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Simplified seismic scenario analysis of existing masonry buildings accounting for local site effects

中国植物病理学会2005年学术年会暨植物病理学报创刊50周年纪念会

作者： Jurez,S. Hartweck,L. Alamillo,J.M. Simón-Mateo,C. Pérez,J.J. Fernn.e.-Fernn.e.,M.R. olszewski,n.e. García,J.A. Department of Plant Molecular Genetics Centro Nacional de Biotecnología(CSIC)Campus Universidad Autónoma de Madrid28049 MadridSpain.Now working in Zhongshan Import & Export Inspection and Quarantine Bureau Department of Plant Biology and Plant Molecular Genetics Institute University of MinnesotaSaint PaulMinnesota 55108USA

Serine and threonine of many nuclear and cytoplasmic proteins are post-translationally modified with O-lin.e. n-acetylglucosamine (O-GlcnAc). This modification is made by O-lin.e. nacetylglucosamine transferases (OGTs). Genetic and biochemical data have demonstrated the existen.e.of two OGTs of Arabidopsis thaliana, SeCReT AGenT (SeC) and SPInDLY (SPY), with at least partly overlapping functions, but there is little information on their target proteins. The n-terminus of the capsid protein (CP) of Plum pox virus (PPV) isolated from nicotiana clevelandii is O-GlcnAc modified. We show here that O-GlcnAc modification of PPV CP also takes place in other plant hosts, n. benthamiana and Arabidopsis. PPV was able to in.e.t the Arabidopsis OGT mutants sec-1, sec-2 and spy-3 but, at early times of the in.e.tion, both rate of virus spread and accumulation were reduced in sec-1 and sec-2 relative to spy-3 and wild-type plants. By MALDI-TOF mass spectrometry, we determined that a 39 residue tryptic peptide from the n-terminus of CP of PPV purified from the spy-3 mutant, but not sec-1 or sec-2, was OGlcnAc modified, suggesting that SeC but not SPY modifies the capsid. While our results indicate that O-GlcnAc modification of PPV CP by SeC is not essential for in.e.tion, they show that the modification has a role(s) in the process.

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Frontiers of Structural and Civil engin.e.ing 2024年第2期18卷 309-318页

作者： Ayşe e.ÖZSOYÖZBAY Işıl SAnRI KARAPInAR Zehra n.KUTLU İsmail e.KILIÇ Department of Civil engin.e.ing Maltepe UniversityIstanbul 34857Turkey School of engin.e.ing and Construction Oryx Universal CollegeDoha 12253Qatar

This study discusses the effects of local sites and hazard amplification on the seismic vulnerability assessment of existing masonry *** this con.e.t,a rapid seismic evaluation procedure was implemen.e. on an old masonry building stock in the historical cen.e. Galata,located inİstanbul,to determine the seismic risk priority of the built *** scenarios were generated for all soil classes,different moment magnitudes,and source-to-site distan.e. to obtain more accurate results for the seismic vulnerability assessment of the studied building ***,damage distributions estimated un.e. nine different scenarios with/without site effects were compared and illustrated in maps to discuss chan.e. in vulnerability owing to amplification *** this study,by re-examining the rapid seismic evaluation procedure by including geo-hazard-based assessment,the importan.e.of site effects on the vulnerability and risk assessment of built heritage was *** proposed framework in.e.rating field data and local site effects is believed to advan.e.the current applications for vulnerability assessment of masonry buildings and provide an improvement in the application of rapid seismic assessment procedures with more reliable results.

关键词： masonry buildings seismic vulnerability assessment cultural heritage local site effect

In vivo astrocyte reprogramming following spinal cord injury

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neural Regeneration Research 2024年第3期19卷 487-488页

作者： Yannick n.Gerber Floren.e.e.Perrin MMDn University of MontpellierEPHEINSERMMontpellierFrance Institut Universitaire de Fran.e.IUF) ParisFrance

Harmful and helpful roles of astrocytes in spinal cord injury(SCI):SCI induce gradable sensory,motor and autonomic impairments that correlate with the lesion severity and the rostro-caudal location of the injury *** absen.e.of spontaneous axonal regeneration after injury results from neuron-intrinsic and neuron.e.trinsic ***,not only adult neurons display limited capability to regrow axons but also the injury environ.e.t contains inhibitors to axonal regeneration and a lack of growth-promoting *** other cell populations that respond to the lesion,reactive astrocytes were first considered as only detrimental to spontaneous axonal ***,astrocytes.

