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Optical imaging of post-embryonic zebrafish using multi orientation raster scan optoacoustic mesoscopy

Light(Science & Applications) 2016年第1期5卷 336-341页

作者： Murad omar johannes Rebling Kai Wicker Tobias Schmitt-Manderbach Mathias Schwarz jérôme Gateau Hérnan López-Schier Timo Mappes Vasilis Ntziachristos Chair for Biological Imaging Technische Universität MünchenMünchen D-81675Germany Institute for Biological and Medical Imaging Helmholtz Zentrum MünchenNeuherberg D-85764Germany Carl Zeiss AG Corporate Research and TechnologyJena D-07745Germany ESPCI Paris PSL Research UniversityCNRSINSERMInstitut LangevinParis F-75005France Research Unit Sensory Biology and Organogenesis Helmholtz Zentrum MünchenNeuherberg D-85764Germany Carl Zeiss Vision International GmbH Technology&InnovationAalen D-73430Germany

Whole-body optical imaging of post-embryonic stage model organisms is a challenging and long sought-after *** requires a combination of high-resolution performance and high-penetration ***(photoacoustic)mesoscopy holds great promise,as it penetrates deeper than optical and optoacoustic microscopy while providing high-spatial ***,optoacoustic mesoscopic techniques only offer partial visibility of oriented structures,such as blood vessels,due to a limited angular detection aperture or the use of ultrasound frequencies that yield insufficient *** introduce 3601 multi orientation(multi-projection)raster scan optoacoustic mesoscopy(MORSOM)based on detecting an ultra-wide frequency bandwidth(up to 160 MHz)and weighted deconvolution to synthetically enlarge the angular *** report unprecedented isotropic inplane resolution at the 9–17μm range and improved signal to noise ratio in phantoms and opaque 21-day-old *** find that MORSOM performance defines a new operational specification for optoacoustic mesoscopy of adult organisms,with possible applications in the developmental biology of adulthood and aging.

关键词： deconvolution development mesoscopy multiview optoacoustics photoacoustics

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Ballistic design and testing of a composite armour reinforced by CNTs suitable for armoured vehicles

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Defence Technology（防务技术） 2024年第2期32卷 173-195页

作者： Evangelos Ch.Tsirogiannis Evangelos Daskalakis Mohamed H.Hassan Abdalla M.omar Paulo Bartolo EODH SA Research and Development DepartmentLakkoma Chalkidikis63080Greece School of Mechanical Aerospace and Civil EngineeringUniversity of ManchesterManchesterM139PLUK Singapore Centre for 3D Printing School of Mechanical and Aerospace EngineeringNanyang Technological University639798Singapore

This paper is investigating the use of composite armour reinforced by nanomaterials, for the protection of light armoured(LAV) and medium armoured military vehicles(MAV), and the interaction between the composite materials and high-performance ballistic projectiles. Four armour materials, consisted of front hybrid fibre reinforced polymer cover layer, ceramic strike-face, fibre reinforced polymer intermediate layer and the metal matrix composite reinforced backplate, were manufactured and assembled by adhesive technology. The proposed laminated protection system is suitable for armoured ground vehicles;however, it could be used as armour on ground, air and naval platforms. The design of the protection system, including material selection and thickness, was elaborated depending on the performance requirements of Level 4 + STANAG 4569 military standard(projectile 14.5 mm × 114 mm API B32) and especially on a design philosophy which is analysed with the specifications. The backplate of this new composite is a hybrid material of Metal Matrix Composite(MMC) reinforced with carbon nanotubes(CNTs), manufactured with the use of powder metallurgy technique. The composite backplate material was morphologically, mechanically and chemically analysed. Results show that all plates are presenting high mechanical properties and ballistic characteristics, compared to commonly used armour plates. Real military ballistic tests according to AEP-STANAG 4569 were carried out for the total composite armour systems. After the ballistic tests, AA2024-CNT3 showed the best protection results, compared with the other plates(AA2024-CNT1 and AA2024-CNT2), with the projectile being unable to fully penetrate the composite plate.

