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Effect of treating chronic hepatitis C with direct-acting antivirals on extrahepatic cutaneous manifestations

World Journal of Hepatology 2020年第10期12卷 841-849页

作者： mohamed El Kassas osama mo hegazy Eman M Salah Department of Endemic Medicine Faculty of MedicineHelwan UniversityCairo 11795Egypt Department of Dermatology Venereology and AndrologyFaculty of MedicineHelwan UniversityCairo 11795Egypt

BACKGROUND Hepatitis C virus(HCV)is a disease with a significant global impact,affecting approximately 2%-2.5%of the world’s *** direct-acting antivirals(DAAs)have been introduced over the past few years with great success in viral *** association of chronic HCV infection with a wide spectrum of cutaneous manifestations has been widely reported in the *** To assess the effect of treating HCV with DAAs on the extrahepatic cutaneous manifestations of *** This prospective observational study included 1039 HCV positive Egyptian patients who were eligible to receive DAAs.A total of 30 patients were diagnosed with extrahepatic cutaneous manifestations and fulfilled the inclusion criteria of the *** these patients,6 had classic lichen planus,8 were diagnosed with psoriasis vulgaris and 16 had *** patients received DAAs from October 2018 to July 2019 in the form of a three-month course of sofosbuvir/daclatasvir *** with lichen planus or psoriasis were dermoscopically evaluated before treatment and 6 mo after treatment,while patients with hepatic pruritus were assessed using the 12-Item Pruritus Severity Scale over the same *** All patients with psoriasis showed significant improvement in all psoriatic plaques,and all patients with hepatic pruritus scored 0 on the 12-Item Pruritus Severity Scale indicating total improvement of *** addition,four of six patients with lichen planus showed complete *** Treatment of HCV with DAAs was significantly effective in improving virusrelated extrahepatic cutaneous manifestations.

关键词： Directly acting antivirals Extrahepatic manifestations Hepatitis C virus Lichen planus Pruritus Cutaneous manifestations

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Evaluation of hybrid closed-loop insulin delivery system in type 1 diabetes in real-world clinical practice:One-year observational study

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World Journal of Diabetes 2024年第3期15卷 455-462页

作者： Ahmed Eldib Shilton Dhaver Karim Kibaa Astrid Atakov-Castillo Tareq Salah Marwa Al-Badri Abdelrahman Khater Ryan McCarragher Omnia Elenani Elena Toschi osama Hamdy Department of Clinical Behavioral&Outcomes ResearchJoslin Diabetes CenterBostonMA 02215United States Department of Medicine Harvard Medical SchoolBostonMA 02115United States

BACKGROUND In 2016,the Food and Drug Administration approved the first hybrid closed-loop(HCL)insulin delivery system for adults with type 1 diabetes(T1D).There is limited information on the impact of using HCL systems on patient-reported outcomes(PROs)in patients with T1D in real-world clinical *** this independent study,we evaluated glycemic parameters and PROs over one year of continuous use of Medtronic’s 670G HCL in real-world clinical *** To assess the effects of hybrid closed loop system on glycemic control and quality of life in adults with *** We evaluated 71 patients with T1D(mean age:45.5±12.1 years;59%females;body weight:83.8±18.7 kg,body mass index:28.7±5.6 kg/m2,A1C:7.6%±0.8%)who were treated with HCL at Joslin Clinic from 2017 to *** measured A1C and percent of glucose time-in-range(%TIR)at baseline and 12 *** measured percent time in auto mode(%TiAM)for the last two weeks preceding the final visit and assessed PROs through several validated quality-of-life surveys related to general health and diabetes *** At 12 mo,A1C decreased by 0.3%±0.1%(P=0.001)and%TIR increased by 8.1%±2.5%(P=0.002).The average%TiAM was only 64.3%±32.8%and was not associated with A1C,%TIR or ***,provided at baseline and at the end of the study,showed that the physical functioning submodule of 36Item Short-Form Health Survey increased significantly by 22.9%(Pmotional burden submodules of dietary diversity score reduced significantly by-44.7%(P=0.001).Furthermore,analysis of Clarke questionnaire showed no increase in awareness of hypoglycemic ***-5 showed no improvements in subject’s wellbeing among participants after starting the 670G HCL ***,analysis of Pittsburgh Sleep Quality Index showed no difference in sleep quality,sleep latency,or duration o

