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Enteropathic spondyloarthropathy:A common genetic background with inflammatory bowel disease?

World Journal of Gastroenterology 2009年第20期15卷 2456-2462页

作者： Elisabetta Colombo Anna Latiano orazio palmieri Fabrizio Bossa Angelo Andriulli Vito Annese Unit of Gastroenterology Department of Medical Sciences IRCCS-CSS Hospital Laboratory of Genetic Research Department of Medical Sciences IRCCS-CSS Hospital Unit of Digestive Endoscopy Department of Medical SciencesIRCCS-CSS Hospital

The association between spondyloarthropathy and in flammatory bowel disease(IBD) is largely established, although prevalence is variable because of different population selection and diagnostic *** studies indicate that as many as 10%15% of cases of IBD are complicated by ankylosing spondylitis(AS) or other forms of spondylarthritis(SpA).Of note, ileal inflammation resembling IBD has been reported in up to two thirds of cases of SpA, and it has been suggested that the presence of ileitis is associated with the chronic ity of articular *** this observation is of interest to unravel the pathophysiology of the disease, systematic screening of patients with SpA by ileocolonos copy is not indicated in the absence of gut symptoms, as only a small proportion of patients with subclinical gut inflammation will develop overt IBD over *** existence of familial clustering of both IBD and AS, the coexistence of both conditions in a patient, the evidence of an increased risk ratio among f irstand seconddegree relatives of affected AS or IBD patients and f inally, the increased crossrisk ratios between AS and IBD, strongly suggest a shared genetic *** far, however, IL23R is the only identified susceptibility gene shared by both IBD and *** functional studies are still needed to better understand its pathogenic role, great ef fort is being spent therapeutically targeting this pathway that may prove effective for both disorders.

关键词： Inflammatory bowel disease Ulcerative colitis Crohn's disease Ankylosing spondlitis Sacroiliitis Spondyloarthropathy

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Replication of interleukin 23 receptor and autophagy-related 16-like 1 association in adult-and pediatric-onset inflammatory bowel disease in Italy

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World Journal of Gastroenterology 2008年第29期14卷 4643-4651页

作者： Anna Latiano orazio palmieri Maria Rosa Valvano Renata D'Incà Salvatore Cucchiara Gabriele Riegler Anna Maria Staiano Sandro Ardizzone Salvatore Accomando Gian Luigi de Angelis Giuseppe Corritore Fabrizio Bossa Vito Annese U.U. O.O. di Gastroenterologia ed Endoscopia Ospedale IRCCS-CSSSan Giovanni Rotondo (Fg) 71013 Italy Cattedra di Gastroenterologia Università di PadovaPadova 35122 Italy Clinica Pediatrica Università "La Sapienza" Roma 00185 Italy Cattedra di Gastroenterologia Università di NapoliNapoli 80131 Italy Clinica Pediatrica Università di Napoli Napoli 80131 Italy Unità di Gastroenterologia Ospedale "Sacco" Milano 20157 Italy Clinica Pediatrica Università di Palermo Palermo 90128 Italy Clinica Pediatrica Università di Parma Parma 43100 Italy

AIM: To investigate gene variants in a large Italian inflammatory bowel disease (IBD) cohort, and to analyze the correlation of sub-phenotypes (including age at diagnosis) and epistatic interaction with other IBD genes. METHODS: Total of 763 patients with Crohn's disease (CD, 189 diagnosed at age < 19 years), 843 with ulcerative colitis (UC, 179 diagnosed <19 years), 749 healthy controls, and 546 healthy parents (273 trios) were included in the study. The rs2241880 [autophagy-related 16-like 1 (ATG16L1)], rs11209026 and rs7517847 [interleukin 23 receptor (IL23R)], rs2066844, rs2066845, rs2066847 (CARD15), rs1050152 (OCTN1), and rs2631367 (OCTN2) gene variants were genotyped. RESULTS: The frequency of G allele of ATG16L1 SNP (Ala197Thr) was increased in patients with CD compared with controls (59% vs 54% respectively) (OR = 1.25, CI = 1.08-1.45, P = 0.003), but not in UC (55%). The frequency of A and G (minor) alleles of Arg381Gln, rs11209026 and rs7517847 variants of IL23R were reduced significantly in CD (4%, OR = 0.62, CI = 0.45-0.87, P = 0.005; 28%, OR = 0.64, CI = 0.55-0.75, P < 0.01), compared with controls (6% and 38%, respectively). The A allele (but not G) was also reduced signifi cantly in UC (4%, OR = 0.69, CI = 0.5-0.94, P = 0.019). No association was demonstrated with sub-phenotypes and interaction with CARD15 , and OCTN1/2 genes, although both gene variants were associated with pediatric-onset disease. CONCLUSION: The present study confirms the association of IL23R polymorphisms with IBD, and ATG16L1 with CD, in both adult- and pediatric-onset subsets in our study population.