关键词： Passive armour protection Protective armour Ballistic performance Hybrid composites Vehicle protection

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Pharmacologic inducers of the uric acid exporter ABCG2 as potential drugs for treatment of gouty arthritis

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Asian journal of Pharmaceutical Sciences 2020年第2期15卷 173-180页

作者： Bojana Ristic Mohd omar Faruk Sikder Yangzom D.Bhutia Vadivel Ganapathy Department of Cell Biology and Biochemistry Texas Tech University Health Sciences CenterLubbockTX 79430United States

Uric acid is the end product of purine catabolism and its plasma levels are maintained below its maximum solubility in water(6–7 mg/dl).The plasma levels are tightly regulated as the balance between the rate of production and the rate of excretion,the latter occurring in urine(kidney),bile(liver)and feces(intestinal tract).Reabsorption in kidney is also an important component of this *** excretion and reabsorption are mediated by specific *** of the balance between production and excretion leads to hyperuricemia,which increases the risk of uric acid crystallization as monosodium urate with subsequent deposition of the crystals in joints causing gouty ***-of-function mutations in the transporters that mediate uric acid excretion are associated with *** ATP-Binding Cassette exporter ABCG2 is important in uric acid excretion at all three sites:kidney(urine),liver(bile),and intestine(feces).Mutations in this transporter cause gout and these mutations occur at significant prevalence in general ***,mutations that are most prevalent result only in partial loss of transport ***,if the expression of these partially defective transporters could be induced,the increased number of the transporter molecules would compensate for the mutation-associated decrease in transport function and hence increase uric acid *** such,pharmacologic agents with ability to induce the expression of ABCG2 represent potentially a novel class of drugs for treatment of gouty arthritis.

关键词： Uric acid excretion Intestine ABCG2 Loss-of-function mutations Gouty arthritis Pharmacologic inducers

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A case series of precipitous cardiac tamponade from suspected perimyocarditis in COVID-19 patients

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journal of Geriatric Cardiology 2021年第5期18卷 403-406,I0002-I0004页

作者： William Kogler Michael omar Naji Maaliki Shaorinkumar Patel Sam Foldy jose Ruiz Department of Internal Medicine University of Florida JacksonvilleJacksonvilleFLUSA Department of Cardiology University of Florida JacksonvilleFLUSA

A 71yearold well controlled hypertensive female presented on day 4 of acute COVID19 illness with atypical chest pain and worsening exertional *** examination,heart rate was 110 beats/min,blood pressure was 125/82 mmHg and there were decreased heart sounds with visible jugular venous *** was not in respiratory distress at rest and was not requiring supplemental *** radiography showed bilateral diffuse opacities(Figure 1).transthoracic echocardiography(TTE)confirmed a moderate pericardial effusion with right ventricular systolic compression,paradoxical right ventricular septal motion,enddiastolic right atrial collapse,and a plethoric inferior vena cava(IVC)with no respiratory *** ejection fraction(EF)was 55%.Initial workup revealed mildly elevated troponin T levels of 0.14 ng/mL,NTPro BNP of 2500 pg/mL.

关键词： hypertensive distress elevated

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Reliability of electric vehicle charging infrastructure:A cross-lingual deep learning approach

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Communications in Transportation Research 2023年第1期3卷 81-91页

作者： Yifan Liu Azell Francis Catharina Hollauer M.Cade Lawson omar Shaikh Ashley Cotsman Khushi Bhardwaj Aline Banboukian Mimi Li Anne Web omar Isaac Asensio School of Public Policy Georgia Institute of TechnologyAtlanta30332USA Sam Nunn School of International Affairs Georgia Institute of TechnologyAtlanta30332USA School of Civil&Environmental Engineering Georgia Institute of TechnologyAtlanta30332USA H.Milton Stewart School of Industrial and Systems Engineering Georgia Institute of TechnologyAtlanta30332USA School of Computer Science Georgia Institute of TechnologyAtlanta30332USA School of Computer Science Stanford UniversityPalo Alto94305USA School of Economics Georgia Institute of TechnologyAtlanta30332USA Institute for Data Engineering&Science(IDEaS) Georgia Institute of TechnologyAtlanta30332USA

Vehicle electrification has emerged as a global strategy to address climate change and emissions externalities from the transportation *** of charging infrastructure is needed to accelerate technology adoption;however,managers and policymakers have had limited evidence on the use of public charging stations due to poor data sharing and decentralized ownership across *** this article,we use machine learning based classifiers to reveal insights about consumer charging behavior in 72 detected languages including *** investigate 10 years of consumer reviews in East and Southeast Asia from 2011 to 2021 to enable infrastructure evaluation at a larger geographic scale than previously *** find evidence that charging stations at government locations result in higher failure rates with consumers compared to charging stations at private points of *** evidence contrasts with predictions in the *** European markets,where the performance is closer to *** also find that networked stations with communication protocols provide a relatively higher quality of charging services,which favors policy support for connectivity,particularly for underserved or remote areas.