关键词： Artificial pancreas Continuous blood glucose monitor Type 1 diabetes Hybrid closed-loop insulin delivery Quality of life

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湘南柿竹园矿田云英岩型钨多金属成矿规律及成矿预测

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矿床地质 2024年第1期43卷 159-176页

作者：侯宇辰刘建平 AHMAD osama 王浩李岩林王周元吴佳锟田旭峰文一卓中南大学地球科学与信息物理学院湖南长沙410083 湖南柿竹园有色金属有限责任公司湖南郴州423037 湖南省矿产资源调查所湖南长沙410000

湘南柿竹园矽卡岩型-云英岩型钨多金属矿田是中国最重要的钨多金属矿产资源基地之一。前人对该矿田的矽卡岩型成矿开展了系统的研究,而对矿田内云英岩型钨矿化研究薄弱,制约了矿田内成矿理论的认识和矿产勘查部署。通过野外调查,文章系... 详细信息

湘南柿竹园矽卡岩型-云英岩型钨多金属矿田是中国最重要的钨多金属矿产资源基地之一。前人对该矿田的矽卡岩型成矿开展了系统的研究,而对矿田内云英岩型钨矿化研究薄弱,制约了矿田内成矿理论的认识和矿产勘查部署。通过野外调查,文章系统总结了矿田内云英岩型矿化样式、空间分布、矿化特征和控矿因素。研究显示柿竹园矿田内云英岩型矿体包含4种矿化样式:第一期斑状黑云母花岗岩中云英岩型矿体、石英斑岩中云英岩型矿体、第二期黑云母花岗岩中云英岩型矿体和矽卡岩-网脉状云英岩复合型矿体。这4种样式的云英岩型钨多金属矿体是柿竹园矿田内不同阶段的花岗岩成矿的产物。白钨矿化学成分显示矽卡岩型矿化的白钨矿低mo,而云英岩型矿化白钨矿富mo,指示云英岩矿化较矽卡岩矿化具有更氧化的环境。柿竹园矿田矿化格局显示云英岩型矿化受矿田和矿床尺度的花岗岩体侵位前锋控制,矿田尺度表现为岩体由北东深部向南西浅部侵位,千里山岩体南部为岩体侵位的前锋,岩体南部发育较大规模的云英岩矿体;矿床尺度上,云英岩体的定位受控于花岗岩岩突的控制。此外,矿田菱形格状构造对岩突产出位置具有重要的控制作用,也具有重要勘查指示意义。结合矿田控矿构造格局、不同期次岩浆岩对云英岩的控制及地球化学异常特征,笔者提出了大吉岭、柿竹园深部和柴山深部3处云英岩型钨多金属矿找矿预测靶区。

关键词：云英岩型钨多金属矿床矿化类型控矿因素成矿预测柿竹园矿田湘南

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Determination of a novel ACE inhibitor in the presence of alkaline and oxidative degradation products using smart spectrophotometric and chemometric methods

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Journal of Pharmaceutical Analysis 2014年第2期4卷 132-143页

作者： Maha Abdel-monem hegazy Maya Shaaban Eissa osama Ibrahim Abd El-Sattar mohamed mohamed Abd El-Kawy Analytical Chemistry Department Faculty of PharmacyCairo UniversityCairoEgypt Analytical Chemistry Department Faculty of PharmacyEgyptian Russian UniversityCairoEgypt National Organization of Drug Control and Research GizaEgypt

Simple, accurate, sensitive and validated UV spectrophotometric and chemometric methods were developed for the determination of imidapril hydrochloride （IMD） in the presence of both its alkaline （AKN） and oxidative （OXI） degradation products and in its pharmaceutical formulation. Method A is the fourth derivative spectra （D4） which allows the determination of IMD in the presence of both AKN and OXD, in pure form and in tablets by measuring the peak amplitude at 243.0 nm. Methods B, C and D, manipulating ratio spectra, were also developed. Method B is the double divisor-ratio difference spectrophotometric one （DD-RD） by computing the difference between the amplitudes of IMD ratio spectra at 232 and 256.3 nm. Method C is the double divisor-first derivative of ratio spectra method （DD-DR1） at 243.2 nm, while method D is the mean centering of ratio spectra （MCR） at 288.0 nm. Methods A, B, C and D could successfully determine IMD in a concentration range of 4.0-32.0 mg/mL. Methods E and F are principal component regression （PCR） and partial least-squares （PLS）, respectively, for the simultaneous determination of IMD in the presence of both AKN and OXI, in pure form and in its tablets. The developed methods have the advantage of simultaneous determination of the cited components without any pre-treatment. The accuracy, precision and linearity ranges of the developed methods were determined. The results obtained were statistically compared with those of a reported HPLC method, and there was no significant difference between the proposed methods and the reported method regarding both accuracy and precision.

