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Mobola plum seed methanolic extracts exhibit mixed type inhibition of angiotensinⅠ-converting enzyme in vitro

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Asian Pacific Journal of Tropical Biomedicine 2017年第12期7卷 1079-1084页

作者： Olamide Olajusi Crown olanrewaju Sam Olayeriju Ayodele oluwaseyi Kolawole Afolabi Clement Akinmoladun Mary Tolulope Olaleye Afolabi Akintunde Akindahunsi Department of Biochemistry the Federal University of TechnologyAkureNigeria

Objective: To explore the possible inhibitory potentials and mechanism by Mobola plum(Parinari curatellifolia) seeds crude methanol(CE) and flavonoid-rich(FE) extracts on angiotensin-1-converting enzyme(ACE Ⅰ).Methods: The sensitivity and kinetic model of inhibition of CE and FE on ACE Ⅰ using N-[3-(2-furyl)-acryloyl]-Phe-Gly-Gly as enzyme substrate for ACE Ⅰ was evaluated by Michealis Menten approach. The inhibition mechanism was explored from Lineweaver–Burk model and IC_(50) was determined from Cheng–Prusoff empirical ***: The IC_(50) of CE and FE were 13.54 and 39.38 mg/m L, respectively. Both extracts exhibited mixed type inhibition with the inhibitory constant(K_i) of CE was between0.38 and 0.37 mg/m L while that of FE showed a two-fold increase(1.62 mg/mL and0.28 mg/mL). FE on ACE Ⅰ demonstrated positive cooperativity with a Hill's coefficient ***: The study reveals the superior ACE Ⅰ inhibitory potential of CE over FE and suggest that mixed inhibition pattern of the enzyme might be the underlying mechanism of antihypertensive activity.

关键词： Angiotensin converting enzyme Blood pressure FAPGG Mixed type inhibition Parinari curatellifolia

I must eat what I want: A roadblock to type 2 diabetes management

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Journal of Integrative Nursing 2022年第2期4卷 91-96页

作者： oluwaseyi Abiodun AKPOR samuel Segun ABEGUNDE Olaolorunpo OLORUNFEMI Oluwaseun Oluwafunmilayo ABIODUN Department of Nursing Science College of Medicine and Health SciencesAfe Babalola UniversityAdo EkitiNigeria Department of Medical Surgical/Adult Health Nursing Federal UniversityOye-EkitiEkiti StateNigeria Department of Nursing Science College of Basic Health ScienceAchievers UniversityOwoOndo StateNigeria

Globally,type 2 diabetes mellitus(T2DM)is considered as one of the most common diseases,which is associated with irreversible risk factors such as age,gene,race,ethnicity,and reversible factors such as diet,physical activity,and *** to dietary regimen is the major factors for rapidly rising incidence of T2DM among developing ***,elevated HbA1c level has also been considered as one of the leading risk factors for developing microvascular and macrovascular *** in the elevated HbA1c level can be achieved through diet management;thus,this study found that improvement in patients’dietary knowledge,attitude toward,and compliance to diet regimen will promote a better control of the *** conclusion,the stakeholders(health-care providers,health facilities,agencies involved in T2DM care)should educate the patients on the importance of dietary modification in the disease ***,there is a need for nurses and other health care professionals to advocate and promote a better holistic management that will encourage patients participation and family involvement in the care.

