Sofia Department of Gastroenterology Hospital Universitario Príncipe de Asturias

AIM： To assess the prevalence of portal hypertension （PH） related colorectal lesions in liver transplant candidates, and to evaluate its association with the severity of PH. METHODS： Between October 2004 and December 2005, colonoscopy was performed in 92 cirrhotic liver transplant candidates. We described the lesions resulting from colorectal PH and their association with the grade of PH in 77 patients who underwent measurement of hepatic venous pressure gradient （HVPG）. RESULTS： Mean age was 55 years and 80.7% of patients were men. The main etiology of cirrhosis wasalcoholism （45.5%）. Portal hypertensive colopathy （PHC） was found in 23.9%, colonic varices in 7.6% and polyps in 38% of patients （adenomatous type 65.2%）. One asymptomatic patient had a well-differentiated adenocarcinoma. The manifestations of colorectal PH were not associated with the etiology of liver disease or with the Child-Pugh grade. Ninety percent of patients with colopathy presented with gastroesophageal varices （GEV）, and 27.5% of patients with GEV presented with colopathy （P = 0.12）. A relationship between higher values of HVPG and presence of colopathy was observed （19.9：1：6.2 mmHg vs 16.8 ± 5.4 mmHg, P = 0.045）, but not with the grade of colopathy （P = 0.13）. Preneoplastic polyps and neoplasm （P = 0.02） and spontaneous bacterial peritonitis （P = 0.006） were more prevalent in patients with colopathy. We did not observe any association between previous β-blocker therapy and the presence of colorectal portal hypertensive vasculopathy. CONCLUSION： PHC is common in cirrhotic liver transplant candidates and is associated with higher portal pressure.

关键词： Liver cirrhosis Portal hypertension Polyps Colopathy Liver transplantation

Arsenite provides a selective signal that coordinates arsenate uptake and detoxification through the regulation of PHR1 stability in Arabidopsis

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Molecular Plant 2021年第9期14卷 1489-1507页

作者： Cristina Navarro Cristian Mateo-Elizalde Thotegowdanapalya C.Mohan Eduardo Sanchez-Bermejo oscar Urrutia Maria Nieves Fernandez-Muniz Jose M.Garcia-Mina Riansares Munoz Javier Paz-Ares Gabriel Castrillo antonio Leyva Department of Plant Molecular Genetics Centro Nacional de Biotecnología-Consejo Superior de Investigaciones CientíficasMadrid 28049Spain Department of Environmental Biology Sciences SchoolUniversity of NavarraPamplona 31008Spain Department of Analytical Chemistry School of Chemical SciencesUniversidad Complutense de MadridMadrid 28040Spain Present address:Department of Biotechnology and Bioinformatics Faculty of Life SciencesJSS Academy of Higher Education and ResearchMysuruKarnataka 570015India Present address:S&A Fresh Produce.Brook Farm MardenHereford HR13ETUK Future Food Beacon of Excellence&School of Biosciences University of NottinghamNottingham LE125RDUK

In nature,plants acquire nutrients from soils to sustain growth,and at the same time,they need to avoid the uptake of toxic compounds and/or possess tolerance systems to cope with *** is particularly challenging when the toxic compound and the nutrient are chemically similar,as in the case of phosphate and *** this study,we demonstrated that regulatory elements of the phosphate starvation response(PSR)coordinate the arsenate detoxification machinery in the *** showed that arsenate repression of the phosphate transporter PHT1;1 is associated with the degradation of the PSR master regulator *** arsenic is sequestered into the vacuole,PHR1 stability is restored and PHT1;1 expression is ***,we identified an arsenite responsive SKP1-like protein and a PHR1 interactor F-box(PHIF1)as constituents of the SCF complex responsible for PHR1 *** found that arsenite,the form to which arsenate is reduced for compartmentalization in vacuoles,represses PHT1;1 expression,providing a highly selective signal versus phosphate to control PHT1;1 expression in response to ***,our results provide molecular insights into a sensing mechanism that regulates arsenate/phosphate uptake depending on the plant’s detoxification capacity.