关键词： Double divisor-ratio difference Double divisor-ratio derivative Mean centering of ratio spectra Chemometry Imidapril hydrochloride

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Latissimus Dorsi Mini-Flap as a Volume Replacement Technique after Partial Mastectomy for Breast Cancer in the Upper and Central Breast Quadrants: A Single Center Experience

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Surgical Science 2016年第11期7卷 496-504页

作者： Waleed Elnahas Ashraf Khater mohamed Hamdy Emadeldeen Hamed osama Eldamshety mohamed hegazy Department of Surgical Oncology Oncology Center Faculty of Medicine Mansoura University Mansoura Egypt

Background: The latissimus dorsi (LD) muscle flap plays an essential role in breast reconstruction after partial mastectomy for cancer because of its stability and versatility. We evaluated both oncologic and aesthetic outcomes in addition to the related complications of this flap as an adjunct to breast conserving surgery in the management of breast cancer patients. Methods: All patients underwent a one-stage procedure with immediate reconstruction through two-steps operation;wider local excision utilizing oncoplastic principles and mini flap harvest & volume replacement. Results: The study included 34 cases with early breast cancer;30 patients had partial breast resection and defect refilling by LD mini-flap, three patients underwent mastectomy and one patient underwent extended LDF. The mean defect volume was (212.63 cm3 ± 59.57) cm3, while the mean flap volume was (218.27 cm3 ± 53.64 cm3). Patient self-evaluation of the cosmetic outcome was excellent in 20%, good in 60% and satisfactory in 20% of patients. Panel evaluation according to Harvard scale showed excellent in 36.7%, good in 36.7%, fair in 26.7% of patients. The median hospital stay was 4 days. The postoperative complications included wound gap in 4 patients (13.3%), postoperative donor site seroma in 16 patients (53.3%). No flap loss or necrosis, no affection on arm or shoulder mobility occurred. Lastly, no tumor recurrence till now. Conclusion: Latissimus dorsi mini-flap can achieve adequate cosmetic and oncologic outcomes with a low incidence of complications in patients with early stage (I/II) breast cancer and small to medium sized breasts.

关键词： Oncoplastic Breast Surgery Latissimus Dorsi Mini-Flap Conservative Surgery

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Small for size syndrome difficult dilemma: Lessons from 10 years single centre experience in living donor liver transplantation

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World Journal of Hepatology 2017年第21期9卷 930-944页

作者： Hany Shoreem Emad Hamdy Gad Hosam Soliman osama hegazy Sherif Saleh Hazem Zakaria Eslam Ayoub Yasmin Kamel Kalid Abouelella Tarek Ibrahim Ibrahim Marawan Hepatobiliary Surgery Department National Liver InstituteMenoufiya Univer-sity Anesthesia Department National Liver InstituteMenoufiya University

AIM To analyze the incidence, risk factors, prevention, treatment and outcome of small for size syndrome(SFSS) after living donor liver transplantation(LDLT). METHODS Through-out more than 10 years: During the period from April 2003 to the end of 2013, 174 adult-to-adults LDLT(A-ALDLT) had been performed at National Liver Institute, Menoufiya University, Shibin Elkoom, Egypt. We collected the data of those patients to do this cohort study that is a single-institution retrospective analysis of a prospectively collected database analyzing the incidence, risk factors, prevention, treatment and outcome of SFSS in a period started from the end of 2013 to the end of 2015. The median period of follow-up reached 40.50 m, range(0-144 m). RESULTS SFSS was diagnosed in 20(11.5%) of our recipients. While extra-small graft [small for size graft(SFSG)], portal hypertension, steatosis and left lobe graft were significant predictors of SFSS in univariate analysis(P = 0.00, 0.04, 0.03, and 0.00 respectively); graft size was the only independent predictor of SFSS on multivariate analysis(P = 0.03). On the other hand, there was lower incidence of SFSS in patients with SFSG who underwent splenectomy [4/10(40%) SFSS vs 3/7(42.9%) no SFSS] but without statistical significance, However, there was none significant lower incidence of the syndrome in patients with right lobe(RL) graft when drainage of the right anterior and/or posterior liver sectors by middle hepatic vein, V5, V8, and/or right inferior vein was done [4/10(28.6%) SFSS vs 52/152(34.2%) no SFSS]. The 6-mo, 1-, 3-, 5-, 7-and 10-year survival in patients with SFSS were 30%, 30%, 25%, 25%, 25% and 25% respectively, while, the 6-mo, 1-, 3-, 5-, 7-and 10-year survival in patients without SFSS were 70.1%, 65.6%, 61.7%, 61%, 59.7%, and 59.7% respectively, with statistical significant difference(P = 0.00). CONCLUSION SFSG is the independent and main factor for occurrence of SFSS after A-ALDLT leading to poor outcome. However, the mana