关键词： Electric vehicles Consumer behavior Charging infrastructure Public policy Machine learning Natural language processing Transformer algorithms

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Tight junctions in inflammatory bowel diseases and inflammatory bowel disease associated colorectal cancer

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World journal of Gastroenterology 2016年第11期22卷 3117-3126页

作者： jonathan Landy Emma Ronde Nick English Sue K Clark Ailsa L Hart Stella C Knight Paul j Ciclitira Hafid omar Al-Hassi IBD Unit St Mark's Hospital Harrow London HA1 3UJ United Kingdom Antigen Presentation Research Group Department of Immunology Imperial College London HA1 3UJ United Kingdom Department of Biosurgery and Surgical Technology Imperial College London HA1 3UJ United Kingdom Department of Gastroenterology The Rayne Institute St Thomas' Hospital London HA1 3UJ United Kingdom

Inflammatory bowel diseases are characterised by inflammation that compromises the integrity of the epithelial barrier. The intestinal epithelium is not only a static barrier but has evolved complex mechanisms to control and regulate bacterial interactions with the mucosal surface. Apical tight junction proteins are critical in the maintenance of epithelial barrier function and control of paracellular permeability. The characterisation of alterations in tight junction proteins as key players in epithelial barrier function in inflammatory bowel diseases is rapidly enhancing our understanding of critical mechanisms in disease pathogenesis as well as novel therapeutic opportunities. Here we give an overview of recent literature focusing on the role of tight junction proteins, in particular claudins, in inflammatory bowel diseases and inflammatory bowel disease associated colorectal cancer.

关键词： Claudin Tight junction Ulcerative colitis Pouchitis Crohn’ s disease

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Targeted protein delivery:carbodiimide crosslinking influences protein release from microparticles incorporated within collagen scaffolds

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Regenerative Biomaterials 2019年第5期6卷 279-287页

作者： Constantin Edi Tanase omar Qutachi Lisa j.White Kevin M.Shakesheff Andrew W.McCaskie Serena M.Best Ruth E.Cameron Department of Materials Science and Metallurgy University of CambridgeCambridge Centre for Medical MaterialsCambridge27Charles Babbage RoadCB30FSUK Centre for Biomolecular Sciences School of PharmacyUniversity of NottinghamUniversity ParkNottingham NG72RDUK Division of Trauma&Orthopaedic Surgery Department of SurgeryUniversity of CambridgeBox 180Addenbrooke’s HospitalHills RoadCambridge CB20QQUK Present address:School of Pharmacy De Montforte UniversityLeicester LE19BHUK

Tissue engineering response may be tailored via controlled,sustained release of active agents from protein-loaded degradable microparticles incorporated directly within three-dimensional(3D)ice-templated collagen ***,the effects of covalent crosslinking during scaffold preparation on the availability and release of protein from the incorporated microparticles have not been ***,we load 3D ice-templated collagen scaffolds with controlled additions of poly-(DL-lactide-co-glycolide)*** probe the effects of subsequent N-(3-dimethylaminopropyl)-N0-ethylcarbodiimide hydrochloride crosslinking on protein release,using microparticles with different internal protein *** isothiocyanate labelled bovine serum albumin is used as a model protein *** scaffolds display a homogeneous microparticle distribution,and a reduction in pore size and percolation diameter with increased microparticle addition,although these values did not fall below those reported as necessary for cell *** protein distribution within the microparticles,near the surface or more deeply located within the microparticles,was important in determining the release profile and effect of crosslinking,as the surface was affected by the carbodiimide crosslinking reaction applied to the *** of microparticles with a high proportion of protein at the surface caused both a reduction and delay in protein *** located within the bulk of the microparticles,was protected from the crosslinking reaction and no delay in the overall release profile was seen.

