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Gastric acid inhibitory and gastric protective effects of cannabis and cannabinoids

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Asian Pacific Journal of Tropical medicine 2016年第5期9卷 401-408页

作者： omar abdel-salam Department of Toxicology and Narcotics Medical Division National Research Centre

Cannabis sativa has long been known for its psychotropic effect. Only recently with the discovery of the cannabinoid receptors, their endogenous legends and the enzymes responsible for their synthesis and degradation, the role of this ‘endocannabinoid system’ in different pathophysiologic processes is beginning to be delineated. There is evidence that CB1 receptor stimulation with synthetic cannabinoids or Cannabis sativa extracts rich in ?9-tetrahydrocannabinol inhibit gastric acid secretion in humans and in experimental animals. This is specially seen when gastric acid secretion is stimulated by pentagastrin, carbachol or 2 deoxy-D-glucose. Cannabis and/or cannabinoids protect the gastric mucosa against noxious challenge with non-steroidal anti-inflammatory drugs, ethanol as well as against stress induced mucosal damage. Cannabis/cannabinoids might protect the gastric mucosa by virtue of its antisecretory, antioxidant, anti-inflammatory, and vasodilator properties.

关键词： Cannabis sativa Gastric mucosa Gastric acid

Nanoscale electropolishing of high-purity nickel with an ionic liquid

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International Journal of minerals,metallurgy and materials 2019年第5期26卷 649-656页

作者： Jon Derek Loftis Tarek m.abdel-Fattah Applied Research Center at Thomas Jefferson National Accelerator Facility and Department of molecular Biology and Chemistry at Christopher Newport University Department of Physical Sciences Virginia Institute of Marine Science College of William and Mary Faculty of Sciences Alexandria University

High purity(>99.9% composition) nickel metal specimens were used in electropolishing treatments with an acid-free ionic liquid electrolyte prepared from quaternary ammonium salts as a green polishing solution. Voltammetry and chronoamperometry tests were conducted to determine the optimum conditions for electrochemical polishing. Atomic force microscopy(AFm) revealed nanoscale effectiveness of each polishing treatment. Atomic force microscopy provided an overall observation of the material interface between the treated and unpolished regions. Surface morphology comparisons summarized electrochemical polishing efficiency by providing root-mean-square roughness averages before and after electrochemical polishing to reveal a mirror finish six times smoother than the same nickel metal surface prior to electropolishing. This transition manifested in a marked change in root-mean-squared roughness from 112.58 nm to 18.64 nm and producing a smooth mirror finish. Finally, the mechanism of the ionic liquid during electropolishing revealed decomposition of choline in the form of a transient choline radical by acceptance of an electron from the nickel-working electrode to decompose to trimethylamine and ethanol.

关键词： electrochemical polishing ionic liquid Ni 2EG:1VB4

Synthesis of new 1,2,4-oxadiazolidin-5-ylthiophenes and thienopyrimidine derivatives by aza-Wittig reaction using a thienyl carbodiimide

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Chinese Chemical Letters 2012年第4期23卷 411-414页

作者： Afaf m.abdel Hameed Chemistry Department Faculty of ScienceMinia University

Azidation of aminothiophene derivative 1 afforded the corresponding azido derivative *** latter reacted with triphenylphosphine to afford iminophosphorane derivatives *** 3 with phenylisocyanate gave the highly reactive carbodiimide intermediate 4,which was reacted with different nitrones to afford new l,2,4-oxadiazolidin-5-ylidene-aminothiophenes 5a-c. Treatment of 4 with absolute EtOH at room temperature gave methyleneamino-5-（methylthio）thiophene 7,（methylthio）-3-（3- phenylureidothiophene）-2-carboxylate 8 or thienopyrimidine 9 and 10 at refluxing *** reaction of carbodiimide intermediate 4 with different secondary amines gave the new thienopyrimidines 11a-c.

