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Advances in Breast Cancer Research 2013年第3期2卷 86-90页

作者： Adel Denewer Waleed Elnahas osama hussein Ashraf Khater Wael El-sadda Khaled M. Abouelkher Mansoura Oncology Center Mansoura Egypt

Background: The treatment of breast cancer in large breast patients represents a great challenge to both surgical oncologist and radiation oncologist. The aim of this study is to evaluate the outcome of inferior pedicle therapeutic mammoplasty in large-breasted patients with upper quadrants early breast cancer. Methods: Thirty five large-breasted patients with early breast cancer were included in this study. Simultaneous bilateral inferior pedicle therapeutic mammoplasty was performed. Results: The age of the patients is ranged from 36 to 61 (median 46) years and tumour size is ranged from one to three and half cm. The weight of tissue removed is ranged from 350 gm to 780 gm and the tumour safety margins are ranged from three to eight cm. Wound dehiscence was the commonest post operative complications and six patients were affected (17.6%). The cosmetic outcome was excellent in 22 patients (64.5%), nine patients (26.5%) showed good results, two patients (6%) were satisfactory and one patient (3%) showed poor result. The follow up period is ranged from 6 to 42 months with one case (3%) of systemic metastasis. Conclusion: Inferior pedicle therapeutic reduction mammoplasty for upper quadrants early breast cancer in large breasted women is a surgically and oncologically safe procedure, and it carries a satisfactory aesthetic outcome.

关键词： Breast Cancer Conservative Surgery Reduction Therapeutic Mammoplasty

Totally Endoscopic (Thoracoscopic and Laparoscopic) Radical Esophagectomy with Gastric Tube Reconstruction through a Small Neck Incision: An Early Experience with Thirty Egyptian Patients

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Surgical Science 2014年第5期5卷 214-223页

作者： Adel Denewer Adel Fathi Ahmed Setit Mohamed Hegazy Ashraf Khater osama hussein Sameh Roshdy Fayez Shahatto Fathy Denewer Department of Surgical Oncology Oncology Center (OCMU) Faculty of Medicine Mansoura University Mansoura Egypt

Background: Minimally invasive esophagectomy nowadays is replacing the classic open technique. Additional studies are needed to confirm its safety and efficacy. Methods: thirty patients with esophageal carcinoma were enrolled in this study. Patients were evaluated preoperatively and they underwent thoracoscopic and laparoscopic procedures for assessment of resectability. Resectablepatients underwent radical esophagectomy with gastric tube reconstruction through a four-cm neck incision. Results: 17 patients were operable and 13 patients were inoperable. The mean operative time for the whole procedure was 5.97 ± 1.66 hours. The mean blood loss was 250 ± 138.07 cc. The mean overall hospital stay was 17.47 ± 5.49 daysdays. Common postoperative complications included pneumonia (13.3%) pleural effusion (6.7%), cervical anastomotic leakage (10%), and wound infection (13.3%). One patient died in the early postoperative period. Conclusions: we conclude that totallyendoscopic (thoracoscopic and laparoscopic) esophagectomy is feasible and relatively safe technique. Beside its efficacy as an assessment tool, total esophagectomy and lymphadenectomy could be performed in the same time.

关键词： Thoracoscopic Laparoscopic Radical Esophagectomy Gastric Reconstruction Esophagus Cancer

Evaluation of Surgical Outcome after Resection of Pancreatic Tumors, Our Experience in Mansoura Oncology Center, a Middle-Volume Center in Egypt

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Journal of Cancer Therapy 2012年第5期3卷 477-481页

作者： Nazem Shams Mahmoud Mosbah Mohammad Hegazy osama hussein Omar Farouk Sameh Roshdy Mohamed Tarek Hafez Ashraf Khater Khaled Abdel Wahab Oncology Center Mansoura University Mansoura Egypt

Background: Pancreatic cancer is the fourth most common cause of cancer related deaths in the world. Surgical resection remains the only potentially curative treatment for adenocarcinoma of the pancreas;only 10% - 20% of patients are candidate for standard pancreatic resection. Objective: To evaluate perioperative mortality, morbidity and survival for patients underwent PD in middle-volume center. Patients and Methods: Sixty patients with pancreatic tumors were enrolled in this study for different surgical procedure according to type of tumors. Results: No early postoperative complications were observed in 60% of patients, whereas 40% of patients developed one or more complication, the median survival for this group was 12.3 months with standard deviation 3.8 months.

