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Evaluation of hybrid closed-loop insulin delivery system in type 1 diabetes in real-world clinical practice:One-year observational study

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World Journal of Diabetes 2024年第3期15卷 455-462页

作者： Ahmed Eldib Shilton Dhaver Karim Kibaa Astrid Atakov-Castillo Tareq Salah marwa Al-Badri Abdelrahman khater Ryan mcCarragher omnia Elenani Elena Toschi Osama Hamdy Department of Clinical Behavioral&Outcomes ResearchJoslin Diabetes CenterBostonMA 02215United States Department of medicine Harvard Medical SchoolBostonMA 02115United States

BACKGROUND In 2016,the Food and Drug Administration approved the first hybrid closed-loop(HCL)insulin delivery system for adults with type 1 diabetes(T1D).There is limited information on the impact of using HCL systems on patient-reported outcomes(PROs)in patients with T1D in real-world clinical *** this independent study,we evaluated glycemic parameters and PROs over one year of continuous use of medtronic’s 670G HCL in real-world clinical *** To assess the effects of hybrid closed loop system on glycemic control and quality of life in adults with *** We evaluated 71 patients with T1D(mean age:45.5±12.1 years;59%females;body weight:83.8±18.7 kg,body mass index:28.7±5.6 kg/m2,A1C:7.6%±0.8%)who were treated with HCL at Joslin Clinic from 2017 to *** measured A1C and percent of glucose time-in-range(%TIR)at baseline and 12 *** measured percent time in auto mode(%TiAm)for the last two weeks preceding the final visit and assessed PROs through several validated quality-of-life surveys related to general health and diabetes *** At 12 mo,A1C decreased by 0.3%±0.1%(P=0.001)and%TIR increased by 8.1%±2.5%(P=0.002).The average%TiAm was only 64.3%±32.8%and was not associated with A1C,%TIR or ***,provided at baseline and at the end of the study,showed that the physical functioning submodule of 36Item Short-Form Health Survey increased significantly by 22.9%(Pmia fear survey/worry scale decreased significantly by 24.9%(Pm Areas In Diabetes reduced significantly by-17.2%(P=0.002).The emotional burden submodules of dietary diversity score reduced significantly by-44.7%(P=0.001).Furthermore,analysis of Clarke questionnaire showed no increase in awareness of hypoglycemic ***-5 showed no improvements in subject’s wellbeing among participants after starting the 670G HCL ***,analysis of Pittsburgh Sleep Quality Index showed no difference in sleep quality,sleep latency,or duration o

关键词： Artificial pancreas Continuous blood glucose monitor Type 1 diabetes Hybrid closed-loop insulin delivery Quality of life

Seroprevalence Survey of HIV and Hepatitis B Virus and Behavioral Characteristics among Heavy Truck Drivers along Port Sudan-Khartoum Highways

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Open Journal of medical microbiology 2024年第1期14卷 11-22页

作者： Sara S. Osman Adam A. mattar omnia m. Hamid Faculty of Public Health Alzaiem Alazhari University Khartoum Sudan Faculty of medical Laboratory Sciences University of Medical Sciences & Technology Khartoum Sudan

The prevalence of human immunodeficiency virus (AIDS) and hepatitis B virus among heavy truck drivers and their assistants has been well documented globally in correlation with their behavioral characteristics. The present study aimed to screen for human immunodeficiency virus (HIV), hepatitis B virus (HBV), and behavioral characteristics among heavy truck drivers in Port Sudan. A cross-sectional study was conducted on 274 heavy truck drivers and their assistants who used the highway Port Sudan-Khartoum in Port Sudan city during 2019-2021. Data on behavioral characteristics and substance use habits were collected using a structured questionnaire, and an ELISA test was used to screen for HIV and HBV infections in the study participants. The chi-square test, odds ratio, and confidence intervals were used to find the association between behavioral characteristics and seropositive HIV/HBV. Of the 274 enrolled participants, the seroprevalence rates of HIV were 2.7% and HBV was 23.7%. Ninety-four (34.3%) of them had a history of high-risk sexual behavior outside of marriage;only two (0.7%) used condoms;14.2% of participants reported alcohol use;and 1.1% reported drug use. Univariate analysis revealed that having a sex history outside of marriage with ≥1 sex partner and never using a condom with a spouse or casual partner were significant risk factors for HIV and HBV among drivers. Fortunately, we found that most of the drivers reported low alcohol and drug use. Concerning this study, the seroprevalence of HIV and HBV is highly associated with a history of having sex outside of marriage and sexual behavior among truck drivers and assistances. Additional studies are needed to further investigate other STIs and behavioral characteristics associated with factors in truck drivers/assistance in different truck stop regions in Sudan.

