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Structural analysis of silk using solid-state NMR

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Magnetic Resonance Letters 2024年第3期4卷 19-34页

作者： tetsuo Asakura Department of Biotechnology Tokyo University of Agriculture and TechnologyKoganeiTokyo184-8588Japan

Silkworms and spiders are capable of generating fibers that are both highly durable and elastic in a short span of time,using a silk solution stored within their bodies at room temperature and normal atmospheric *** dragline silk fiber,which is essentially a spider's lifeline,surpasses the strength of a steel wire of equivalent ***,humans have yet to replicate this process to produce fibers with similar high strength and elasticity in an eco-friendly ***,it is of utmost importance to thoroughly comprehend the extraordinary structure and fibrillation mechanism of silk,and leverage this understanding in the manufacturing of high-strength,high-elasticity *** review will delve into the recent progress in comprehending the structure of silks derived from silkworms and spiders,emphasizing the distinctive attributes of solidstate NMR.

关键词： Silk Bombyx mori Spider Solid-state NMR Structure

基于溶胶-凝胶技术结合多壁纳米碳管化学修饰电极的方法制备高灵敏葡萄糖生物传感器的研究

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高技术通讯 2006年第5期16卷 492-496页

作者：黄加栋宋昭杨钰吴宝艳史海滨长哲郎陈强南开大学生命科学学院天津300071 日本东北大学药学部仙台980-8578

基于多壁纳米碳管修饰铂电极与二氧化硅溶胶-凝胶（sol-gel）固定化酶相结合的技术制备了葡萄糖氧化酶传感器,充分利用了溶胶-凝胶固定化酶稳定的优点和纳米碳管的高灵敏电催化作用,优化了该酶传感器的制备过程,提高了传感器的电流响应... 详细信息

基于多壁纳米碳管修饰铂电极与二氧化硅溶胶-凝胶（sol-gel）固定化酶相结合的技术制备了葡萄糖氧化酶传感器,充分利用了溶胶-凝胶固定化酶稳定的优点和纳米碳管的高灵敏电催化作用,优化了该酶传感器的制备过程,提高了传感器的电流响应和反应线性.结果表明,sol-gel构建的优化条件是：H2O：TEOS为2.5～3.5,TritonX-100浓度为5%,pH值为5.5.在本实验条件下,多壁纳米碳管的最适固定量为5μl（0.25g/L）,溶胶-凝胶与酶的优化体积比为3：2.工作电位＋0.55V、pH 6.5、25℃为制备传感器的最适工作条件.该传感器对葡萄糖在0.5～6 mmol/L呈线性响应,响应时间为20 s,检出限为0.05mmol/L,45天时的响应值仍保持90%.

关键词：溶胶-凝胶多壁纳米碳管化学修饰电极葡萄糖氧化酶电流型生物传感器

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纳米颗粒对葡萄糖生物传感器性能影响的研究

高技术通讯 2005年第6期15卷 50-54页

作者：吴宝艳杨钰宋昭赵紫霞安(齐)顺一长哲郎陈强南开大学生命科学学院天津300071 日本东北大学大学院药学研究科仙台9808578

制备了纳米金颗粒和纳米铜颗粒,分别用以修饰葡萄糖生物传感器,并选用丝网印刷金电极测试研究了纳米颗粒对葡萄糖生物传感器性能的影响.结果表明:纳米铜颗粒不能增强葡萄糖生物传感器的响应电流,并且延长了其响应时间;纳米金颗粒增强了... 详细信息

制备了纳米金颗粒和纳米铜颗粒,分别用以修饰葡萄糖生物传感器,并选用丝网印刷金电极测试研究了纳米颗粒对葡萄糖生物传感器性能的影响.结果表明:纳米铜颗粒不能增强葡萄糖生物传感器的响应电流,并且延长了其响应时间;纳米金颗粒增强了葡萄糖生物传感器的响应电流,缩短了其响应时间,提高了其抗干扰性,但不能拓宽其检测的线性范围,并且响应电流受工作电压的影响较大;随着工作电压的下降,响应电流迅速下降,与未修饰葡萄糖生物传感器响应电流下降趋势一致.