关键词： Pancreatic Cancer Whipple Complication Survival

Therapeutic Mammoplasty in Management of Breast Cancer: A Prospective Clinical Study

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Advances in Breast Cancer Research 2017年第4期6卷 107-116页

作者： Ahmed Mohamed Farahat Amr Abdel Meguid Attia Mohamed Aly M. El Shafei El Zawahry Mohamed H. Zedan hussein osama Soliman National Cancer Institute Cairo University Giza Egypt

Background: The introduction of oncoplasticbreast surgery, with a concomitant contralateral symmetrization procedure, allows the surgical oncologist the freedom to perform wider excisions, with more favorable cosmetic outcomes. Objective: To assess the feasibility of bilateral breast reduction for the management of breast cancer, and to determine the most suitable surgical technique of therapeutic mammoplasty for each patient. And to evaluate the cosmetic outcome during the postoperative period. Methods: This study was from June 2014 until June 2016, and included 86 female patients with breast cancer;divided in 3 groups;group A;had bilateral superior pedicle reduction mammoplasty, group B;had bilateral inferior pedicle reduction mammoplasty, group C;had bilateral batwing mastopexy. 1 month postoperative, patients were asked to answer a 5-scale questionnaire evaluating their own cosmetic outcome. Criteria they were asked to evaluate were: symmetry, shape and volume, projection, correction of ptosis, visibility of the scars and overall satisfaction. A similar questionnaire was answered by a panel made up of a surgeon and breast-care nurse after seeing the pre- and post-operative photos of the patients in question. Results: Group A had a mean tumor size of 2.7 ± 0.69 cm, least resected margins 1.2 - 4.3 cm, Group B had a mean tumor size of 3.2 ± 1.19 cm, least resected margins 0.7 - 3.8 cm, Group C had a mean tumor size of 3.4 ± 1.12 cm, least resected margins 1.7 - 5.2 cm. Cosmetic results fared high above average. Group C fared better in overall satisfaction but Group B fared better in ptosis correction, projection and symmetry. The panel answers showed difference regarding shape and volume;the only two criteria to be almost of the same result among the three groups. Conclusion: Bilateral TM has some advantages when compared to standard conventional BCS techniques without having any unfavorable effects on surgical margin confidence, local recurrence, and survival rat

关键词： Breast Oncoplasty Therapeutic Mammoplasty Surgery Oncology Plastic Symmetry

In-hospital outcomes of transapical versus surgical aortic valve replacement: from the U.S. national inpatient sample

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Journal of Geriatric Cardiology 2021年第9期18卷 702-710页

作者： Ashraf Abugroun osama Hallak Ahmed Taha Alejandro Sanchez-Nadales Saria Awadalla hussein Daoud Efehi Igbinomwanhia Lloyd W Klein Department of Internal Medicine Medical College of Wisconsin(MCW)WIUSA Division of Cardiology Ketter-ing Medical CenterOHUSA Department of Internal Medicine School of MedicineIndiana UniversityIndianapolisIndianaUSA Department of Cardiovascular Disease Cleveland Clinic FloridaFLUSA Division of Epidemiology&Biostatistics University of Illinois-ChicagoILUSA Division of Cardiology Creighton UniversityNEUSA Department of Cardiology Case Western Reserve University(MetroHealth)OHUSA University of California San Francisco(UCSF)San FranciscoCAUSA

OBJECTIVE To compare the outcomes of transapical transcatheter aortic valve replacement(TA-TAVR)and surgical aortic valve replacement(SAVR)using a large US population *** The *** Inpatient Sample was queried for all patients who underwent TA-TAVR or SAVR during the *** primary outcome was all-cause in-hospital *** outcomes were in-hospital stroke,pericardiocentesis,pacemaker insertion,mechanical ventilation,vascular complications,major bleeding,acute kidney injury,length of stay,and cost of *** were modeled using multi-variable logistic regression for binary outcomes and generalized linear models for continuous *** A total of 1560 TA-TAVR and 44,280 SAVR patients were *** who underwent TA-TAVR were older and *** to SAVR,TA-TAVR correlated with a higher mortality(4.5%vs.2.7%,effect size(SMD)=0.1)and higher periprocedural *** multivariable analysis,both TA-TAVR and SAVR had a similar adjusted risk for in-hospital ***-TAVR correlated with lower odds of bleeding with(adjusted OR(aOR)=0.26;95%CI:0.18-0.38;P<0.001),and a shorter length of stay(adjusted mean ratio(aMR)=0.77;95%CI:0.69-0.84;P<0.001),but higher cost(aMR=1.18;95%CI:1.10-1.28;P<0.001).No significant differences in other study *** subgroup analysis,TA-TAVR in patients with chronic lung disease had higher odds for mortality(aOR=3.11;95%CI:1.37-7.08;P=0.007).CONCLUSION The risk-adjusted analysis showed that TA-TAVR has no advantage over SAVR except for patients with chronic lung disease where TA-TAVR has higher mortality.

