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Hypergonadotrophic Hypogonadism with Cerebellar Ataxia in a Twenty-Six-Year-Old Female: A Case Report

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Correlates of Tobacco and Marijuana Use among Urban Dwellers in Enugu, Nigeria

Open Journal of Modern Neurosurgery（现代神经外科学进展） 2024年第1期

作者： Bibiana I.Oti Geoffrey Okorie Peter Chime Ethel Chime Birinus Ezeala-Adikaibe casmir orjioke Fintan Ekochin Michael C.Abonyi

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Open Journal of Preventive Medicine 2019年第7期9卷 80-94页

作者： Onodugo Obinna Donatus orjioke casmir Obumneme Bennett Anyim Ezeala-Adikaibe Birinus Adikaibe Chime Peter Onodugo Pauline Nkiruka Mbadiwe Nkeiruka Obumneme-Anyim Ijeoma Nnenne Ekochin Fintan Achor Justin Ezeala-Adikaibe Ngozi Praise Department of Medicine University of Nigeria Teaching Hospital Enugu Nigeria Department of Medicine Enugu State University of Science and Technology Teaching Hospital Enugu Nigeria Department of Pediatrics University of Nigeria Teaching Hospital Enugu Nigeria Federal Neuropsychiatric Hospital Enugu Enugu Nigeria Department of Community Medicine University of Nigeria Teaching Hospital Enugu Nigeria

Introduction: Tobacco and marijuana use is a public health challenge all over the world and especially in Sub Saharan Africa. The combination of low socioeconomic status and substance use can be described as a social and economic disaster for many poor families of Africa. While majority of studies concentrated on cigarette smoking, few studies in Nigeria has been conducted on non-smoke forms of tobacco. The burden of marijuana abuse is also rising in the Nigeria. Similar to cigarette smoking, cannabis use is more common among males. Knowledge of the pattern of tobacco and cannabis use in the community is important considering the public health implications. The aim of this study was to determine the prevalence of tobacco (cigarette smoking and snuff) and cannabis use among adults in an urban communities Enugu, southeast Nigeria. Methods: This was a cross-sectional descriptive study conducted in urban slum settlements in Enugu, the capital of Enugu State, southeast Nigeria. Using a semi structured questionnaire, we collected data selected socio-demographic characteristics, including tobacco use and cannabis use in the last 30 days. The study was conducted between August and December 2013. For database management and statistical analyses, we used the SPSS version 23. Results: The total number of individuals recruited in the study was 1572;844 (52.8%) females and 728 (45.5%) males with a male to female ratio of 0.9:1. Tobacco was used by a total of 270 (17.2%) individuals within the last 4 weeks and marijuana by 23 (1.5%) of the population. Overall, 280 (17.8%) used either one or both tobacco and marijuana. While snuff was predominately used from 60 years and above, cigarette smoking peaked at 30 - 39 years and marijuana use peaked at a younger age of 20 - 29 years. Cigarette smoking positively correlated with male gender (male 1, female 0) and alcohol use (Yes 1, No 0). P Conclusion: The prevalence of cigarette smoking (5.5%), snuff (11.6%) and marijuana use (1.6%) wa

关键词： Tobacco Cigarette Snuff Alcohol Marijuana Nigeria

Diabetes and Pre-Diabetes among Adults in an Urban Slum in South East Nigeria

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Journal of Diabetes Mellitus 2018年第4期8卷 131-144页

作者： Birinus Adikaibe Ezeala-Adikaibe Nkeiruka Mbadiwe Celestine Okwara Obinna Onodugo Chinwe Onyekonwu Uchenna Ijoma Oluchi Stella Ekenze casmir orjioke Peter Chime Eddy Aneke Chidimma Brenda Nwatu Ekenechukwu Young Obumneme Anyim Department of Medicine University of Nigeria Teaching Hospital Enugu Nigeria Department of Medicine Enugu State University Teaching Hospital Enugu Nigeria