关键词： Inflammatory bowel disease Crohn'sdisease Ulcerative colitis Genetic predisposition Autophagy-related 16-like 1 Interleukin 23 receptor Genome-wide association study Pediatric inflammatorybowel disease

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BOUNDARY CONTROL OF TWO PDE'S SEPARATED BY INTERFACE CONDITIONS

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Journal of Systems Science & Complexity 2010年第3期23卷 431-437页

作者： orazio ARENA Walter LITTMAN Dipartimento di Matematica e Applicazioni per l'Architettura Universit di Firenze School of Mathematics University of Minnesota Minneapolis

This paper discusses the null boundary controllability of two PDE's,modeling a compositesolid with different physical properties in each *** conditions are imposed.

关键词： Heat equation interface condition null boundary control Schroinger equation.

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A probabilistic model to evaluate the effectiveness of main solutions to COVID-19 spreading in university buildings according to proximity and time-based consolidated criteria

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Building Simulation 2021年第6期14卷 1795-1809页

作者： Marco D'orazio Gabriele Bernardini Enrico Quagliarini Department of Construction Civil Engineering and ArchitectureUniversita Politecnica delle Marchevia Brecce Blanche 60131 AnconaItaly

University buildings are one of the most relevant closed environments in which the COVID-19 event clearly pointed out stakeholders'needs toward safety issues,especially because of the possibility of day-to-day presences of the same users(***,teachers)and overcrowding causing long-lasting contacts with possible"infectors".While waiting for the vaccine,as for other public buildings,policy-makers’measures to limit virus outbreaks combine individual’s strategies(facial masks),occupants,capacity and access ***,up to now,no easy-to-apply tools are available for assessing the punctual effectiveness of such *** fill this gap,this work proposes a quick and probabilistic simulation model based on consolidated proximity and exposure-time-based rules for virus transmission confirmed by international health *** building occupancy is defined according to university scheduling,identifying the main"attraction areas"in the building(classrooms,break-areas).Scenarios are defined in terms of occupants’densities and the above-mentioned mitigation *** model is calibrated on experimental data and applied to a relevant university *** demonstrate the model *** particular,it underlines that if such strategies are not combined,the virus spreading can be limited by only using high protection respiratory devices(***3)by almost every *** the contrary,the combination between access control and building capacity limitation can lead to the adoption of lighter protective devices(*** masks),thus improving the feasibility,users'comfort and favorable *** rules to combine acceptable mask filters-occupants,density are thus provided to help stakeholders in organizing users'presences in the building during the pandemic.

关键词： simulation model closed built environment building occupancy crowd models proximity exposure COVID-19

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The potential of natural products for targeting PPARα

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Acta Pharmaceutica Sinica B 2017年第4期7卷 427-438页

作者： Daniela Rigano Carmina Sirignano orazio Taglialatela-Scafati Department of Pharmacy University of Naples Federico IINaples I-80131Italy

Peroxisome proliferator activated receptors(PPARs) α,-γ and-β/δ are ligand-activated transcription factors and members of the superfamily of nuclear hormone receptor. These receptors play key roles in maintaining glucose and lipid homeostasis by modulating gene expression. PPARs constitute a recognized druggable target and indeed several classes of drugs used in the treatment of metabolic disease symptoms, such as dyslipidemia(fibrates, e.g. fenofibrate and gemfibrozil) and diabetes(thiazolidinediones, e.g. rosiglitazone and pioglitazone) are ligands for the various PPAR isoforms. More precisely, antidiabetic thiazolidinediones act on PPARγ, while PPARα is the main molecular target of antidyslipidemic fibrates. Over the past few years, our understanding of the mechanism underlying the PPAR modulation of gene expression has greatly increased. This review presents a survey on terrestrial and marine natural products modulating the PPARα system with the objective of highlighting how the incredible chemodiversity of natural products can provide innovative leads for this "hot" target.