关键词： Living donor liver transplantation Outcome after living donor liver transplantation Small for size syndrome Small for size graft Portal inflow Venous outflow

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Comparing the efficacy of regen-cov,remdesivir,and favipiravir in reducing invasive mechanical ventilation need in hospitalized COVID-19 patients

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世界临床病例杂志 2023年第26期11卷 6105-6121页

作者： Sahar Kmal hegazy Samar Tharwat Ahmed Hosny Hassan Clinical Pharmacy Department Faculty of PharmacyTanta UniversityTanta 31511Egypt Rheumatology and Immunology Unit Internal Medicine DepartmentFaculty of MedicineMansoura universityMansoura 35511Egypt Clinical Pharmacy Department Mansoura University HospitalMansoura 35511Egypt

BACKGROUND Coronavirus disease 2019(COVID-19)pandemic stimulates research works to find a solution to this crisis from starting 2020 year up to *** ending of the 2021-year,various advances in pharmacotherapy against COVID-19 have *** antiviral therapy,casirivimab and imdevimab antibody combination is a type of new immunotherapy against *** antiviral therapy against COVID-19 includes Remdesivir and *** To evaluate the efficacy of antibodies cocktail(casirivimab and imdevimab)compared to standard antiviral therapy in reducing the need for invasive mechanical ventilation(IMV).METHODS 265 COVID-19 polymerase chain reaction confirmed patients with indication for antiviral therapy were included in this study and were divided into 3 groups(1:2:2):Group A:REGN3048-3051 antibodies cocktail(casirivimab and imdevimab),group B:Remdesivir,group C:*** study design is a single-blind nonrandomized controlled trial Mansoura University Hospital owns the study’s *** duration of the study was about 6 mo after ethical *** Casirivimab and imdevimab achieve less need for O2 therapy and IMV,with less duration of this need than remdesivir and *** Group A(casirivimab and imdevimab)achieve better clinical outcomes than groups B(remdesivir)and C(favipiravir)intervention groups.

关键词： Antivirals Casirivimab and imdevimab Coronavirus disease 2019 Favipiravir Remdesivir

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Totally Endoscopic (Thoracoscopic and Laparoscopic) Radical Esophagectomy with Gastric Tube Reconstruction through a Small Neck Incision: An Early Experience with Thirty Egyptian Patients

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Surgical Science 2014年第5期5卷 214-223页

作者： Adel Denewer Adel Fathi Ahmed Setit mohamed hegazy Ashraf Khater osama Hussein Sameh Roshdy Fayez Shahatto Fathy Denewer Department of Surgical Oncology Oncology Center (OCMU) Faculty of Medicine Mansoura University Mansoura Egypt

Background: Minimally invasive esophagectomy nowadays is replacing the classic open technique. Additional studies are needed to confirm its safety and efficacy. Methods: thirty patients with esophageal carcinoma were enrolled in this study. Patients were evaluated preoperatively and they underwent thoracoscopic and laparoscopic procedures for assessment of resectability. Resectablepatients underwent radical esophagectomy with gastric tube reconstruction through a four-cm neck incision. Results: 17 patients were operable and 13 patients were inoperable. The mean operative time for the whole procedure was 5.97 ± 1.66 hours. The mean blood loss was 250 ± 138.07 cc. The mean overall hospital stay was 17.47 ± 5.49 daysdays. Common postoperative complications included pneumonia (13.3%) pleural effusion (6.7%), cervical anastomotic leakage (10%), and wound infection (13.3%). One patient died in the early postoperative period. Conclusions: we conclude that totallyendoscopic (thoracoscopic and laparoscopic) esophagectomy is feasible and relatively safe technique. Beside its efficacy as an assessment tool, total esophagectomy and lymphadenectomy could be performed in the same time.

