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Combinatory effect of hesperetin and mesenchymal stem cells on the deteriorated lipid profile,heart and kidney functions and antioxidant activity in STZ-induced diabetic rats

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BIOCELL 2020年第1期44卷 27-39页

作者： osama m.ahmed mohamed A.HASSAN Ablaa S.SALEH Experimental Obesity and Diabetes Research Lab(EODRL) Physiology DivisionZoology DepartmentFaculty of ScienceBeni-Suef UniversityPO 62521Beni-SuefEgypt Biochemistry Department Faculty of ScienceBeni-Suef UniversityPO 62521Beni-SuefEgypt

This study aimed to assess the effect of hesperetin and/or bone marrow-derived mesenchymal stem cells(Bm-mSCs)on disturbed lipid profile,heart and kidney functions,oxidative stress and antioxidant defense system in streptozotocin(STZ)-induced diabetic *** 1 diabetes mellitus(T1Dm)was induced in male Wistar rats by injecting 40 mg/kg body weight(b.w.)STZ dissolved in citrate buffer(pH 4.5).The diabetic rats were treated with hesperetin orally administered at dose 20 mg/kg b.w.,Bm-mSCs intravenously injected at a dose of 1 x 106 cells/rat/week and their combination for 6 *** diabetic rats exhibited lipid abnormalities manifested by elevated serum levels of total cholesterol,triglycerides,LDL-cholesterol and VLDL-cholesterol and lowered HDL-cholesterol as well as elevated liver cholesterol and triglycerides content in association with the resultant fasting and postprandial hyperglycemia and insulin *** heart function biomarkers including CK-mB,AST and LDH activities as well as levels of kidney function parameters,creatinine,and urea,were significantly raised in the serum of diabetic *** changes were concomitant with abnormal redox balance represented by elevated lipid peroxidation,decreased glutathione content,and suppressed antioxidant enzyme activities in both heart and kidney of diabetic *** previous deleterious alterations were significantly ameliorated after the treatment of diabetic rats with hesperetin and Bm-mSCs singly or in combination;the treatment with hesperetin together with Bm-mSCs was the most *** on these findings,it can be concluded that the use of hesperetin with Bm-mSCs may have more additive therapeutic value than their uses singly in *** addition,the ameliorative effects of hesperetin and Bm-mSCs on lipid profile and heart and kidney functions in diabetic rats may be mediated,at least in part,via their suppressive effects on oxidative stress and ameliorative effects on the antioxidant defense system

关键词： Bm-mSCs Hesperetin Streptozotocin-induced diabetes

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Thyme oil and thymol abrogate doxorubicin-induced nephrotoxicity and cardiotoxicity in Wistar rats via repression of oxidative stress and enhancement of antioxidant defense mechanisms

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BIOCELL 2020年第1期44卷 41-53页

作者： osama m.ahmed Sanaa R.GALALY mai RASLAN mennah-Allah m.A.mOSTAFA Physiology Division Zoology DepartmentFaculty of ScienceBeni-Suef UniversityP.O.Box 62521Beni-SuefEgypt Cell Biology Histology and Genetics DivisionZoology DepartmentFaculty of ScienceBeni-Suef UniversityP.O.Box 62521Beni-SuefEgypt Biotechnology and Life Sciences Department Faculty of Postgraduate Studies for Advanced SciencesBeni-Suef UniversityBeni-SuefB.O.Box 62511Egypt

This study aimed to assess the preventive effects of thyme oil and thymol on doxorubicin(DOX)-induced renotoxicity,cardiotoxicity,and oxidative stress in Wistar *** oil was subjected to GC-mS analysis,which indicated that thymol was the major constituent representing 33.896%.Rats intraperitoneally injected with DOX at a dose of 2 mg/kg b.w./one per week for 7 weeks were co-treated with thyme oil and its major constituent,thymol,at doses 250 and 100 mg/kg b.w./every other day,respectively,by oral gavage for the same *** oil and thymol markedly ameliorated the raised levels of serum urea,uric acid,and creatinine in DOX-administered *** also reduced the elevated activities of serum CK-mB and *** oil was more effective than thymol in decreasing the elevated serum creatinine level and serum CK-mB activity in DOX-administered rats,thereby reflecting its more potent effect on kidney and heart *** peroxidation significantly decreased while GSH level and GST and GPx activities significantly increased in kidney and heart of DOX-administered rats treated with thyme oil and *** DOX-induced perturbed kidney histological changes including congestion of glomerulus tuft,inflammatory cells infiltration,protein cast in lumina of the renal tubule,and thickening of the parietal layer of Bowman’s capsule were remarkably ameliorated as a result of treatment with thyme oil and thymol;thyme oil was more *** addition,DOX-induced deleterious heart histological alterations,including intramuscular infiltration of inflammatory cells,focal necrosis of cardiac myocytes,and edema,were remarkably reduced by treatment with thyme oil and ***,it can be concluded that DOX could induce marked toxicity in kidney and heart,and the treatment with thyme oil or thymol produced potential improvement of kidney and heart function and histological integrity via repression of oxidative stress and enhancement of antioxidant defense mechanisms.