关键词： Dietary compliance dietary management Roles of family members type 2 diabetes mellitus

Forecasting the Monthly Reported Cases of Human Immunodeficiency Virus (HIV) at Minna Niger State, Nigeria

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Open Journal of Statistics 2020年第3期10卷 494-515页

作者： Nwanne Christiana Umunna samuel Olayemi olanrewaju Department of Statistics University of Abuja Abuja Nigeria

There has been a moderate increase in newly diagnosed HIV-infected Minna populace, which calls for serious attention. This study used time series data based on monthly HIV cases from January 2007 to December 2018 taken from the statistical data document on HIV prevalence recorded in General Hospital Minna, Niger State. The methodology employed to analyze the data is based on mathematical models of ARMA, ARIMA and SARIMA which were computed and diagnosed. From the results of parameter estimation of the models, ARMA(2, 1) model was the best model among the other ARMA models using information criteria (AIC). Diagnostic test was run on the ARMA(2, 1) model where the results show that the model was adequate and normally distributed using Box-Lung test and Q-Q plot respectively. Furthermore, ARIMA of first and second differences was estimated and ARIMA(1, 0, 1) was the best model from the result of the AIC and diagnostic test carried out which revealed that the model was adequate and normally distributed using Box-Lung and Q-Q plot respectively. Furthermore, the results obtained in the ARMA and ARIMA models were used to arrive at a combined model given as ARIMA(1, 0, 1) Human Immunodeficiency Virus Autoregressive Moving Average Autoregressive Integrated Moving Average Seasonal Autoregressive Integrated Moving Average Forecasting

Investigating Performances of Some Statistical Tests for Heteroscedasticity Assumption in Generalized Linear Model: A Monte Carlo Simulations Study

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Open Journal of Statistics 2020年第3期10卷 453-493页

作者： Oluwafemi Clement Onifade samuel Olayemi olanrewaju Department of Statistics Faculty of Science University of Abuja Abuja Nigeria

In a linear regression model, testing for uniformity of the variance of the residuals is a significant integral part of statistical analysis. This is a crucial assumption that requires statistical confirmation via the use of some statistical tests mostly before carrying out the Analysis of Variance (ANOVA) technique. Many academic researchers have published series of papers (articles) on some tests for detecting variance heterogeneity assumption in multiple linear regression models. So many comparisons on these tests have been made using various statistical techniques like biases, error rates as well as powers. Aside comparisons, modifications of some of these statistical tests for detecting variance heterogeneity have been reported in some literatures in recent years. In a multiple linear regression situation, much work has not been done on comparing some selected statistical tests for homoscedasticity assumption when linear, quadratic, square root, and exponential forms of heteroscedasticity are injected into the residuals. As a result of this fact, the present study intends to work extensively on all these areas of interest with a view to filling the gap. The paper aims at providing a comprehensive comparative analysis of asymptotic behaviour of some selected statistical tests for homoscedasticity assumption in order to hunt for the best statistical test for detecting heteroscedasticity in a multiple linear regression scenario with varying variances and levels of significance. In the literature, several tests for homoscedasticity are available but only nine: Breusch-Godfrey test, studentized Breusch-Pagan test, White’s test, Nonconstant Variance Score test, Park test, Spearman Rank, Glejser test, Goldfeld-Quandt test, Harrison-McCabe test were considered for this study;this is with a view to examining, by Monte Carlo simulations, their asymptotic behaviours. However, four different forms of heteroscedastic structures: exponential and linear (ge

关键词： Homoscedasticity Heteroscedasticity Generalized Linear Model Monte Carlo

Impact of Sub-Economic on Money Supply in Nigeria: An Autoregressive Distribution Lag (ARDL) Approach

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Open Journal of Statistics 2020年第3期10卷 375-401页

作者： Yasin Abdelhaleem Yasin Abuhabel samuel Olayemi olanrewaju Department of Statistics University of Abuja Abuja Nigeria

The escalation in dollar rates and the price instability in the Nigerian economy went through some significant structural and institutional changes such as the liberalization of the external trade, the elimination of price and interest rate controls, and the adoption of a managed float exchange rate system as well as the changes in monetary policy including innovations in the banking sector. Hence, the study examines the impact of financial development on money demand in Nigeria by means of ARDL approach. It examined the quarterly returns of M2, exchange rate (EXR), inflation rate (IFR), currency in credits to private sector (CPS) and circulation (CIC). The data span from 1991 to 2018. The study utilizes regression model techniques where the regression model’s residual is tested for Cointegration using Engle-Granger residual approach, the significances of the variable’s co-movement are checked by pairwise Granger Causality tests and ARDL and VECM are estimated in order to account for the short run and long run relationship among the variables. From the empirical results, Engle-Granger residuals and pairwise Granger Causality tests confirm cointegration among variables. The ARDL and VECM confirm the long run relation between mon