关键词： PPARα Natural product Mechanism of action Dyslipidemia Metabolic syndrome

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The reaction of cinnamaldehyde and cinnam(o)yl derivatives with thiols

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Acta Pharmaceutica Sinica B 2017年第4期7卷 523-526页

作者： Alessandro Autelitano Alberto Minassi Alberto Pagani orazio Taglialatela-Scafati Giovanni Appendino Dipartimento di Scienze del Farmaco Università del Piemonte Orientale Dipartimento di Farmacia Università di Napoli Federico Ⅱ

Spurred by the alleged relevance of the thia-Michael reaction in the bioactivity of various classes of cinnam(o)yl natural products and by the development of a quick NMR assay to study this reaction, we have carried out a systematic study of the "native" reactivity of these compounds with dodecanethiol and cysteamine as models, respectively, of simple thiols and reactive protein thiols that can benefit from iminium ion catalysis in Michael reactions. Cinnamoyl esters and amides, as well as cinnamyl ketones and oximes, did not show any reactivity with the two probe thiols, while cinnamaldehyde(1a) reacted with cysteamine to afford a mixture of a thiazoline derivative and compounds of multiple addition, and with aliphatic thiols to give a single bis-dithioacetal(6). Chalchones and their vinylogous C5-curcuminoid derivatives were the only cinnamoyl derivatives that gave a thiaMichael reaction. From a mechanistic standpoint, loss of conjugation in the adduct might underlie the lack of a native Michael reactivity. This property is restored by the presence of another conjugating group on the carbonyl, as in chalcones and C5-curcuminoids. A critical mechanistic revision of the chemical and biomedical literature on cinnamaldehyde and related compounds seems therefore required.

关键词： Cinnmaldeyde Michael addition Electrophiles Conjugation Cysteamine Chalcones

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Botulinum toxin associated with fissurectomy and anoplasty for hypertonic chronic anal fissure: A case-control study

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World Journal of Clinical Cases 2021年第32期9卷 9722-9730页

作者： Beatrice D'orazio Girolamo Geraci Fausto Famà Gloria Terranova Gaetano Di Vita Department of Surgical Oncological and Stomatological SciencesUniversity of PalermoPalermo 90100SicilyItaly Department of Human Pathology in Adulthood and Childhood"G.Barresi" University Hospital of MessinaMessina 98121SicilyItaly Department of Surgical Oncological and Stomatological SciencesPostgraduate Medical School in General SurgeryUniversity of PalermoPalermo 90100SicilyItaly

BACKGROUND Lateral internal sphincterotomy is still the approach of choice for the treatment of chronic anal fissure(CAF)with internal anal sphincter(IAS)hypertonia,but it is burdened by high-risk postoperative faecal incontinence(FI).Sphincter saving procedures have recently been reconsidered as treatments to overcome this *** most employed procedure is fissurectomy with anoplasty,eventually associated with pharmacological *** To evaluate whether fissurectomy and anoplasty with botulinum toxin injection improves the results of fissurectomy and anoplasty *** We conducted a case-control study involving 30 male patients affected by CAF with hypertonic IAS who underwent fissurectomy and anoplasty with V-Y cutaneous flap *** patients were divided into two groups:Those in group I underwent surgery alone,and those in group II underwent surgery and a botulinum toxin injection directly into the *** were followed up for at least 2 *** goals were to achieve complete healing of the patient and to assess the FI and recurrence rate along with manometry *** The intensity and duration of post-defecatory pain decreased significantly in both groups of patients starting with the first defecation,and this reduction was higher in group *** days after surgery,we achieved complete wound healing in all the patients in group II but only in 80%of the patients in group I(P<0.032).We recorded 2 cases of recurrence,one in each group,and both healed with conservative *** recorded one temporary and low-grade postoperative case of“de novo”*** parameters reverted to the normal range earlier for group II *** The injection of botulinum toxin A in association with fissurectomy and anoplasty with a V-Y advancement flap improves the results of surgery alone in patients affected by CAF with IAS hypertonia.