关键词：纳米颗粒葡萄糖生物传感器丝网印刷金电极性能测试

石英晶体微天平实时监测低密度脂蛋白在胆固醇修饰葡聚糖上的吸附及其动力学研究

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高等学校化学学报 2005年第6期26卷 1166-1169页

作者：韩松岩刘东波黄亮王深琪刘清平安齐顺一长哲郎陈强南开大学生命科学学院天津300071 南开大学生物活性材料教育部重点实验室天津300071 日本东北大学大学院药学研究科仙台9808578

利用石英晶体微天平实时监测低密度脂蛋白(LDL)在胆固醇修饰葡聚糖(CMD)上的吸附,并对其吸附动力学进行研究.结果表明,CMD与LDL之间的相互作用符合Langmuir吸附方程,当LDL浓度(ng/μL)为9.9,12.38和14.14时,其吸附平衡常数[K/(mol·L-1... 详细信息

利用石英晶体微天平实时监测低密度脂蛋白(LDL)在胆固醇修饰葡聚糖(CMD)上的吸附,并对其吸附动力学进行研究.结果表明,CMD与LDL之间的相互作用符合Langmuir吸附方程,当LDL浓度(ng/μL)为9.9,12.38和14.14时,其吸附平衡常数[K/(mol·L-1·s-1)]分别为0.0477,0.0536和0.0628,表面吸附量(ng/cm2)分别为107.6,139.6和167.9.最大吸附量达到284.8ng/cm2,吸附率为72.91%.

关键词：石英晶体微天平胆固醇修饰葡聚糖低密度脂蛋白吸附

Herpes simplex keratitis:A brief clinical overview

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World Journal of Virology 2024年第1期13卷 5-32页

作者： Mutali Musa Ehimare Enaholo Gladness Aluyi-osa George Nnamdi Atuanya Leopoldo Spadea Carlo Salati Marco Zeppieri Department of Optometry University of BeninBenin 300283Nigeria Department of Ophthalmology Africa Eye Laser CentreKm 7Benin 300105Nigeria Department of Ophthalmology Centre for Sight AfricaNkpor 434101Nigeria Eye Clinic Policlinico Umberto I"Sapienza"University of RomeRome 00142Italy of Ophthalmology University Hospital of UdineUdine 33100Italy

The aim of our minireview is to provide a brief overview of the diagnosis,clinical aspects,treatment options,management,and current literature available regarding herpes simplex keratitis(HSK).This type of corneal viral infection is caused by the herpes simplex virus(HSV),which can affect several tissues,including the *** significant aspect of HSK is its potential to cause recurrent episodes of inflammation and damage to the *** the initial infection,the HSV can establish a latent infection in the trigeminal ganglion,a nerve cluster near the *** virus may remain dormant for extended *** reactivation of the virus can occur,leading to recurrent episodes of *** triggering reactivation include stress,illness,immunosuppression,or *** episodes can manifest in different clinical patterns,ranging from mild epithelial involvement to more severe stromal or endothelial *** severity and frequency of recurrences vary among *** cases of HSK,especially those involving the stroma and leading to scarring,can result in vision impairment or even blindness in extreme *** cornea's clarity is crucial for good vision,and scarring can compromise this,potentially leading to visual *** management of HSK involves not only treating acute episodes but also implementing long-term strategies to prevent recurrences and attempt repairs of corneal nerve endings via *** medications,such as oral Acyclovir or topical Ganciclovir,may be prescribed for *** immune response to the virus can contribute to corneal ***,caused by the body's attempt to control the infection,may inadvertently harm the corneal *** should be informed about triggers and advised on measures to minimize the risk of *** summary,the recurrent nature of HSK underscores the importance of both acute and long-term management strategies to preserve corneal health and maintai

关键词： Herpes simplex virus Herpes simplex keratitis Acyclovir Neurotization Reactivation