Background: Despite the rising prevalence of diabetes in Nigeria and sub-Saharan Africa, few studies have assessed the prevalence of prediabetes and diabetes in people with low socioeconomic status or urban slums. Methods: Using the WHO STEP-wise approach to surveillance of noncommunicable diseases, we estimated the prevalence of diabetes and prediabetes among adults 20 years and older living in two urban slums in Enugu south east Nigeria. Diabetes was defined as previous history of diabetes, use of hypoglycemic agents and fasting blood glucose within the diabetes range on two occasions during the survey period. Study duration was 5 months. Results: Out of the 811 individuals invited to the clinic, 605 (74.6%) participants had their fasting blood glucose measured based on the study protocol. The prevalence of diabetes and prediabetes in the population was 11.7% (95% CI;9.2 - 14.3) and 7.6% (95% CI;5.0 - 9.7) respectively. About 54.9% were newly detected and 28.1% of them had normal control. The prevalence of diabetes peaked at 55 - 64 years. The odds ratio for diabetes was significantly higher in participants ≥ 45 years (1.033, 95% CI;1.208 - 3.420), participants with hypertension (0.442, 95% CI;0.257 - 0.762) and stroke (1.638, 95% CI;0.459 - 5.848). Conclusion: There is a relatively high prevalence of diabetes among adults in two urban slums in Enugu. Public health educational measures promoting prevention and early detection of diabetes should be encouraged. Efforts should be made to educate the populace on the need for early detection and treatment.

关键词： Diabetes Nigeria Obesity Prediabetes Epidemiology Urban Dwellers

Assessment of Migraine Disability Using the Migraine Disability Assessment Questionnaire in Young Nigerians

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World Journal of Neuroscience 2018年第4期8卷 411-422页

作者： Birinus Adikaibe Ezeala-Adikaibe Chinwe Onyekonwu Uchenna Ijoma Nkeiru Mbadiwe Oluchi Stella Ekenze casmir orjioke Ekenechukwu Young Peter Chime Obinna Onodugo Obumneme Anyim Chidimma Brenda Nwatu Celestine Okwara Ikenna Obinwanne Onwuekwe Department of Medicine University of Nigeria Teaching Hospital Enugu Nigeria Department of Medicine Enugu State University of Science and Technology Enugu Nigeria

Background and purpose: Migraine is a common debilitating condition with variable prevalence in young Nigerians with significant deterioration in normal daily functioning and in the quality of life. Few data exist on the disability of migraine in Nigeria. The aim of this study was to measure the headache related disability of patients with migraine using the MIDAS among young Nigerians. Methods: This was a cross sectional study conducted in Enugu South East Nigeria. The questionnaire was designed to assess headache profiles according to ICHD-III beta and disability using the Migraine Disability Assessment Questionnaire. Results: About 40.6% of migraineurs were concerned about headache attacks and 39.1% consulted a doctor because of migraine. Most students were affected due to reduced effectiveness at school and number of days missed from housework—18.8% and 20.3% respectively. Overall, 47.8% had at least one day affected by headache in the last three months. The mean number of days disabled by headache was 14.3 days. The mean headache frequency was 5.7 days and the mean pain intensity was 4.2. About 27.5% of the migraineurs had moderate to severe disability due to migraine. There were no significant differences between males and females. Conclusion: Most with migraine experienced reduction in effectiveness at school and number of days missed from housework. Overall, 47.8% had at least one day affected by headache with an average of 14.3 days disabled by headache and 27.5% of the migraineurs had moderate to severe disability due to migraine.

关键词： Migraine Disability Students Nigerians

Factors Associated with Asymptomatic Proteinuria in Adult Nigerians. A Community-Based Study

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Health 2019年第6期11卷 609-620页

作者： Obinna Onodugo Adikaibe Ezeala-Adikaibe casmir orjioke Pauline Nkiruka Onodugo Uchenna Nkemdilim Ijoma Peter Chime Nkeiruka Mbadiwe Chinwe Onyekonwu Obumneme Benneth Anyim Ijeoma Nnenne Obumneme-Anyim Ekenechukwu Young Chidimma Brenda Nwatu Julius Uwabunkeonye Okoye Monday Ume Nwobodo Department of Medicine University of Nigeria Teaching Hospital Enugu Nigeria Department of Medicine Enugu State University Teaching Hospital Enugu Nigeria Department of Pediatrics University of Nigeria Teaching Hospital Enugu Nigeria