关键词： Carbodiimide Cycloaddition 1 2 4-Oxadiazolidin-5-ylideneaminothiophene derivatives Thienopynmidine Aza-Wittig reaction

Petrology and Geochemistry of Some Ophiolitic metaperidotites from the Eastern Desert of Egypt:Insights into Geodynamic Evolution and metasomatic Processes

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Acta Geologica Sinica(English Edition) 2021年第4期95卷 1139-1157页

作者： abdel-Aal m.abdel-KARIm mokhles K.AZER Shaimaa A.EL-SHAFEI Geology Department Faculty of ScienceZagazig UniversityZagazig 44519Egypt Geological Sciences Department National Research Centre12622-DokkiCairoEgypt

Ophiolitic peridotites exposed in the Eastern Desert(ED)of Egypt record multiple stages of evolution,including different degrees of partial melting and melt extraction,serpentinization,carbonatization and *** present study deals with metaperidotites at two selected localities in the central and southern ED,namely Wadi El-Nabáand Wadi Ghadir,*** represent residual mantle sections of a Neoproterozoic dismembered ophiolite that tectonically emplaced over a volcano-sedimentary succession that represents island–arc *** studied metaperidotites are serpentinized,with the development of talc-carbonate and quartz-carbonate rocks,especially along shear and fault *** relics of primary minerals(olivine,orthopyroxene and Cr-spinel)are preserved in a few samples of partiallyserpentinized *** of the Cr-spinel crystals have fresh cores followed by outer zones of ferritchromite and Crmagnetite,which indicates that melt extraction from the mantle protolith took place under oxidizing *** protoliths of the studied metaperidotites were dominated by harzburgites,which is supported by the abundance of mesh and bastite textures in addition to some evidence from mineral and whole-rock chemical *** high Cr#(0.62–0.69;Av.0.66)and low TiO_(2)(mary olivine relics,together with the high mg#(0.91–0.93;Av.91)and low CaO,Al2 O3 and TiO_(2)of the orthopyroxene relics,are all comparable with depleted to highly depleted forearc harzburgite from a suprasubduction zone *** investigated peridotites have suffered subsequent phases of metasomatism,from oceanfloor hydrothermal alteration(serpentinization)to magmatic hydrothermal *** enrichment of the studied samples in light rare earth elements(LREEs)relative to the heavy ones(HREEs)is attributed to most probably be due to the contamination

关键词： ophiolitic metaperidotites partial melting melt extraction geodynamic evolution Eastern Desert Egypt

Crosstalk between androgen signaling and the chemokine receptor CXCR4:a novel strategy to promote myelin regeneration

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Neural Regeneration Research 2025年第9期20卷 2581-2582页

作者： marianne Bardy-Lagarde Narimène Asbelaoui abdel mouman Ghoumari UmR1195 “Diseases and Hormones of the Nervous System”Inserm and University Paris-SaclayKremlin-BicêtreFrance

multiple sclerosis(mS)is the most common chronic disease of the central nervous system(CNS)in young adults and represents the first cause of severe handicap,originally non-traumatic(Oh et al.,2018).mS is chara cterized by the infiltration of auto reactive lymphocytes specific to myelin through the blood-brain barrier,which results in the appearance of inflammatory demyelinating lesions caused by the death of the central nervous system myelinating cells,oligodendrocytes(Oh et al.,2018).There is a prevalence sexual with a ratio of three times more affected women than men.

关键词： myelin CXCR4

Can lanthanum doping enhance catalytic performance of silver in direct propylene epoxidation over NamoAg/SiO_2?

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Journal of Rare Earths 2019年第5期37卷 500-507页

作者： Hany m.abdel Dayem Shar S.Al-Shihry Salah A.Hassan Chemistry Department Faculty of Science Ain Shams University Chemistry Department College of Science King Faisal University

In the attempt to reduce surface free energy of silica to improve interaction of silica with silver, silica was doped by different amounts of low surface energy lanthanum, La_2O_3, through impregnation. The doped and undoped silica were used as supports for preparation of Na/Ag/mo/La_2O_3-SiO_2 catalysts. Catalytic performances of the catalysts were evaluated in direct epoxidation of propylene(DPO) using molecular oxygen under atmospheric pressure and without adding hydrogen. Adding 5 wt%La to the Na/Ag/mo/SiO_2 catalyst improves both the catalysts electivity in DPO and its stability over 20h of *** characterization results show that La_2O_3 species interact strongly with silver particles on the silica surface which result in significant improvement in the dispersion profile of silver and marked decrease in the size of silver nanoparticles(AgNPs). The estimated mean diameter of AgNPs is ca. 4.0 nm in Na/Ag/mo/5 wt%La_2O_3-SiO_2, which is smaller than that(53.9 nm) found in Na/Ag/SiO_2. The presence of subnanometer AgNPs on Ag/La_2O_3-SiO_2 prior addition of moO_3 and NaCl to the sample can enhance the mutual electronic synergism between Ag, moO_3 and Na for selective production of propylene oxide.