Basic Research on the Burden of Dropping off and Picking up Children: Differences by Employment Type and Gender in the Tokyo Metropolitan Area

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Journal of Transportation Technologies 2024年第3期14卷 445-461页

作者： Jun Morio Koshi Isono Masahiko Kikuchi tetsuo Morita The Institute of Behavioral Sciences (IBS) Tokyo Japan City Bureau Ministry of Land Infrastructure Transport and Tourism Tokyo Japan Maebashi Institute of Technology Maebashi Japan

There is a need to reduce the burden of child drop-off and pick-up for child-rearing generations, but most studies on the actual situation in Japan are based on survey results. In this study, we analyzed differences in child drop-off and pick-up by employment type and gender, utilizing the “Metropolitan Area Person Trip Survey,” which is a statistical data set. The study targeted households in which both spouses were between 30 and 49 years old, had children under the age of 6, and included the following three groups. 1) Dual-income Group 1 (both spouses employed/on contract/temporary);2) Dual-income Group 2 (husband employed/on contract/temporary, wife part-time);3) Full-time housewife group (husband employed, wife unemployed). The analysis revealed that a) wives are almost always responsible for dropping off and picking up their children;b) husbands drop off and pick up their children less frequently in dual-income households;and c) households with children raising within 10 to 30 km of Tokyo Station have longer commuting times and need to reduce the burden of dropping off and picking up their children.

关键词： Drop-Off and Pick-Up Employment Type Gender Dual-Income Households Tokyo Metropolitan Area

Possible viral agents to consider in the differential diagnosis of blepharoconjunctivitis

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World Journal of Virology 2024年第4期13卷 120-134页

作者： Mutali Musa Babatunde Ismail Bale Ayuba Suleman Gladness Aluyi-osa Ekele Chukwuyem FabianaD’Esposito Caterina Gagliano Antonio Longo Andrea Russo Marco Zeppieri Department of Optometry University of BeninBenin 300283Nigeria Department of Ophthalmology Africa Eye Laser Centre LtdBenin 300105Nigeria Department of Ophthalmology Centre for Sight Africa LtdNkpor 434212Nigeria Imperial College Ophthalmic Research Group Unit Imperial CollegeLondon NW15QHUnited Kingdom GENOFTA srl Via A.Balsamo93Naples 80065Italy Department of Medicine and Surgery University of Enna"Kore"Catania 94100Italy Eye Clinic Catania University San Marco HospitalCatania 95121Italy Department of Ophthalmology University Hospital of CataniaCatania 95123Italy Department of Ophthalmology University Hospital of UdineUdine 33100Italy

BACKGROUND Blepharoconjunctivitis poses a diagnostic challenge due to its diverse etiology,including viral *** can be acute or chronic,selflimiting,or needing medical *** To review possible viral agents crucial for accurate differential diagnosis in cases of *** The PubMed database was searched for records relating to viral *** search string generated was“("virally"[All Fields]OR"virals"[All Fields]OR"virology"[MeSH Terms]OR"virology"[All Fields]OR"viral"[All Fields])AND"Blepharoconjunctivitis"[All Fields]".RESULTS A total of 24 publications were generated from the search *** lists from each relevant article were also searched for more information and included in this *** etiologies such as adenovirus,herpes simplex virus(HSV),varicella-zoster virus(VZV),and Epstein-Barr virus(EBV)are frequently *** infections manifest with follicular conjunctivitis and preauricular lymphadenopathy,often presenting as epidemic *** and VZV infections can result in herpetic keratitis and may exhibit characteristic dendritic corneal ***,although less common,can cause unilateral or bilateral follicular conjunctivitis,particularly in immunocompromised *** potential viral agents,such as enteroviruses and molluscum contagiosum virus,should also be considered,especially in pediatric *** Prompt recognition of these viral etiologies is essential for appropriate management and prevention of ***,a thorough understanding of the clinical presentation,epidemiology,and diagnostic modalities is crucial for accurate identification and management of viral blepharoconjunctivitis.