关键词： Thoracoscopic Laparoscopic Radical Esophagectomy Gastric Reconstruction Esophagus Cancer

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Evaluation of Surgical Outcome after Resection of Pancreatic Tumors, Our Experience in Mansoura Oncology Center, a Middle-Volume Center in Egypt

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Journal of Cancer Therapy 2012年第5期3卷 477-481页

作者： Nazem Shams Mahmoud mosbah mohammad hegazy osama Hussein Omar Farouk Sameh Roshdy mohamed Tarek Hafez Ashraf Khater Khaled Abdel Wahab Oncology Center Mansoura University Mansoura Egypt

Background: Pancreatic cancer is the fourth most common cause of cancer related deaths in the world. Surgical resection remains the only potentially curative treatment for adenocarcinoma of the pancreas;only 10% - 20% of patients are candidate for standard pancreatic resection. Objective: To evaluate perioperative mortality, morbidity and survival for patients underwent PD in middle-volume center. Patients and Methods: Sixty patients with pancreatic tumors were enrolled in this study for different surgical procedure according to type of tumors. Results: No early postoperative complications were observed in 60% of patients, whereas 40% of patients developed one or more complication, the median survival for this group was 12.3 months with standard deviation 3.8 months.

关键词： Pancreatic Cancer Whipple Complication Survival

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Major Hepatic Resection in Hepatic Hydatidosis

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Surgical Science 2013年第1期4卷 20-28页

作者： Ibrahim Abdelkader Salama mohammed Abdallah Aboushady osama hegazy Abdelsalam Sherif mohamed Saleh Hany Abdel Mageed Shoreem mohammed Houseni El-Amir Mahmoud Amir Department of Hepatobiliary Surgery National Liver Institute Menophyia University Shiben Elkom Egypt Department of Parasitology National Liver Institute Menophyia University Shiben Elkom Egypt Department of Radiology National Liver Institute Menophyia University Shiben Elkom Egypt

Background: Ecchinococcal disease is still a serious problem in certain parts of the world, with liver as the most affected organ. Surgery remains the mainstay of treatment of hydatidosis, but the optimal surgical procedure remains unsettled. Objective: Safety and efficacy of major hepatic resection in multiple and giant hepatic hydatidosis. Patients & Methods: 63 patients had hepatic hydatidosis associated with spleen, lung, and suprarenal hydatidosis were managed by major hepatic resection between April 2005 to April 2011. 43 (68%) males and 20 (32%) females, age range 8 - 56 years. Cysts were found in the liver only in 51 (81%) patients, liver with spleen in 5 (8%), liver, spleen with lung in 2 (3.1%), liver and lung in 4 (6.3%), liver and suprarenal in one patient (1.6%). Results: Multiple cysts were found in 38 (60%) and solitary cyst in 25 (40%) with Cysts diameter ≤5 cmin 22 (35%), 5 - 10 cm in 16 (25%), and 10 - 38 in 25 (40%). Right hepatectomy in 24 (38%), right trisectionectomy in 2 (3.2%), right hepatectomy with Segment III in 4 (6.3%), right hepatectomy with Segment I in 2 (3.2%), left hepatectomy in 12 (19%), left lateral sectionectomy in 6 (9.5%), left hepatectomy with Segment VI in 3 (4.8%), left lateral sectionectomy with right posterior sectionectomy in 2 (3.2%), right hepatectomy with splenectomy in 7 (11%) and right hepatectomy with right suprarenal in one (1.6%) patient were performed. Hospital stay was 4.2 (3 - 13 days) There was one mortality and 12 (19%) morbidities. No recurrence on follow up period (8 - 60 months) was observed. Conclusion: Radical procedure is safe and effective option for hepatic hydatidosis and should be performed when the entire lobe is diffusely involved by huge or multiple hydatidosis with little healthy liver tissue.

关键词： Ecchinococcosis Hepatic Hydatidosis Hepatic Resection mortality morbidity

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