关键词： Direct epoxidation Propylene Gas phase Silver Subnanometer Lanthanum

Development of new potentiometric sensors for the determination of proguanil hydrochloride in serum and urine

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Chinese Chemical Letters 2016年第6期27卷 857-863页

作者： Fatehy m.abdel-Haleem mohamed Saad mohamed S.Rizk Chemistry Department Faculty of Science Cairo University

Potentiometric electrodes were developed for the rapid determination of proguanil hydrochloride in pure samples, pharmaceutical preparations and spiked serum and urine samples using PVC membrane,screen printed（SPE）, coated wired（CWE）, carbon paste（CPE） and modified carbon paste（mCPE）electrodes based on the ion-exchanger of proguanil with phosphotungestic acid（Pr-PT） as a chemical modifier. The prepared electrodes showed Nernestian slopes of 59.7, 58.1, 58.5, 58.5 and 57.0 for the PVC,SPE, CWE, CPE and mCPE for the proguanil ions in a wide concentration range of 1.0 ＊ 10^-5–1.0 ＊ 10^-2mol L^-1 at 25°C with detection limits of 7.94 ＊ 10^-6, 1.0 ＊ 10^-5, 1.0 ＊ 10^-6, 7.07 ＊ 10^-6 and 2.5 ＊ 10^-6 mol L^-1, respectively. The prepared electrodes exhibited high proguanil selectivity in relation to several inorganic ions and sugars and they could be successfully utilized for its determination in pure solutions, pharmaceutical preparations and serum and urine samples using the direct potentiometry and standard addition methods with very good recovery values.

关键词： Proguanil hydrochloride PVC membrane electrode Carbon paste electrode Screen printed electrode mWCNTs Coated wire electrode

Skew Information for a Single Cooper Pair Box Interacting with a Single Cavity Field

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Communications in Theoretical Physics 2013年第6期59卷 769-772页

作者： N.metwally A.Al-mannai m.abdel-Aty mathematics Department College of Science University of Bahrain mathematics Department Faculty of Science Aswan University of Aswan Scientific Publishing Center University of Bahrain mathematics Department Faculty of Science Sohag University of Sohag

The dynamics of the skew information (SI) is investigated for a single Cooper Pair Box (CPB) interacting with a single cavity field. By suitably choosing the system parameters and precisely controlling the dynamics, novel connection is found between the SI and entanglement generation. It is shown that SI can be increased and reach its maximum value either by increasing the number of photons inside the cavity or considering the far off-resonant *** number of oscillations of SI is increased by decreasing this ratio between the Josephson junction capacity and the gate capacity. This leads to significant improvement of the travelling time between the maximum and minimum values.

关键词： entanglement skew information Cooper Pair Box

multifunction Battery Energy Storage System for Distribution Networks

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Energy Engineering 2022年第2期119卷 569-589页

作者： omar H.Abdalla Gamal abdel-salam Azza A.A.mostafa Department of Electrical Power&machines Helwan UniversityCairoEgypt Technical Affairs Sectors South Cairo Electricity Distribution CompanyCairoEgypt Department of Energy Efficiency and Renewables Egyptian Electric Utility and Customer Protection Regulatory AgencyCairoEgypt

Battery Energy Storage System(BESS)is one of the potential solutions to increase energy system flexibility,as BESS is well suited to solve many challenges in transmission and distribution *** of distribution network’s challenges,which affect network performance,are:(i)Load disconnection or technical constraints violation,which may happen during reconfiguration after fault,(ii)Unpredictable power generation change due to Photovoltaic(PV)penetration,(iii)Undesirable PV reverse power,and(iv)Low Load Factor(LF)which may affect electricity *** this paper,the BESS is used to support distribution networks in reconfiguration after a fault,increasing Photovoltaic(PV)penetration,cutting peak load,and loading valley *** paper presents a methodology for BESS optimal locations and sizing considering technical constraints during reconfiguration after a fault and PV power generation *** determining themaximumpower generation change due to PV,actual power registration of connected PV plants in South Cairo Electricity Distribution Company(SCEDC)was considered for a *** addition,the paper provides a procedure for distribution network operator to employ the proposed BESS to perform multi functions such as:the ability to absorb PV power surplus,cut peak load and fill load valley for improving network’s *** methodology is applied to a modified IEEE 37-node and a real network part consisting of 158 nodes in SCEDC *** simulation studies are performed using the DIgSILENT PowerFactory software andDPL programming *** mixed Integer Linear Programming optimization technique(mILP)in mATLAB is employed to choose the best locations and sizing of BESS.

关键词： Battery energy storage system photovoltaic penetration peak load reduction valley filling mILP optimization