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Regulator of G protein signaling 6 mediates exercise-induced recovery of hippocampal neurogenesis,learning,and memory in a mouse model of Alzheimer’s disease

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Neural Regeneration Research 2025年第10期20卷 2969-2981页

作者： Mackenzie M.Spicer Jianqi Yang Daniel Fu Alison N.DeVore Marisol Lauffer Nilufer S.Atasoy deniz Atasoy Rory A.Fisher Department of Neuroscience and Pharmacology University of Iowa Carver College of MedicineIowa CityIAUSA Iowa Neuroscience Institute University of Iowa Carver College of MedicineIowa CityIAUSA Interdisciplinary Graduate Program in Molecular Medicine University of Iowa Carver College of MedicineIowa CityIAUSA Neural Circuits and Behavior Core University of Iowa Carver College of MedicineIowa CityIAUSA

Hippocampal neuronal loss causes cognitive dysfunction in Alzheimer’s *** hippocampal neurogenesis is reduced in patients with Alzheimer’s *** stimulates adult hippocampal neurogenesis in rodents and improves memory and slows cognitive decline in patients with Alzheimer’s ***,the molecular pathways for exercise-induced adult hippocampal neurogenesis and improved cognition in Alzheimer’s disease are poorly ***,regulator of G protein signaling 6(RGS6)was identified as the mediator of voluntary running-induced adult hippocampal neurogenesis in ***,we generated novel RGS6fl/fl;APP_(SWE) mice and used retroviral approaches to examine the impact of RGS6 deletion from dentate gyrus neuronal progenitor cells on voluntary running-induced adult hippocampal neurogenesis and cognition in an amyloid-based Alzheimer’s disease mouse *** found that voluntary running in APP_(SWE) mice restored their hippocampal cognitive impairments to that of control *** cognitive rescue was abolished by RGS6 deletion in dentate gyrus neuronal progenitor cells,which also abolished running-mediated increases in adult hippocampal *** hippocampal neurogenesis was reduced in sedentary APP_(SWE) mice versus control mice,with basal adult hippocampal neurogenesis reduced by RGS6 deletion in dentate gyrus neural precursor ***6 was expressed in neurons within the dentate gyrus of patients with Alzheimer’s disease with significant loss of these RGS6-expressing ***,RGS6 mediated voluntary running-induced rescue of impaired cognition and adult hippocampal neurogenesis in APP_(SWE) mice,identifying RGS6 in dentate gyrus neural precursor cells as a possible therapeutic target in Alzheimer’s disease.

关键词： adult hippocampal neurogenesis Alzheimer’s disease dentate gyrus exercise learning/memory neural precursor cells regulator of G protein signaling 6(RGS6)

Effect of gamification applications on success of dentistry students

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World Journal of Methodology 2025年第1期15卷 80-87页

作者： Hatice Ahsen deniz Elif Polat Balkan Burak İncebeyaz Kıvanç Kamburoğlu Department of Dentomaxillofacial Radiology Ankara University Faculty of DentistryAnkara 06500Türkiye

BACKGROUND Gamification,the use of game materials in education,has been used in several scientific fields,and studies have demonstrated its effectiveness in student *** To evaluate whether the success of 4th-and 5th-grade dentistry students increases when using the gamification applications Kahoot!and *** An experimental design was used to measure the effect of gamification applications on students who were taught using the traditional *** this purpose,Mentimeter and Kahoot!applications were used in this experimental *** groups of 4th-and 5th-grade students were formed:Mentimeter,Kahoot!,and control *** effect of gamification applications on achievement was evaluated by administering a post-test to these groups after the instructional ***-way analysis of variance and t-tests were used for statistical *** A total of 35.5%of the students were in the Mentimeter group,29.8%in the Kahoot!group,and 34.6%in the control *** the total number of students,54.8%were female and 45.2%were male,while 52.2%were 5th-grade students and 47.8%were 4th-grade *** overall grade point average was found to be 66.65(range,24-100).There was a statistically significant difference in average success scores between students of different groups(P=0.003<0.05)and grades(P=0.036<0.05).The average success score was the highest in the Mentimeter group(71.64)and the lowest in the Kahoot!group(62.15).In the control group,this score was *** average success score was higher for students in the 5thgrade(68.16)and for female students(68.84).CONCLUSION Gamification has a great potential in the education of dentomaxillofacial radiology *** outperformed both the Kahoot!and the traditional method in terms of average student success rates.

关键词： Gamification Mentimeter Kahoot! Education Dentistry

Natural Products as Potential Leads Against Coronaviruses: Could They be Encouraging Structural Models Against SARS-CoV-2?