关键词： Proctology Fissurectomy Anoplasty Anal fissure Botulinum toxin

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Thrombosis of celiacomesenteric trunk:Report of a case

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World Journal of Gastroenterology 2012年第29期18卷 3917-3920页

作者： Federico Lovisetto Gianbattista Finocchiaro De Lorenzi Piera Stancampiano Carmen Corradini Fabio De Cesare orazio Geraci Mario Manzi Francesco Arceci Division of General and Vascular Surgery San Biagio Hospital28845 DomodossolaItaly Division of General and Vascular Surgery Castelli Hospital28921 VerbaniaItaly

Here we present the case of a 79-year-old woman who complained of acute abdominal pain,vomiting and *** exams demonstrated a severe metabolic *** X-rays showed bowel overdistension and pneumatosis of the stomach *** tomography revealed infarction of the stomach,duodenum and small bowel due to thrombosis of the celiacomesenteric *** laparotomy revealed ischemia of the liver,spleen infarction and necrosis of the gastro-intestinal tube(from the stomach up to the first third of the transverse colon).No further surgical procedures were *** patient died the following *** our knowledge,this is the first reported case about severe gastro-intestinal ischemia due to thrombosis of the celiacomesenteric trunk,a rare anatomic variation of the gastrointestinal vascularisation.

关键词： Celiacomesenteric trunk Celiac trunk Thrombosis Anomalies Gastrointestinal vascularisation

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The dimerization of ⊿~9-tetrahydrocannabinolic acid A(THCA-A)

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Acta Pharmaceutica Sinica B 2019年第5期9卷 1078-1083页

作者： Arben Cuadari Federica Pollastro Juan D.Unciti-Broceta Diego Caprioglio Alberto Minassi Annalisa Lopatriello Eduardo Munoz orazio Taglialatela-Scafati Giovanni Appendino Dipartimento di Scienze del Farmaco Universita del Piemonte OrientaleNovara28100Italy Emerald Health Biotechnology Espana Calle Cecilia PayneCordoba14014Spain Dipartimento di Farmacia Universita di Napoli Federico IINapoli80131Italy Maimonides Biomedical Research Institute of Cordoba Cordoba14004Spain Department of Cellular Biology Physiology and ImmunologyUniversity of CordobaCordoba14004Spain University Hospital Reina Sofia Avenida de Menendez Pidal s/nCordoba14004Spain

The renewed interest in dimeric salicylates as broad-spectrum anti-inflammatory and antidiabetic agents provided a rationale to investigate the dimerization of the substituted salicylate D9-tetrahydrocannabinolic acid(THCA-A, 3 a) as a strategy to solve its instability to decarboxylation and to generate analogues and/or pro-drugs of this native pre-cannabinoid. Activation of the carboxylic group with the DCC-HOBt-DMAP protocol afforded a high yield of the OBt ester 4, that was next converted into the highly crystalline di-depsidic dimer 5 upon treatment with DMAP. The mono-depsidic dimer 6 was also formed when the reaction was carried out with partially decarboxylated THCA-A samples. The structure of the depsidic dimers was established by spectroscopic methods and by aminolysis of 5 into the pre-cannabinoid amide 7. Both dimers showed excellent shelf stability and did not generate significant amounts of D9-THC upon heating. However, only the didepsidic dimer 5 activated PPAR-g, the major target of pre-cannabinoids, but strong binding to serum proteins abolished this activity, also shielding it from the action of esterases.

关键词： Phytocannabinoids Dimerization D9-Tetrahydrocannabinolic acid A D9-Tetrahydrocannabinol PPAR-g

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Conversion of Existing Roundabouts into Turbo-Roundabouts： Case Studies from Real World

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Journal of Civil Engineering and Architecture 2012年第8期6卷 953-962页

作者： orazio Giuffrè Marco Guerrieri Anna Granà Department of Civil Environmental Aerospace Materials Engineering Università degli Studi di Palermo Palermo90128 Italy

Compared with roundabouts the main advantages of turbo-roundabouts are the reduction in the number of potential conflicting points and the lower speed of vehicles passing through the intersection, they both can improve safety conditions at the .junction. Moreover, the physical delimitation among lanes limits the side-by-side accident risk. These aspects make turbo-roundabouts more appropriate than roundabouts when a higher level of safety has to be guaranteed, particularly in presence of relevant pedestrian and two-wheels traffic volumes. The present paper has three main objectives：（1） to discuss general design criteria and functional principles of turbo roundabouts, （2） to give the geometric design principles of the central island and circulating lanes and （3） to present three case studies from real world concerning the conversion of existing roundabouts into turbo roundabouts.

关键词： Roundabout turbo roundabout capacity.

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