关键词： Sub-Economy Money Supply ARDL Cointegration Error Correction Model

Influence of Non-Natural Ageing Temperature on the Microstructural Characteristics and Mechanical Properties of Cast Aluminum 6063 Alloy

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Journal of Minerals and Materials Characterization and Engineering 2024年第2期12卷 91-99页

作者： Oluwole Oladele Ayodele Adedeke Olajesu olanrewaju samuel Olusunle Department of Metallurgical and Materials Engineering Federal University of Technology Akure Ondo State Nigeria Engineering Materials Development Institute NASENI Akure Ondo State Nigeria Department of Materials Science and Engineering Iowa State University Ames IA USA NASENI Abuja Nigeria

This research considered the effect of non-natural aging on the microstructural characteristics and mechanical properties of as-cast aluminum 6063 alloys. The samples were developed through a sand casting process and machined into tensile and impact test samples before carrying out solution heat treatment at 550?C (0.83 Tm) on two parts of the samples while retaining one part as the control. The two parts were further divided into sets denoted A and B and were aged at 180?C (0.27 Tm) and 160?C (0.24 Tm), respectively, for 12 hours. The results showed that sample A has the optimal yield strength and ultimate tensile strength of 192 and 206 MPa, respectively. Likewise, the sample gave the highest impact strength value of about 9.63 J/mm2. The observed results were supported by the optical micrograph, which revealed that the sample has evenly dispersed precipitates in its microstructure. This is deemed responsible for the observed increase in strength of the sample.

关键词： Aluminum Alloy Non-Natural Ageing Mechanical Properties Microstructural Features

Addressing neglected tropical diseases in Africa:a health equity perspective

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Global Health Research and Policy 2023年第1期8卷 233-239页

作者： Nsikakabasi samuel George Success Chekwube David Maxencia Nabiryo Blessing Abai Sunday Omotayo Faith olanrewaju Yonah Yangaza Deborah Oluwaseun Shomuyiwa Kano State Ministry of Health KanoNigeria Faculty of Pharmaceutical Sciences University of NigeriaNsukkaNigeria Integrated Community Health Initiative Organization KampalaUganda School of Public Health Department of Community Health and Behavioural SciencesMakerere University College of Health SciencesKampalaUganda Faculty of Pharmacy University of UyoUyoNigeria Muhimbi University of Heath and Allied Science Dar es SalaamTanzania Faculty of Pharmacy University of LagosLagosNigeria

Africa accounts for over one-third of the global burden of neglected tropical diseases(NTDs).Although continental efforts have been made to combat these diseases,there still exists a significant gap in the fight,ranging from a lack of data to multisectoral participation and,most critically,health ***,we assess the effort made to combat challenges caused by health disparities to prevent and control neglected tropical *** article engages a health equity view to addressing the need for inclusion in achieving universal health coverage towards eradicating NTDs and outlines strategies to achieve *** disparities exist,and there is substantial and irrefutable evidence for *** distribution and limited access to basic and essential life resources such as water,housing,toilets,soap,and literacy continue to facilitate the existence of NTDs such as Schistosomiasis,soil-transmitted helminths,and trachoma,the occurrence of which can be avoided if affected populations have better access to those *** eradicate NTDs,health disparities must be addressed to provide excellent health care to all populations and adequate universal health coverage for long-term *** programmes need to be data-driven to ensure better decision-making and ensure the inclusion of diverse population groups including women,children,and *** will ensure that no one is left behind,drawing upon the sustainable development *** participation and engagement should also be considered as an essential approach to ensure people are at the centre of health programmes and their implementation.