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Natural Products and Bioprospecting 2020年第4期10卷 171-186页

作者： Ilkay Erdogan orhan F.Sezer Senol deniz Department of Pharmacognosy Faculty of PharmacyGazi University06330 AnkaraTurkey

New coronavirus referred to SARS-CoV-2 has caused a worldwide pandemic(COVID-19)declared by *** disease 2019(COVID-19)is an infectious disease with severe acute respiratory syndrome caused by coronavirus-2(SARS-CoV-2).SARS-CoV-2 is akin to SARS-CoV,which was the causative agent of severe acute respiratory syndrome(SARS)in 2002 as well as to that of Middle East respiratory syndrome(MERS)in ***-CoV-2 has been revealed to belong to Coronaviridiae family as a member ofβ-*** has a positive-sense single-stranded RNA with the largest RNA *** its genomic sequence has a notable similarity to that of SARS-CoV,antiviral drugs used to treat SARS and MERS are now being also applied for COVID-19 *** order to combat SARS-CoV-2,many drug and vaccine development studies at experimental and clinical levels are currently conducted *** this sense,medicinal plants and the pure natural molecules isolated from plants have been reported to exhibit significant inhibitory antiviral activity against SARS-CoV and other types of *** the present review,plant extracts and natural molecules with the mentioned activity are discussed in order to give inspiration to researchers to take these molecules into consideration against SARS-CoV-2.

关键词： Coronavirus SARS-CoV Medicinal plants Natural products Antiviral

Mica Types as Indication of Magma Nature,Central Anatolia,Turkey

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Acta Geologica Sinica(English Edition) 2022年第3期96卷 844-857页

作者： Kiymet deniz Department of Geological Engineering Ankara UniversityAnkaraTurkey Ankara University Faculty of EngineeringDepartment of Geological Engineering06830Golbasi-AnkaraTurkey

This study focuses on the nature of giant micas occurring at the contact between theÖzvatan(foid-bearing)syenites and the metamorphic basement in Central *** studied micas are dark greenish-black in color and crystallized within vein shape like bodies as a narrow *** origin and processes responsible for the formation of these independent crystals of the giant micas were investigated by mineralogical,petrographical and geochemical analyses with the use of Confocal Raman Spectroscopy(CRS),Fourier Transform Infrared(FTIR)Spectroscopy,X-Ray Diffraction(XRD),Polarized Energy Dispersive X-Ray Fluorescence Spectrometer(PED-XRF)and Electron Probe Micro Analysis(EPMA).According to XRD,CRS,FTIR and EPMA data,the giant micas are *** results reveal that studied mica minerals represent the products of re-equilibrated primary mica characterized by high MgO and FeO and low Al2O3 and TiO2 *** trace element concentrations of the giant micas display similar patterns with the upper *** giant micas are crystallized within small cubicles from an alkaline magma and their composition is possibly modified by a mixing event between the crust-and mantle-derived magmas and contaminated at varying extent by the basement metamorphic rocks.

关键词： phlogopite spectroscopy geothermobarometry oxygen fugacity Central Anatolia Turkey

Optimization of selective copper extraction from chalcopyrite concentrate in presence of ammonium persulfate and ammonium hydroxide

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International Journal of Minerals,Metallurgy and Materials 2019年第8期26卷 946-952页

作者： Mehmet deniz Turan Department of Metallurgical and Materials Engineering Firat University

The dissolution of copper and iron from chalcopyrite concentrate in the presence of ammonium persulfate(APS)and ammonium hydroxide was investigated under atmospheric leaching *** were designed by central composite design(CCD).Under the optimum leaching conditions((NH4)2S2O8 concentration=328 g/L;NH4OH addition=16vol%;leaching temperature=321 K(48℃);leaching time=120 min;liquid-to-solid ratio=16;stirring speed=400 r/min),selective leaching was achieved.98.14%of the copper was leached,whereas iron did not pass into the solution.X-ray diffraction analysis of the leaching residue showed that iron compounds were *** the leaching results,the fact that the leaching process does not include uneconomical leaching stages such as extended milling/mechanical activation or high pressures/temperatures,and the low copper dissolution conditions,the attained selective leaching yield may be remarkable.

关键词： leaching complex reaction selectivity copper chalcopyrite

THIRD-ORDER DIFFERENTIAL SUBORDINATION RESULTS FOR ANALYTIC FUNCTIONS INVOLVING THE GENERALIZED BESSEL FUNCTIONS

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Acta Mathematica Scientia 2014年第6期34卷 1707-1719页

作者：汤获 Erhan deniz School of Mathematics and Statistics Chifeng University School of Mathematical Sciences Beijing Normal University Department of Mathematics Faculty of Science and LettersKafkas University

In the present paper, we derive some third-order differential subordination results for analytic functions in the open unit disk, using the operator Bcκf by means of normalized form of the generalized Bessel functions of the first kind, which is defined as z（Bκ＋1^c f（z））′= κBκ^c f（z）-（κ- 1）Bκ＋1^c f（z）,where b, c, p ∈ C and κ = p ＋（b ＋ 1）/2 ∈ C ／ Z0^-（Z0^-= {0,-1,-2, … }）. The results are obtained by considering suitable classes of admissible functions. Various known or new special cases of our main results are also pointed out.