关键词： logistic In-hospital outcomes of transapical versus surgical aortic valve replacement from the U.S national inpatient sample

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GNSS定位接收器的校准

Journal of Measurement Science and Instrumentation 2021年第2期12卷 160-169页

作者： Karim Elglmadya Hatem hussein osama Terra Mohamed Medhat 国家标准学会吉萨12211 艾因夏姆斯大学理学院开罗11435

目前,全球导航卫星系统(Global navigation satellite system,GNSS)接收器不仅是精密测量的主要工具,而且还用于大地测量、地球物理和许多其他工业应用中。确保GNSS测量精度、通用性和寿命的唯一方法是对其接收机进行校准。本文讨论了... 详细信息

目前,全球导航卫星系统(Global navigation satellite system,GNSS)接收器不仅是精密测量的主要工具,而且还用于大地测量、地球物理和许多其他工业应用中。确保GNSS测量精度、通用性和寿命的唯一方法是对其接收机进行校准。本文讨论了影响单台GNSS接收机标定精度的参数,并根据以往的经验研究,建立了一个大地基准点作为校准的参考。此外,还讨论了这种校准对国际单位(Systeme international unit,SI unit)的可追溯性。通过三年多的长期测量,验证了基准点的稳定性。最后,对单台样本GNSS接收机进行了标定,并推导了不确定度计算公式。

关键词：全球导航卫星系统全球定位系统接收器校准

Coxiella burnetii,the causative agent of Q fever in Saudi Arabia:molecular detection from camel and other domestic livestock

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Asian Pacific Journal of Tropical Medicine 2014年第9期7卷 715-719页

作者： osama B.Mohammed Abdulrahman A.Jarelnabi Riyadh S.Aljumaah Mohammed A.Alshaikh Amel O.Bakhiet Sawsan A.Omer Abdulaziz N.Alagaili Mansour F.hussein KSU Mammals Research Chair Department of ZoologyCollege of ScienceKing Saudi University Department of Animal Production College of Food & Agricultural SciencesKing Saudi University College of Veterinary Medicine Sudan University of Science and Technology Department of Zoology College of ScienceKing Saud UniversityUniversity Centre for Women StudentsRiyadh 11495Saudi Arabia Saudi Wildlife Authority Riyadh 11575Saudi Arabia

Objective:To detect Coxiella burnetii(***)DNA in clinical specimens from camel,goats,cattle and sheep in the Kingdom of Saudi ***:A total of 367 clinical samples including blood,milk,faeces and urine were collected from different livestock and subjected to PCR amplification using primers which amplify transposon-like region and transposase ***:Positive amplification from both regions was obtained from camel,goats and cattle but not from sheep.A percentage of 10.8%samples yielded positive PCR amplification from both blood and milk,where 15 of 139 blood and 16 of 148 milk samples were *** and urine showed higher percentages of positive samples reaching 40.8%and 23.8%***:The preferred route of shedding in camel appeared to be the faeces followed by urine,while that of goats appeared to be the faeces and that of the cattle appeared to be the milk.

关键词： Coxiella burnetii Camel PCR Saudi Arabia Zoonotic disease

Energy Auditing and Improvement Scheme for Faculty of Applied Medical Sciences at Taibah University

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Open Journal of Energy Efficiency 2020年第1期9卷 64-80页

作者： Khaled S. AlQdah osama Alhazmi Mustafa Mohammad Abdulelah Alzahrani hussein Alaqeel Mechanical Engineering Department College of Engineering Taibah University Medina KSA

In this work, a survey is used to investigate the current energy performance for Faculty of Applied Medical Sciences (previously Faculty of Engineering) at Taibah University in Medina city. The results of the survey show that several factors affect the energy performance in this building. It revealed that the building has been poorly designed from the point of view of thermal performance. Therefore, the building energy consumption needs to be monitored and maintained through energy auditing program. To determine the energy profile, the power consumption was calculated;the cooling load was estimated and analyzed to know the actual capacity required. The level of comfort in the building has been evaluated. Against the installed air conditioning capacity of 200-ton refrigeration, the cooling load calculations showed that the maximum cooling load needed, which is in August is only 83.22-ton refrigeration. In addition, illumination levels were measured and compared to the standard levels. Based on obtained results, two solutions were proposed: to install a building management system with approximate cost of 337,904 SR and to replace the existing chiller. Finally, the payback period for the proposed system has been estimated and found to be about 5.4 years.