关键词： injury impairment programming

nanomotion of bacteria to determine metabolic profile

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nanotechnology and Precision.e.gin.e.ing 2024年第1期7卷 1-9页

作者： S.n.Pleskova e.V.Lazarenko n.A.Bezrukov R.n.Kriukov A.V.Boryakov M.e.Dokukin S.I.Surodin Research Laboratory of Scanning Probe Microscopy Lobachevsky State University of Nizhny NovgorodNizhny Novgorod 603950Russia Department of nanotechnology and Biotechnology Nizhny Novgorod State Technical University n.a.R.E.AlekseevNizhny Novgorod 603950Russia Sarov Physics and Technology Institute National Research Nuclear University MEPhISarov 607186Russia

In addition to their visible motion such as swimming(e.g.,with the help ofﬂagella),bacteria can also exhibit nanomotion that is detectable only with highly sensitive instruments,and this study shows that it is possible to detect bacterial nanomotion using an AFM detection *** results show that the nanomotion characteristics depend on the bacterial strain,and that nanomotion can be used to sen.e.the metabolic activity of bacteria because the oscillations are sensitive to the food preferen.e. of the bacteria and the type of surrounding medium.

关键词： nanomotion Bacteria Cantilever Oscillation Atomic force microscopy Metabolism

new trends in diagnosis and management of gallbladder carcinoma

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World Journal of Gastroin.e.tinal Oncology 2024年第1期16卷 13-29页

作者： efstathios T Pavlidis Ioannis n Galanis Theodoros e Pavlidis ^(nd)Propedeutic Department of Surgery Hippokration General HospitalSchool of MedicineAristotle University of ThessalonikiThessaloniki 54642Greece

Gallbladder(GB)carcinoma,although relatively rare,is the most common biliary tree cholangiocarcinoma with aggressiveness and poor *** is closely associated with cholelithiasis and long-standing large(>3 cm)gallstones in up to 90%of *** other main predisposing factors for GB carcinoma include molecular factors such as mutated genes,GB wall calcification(porcelain)or mainly mucosal microcalcifications,and GB polyps≥1 cm in *** is made by ultrasound,computed tomography(CT),and,more precisely,magnetic resonan.e.imaging(MRI).Preoperative staging is of great importan.e.in decisionmaking regarding therapeutic *** staging is based on MRI findings,the leading technique for liver metastasis imaging,enhan.e. three-phase CT angiography,or magnetic resonan.e.angiography for major vessel *** is also necessary to use positron.e.ission tomography(PeT)-CT or ^(18)F-FDG PeT-MRI to more accurately detect metastases and any other occult deposits with active metabolic *** laparoscopy may detect dissemination not otherwise found in 20%-28.6%of *** treatment is n.e.ed,including surgical resection,targeted therapy by biological agents according to molecular testing gene mapping,chemotherapy,radiation therapy,and *** is of great importan.e.to un.e.stand the updated guidelines and current treatment *** extent of surgical in.e.vention depends on the disease stage,ranging from simple cholecystectomy(T1a)to exten.e. resections and including exten.e. cholecystectomy(T1b),with wide lymph node resection in.e.ery case or IV-V segmen.e.tomy(T2),hepatic trisegmen.e.tomy or major hepatectomy accompan.e. by hepaticojejunostomy Roux-Y,and adjacent organ resection if necessary(T3).Laparoscopic or robotic surgery shows fewer postoperative complications and equivalent oncological outcomes when compared to open surgery,but much attention must be paid to avoiding *** addition to surgery,novel targe