关键词： Doxorubicin Nephrotoxicity Cardiotoxicity Oxidative stress Thyme oil Thymol

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Anti-proliferative and apoptotic efficacy of diallyl disulfide onEhrlich ascites carcinoma

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Hepatoma Research 2015年第1期1卷 67-74页

作者： osama m.ahmed Rasha R.ahmed Physiology Division Zoology DepartmentFaculty of ScienceBeni-Suef UniversityBeni-Suef 62514Egypt Faculty of Oral and Dental medicine Nahda UniversityBeni-Suef 11787Egypt Cell Biology Histology and Genetics DivisionZoology DepartmentFaculty of ScienceBeni-Suef UniversityBeni-Suef 62514Egypt

Aim:This study was conducted to assess the in vivo and in vitro anti-tumor effects of diallyl disulfi de(DADS)against Ehrlich ascites carcinoma(EAC)and to suggest its probable mechanism of ***:EAC was induced in female mice by intraperitoneal injection of EAC-cells from stock ***-bearing mice were orally treated with 100 mg/kg body weight for 2 weeks beginning from the 1st day of EAC intraperitoneal *** effects of DADS against EAC-cells in vitro were investigated at different concentrations(0,6.25,12.5,25,50,and 100μg/mL)of DADS using trypan blue exclusion ***:Data from this study exhibited a signifi cant decrease in EAC-aliquot volume as well as total and alive EAC-cell number and a marked increase in dead EAC-cell number and percent in EAC-bearing mice treated with DADS as compared with EAC-bearing *** changes were consistent with increased number of cells which exhibited phenotypic apoptotic signs marked by a decrease in the expression of anti-apoptotic protein Bcl-2,an increase of pro-apoptotic and cell cycle arrest mediator p53 and an elevation of DNA fragmenting indicator terminal deoxynucleotidyl transferase in EAC-bearing mice treated with *** addition,the tumor marker sialic acid level was markedly decreased in plasma and Ehrlich ascites in EAC-bearing mice treated with *** vitro,DADS also produced anti-proliferative and anti-tumor cytotoxic potentials against ***:DADS may have anti-cancer effects which may be mediated via modulation of apoptosis and cell cycle arrest.

关键词： Anti-proliferative effects apoptosis diallyl disulfi de Ehrlich ascites carcinoma imaging semi-quantitative analysis

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Perspective on early lens extraction for primary angle-closure glaucoma

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Eye Science 2017年第1期32卷 9-11页

作者： osama m.ahmed Lisa A.Hark michael Waisbourd Glaucoma Research Center Wills Eye HospitalPhiladelphiaPAUSA Department of Ophthalmology Tel-Aviv Medical CenterAffiliated to the Sackler Faculty of MedicineTel-Aviv UniversityTel-AvivIsrael

Primary angle-closure glaucoma(PACG)is a subtype of glaucoma that affects 16 million people worldwide,of whom4 million are bilaterally *** prevalence of PACG is expected to increase to 21 million cases by 2020,and it ... 详细信息

关键词： PACG IOP Perspective on early lens extraction for primary angle-closure glaucoma LPI

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Surface activation of viscose textiles via air,argon,and oxygen dielectric barrier discharge plasma:influence of peak voltage

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Plasma Science and Technology 2024年第7期26卷 134-147页

作者： Shrouk ELASHRY Usama m.RASHED mostafa A.WAHBA Hend m.ahmed Nabil m.ELSIRAGY Plasma Laboratory Physics DepartmentFaculty of scienceTanta UniversityTanta 31527Egypt Physics Department Faculty of Science(Male)Al-Azhar UniversityCairo 11651Egypt Textile Research Industrial Division National Research CentreDokkiGiza 12622Egypt