关键词： collagen scaffolds PLGA microparticles FITC-BSA EDC crosslinking pore size percolation diameter

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多层鳍线本征模的精确有效和完备求解(英文)

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红外与毫米波学报 1999年第1期18卷 1-11页

作者：徐云生 omar Abbas Sayed 中国科学技术大学电子工程与信息科学系

对多层鳍线现有的奇异积分方程法进行了如下改进：１）适当选择导体带所在平面切向电场和表面电流的线性组合，以使得导出奇异积分方程的级数具有很快的收敛特性；２）对于附加的边界条件，利用其级数的渐近特性来加速其收敛；３）给出... 详细信息

对多层鳍线现有的奇异积分方程法进行了如下改进：１）适当选择导体带所在平面切向电场和表面电流的线性组合，以使得导出奇异积分方程的级数具有很快的收敛特性；２）对于附加的边界条件，利用其级数的渐近特性来加速其收敛；３）给出系统计算任意阶特征矩阵元素的解析方法，以避免数值积分或对无穷级数求和；４）为完备地求解本征模的传播常数，构造了一个解析函数，保留特征矩阵行列式的所有零点，但消除其所有奇点．采用本文的奇异积分方程法，首次精确有效完备地求解了鳍线中的大量本征模．

关键词：本征模鳍线奇异积分方程法精确解

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Synthesis and applications of fungal mycelium-based advanced functional materials

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journal of Bioresources and Bioproducts 2021年第1期6卷 1-10页

作者： Sehrish Manan Muhammad Wajid Ullah Mazhar Ul-Islam omar Mohammad Atta Guang Yang Department of Biomedical Engineering Huazhong University of Science and TechnologyWuhan 430074China Department of Chemical Engineering College of EngineeringDhofar UniversitySalalahSultanate of Oman

Over the last couple of decades,the introduction of living systems to material science for the synthesis of functional materials from biological resources is receiving immense *** is also in accordance with the need for green and sustainable development of new *** example,the growing concerns of the degradation of synthetic plastics are shifting the direction of materials-related research to the use of polymeric materials acquired from renewable *** example,the fungal mycelium-based materials are produced by growing the vegetative part of mushroom-forming fungi on different organic *** fungi are known for their ability to degrade agricultural wastes such as straws and *** mycelium-based composites having tailored structural,physical,chemical,mechanical,and biological properties are relying on the strain,feeding substrate,and the manufacturing *** mycelium cell wall mainly contains the chitin,glucans,proteins,and lipids,whose concentrations depend upon the feeding substrate that ultimately defines the final properties of the synthesized *** mycelium-based functional materials with tunable properties are synthesized by selecting the desired components and the synthesis *** pure and composites of stiff,elastic,porous,less dense,fast-growing,and low-cost mycelium-derived materials with efficient antimicrobial,antioxidant,and skin whitening properties pave their way in various applications such as construction,packaging,medicine,and *** review describes the synthesis and structural organization of mycelium-based *** further discusses the effect of different factors on the material ***,it summarizes different applications of mycelium-based materials in medicine,cosmetics,packaging,and construction fields.

关键词： Mycelium Material science Biomedical Cosmetics Packaging Construction

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A framework to develop and test a model-free motion control system for a forestry crane

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Biomimetic Intelligence & Robotics 2023年第4期3卷 75-87页

作者： Pedro La Hera omar Mendoza-Trejo Hakan Lideskog Daniel Ortíz Morales Swedish University of Agricultural Sciences Department of Forest Biomaterials and TechnologyUmea90183Sweden Lulea University of Technology Department of Engineering Sciences and MathematicsLulea 97187Sweden CRANAB AB Vindeln 92232Sweden

This article has the objective of presenting our method to develop and test a motion control system for a heavy-duty hydraulically actuated manipulator,which is part of a newly developed prototype featuring a fully-autonomous unmanned forestry *** control algorithm is based on functional analysis and differential algebra,under the concepts of a new type of approach known as model-free intelligent PID control(iPID).As it can be unsafe to test this form of control directly on real hardware,our main contribution is to introduce a framework for developing and testing control *** framework incorporates a desktop-size mockup crane equipped with comparable hardware as the real one,which we design and manufactured using *** downscaled mechatronic system allows to safely test the implementation of control software in real-time hardware directly on our desks,prior to the actual testing on the real *** results demonstrate that this development framework is useful to safely test control software for heavy-duty systems,and it helped us present the first experiments with the world’s first unmanned forestry machine capable of performing fully autonomous forestry tasks.

关键词： Model-free control Hydraulic manipulator Forestry crane control Intelligent PID control Forestry automation Controller implementation

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