Introduction: Early detection of proteinuria is early detection is a cost-effective method of assessing individuals with and without risk factors for chronic renal disease. Proteinuria is common in adults and may present a clinical challenge in the absence of obvious renal disease or risk factors especially in the tropics. Few studies in Nigeria have assessed the prevalence of proteinuria in adults using the dipstick method. The aim of this study was to document the prevalence of proteinuria among residents of a community in Enugu, south east Nigeria. Methods: This was a cross-sectional descriptive study carried out in an isolated urban slum settlement in Enugu, south east Nigeria. Dipstick testing of freshly voided early morning mid-stream urine samples was done to detect proteinuria. For database management and statistical analyses, SPSS version 23 was used. Results: A total of 262 individuals were recruited for the study, 165 (63%) females and 97 (37%) males. The participants’ age ranged from 18 to 90 years, averaging 43.7 ± 15.5. Trace amounts of protein were detected in urine samples of 225 (85.9%) individuals. Significant proteinuria was detected in 3.8% of the participants and was significantly higher 40 - 49-year-olds (6%). p = 0.02 and 0.02 respectively. Significant correlates of proteinuria were lower diastolic blood pressure and current tobacco use. Lower body mass index weakly correlated with proteinuria. Conclusion: The prevalence of significant early morning proteinuria in a community-based study in Enugu was 3.8%. Significant correlates of proteinuria included low diastolic blood pressure and tobacco use. Community based awareness programs targeted at prevention of chronic renal diseases should be incorporated in public health programs.

关键词： Proteinuria Chronic Renal Disease Risk Factors Nigeria

The Prevalence of Stroke Survivors in Urban Slums in Enugu, Nigeria

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Open Journal of Preventive Medicine 2019年第6期9卷 51-67页

作者： Oluchi Stella Ekenze Ezeala-Adikaibe Birinus Adikaibe Onodugo Obinna Chime Peter orjioke casmir Onodugo Pauline Nkiruka Mbadiwe Nkeiruka Onyekonwu Chinwe Ijoma Nkemdilim Uchenna Okoye Julius Uwabunkeonye Obumneme-Anyim Ijeoma Nnenne Ekochin Fintan Ernest Okwundu Nwazor Emmanuel Uzodimma Iwuozo Department of Medicine University of Nigeria Teaching Hospital Enugu Nigeria Department of Medicine Enugu State University of Science and Technology Teaching Hospital Enugu Nigeria Department of Pediatrics University of Nigeria Teaching Hospital Enugu Nigeria Department of Medicine Federal Medical Center Owerri Nigeria Federal Medical Center Makurdi Nigeria

Background: Stroke is one of the commonest non-communicable diseases and the commonest cause of death in adult neurology wards. Stroke preva-lence in sub Saharan Africa has dramatically increased over the past decades possibly due to changing life styles, poverty, poor health infrastructures which had led to increased risk factors for stroke. Poor nutrition and lack of access to standard medical care, predispose to high rates of stroke morbidity and mor-tality hence possible low prevalence. Little is known about the prevalence of stroke in people with low socio-economic status in Nigeria. Objectives: The main objective of this study was to determine the prevalence of stroke in two urban slums in south east Nigeria. Materials and Methods: This was a cross sectional descriptive study carried out in two slums in Enugu, South East Nige-ria. Participants were screened using a stroke specific questionnaire and further examined by two independent neurologists for evidence of focal neurological deficits. Analysis was done by SPSS version 22. Results: A total of 1440 par-ticipants were surveyed in the study;769 (53.4) females and 671 (46.6%) males. About 22.3% (321) screened positive for various neurological diseases out of which 17 (5.3%) had evidence for stroke giving an overall prevalence of 1.2% (males 9 (1.3%) vs females 8 (1%) p = 0.6). The mean age of stroke sur-vivors was 60.1 years, similar in males and females (p = 0.6). The odds ratio for stroke from 40 years showed progress increment doubling between 60 and 70 years and tripled between 40 and 70 years. Age, lower level of education, positive history of hypertension, sickle cell disease, leg swelling and use of snuff positively are correlated with clinical diagnosis of stroke. Conclusion: The prevalence of stroke in two urban slums in Enugu metropolis was 12/1000. Hypertension, diabetes, use of snuff, and low levels of education were signifi-cant risk factors for stroke. Public health educational measures, promoti

关键词： Stroke Prevalence Nigeria

Factors Associated with Overweight and Obesity in an Urban Area of South East Nigeria

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Food and Nutrition Sciences 2019年第7期10卷 735-749页