This paper discusses the use of atmospheric pressure dielectric barrier discharge(DBD)plasma treatment to enhance the surface qualities of viscose *** study explores the effects of different plasma gases,discharge voltages,and exposure times on the treated *** findings emphasize the importance of optimizing the plasma's peak voltage to achieve the desired surface treatment *** document also presents data on colour strength,wettability,colour fastness,and tensile strength of the treated fabrics,as well as scanning electron microscopy(SEm)analysis of surface morphology and chemical analysis using fouriertransition infrared spectroscopy(FTIR)and energy dispersive X-ray(EDX).The results show that treatment at a peak voltage of 11.83 k V is more efficient,except for the tensile strength which is enhanced at a peak voltage of 8.92 k *** oxygen plasma treatment significantly improves the colour strength,which exhibits an increase from 11 to *** intensified colour was attributed to the significant influence of electrostatic interactions between the charged hydroxyl groups of the oxygen plasma treated viscose textiles and the dye molecules,which enhance the *** oxygen DBD plasma exhibits a higher ability to enhance the properties of textiles when compared to air and argon *** study presents a sustainable,economical,secure,and ecologically friendly approach to explore new fabrics for specific uses.

关键词： Lissajous diagrams printability wettability tensile strength SEm EDX FTIR

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Arrhythmia Detection by Using Chaos Theory with machine Learning Algorithms

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Computers, materials & Continua 2024年第6期79卷 3855-3875页

作者： maie Aboghazalah Passent El-kafrawy Abdelmoty m.ahmed Rasha Elnemr Belgacem Bouallegue Ayman El-sayed math and Computer Science Department Faculty of ScienceMenoufia UniversityShebin El-komEgypt College of Engineering Computer Science DepartmentEffat UniversityJeddahKingdom of Saudi Arabia Department of Computer Engineering College of Computer ScienceKing Khalid UniversityAbha61421Saudi Arabia Computer Science and Engineering Department Faculty of Electronic EngineeringMenoufia UniversityShebin El-komEgypt Climate Change Information Center and Expert Systems Agriculture Research CenterGizaEgypt

Heart monitoring improves life ***(ECGs or EKGs)detect heart *** learning algorithms can create a few ECG diagnosis processing *** first method uses raw ECG and time-series *** second method classifies the ECG by patient *** third technique translates ECG impulses into Q waves,R waves and S waves(QRS)features using richer *** ECG signals vary naturally between humans and activities,we will combine the three feature selection methods to improve classification accuracy and *** using all three approaches have not been examined till *** researchers found that machine Learning(mL)techniques can improve ECG *** study will compare popular machine learning techniques to evaluate ECG *** algorithms—Support Vector machine(SVm),Decision Tree,Naive Bayes,and Neural Network—compare categorization *** plus prior knowledge has the highest accuracy(99%)of the four mL *** characteristics failed to identify signals without chaos *** 99.8%classification accuracy,the Decision Tree technique outperformed all previous experiments.

关键词： ECG extraction ECG leads time series prior knowledge and arrhythmia chaos theory QRS complex analysis machine learning ECG classification

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Tilted global solar irradiance in Bahrain:an experimental study

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Clean Energy 2024年第2期8卷 27-34页

作者： N.Vasilikos C.Georgantopoulou H.Alajaimi S.H.Almajed m.ahmed D.mathioulakis School of mechanical Engineering Bahrain PolytechnicIsa TownPO Box 33349Kingdom of Bahrain School of mechanical Engineering National Technical University of AthensHeroon Polytechniou 7 StZografos 15773AthensGreece

In the present work,tilted global solar irradiance data are presented and analysed,measured for a period of 1 year on the campus of Bahrain Polytechnic,Kingdom of Bahrain,from both a fixed photovoltaic panel and a moving one via a two-axis solar *** fixed panel faces south with an angle of 26°with respect to the horizontal,coinciding with the local geographical *** second panel is moved by two motors,controlled by a global positioning system and suitable software so that the Sun’s rays are perpendicular to the panel surface.A pyranometer is installed on each panel,recording the tilted global solar irradiance,stored by using a data *** analysis of the data obtained shows a 33%solar energy gain on an annual basis for the moving panel(2780 versus 2088 kWh/m^(2) on the fixed panel).more importantly,in June,when the energy demand in Bahrain is elevated due to the increased residential cooling loads,the solar energy received by the moving panel is 54.7%higher compared with that of the fixed *** a percentage basis,the increase in solar energy from the moving panel is profound in the early morning and late evening ***,the reduction in the solar energy received by the fixed panel from may to June does not appear in the moving panel because of the adjustable orientation of the *** the year,the mean daily solar power varies between 0.37 and 0.56 kW/m^(2) for the fixed panel,and 0.45 and 0.70 kW/m^(2) for the moving *** winter,solar energy fluctuations are elevated due to erratic weather conditions that present a peak standard deviation of 28%of the corresponding *** data presented are useful for potential solar investments in Gulf countries.