关键词： Biliary tract neoplasms extrahepatic cholangiocarcinoma Gallbladder carcinoma Gallbladder diseases Biliary tree diseases Gastroin.e.tinal malignancies

Management of obstructed colorectal carcinoma in an.e.ergency setting:An update

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World Journal of Gastroin.e.tinal Oncology 2024年第3期16卷 598-613页

作者： efstathios T Pavlidis Ioannis n Galanis Theodoros e Pavlidis 2nd Propedeutic Department of Surgery Hippokration General HospitalSchool of MedicineAristotle University of ThessalonikiThessaloniki 54642Greece

Colorectal carcinoma is common,particularly on the left *** 20%of patients,obstruction and ileus may be the first clinical manifestations of a carcinoma that has advan.e.(stage II,III or even IV).Diagnosis is based on clinical presentation,plain abdominal radiogram,computed tomography(CT),CT colonography and positron.e.ission tomography/*** best management strategy in terms of short-term operative or in.e.ventional and long-term oncological outcomes re-mains *** the most common left-sided obstruction,the first choice should be either emergency surgery or endoscopic decompression by self-expen-dable metal stents or *** operative plan should be either one-stage or two-stage ***-stage resection with on-table bowel decompression and irrigation can be accompan.e. or not accompan.e. by proximal defunctioning stoma(colostomy or ileostomy).Primary anastomosis is more con.e.ient but has increased risks of anastomotic leakage and ***-stage resection(Hart-mann’s procedure)is safer and the most widely used despite temporally affecting quality of *** control surgery in high-risk frail patients is less frequently performed sin.e.it can be successfully substituted with endoscopic stenting or *** the less common right-sided obstruction,one-stage surgical resection is more beneficial than.e.doscopic *** role of minimally invasive surgery(laparoscopic or robotic)is a subject of *** laparoscopic-assisted management is advantageous to some extent but requires much expertise due to in.e.ent difficulties in dissecting the disten.e. colon and the risk of rup-ture and subsequent septic *** decompressing stent as a bridge to elective surgery more substantially decreases the risks of morbidity and mortality than.e.ergency surgery for decompression and has equivalent medium-term overall survival and disease-free survival *** combination with neoadjuvant chemotherapy or radiation may have a p

关键词： Acute abdomen Obstructive ileus Colorectal carcinoma emergency surgery Colectomy Intraluminal metal stents

Current considerations on intraductal papillary neoplasms of the bile duct and pancreatic duct

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World Journal of Gastroen.e.ology 2024年第10期30卷 1461-1465页

作者： efstathios T Pavlidis Ioannis n Galanis Theodoros e Pavlidis 2^(nd) Propedeutic Department of Surgery Hippokration General HospitalSchool of MedicineAristotle University of ThessalonikiThessaloniki 54642Greece

Pancreatobiliary intraductal papillary neoplasms(IPns)represent precursors of pancreatic can.e. or bile duct cholangiocarcinoma that can be detected and *** advan.e. in diagnostic methods,identifying these premalignant lesions is still challenging for treatment *** imaging,biomarkers and molecular tests for genomic alterations can be used for diagnosis and *** in.e.vention in combination with new chemotherapeutic agents is considered the optimal treatment for malignant *** balan.e.between the risk of malignancy and any risk of resection guides management policy;therefore,treatment should be individualized based on a meticulous preoperative assessment of high-risk *** of the bile duct is more aggressive;thus,early diagnosis and surgery are *** con.e.vative management of low-risk pancreatic branch-duct lesions is safe and effective.