关键词： arsenic signaling F-box protein arsenate uptake arsenic detoxification phosphate starvation phytoremediation

Dosing strategies for de novo once-daily extended release tacrolimus in kidney transplant recipients based on CYP3A5 genotype

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World Journal of Transplantation 2023年第6期13卷 368-378页

作者： Adam Diamond Sunil Karhadkar Kenneth Chavin Serban Constantinescu Kwan N.Lau oscar Perez-Leal Kerry Mohrien Nicole Sifontis antonio Di Carlo Department of Pharmacy Temple University HospitalPhiladelphiaPA 19140United States Department of Surgery Temple University HospitalPhiladelphiaPA 19140United States Department of Medicine Temple University School of MedicinePhiladelphiaPA 19140United States Department of Pharmaceutical Sciences Jayne Haines Center for Pharmacogenomics and Drug SafetyTemple University School of PharmacyPhiladelphiaPA 19140United States Department of Pharmacy Practice Temple University School of PharmacyPhiladelphiaPA 19140United States

BACKGROUND Tacrolimus extended-release tablets have been Food and Drug Administrationapproved for use in the de novo kidney transplant *** requirements often vary for tacrolimus based on several factors including variation in metabolism based on CYP3A5 *** who express CYP3A5 often require higher dosing of immediate-release tacrolimus,but this has not been established for tacrolimus extended-release tablets in the de novo *** To obtain target trough concentrations of extended-release tacrolimus in de novo kidney transplant recipients according to CYP3A5 *** Single-arm,prospective,single-center,open-label,observational study(***:NCT037-13645).Life cycle pharma tacrolimus(LCPT)orally once daily at a starting dose of 0.13 mg/kg/day based on actual body *** weight is more than 120%of ideal body weight,an adjusted body weight was *** dose was adjusted to maintain tacrolimus trough concentrations of 8-10 ng/*** analysis of CYP3A5 genotype was performed at study *** Mean time to therapeutic tacrolimus trough concentration was longer in CYP3A5 intermediate and extensive metabolizers vs CYP3A5 non-expressers(6 d vs 13.5 d vs 4.5 d;P=0.025).Mean tacrolimus doses and weight-based doses to achieve therapeutic concentration were higher in CYP3A5 intermediate and extensive metabolizers vs CYP3A5 non-expressers(16 mg vs 16 mg vs 12 mg;P=0.010)(0.20 mg/kg vs 0.19 mg/kg vs 0.13 mg/kg;P=0.018).CYP3A5 extensive metabolizers experienced lower mean tacrolimus trough concentrations throughout the study period compared to CYP3A5 intermediate metabolizers and non-expressers(7.98 ng/mL vs 9.18 ng/mL vs 10.78 ng/mL;P=00.008).No differences were identified with regards to kidney graft function at 30-d *** adverse events were reported for 13(36%)*** Expression of CYP3A5 leads to higher starting doses and incremental dosage titration of extended-release

关键词： Immunosuppression Kidney transplant Dosing Tacrolimus Therapeutic drug monitoring Genotype

Efficacy of neoadjuvant therapy and surgical rescue for locally advanced hepatoblastomas:10 year single-center experience and literature review

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World Journal of Gastroenterology 2014年第29期20卷 10137-10143页

作者： Dolores Ayllon Teran oscar Gómez Beltran Rubén Ciria Bru Elena Mateos González María José Pea Rosa antonio Luque Molina Pedro López Cillero Javier Briceo Delgado Department of Surgery Reina Sofia Hospital Department of Pediatric Surgery Reina Sofia Hospital Department of Pediatric Oncology Reina Sofia Hospital

AIM: To report our experience with long-term outcomes after multimodal management therapy.

关键词： Liver tumors Chemotherapy Liver surgery Multimodal management

Polymer Surface Roughness Determination throughout the Hurst Analysis from Optical Signal Measurements

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材料科学与工程（中英文版） 2010年第11期4卷 26-31页

作者： antonio Marban oscar Sarmiento-Martinez Darwin Mayorga-Cruz Carmina Menchaca Jorge Uruchurtu Centro de Investigaciones en Ingenieria y Ciencias Aplieadas-CIICAp Av Universidad 1001 Chamilpa Cuernavaca MorelosMexico Universidad Autonoma Metropolitana- UAM Azcapotzalco Avenida del Rosario Azcapotzalco Mexico D.F.