关键词： Viral Blepharoconjunctivitis Herpes simplex virus Varicella-Zoster Epstein-Barr

Anti-Obesity Effects of Dietary d-Allulose and Medium-Chain Triglycerides in High-Fat Diet-Fed Rats

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Food and Nutrition Sciences 2024年第8期15卷 701-710页

作者： Tatsuhiro Matsuo Chihiro Yokoyama Takako Yamada tetsuo Iida Susumu Mochizuki Akihide Yoshihara Kazuya Akimitsu Faculty of Agriculture Kagawa University Miki-cho Japan Research and Development Matsutani Chemical Industry Co. Ltd. Itami Japan

d-Allulose, a rare sugar, exerts anti-obesity effects by inhibiting hepatic lipogenesis and promoting energy expenditure. Medium-chain triglycerides (MCTs) consist of three medium-chain fatty acids connected by glycerol. MCTs have been extensively investigated for their ability to reduce body fat accumulation. We previously investigated the anti-obesity effects of a combination of dietary d-allulose and MCT (5% - 13%) in rats;however, we could not confirm the anti-obesity effects of MCT or observed synergetic effects between d-allulose and MCT on body fat loss. We speculated that our previous studies were influenced by the excessive amount of MCT in the diets. Therefore, in this study, we aimed to investigate the anti-obesity effects of the simultaneous intake of d-allulose and MCT in rats fed an obesity-inducing high-fat diet with a low amount of MCTs (2%). Thirty-two male Wistar rats (3-week-old) were randomly divided into four groups: control, d-allulose, MCT, and d-allulose + MCT groups. Rats in each group were fed ad libitum on a control (no d-Allulose or MCT), 5% d-allulose, 2% MCT, or 5% d-allulose + 2% MCT diets for 16 weeks. Abdominal adipose tissue weights were significantly lower in the d-allulose diet group than in the control group, whereas no differences were observed between results of the MCT-supplemented groups. The total body fat mass was significantly lower in the d-allulose and MCT diet groups than in the control group, but no differences were observed between the MCT-supplemented groups. These results suggested that anti-obesity effects of dietary d-allulose were observed, and the effects of dietary MCTs were weaker than those of d-allulose. Moreover, we confirmed the interaction between dietary d-allulose and MCT on indicators of obesity. Interestingly, their effects were not synergistic, as MCT supplementation offset the anti-obesity effects of dietary d-allulose. However, the specific mechanisms underlying those effects remain unknown, warran

关键词： Rare Sugar d-Allulose Medium-Chain Triglycerides Body Fat Rat

日本东京的极化与分化——基于新自由主义城市政策的分析

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国际城市规划 2024年第2期39卷 40-46页

作者：魏阳城所哲夫西南交通大学东京大学都市工学系

自1970年代以来,新自由主义伴随着全球化的进程从欧美向全球蔓延,日本的城市政策也深受其影响。本文首先提出一个假说,即日本新自由主义的城市政策造成了东京的极化与分化现象。通过国土尺度的分析,笔者观察到自2000年新自由主义成为日... 详细信息

自1970年代以来,新自由主义伴随着全球化的进程从欧美向全球蔓延,日本的城市政策也深受其影响。本文首先提出一个假说,即日本新自由主义的城市政策造成了东京的极化与分化现象。通过国土尺度的分析,笔者观察到自2000年新自由主义成为日本主流城市政策后,东京的单极化趋势明显加速;城市尺度的空间与政策分析结果则反映了东京内部的城市分化日益显著。本文的分析检验并支撑了本文所提假说的有效性,同时证明了东京都政府和各区政府的城市政策与区域绅士化之间存在很强的相关性。本文呼吁,城市规划相关政策应从新自由主义式转向区域协作型,并从大规模城市再开发导向转变为渐进式城市更新导向。在后新自由主义的当下,本文为中国规划理论的范式转型提供了一种路径思考。

关键词：新自由主义单极化城市分化城市政策东京