关键词： tilted solar irradiance renewable energy solar tracking photovoltaic Gulf Cooperation Council Countries

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EDSUCh:A robust ensemble data summarization method for effective medical diagnosis

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Digital Communications and Networks 2024年第1期10卷 182-189页

作者： mohiuddin ahmed A.N.m.Bazlur Rashid School of Science Edith Cowan UniversityPerthAustralia

Identifying rare patterns for medical diagnosis is a challenging task due to heterogeneity and the volume of *** summarization can create a concise version of the original data that can be used for effective *** this paper,we propose an ensemble summarization method that combines clustering and sampling to create a summary of the original data to ensure the inclusion of rare *** the best of our knowledge,there has been no such technique available to augment the performance of anomaly detection techniques and simultaneously increase the efficiency of medical *** performance of popular anomaly detection algorithms increases significantly in terms of accuracy and computational complexity when the summaries are ***,the medical diagnosis becomes more effective,and our experimental results reflect that the combination of the proposed summarization scheme and all underlying algorithms used in this paper outperforms the most popular anomaly detection techniques.

关键词： Data summarization Ensemble medical diagnosis Sampling

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A statistical approach to enhance the productivity of Streptomyces baarensis mH-133 for bioactive compounds

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Synthetic and Systems Biotechnology 2024年第2期9卷 196-208页

作者： mohamed H.Kalaba Gamal m.El-Sherbiny osama m.Darwesh Saad A.moghannem Botany and microbiology Department Faculty of Science(Boys)Al-Azhar UniversityCairo 11884Egypt Agricultural microbiology Department National Research CentreDokkiCairoEgypt

The goal of this study was to use statistical optimization to change the nutritional and environmental conditions so that Streptomyces baarensis mH-133 could make more active *** trials were used to screen for critical variables influencing productivity using the Placket-Burman Design *** mH-133 is significantly influenced by elicitation,yeast extract,inoculum size,and incubation period in terms of antibacterial activity.A total of 27 experimental trials with various combinations of these factors were used to carry out the response surface technique using the Box-Behnken *** analyses revealed that the model was highly significant(pmination(R2)of ***,the model predicted that the response as inhibition zone diameter would reach a value of 27 *** optimal conditions,*** mH-133 produced 18.0 g of crude extract to each 35L and was purified with column *** active fraction exhibiting antibacterial activity was characterized using spectroscopic *** mIC and mBC values varied between 37.5 and 300μg/ml and 75 and 300μg/ml,*** conclusion,the biostatistical optimization of the active fraction critical variables,including environmental and nutritional conditions,enhances the production of bioactive molecules by Streptomyces species.

关键词： S.baarensis mH-133 Placket-Burman designBox-Behnken design ESKAPE Antibacterial activity

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Improving the Transmission Security of Vein Images Using a Bezier Curve and Long Short-Term memory

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Computers, materials & Continua 2024年第6期79卷 4825-4844页

作者： ahmed H.Alhadethi Ikram Smaoui ahmed Fakhfakh Saad m.Darwish Computer Science and School of Electronics and Telecommunications University of SfaxSfax3029Tunisia LETI Laboratory University of SfaxSfax3029Tunisia Digital Research Center of Sfax Technopark of SfaxSfax3029Tunisia Department of Information Technology Institute of Graduate Studies and ResearchAlexandria UniversityAlexandriaEgypt

The act of transmitting photos via the Internet has become a routine and significant *** the security measures to safeguard these images from counterfeiting and modifications is a critical domain that can still be further *** study presents a system that employs a range of approaches and algorithms to ensure the security of transmitted venous *** main goal of this work is to create a very effective system for compressing individual biometrics in order to improve the overall accuracy and security of digital photographs by means of image *** paper introduces a content-based image authentication mechanism that is suitable for usage across an untrusted network and resistant to data loss during *** employing scale attributes and a key-dependent parametric Long Short-Term memory(LSTm),it is feasible to improve the resilience of digital signatures against image deterioration and strengthen their security against malicious ***,the successful implementation of transmitting biometric data in a compressed format over a wireless network has been *** applications involving the transmission and sharing of images across a *** suggested technique utilizes the scalability of a structural digital signature to attain a satisfactory equilibrium between security and picture *** effective adaptive compression strategy was created to lengthen the overall lifetime of the network by sharing the processing of *** scheme ensures a large reduction in computational and energy requirements while minimizing image quality *** approach employs multi-scale characteristics to improve the resistance of signatures against image *** proposed system attained a Gaussian noise value of 98%and a rotation accuracy surpassing 99%.

关键词： Image transmission image compression text hiding Bezier curve Histogram of Oriented Gradients(HOG) LSTm image enhancement Gaussian noise rotation

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