作者： Uchenna Nkemdilim Ijoma Peter Chime Chinwe Onyekonwu Birinus Adikaibe Ezeala-Adikaibe casmir orjioke Obumneme Benneth Anyim Obinna Donatus Onodugo Eddy Aneke Chidimma Brenda Nwatu Ekenechukwu Young Nkeiruka Mbadiwe Oluchi Stella Ekenze Julius Uwabunkeonye Okoye Michael Abonyi Ifeoma Isabella Ulasi Anthony Mbah Pauline Nkiruka Onodugo Department of Medicine University of Nigeria Teaching Hospital Enugu Nigeria Department of Medicine Enugu State University Teaching Hospital Enugu Nigeria

Background: Overweight and obesity present a growing health problem among Africans from all socioeconomic status. In Sub Saharan African, obesity is not only a consequence of overnutrition but possibly from excessive consumption of unbalanced diet dominated by carbohydrates and saturated fats. Characteristics of the distribution of obesity/overweight in Nigeria include its high prevalence along with socioeconomic class and in mid-life. Methods: Using the WHO STEP-wise approach to surveillance of noncommunicable diseases, we conducted a cross-sectional descriptive study of the adult population living in two urban slums in Enugu. The study was carried out in 2013. Statistical analysis was done using SPSS version. Results: A total of 605 (414 women (68.4%) and 191 (31.6%) men were recruited and analysed. The mean body mass index was 25.8 kg/m2 higher in females (26.7 kg/m2) than males (24 kg/m2) p is 29.4% (178/605) and 19.5% (118/605) respectively. There also a modest prevalence of underweight 4% (24/605) among the population. All classes of obesity were significantly more prevalent in females. Significant positive correlates of BMI were: female sex (r = 0.21, p < 0.001), systolic blood pressure (0.25, p < 0.001), DBP (0.27, p < 0.001), fasting blood glucose (0.19, p < 0,001) and positive history of hypertension (0.23, P < 0.001). Negative correlates were physical activity and use of tobacco (0.2 (<0.001) and -0.16 (Conclusion: The prevalence of obesity is relatively high in two urban slums in Enugu and co-exists with a modest rate of underweight. Public health and community-based approaches should be used to tackle these two-opposing social/health problems.

关键词： Obesity Overweight Hypertension Diabetes Nigeria

Medical Morbidity Profile of Adults in a Rural Community in Enugu, Southeast Nigeria: A Cross Sectional Survey

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Health 2023年第7期15卷 711-727页

作者： Nkeiruka Chigekwu Mbadiwe Birinus Adikaibe Ezeala-Adikaibe Celestine Chibuzor Okwara Monday Umeh Nwobodo Fintan C. Ekochin casmir orjioke Nkiruka P. Onodugo Titus Okpara Denise Paul Okoli Uzoma C. Okechukwu Mark Ezeme Obumneme B. Anyim Grace O. Eneh Obinna Donatus Onodugo Innocent Okoye Uchenna N. Ijoma Department of Medicine Enugu State University Teaching Hospital Enugu Nigeria Department of Medicine University of Nigeria Teaching Hospital Enugu Nigeria Memfys Hospital for Neurosurgery Enugu Nigeria Anambra State University Teaching Hospital Awka Nigeria

Introduction: People in rural communities are exposed to the risk factors for non-communicable disease as those in urban areas. Correct interpretation and management of symptoms are important in primary care especially in rural communities where diagnostic facilities are not readily available. Materials and Methods: This was a cross-sectional study carried out in a village in Enugu South Local Government area of Enugu State. Thorough medical history was taken from all eligible participants who gave their consent. Data were analyzed using SPSS version 26. Results: Data from a total of 1019 (64.7%) out of 1576 participants were analysed. Fever was by far the most common presenting complaint 580 (56.9%) of all participants and 67.9% of medical complaints seen in the clinic. This was followed remotely by musculoskeletal problems and neurological problems 15.6% and 3.8% of the participants respectively. Across all age groups, febrile illness was more than non-febrile illness except in those 65 years. Generalized body pains 74 (7.3%), back pains 55 (5.1), headache 33 (3.2%) and abdominal pains 24 (2.4%) were the commonest symptoms presented by the participants. About 15 (1.5%) of the population surveyed had had trauma/surgery in the past. This was twice the number who presented to the clinic with symptoms related to injury and trauma 7 (0.7%). Conclusions: Fever and musculoskeletal pains are the dominant medical complaints presented by adults in a rural community clinic. This may be related to the season of the year and the occupation of the population studied.

关键词： Symptoms Infectious Diseases Non-Communicable Diseases Rural Community Southeast Nigeria

Correlates of Tobacco and Marijuana Use among Urban Dwellers in Enugu, Nigeria

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