关键词： differential subordination univalent functions Hadamard product admissible functions generalized Bessel functions

Thermal entanglement in the mixed three-spin XXZ Heisenberg model on a triangular cell

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Chinese Physics B 2014年第5期23卷 73-79页

作者： Seyit deniz Han Ekrem Aydiner Department of Physics Istanbul University

We numerically investigate the thermal entanglements of spins （1/2, 1） and spins （1/2, 1/2） in the three-mixed （1/2, 1, 1/2） anisotropic Heisenberg XXZ spin system on a simple triangular cell under an inhomogeneous magnetic field. We show that the external magnetic field induces strong plateau formation in the pairwise thermal entanglement for fixed parame-ters of the Hamiltonian in the cases of ferromagnetic and antiferromagnetic interactions. We also .observe an unexpected critical point at finite temperature in the thermal entanglement of spins （1/2, 1） for the antiferromagnetic case, while the entanglement of spins （1/2, 1） in the ferromagnetic case and the entanglement of spins （1/2, 1/2） in both ferromagnetic and antiferromagnetic cases almost decay exponentially to zero with increasing temperature. The critical point in the en-tanglement of spins （1/2, 1） in the antiferromagnetic case may be a signature of the quantum phase transition at finite temperature.

关键词： quantum entanglement quantum phase transition negativity

Characterization and corrosion studies of ternary Zn–Ni–Sn alloys

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International Journal of Minerals,Metallurgy and Materials 2020年第1期27卷 74-82页

作者： Reyhan Solmaz B.deniz Karahan Department of Metallurgical and Materials Engineering Istanbul Technical UniversityMaslakIstanbul 34469Turkey School of Engineering and Natural Sciences Istanbul Medipol UniversityBeykozIstanbul 34810Turkey

Nine distinct zinc-nickel-tin films with different compositions have been galvanostatically electrodeposited. The films have been characterized by scanning electron microscopy(SEM) and energy dispersive spectrometry(EDS). Their corrosion potentials and densities have been estimated using Tafel extrapolation. Next, the electrochemical behaviors of the films(deposited through the electrolytes containing 0, 6, 8, and10 g/L SnCl2?6H2O) have been examined based on cyclic voltammetry(CV) measurements. Further, these films have been immersed in 3.5 wt%Na Cl solution for 1 h, 1 d, 7 d, 14 d, 28 d, and 42 d followed by application of Tafel extrapolation and electrochemical impedance spectroscopy(EIS) tests on each aged sample. Finally, to analyze the morphologies and the compositions of the oxide films covering the surfaces of the 42-d aged films, FT-IR and SEM analyses have been performed. The results indicated that the Zn–Ni–Sn film produced through the bath including 6g/L SnCl2?6H2 O exhibits superior corrosion resistance because of the high Ni content in the presence of Sn that promotes the barrier protection capability of the deposit.

关键词： ternary alloys corrosion electro galvanizing anomalous deposition Tafel

Effects of bioenergy production on environmental sustainability:a preliminary study based on expert opinions in Italy and Turkey

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Journal of Forestry Research 2018年第6期29卷 1611-1626页

作者： Tugba deniz Alessandro Paletto Department of Forest Economics Faculty of ForestryIstanbul University34473 BahcekoyIstanbulTurkey Consiglio per la ricerca in agricoltura e l’analisi dell’economia agraria-Research Centre for Forestry and Wood(CREA) Piazza Nicolini638123 TrentoItaly

In future decades, initiatives on biomass-based energy development in Europe should reduce fossil fuel dependence and help to combat climate change as required by the conference of the parties 21. In this context, forest biomass can play a key role within the bioenergy sector due to its high growth potential. The use of forest biomass for energy has positive and negative effects on other ecosystem services, on stand characteristics, and on forest management practices. The aim of this study is to analyse the effects of forest bioenergy production on six ecosystem services(biodiversity, recreation, landscape aesthetics,carbon sequestration, soil erosion protection, water quality). These effects have been assessed by 80 experts in two countries(Italy and Turkey), considering two different forest management practices(clear-cutting of coppices and woody residue removal after felling in high forests). The results show that coppice clear-cutting has negative effects on almost all ecosystem services according to the experts’ opinions. The highest negative effects are on landscape aesthetics and soil protection. The effects of woody residue removal on biodiversity, carbon sequestration, soil erosion protection, and water quality are considered negative by the experts, while the effects on recreation activities and landscape aesthetics are considered positive. The highest negative effects of this forest management scenario are on soil protection and biodiversity. The experts’ opinions about the effects of forest management practices on ecosystem services can provide information to understand the environmental sustainability of bioenergy development in future years.

关键词： Forest biomass Bioenergy Forest management Ecosystem services