关键词： Neglected tropical diseases Health equity Africa Epidemiology Social determinants of health

Time Series Analysis on Reported Cases of Tuberculosis in Minna Niger State Nigeria

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Open Journal of Statistics 2020年第3期10卷 412-430页

作者： samuel Olayemi olanrewaju Emmanuel Oluwatosin Ojo Emmanuel Segun Oguntade Department of Statistics University of Abuja Abuja Nigeria Department of Statistics Federal University of Technology Minna Niger State Nigeria

Predicting the trend of non-seasonal data is a difficult task in Social Science. In this research work, we used time series analysis of 144 observations on monthly basis for record of reported cases of tuberculosis patients in Minna General Hospital, Niger State from the period of 2007-2018. Exploratory Data Analysis (EDA: Time Plot and Descriptive Statistics), Stationarity Test (ADF), Trend estimation (Tt), Normality Test, and Forecast evaluation were carried out. The Augmented Dickey Fuller test for stationarity was conducted and the result revealed that the series are not stationary but became stationary after first difference. The correlogram established that the ARIMA (2, 1, 3) was the best model this was further confirmed from the result of L-jung Box. Equation for ARIMA (2, 1, 3) was given as Xt + 0.6867Xt-1 – 0.8859Xt-2 = Et + 1.3077Et-1 - 1.2328E

关键词： Tuberculosis Infectious Vaccine Stationarity White Noise Process Stochastic Process Gaussian Process

Impact of intragastric balloon on blood pressure reduction:A retrospective study in Eastern North Carolina

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World Journal of Gastrointestinal Endoscopy 2021年第5期13卷 115-124页

作者： Gbeminiyi olanrewaju samuel Karissa Lambert Elijah Asagbra Glenn Harvin Eric Ibegbu Division of Gastroenterology East Carolina UniversityGreenvilleNC 27834United States Department of Internal Medicine Brody School of MedicineEast Carolina UniversityGreenvilleNC 27834United States Department of Health Services and Information Management East Carolina UniversityCollege of Allied Health SciencesGreenvilleNC 27834United States

BACKGROUND Obesity has evolved into a global *** prevalence of obesity and hypertension in eastern North Carolina are comparable,if not higher,than the national *** the United States,an estimated 34%of adults have hypertension,the most modifiable risk factor for heart disease and *** and pharmacological interventions often do not provide sustained weight loss in obese *** surgery offers an effective weight reduction with short-and long-term health improvements;however,a higher body mass index is associated with higher surgical morbidity and mortality,longer hospitalization,and increasing rates of 30-day readmission due to *** balloon may bridge a critical gap in the treatment of *** objective of this paper is to showcase the impact of endoscopic bariatric therapy on blood pressure *** To investigate the impact of intragastric balloon on blood pressure *** A retrospective chart review was conducted from January 1,2016 to January 31,2019 of consecutive adults who received intragastric balloon therapy(IGBT)in a gastroenterology private practice in Eastern North *** balloon was introduced into the stomach under endoscopic guidance,and while in the region of the gastric body,inflation with saline was performed at increments of 50 mL until target volume between 500 to 650 mL of saline was attained depending on the patient's gastric *** procedural complications were noted during endoscopic placement and removal of the balloon.A cohort study design was used for data analysis.A total of 172 patients had the Orbera^(■)intragastric balloon *** the 172 patients who had IGBT at baseline,11 patients(6.4%)requested early balloon removal due to foreign body sensation(n=1),and/or intolerable gastrointestinal adverse events(n=10).The reported gastrointestinal adverse events were nausea,vomiting,abdominal pain,and ***,6-mo follow-up data were ava

关键词： Intragastric balloon Orbera^(■) Obesity Hypertension Systolic blood pressure Diastolic blood pressure