关键词： Sexual Transmitted Infection Port Sudan Truck Drivers/Assistance

New exact solutions for the time fractional coupled Boussinesq-Burger equation and approximate long water wave equation in shallow water

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Journal of Ocean Engineering and Science 2017年第3期2卷 223-228页

作者： mostafa m.a.khater Dipankar Kumar Department of mathematics Faculty of ScienceJiangsu UniversityJiangsuChina Faculty of Science Department of MathematicsMansoura University35516 MansouraEgypt Doctoral Student Division of Engineering Mechanics and EnergyGraduate School of Systems and Information EngineeringUniversity of TsukubaTennodai 1-1-1TsukubaIbarakiJapan Department of mathematics Bangabandhu Sheikh Mujibur Rahman Scienceand Technology UniversityGopalganj 8100Bangladesh

The aim of the article is to construct exact solutions for the time fractional coupled Boussinesq-Burger and approximate long water wave equations by using the generalized Kudryashov *** fractional differential equation is converted into ordinary differential equations with the help of fractional complex transform and the modified Riemann-Liouville derivative *** the generalized Kudryashov method through with symbolic computer maple package,numerous new exact solutions are successfully *** calculations in this study have been established and verified back with the aid of the maple package *** executed method is powerful,effective and straightforward for solving nonlinear partial differential equations to obtain more and new solutions with the integer and fractional order.

关键词： The generalized Kudryashov method The time fractional coupled Boussinesq-Burger equation The time fractional approximate long water wave equation Exact solutions

Plenty of analytical and semi-analytical wave solutions of shallow water beneath gravity

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Journal of Ocean Engineering and Science 2022年第3期7卷 237-243页

作者： mostafa m.a.khater SamirA.Salama Department of mathematics Faculty of ScienceJiangsu UniversityZhenjiang 212013China Department of mathematics Obour High Institute For Engineering and TechnologyCairo 11828Egypt Division of Biochemistry Department of PharmacologyCollege of PharmacyTaif UniversityP.O.Box 11099Taif 21944Saudi Arabia

This article studies novel soliton wave solutions of the nonlinear fractional ill-posed Boussinesq(NLFIPB)dynamic wave equation by applying the extended Riccati-expansion(ERE)*** Hadamard has formulated the investigated model to figure out the dynamic characterizations of waves in shallow water under *** obtained solutions are explained through some sketches in 2D and 3D and contour *** the same time,the results’accuracy is checked by comparing the obtained solutions with semianalytical solutions through the well-known Adomian decomposition(AD)*** superiority of the ERE method over the original method is *** constructed solutions are checked by submitting them back into the original model through mathematica 12 software.

关键词： Ill-posed Boussinesq dynamical wave Analytical and semi-analytical simulations

Semi-analytical and numerical simulations of the modified Benjamin-Bona-mahony model

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Journal of Ocean Engineering and Science 2022年第3期7卷 264-271页

作者： mostafa m.a.khater SamirA.Salama Department of mathematics Faculty of ScienceJiangsu UniversityZhenjiang212013China Department of mathematics Obour High Institute For Engineering and TechnologyCairo11828Egypt Division of Biochemistry Department of PharmacologyCollege of PharmacyTaif UniversityP.O.Box 11099Taif 21944Saudi Arabia

In this article,semi-analytical and numerical simulations of the well-known modified Benjamin-Bona-mahony(mBBm)equation are *** study targets to check the accuracy of the obtained analytical solutions of the mBBm model that have been obtained in[1]through three recent analytical schemes(extended simplest equation(ESE)method,modified kudryashov(mKud)method,and SechTanh(ST)expansion method).The considered model describes the propagation of long waves in the nonlinear dispersive media in a visual *** Homotopy iteration(HI)method,exponential cubic-B-spline(ECBS)method,and trigonometric-quantic-B-spline(TQBS)method are employed to construct novel semi-analytical and accurate numerical *** obtained solutions’accuracy has been checked through some different types of two-dimensional graphs.

关键词： modified Benjamin-Bona-mahony equation Approximate solutions

Solitary wave solutions for the generalized Zakharov-Kuznetsov-Benjamin-Bona-mahony nonlinear evolution equation

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Journal of Ocean Engineering and Science 2017年第2期2卷 137-142页

作者： Aly R.Seadawy Dianchen Lu mostafa m.a.khater Department of mathematics Faculty of ScienceTaibah UniversityAl-UlaSaudi Arabia Department of mathematics Faculty of ScienceJiangsu UniversityChina Department of mathematics Faculty of ScienceMansoura University35516 MansouraEgypt

In this paper,we utilize the exp(−ϕ(ξ))-expansion method to find exact and solitary wave solutions of the generalized Zakharov-Kuznetsov-Benjamin-Bona-mahony nonlinear evolution *** generalized Zakharov-Kuznetsov-Benjamin-Bona-mahony nonlinear evolution equation describes the model for the propagation of long waves that mingle with nonlinear and dissipative *** model is used in the analysis of the surface waves of long wavelength in hydro magnetic waves in cold plasma,liquids,acoustic waves in harmonic crystals and acoustic-gravity waves in compressible *** using this method,seven different kinds of traveling wave solutions are successfully obtained for this *** considered method and transformation techniques are efficient and consistent for solving nonlinear evolution equations and obtain exact solutions that are applied to the science and engineering fields.