关键词： Auditing Payback Period Cooling Load Building Management System Illumination

Differential control of growth,apoptotic activity and gene expression in human colon cancer cells by extracts derived from medicinal herbs,Rhazya stricta and Zingiber officinale and their combination

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World Journal of Gastroenterology 2014年第41期20卷 15275-15288页

作者： Ayman I Elkady Rania Abd El Hamid hussein osama A Abu-Zinadah Department of Biological Sciences Faculty of SciencesKing Abdulaziz University Zoology Department Faculty of ScienceAlexandria University Department of Clinical Nutrition Faculty of Applied Medical SciencesKing Abdulaziz University Gamal Abd El Nasser Hospital

AIM:To investigate the effects of extracts from Rhazya stricta(***) and Zingiber officinale(***) on human colorectal cancer ***:Human colorectal cancer cells(HCT116) were subjected to increasing doses of crude alkaloid extracts from ***(CAERS) and crude flavonoid extracts from ***(CFEZO).Cells were then harvested after 24,48 or 72 h and cell viability was examined by trypan blue exclusion dye test; clonogenicity and soft agar colony-forming assays were also carried *** stain(Hoechst 33342),acridine orange/ethidium bromide double staining,agarose gel electrophoresis and comet assays were performed to assess pro-apoptotic potentiality of the *** reverse transcription-polymerase chain reaction(qRT-PCR),using gene-specific primers and Western blot analyses were performed to assess the impact of CAERS and CFEZO on the expression levels of key regulatory proteins in HCT116 ***:Treatment with a combination of CAERS and CFEZO synergistically suppressed the proliferation,colony formation and anchorage-independent growth of HCT116 *** IC50,after 24,48 and 72 h,were 70,90 and 130 μg/mL for CAERS,65,85 and 120 μg/mL for CFEZO and 20,25 and 45 μg/mL for both agents,***- and CFEZO-treated cells exhibited morphologic and biochemical features of apoptotic cell *** induction of apoptosis was associated with the release of mitochondrial cytochrome c,an increase in the Bax/Bcl-2 ratio,activation of caspases 3 and 9 and cleavage of poly ADP-ribose *** and CFEZO treatments downregulated expression levels of anti-apoptotic proteins including Bcl-2,Bcl-X,Mcl-1,survivin and XIAP,and upregulated expression levels of proapoptotic proteins such as Bad and *** and CFEZO treatments elevated expression levels of the oncosuppressor proteins,p53,p21 and p27,and reduced levels of the oncoproteins,cyclin D1,cyclin/cyclin-dependent kinase-4 and ***:These data

关键词： Apoptosis Colorectal cancer Oncogenes Phytochemica

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干涉测距仪测量不确定度评估(英文)

Journal of Measurement Science and Instrumentation 2014年第3期5卷 73-78页

作者： osama Terra Hatem hussein Mohamed Amer Primary Length Standard and Laser Technology Laboratory National Institute for Standard (NIS) Engineering and Surface Metrology Laboratory National Institute for Standard (NIS)

本文对与干涉测距仪(IDM)测量不确定度有关的参数进行了讨论。采用一个简单、鲁棒装置测量了约12 cm距离,扩展不确定性为±16.4μm,发现测量不确定度受波长测量精度制约。该设置可测量距离达56 m,它也能够轻松确定测量臂和参考臂之间等... 详细信息

本文对与干涉测距仪(IDM)测量不确定度有关的参数进行了讨论。采用一个简单、鲁棒装置测量了约12 cm距离,扩展不确定性为±16.4μm,发现测量不确定度受波长测量精度制约。该设置可测量距离达56 m,它也能够轻松确定测量臂和参考臂之间等光程差的点。LabVIEW程序用于条纹的计数,快速傅立叶变换(FFT)对噪声按频率进行选择性过滤。虽然本文对不确定性的测定不能代表同类测量距离的最高不确定度,但该测量方法提供了可溯源于长度单位为米的测量值。

关键词：距离测量长度测量光学干涉仪