关键词： Biliary tree diseases Pancreatic cystic neoplasms Biliary tract neoplasms extrahepatic cholangiocarcinoma Pancreatic adenocarcinoma

Current considerations for the surgical management of gallbladder adenomas

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World Journal of Gastroin.e.tinal Surgery 2024年第6期16卷 1507-1512页

作者： efstathios T Pavlidis Ioannis n Galanis Theodoros e Pavlidis The Second Department of Propaedeutic Surgery Hippokration General HospitalSchool of MedicineAristotle University of ThessalonikiThessaloniki 54642Greece

Gallbladder adenomas are rare lesions(0.5%)associated with potential malignant transformation,particularly with gallbladder adenomas that are≥1 cm in *** detection and management are crucial for preventing lethal carcinoma *** polyps can often be distinguished from the more often non.e.-plastic cholesterol pseudopolyps(5%-10%),which are *** is the first-line tool for initial diagnosis and follow-up when *** question is whether cholecystectomy is always necessary for all *** manage-ment of gallbladder adenomas is determined according to the size of the tumor,the growth rate of the tumor,the patient’s symptoms and whether risk factors for malignancy are ***≥1 cm in size,an age>50 years and a familial history of gallbladder carcinoma are indications for immediate laparoscopic ***,ultrasound follow-up is *** adenomas 6-9 mm in size,the absen.e.of≥2 mm growth at 6 months,one year,and two years,as well as an adenoma sizedexisting risk factors indicates that no further surveillan.e.is ***,it would be preferable to individualize the management in doubtful *** in.e.ventional modalities for preserving the gallbladder n.e. further evaluation.e.pecially to determine the long-term outcomes.

关键词： Biliary diseases True neoplastic polyps Gallbladder adenomas Benign bi-liary tumors Gallbladder polyps extrahepatic biliary neoplasms

Characterization of bright betatron radiation generated by direct laser acceleration of electrons in plasma of near critical density

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Matter and Radiation at extremes 2024年第2期9卷 26-35页

作者： J.Cikhardt M.Gyrdymov S.Zähter P.Tavana M.M.Günther n.Bukharskii n.Borisenko J.Jacoby X.F.Shen A.Pukhov n.e.Andreev O.n.Rosmej Faculty of electrical engin.e.ing Czech Technical University in Prague16627 Prague 6Czech Republic Goethe University FrankfurtMax-von-Laue-Straße 160438 Frankfurt am MainGermany GSI Helmholtzzentrum für Schwerionenforschung GmbH Planckstraße 164291 DarmstadtGermany Focused energy GmbH Im Tiefen See 4564293 DarmstadtGermany national Research nuclear University MePhI Kashirskoe shosse 31115409 MoscowRussian Federation Lebedev Physical Institute RAS Leninskiy Prospekt 53119991 MoscowRussian Federation Heinrich-Heine-University Düsseldorf Universitätsstrasse 1DüsseldorfGermany Joint Institute for High Temperatures RASIzhorskaya st.13Bldg.2125412 MoscowRussian Federation Moscow Institute of Physics and Technology Institutskiy Pereulok 9141700 DolgoprudnyRussia

Directed x-rays produced in the in.e.action of sub-picosecond laser pulses of moderate relativistic in.e.sity with plasma of near-critical density are in.e.tigated. Synchrotron-like (betatron) radiation occurs in the process of direct laser acceleration (DLA) of electrons in a relativisticlaser chan.e. when the electrons un.e.go transverse betatron oscillations in self-generated quasi-static electric and magnetic fields. In anexperiment at the PHeLIX laser system, high-current directed beams of DLA electrons with a mean.e.ergy ten times higher than the pon.e.omotive potential and maximum energy up to 100 MeV were measured at 10^(19) W/cm^(2)laser in.e.sity. The spectrum of directed x-raysin the ran.e.of 5–60 keV was evaluated using two sets of Ross filters placed at 0°and 10°to the laser pulse propagation axis. The differential x-ray absorption method allowed for absolute measurements of the angular-depen.e.t photon fluen.e. We report 10^(13) photons/sr withenergies >5 keV measured at 0°to the laser axis and a brillian.e.of 10^(21) photons s^(−1) mm^(−2) mrad−2(0.1%BW)−1. The angular distributionof the emission has an FWHM of 14°–16°. Thanks to the ultra-high photon fluen.e. point-like radiation source, and ultra-short emissiontime, DLA-based keV backlighters are promising for various applications in high-energy-density research with kilojoule petawatt-class laserfacilities.

关键词： laser acceleration critical