关键词： The exp(−ϕ(ξ))-expansion method The generalized Zakharov-Kuznetsov-Benjamin-Bona-mahony nonlinear evolution equation Traveling wave solutions Solitary wave solutions

Analytical and Approximate Solutions for Complex Nonlinear Schr?dinger Equation via Generalized Auxiliary Equation and Numerical Schemes

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Communications in Theoretical Physics 2019年第11期71卷 1267-1274页

作者： mostafa m.a.khater Dian-Chen Lu Raghda A.m.Attia mustafa Inc Department of mathematics Faculty of ScienceJiangsu UniversityChina Science Faculty Firat University23119 ElazigTurkey

This article studies the performance of analytical, semi-analytical and numerical scheme on the complex nonlinear Schr¨odinger(NLS) equation. The generalized auxiliary equation method is surveyed to get the explicit wave solutions that are used to examine the semi-analytical and numerical solutions that are obtained by the Adomian decomposition method, and B-spline schemes(cubic, quantic, and septic). The complex NLS equation relates to many physical phenomena in different branches of science like a quantum state, fiber optics, and water waves. It describes the evolution of slowly varying packets of quasi-monochromatic waves, wave propagation, and the envelope of modulated wave groups, respectively. moreover, it relates to Bose-Einstein condensates which is a state of matter of a dilute gas of bosons cooled to temperatures very close to absolute zero. Some of the obtained solutions are studied under specific conditions on the parameters to constitute and study the dynamical behavior of this model in two and three-dimensional.

关键词： complex NLS equation generalized auxiliary equation method adomian decomposition method B-splines schemes(cubic&quintic&septic)

Numerical solutions of nonlinear fractional Wu-Zhang system for water surface versus three approximate schemes

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Journal of Ocean Engineering and Science 2019年第2期4卷 144-148页

作者： mostafa m.a.khater Raghda A.m.Attia Dianchen Lu Department of mathematics Faculty of ScienceJiangsu UniversityChina Department of Basic Science Higher technological institute 10 th of Ramadan cityEgypt

This paper examines the effects of three distinct numerical schemes(Adomian Decomposition,quintic&septic Spline methods)to investigate semi-analytical and approximate solutions on Wu-Zhang(ZW)*** describes the(1+1)-dimensional dispersive long wave in two horizontal directions on shallow *** ZW model is one of the fractional nonlinear partial differential *** derivatives properties are employed to convert the nonlinear fractional partial differential equation into an ordinary differential equation with integer order so as to obtain the approximate solutions for this *** solutions obtained for each technique were compared to reveal their relationship to their characteristics illustrated under the suitable choice of the parameters *** obtained solutions showed the power,easiness,and effectiveness of these methods on nonlinear partial differential equations.

关键词： Fractional nonlinear Wu-Zhang system Conformable fractional derivatives Numerical schemes.

Biochemical Liver Functions and molecular Identification of Fasciola hepatica from Experimentally Infected Rat model

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Open Journal of Animal Sciences 2024年第2期14卷 88-100页

作者： omnia m. Kandil Emad B. Ata margarita P. Gabrashanska Hatem A. Shalaby Tamer H. Abd El-Aziz Noha m. F. Hassan Soad m. Nasr mohamed A. Helal Ebtesam m. Al-Olayan Department of Parasitology & Animal Diseases Veterinary Research Institute National Research Centre Giza Egypt Institute of Experimental morphology Pathology and Anthropology with Museum Bulgarian Academy of Sciences Sofia Bulgaria Department of Zoology Collage of Science King Saud University Riyadh Saudi Arabia

The current study was performed to evaluate the liver function status as well as molecular characterization of the recovered worms in rats experimentally infected with F. hepatica. Sixteen male Wister rats aged 30 days were randomly allocated into two groups (n = 8). The first group was infected orally with 15 viable encysted metacercaria of F. hepatica per animal. The other group was kept non-infected (control group). At zero time (before infection), the 2nd, 4th, 6th, 8th, 10th, 12th and 14th weeks post-infection (WPI), blood and serum samples were collected via puncture of retro-orbital plexus of veins from each rat. Serum enzyme level (AST and ALT) and total protein were measured, and the serum protein profile was carried out using agarose gel electrophoresis. During the period of the experiment, serum ALT and AST activities and serum total globulins significantly increased while serum total proteins and albumin markedly decreased in the infected group. On the 14th WPI, the data of the electropherogram showed that globulin fractions (α1-, β- and γ-globulin) levels were significantly increased while α2-globulin was markedly decreased in the infected group. The molecular analysis confirmed the amplification of the ITS1, ITS2 and NDI genes of F. hepatica recovered from the infected liver of rats with amplicon sizes of 630, 510 and 560 bp, respectively. Sequencing of the amplified ITS gene resulted in the determination of 3 strains (PP108836, PP108837, and PP108838). Also, analysis of the ITS2 gene resulted in obtaining 3 isolates under the accession numbers (PP109065, PP109066, and PP109067). In conclusion, fasciolosis in the rat model is suitable for routine experimental infections and caused a pronounced liver dysfunction with discharging of the Fasciola eggs in the faeces and the development of adult stages in the bile ducts. Furthermore, molecular techniques are a sensitive

关键词： Fasciola hepatica Liver Functions Serum Enzymes Serum Protein Electrophoresis molecular Characterization