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macroencapsulation Devices for Cell Therapy

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Engineering 2022年第6期8卷 53-70页

作者： Wei Liu Yanfang Wang Jinqiang Wang olivia LLanier marissa EWechsler Nicholas A.Peppas Zhen Gu Key Laboratory of Advanced Drug Delivery Systems of Zhejiang Province College of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058China Department of General Surgery Sir Run Run Shaw HospitalSchool of MedicineZhejiang UniversityHangzhou 310016China Department of Biomedical Engineering The University of Texas at AustinAustinTX 78712USA Department of Biomedical Engineering and Chemical Engineering The University of Texas at San AntonioSan AntonioTX 78249USA Division of molecular Pharmaceutics and Drug Delivery College of PharmacyThe University of Texas at AustinAustinTX 78712USA Zhejiang Laboratory of Systems and Precision medicine Zhejiang University Medical CenterHangzhou 311121China mOE Key Laboratory of macromolecular Synthesis and Functionalization Department of Polymer Science and EngineeringZhejiang UniversityHangzhou 310027China

macroencapsulation has been widely used in cell therapy due to its capability to provide immune-privileged sites for implanted allogeneic or xenogeneic *** also serves to provide mechanical and physiochemical support for maintaining cell expansion and promoting therapeutic *** devices such as membrane-controlled release systems,hydrogels,micronee-dle(mN)array patches,and three-dimensional(3D)stents have shown promising in-lab and preclinical results in the maintenance of long-term cell survival and the strengthening of treatment *** studies focus on expanding the applications of these devices to new cell-based areas such as chimeric antigen receptor(CAR)-T cell delivery,cardiovascular disease therapy,and the exploration of new materials,construction methods,and working principles to augment treatment efficacy and prolong therapy ***,we survey innovative platforms and approaches,as well as translation outcomes,for advancing the performance and applications of macrodevices for cell-based therapies.A discussion and critique regarding future opportunities and challenges is also provided.

关键词： Drug delivery Cell encapsulation Cell therapy Cell transplantation Biomedical devices

Structural and functional roles of ether lipids

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Protein & Cell 2018年第2期9卷 196-206页

作者： John m. dean Irfan J. Lodhi Division of Endocrinology Metabolism and Lipid Research Department of Medicine Washington University School of Medicine Saint Louis MO 63110 USA

Ether lipids, such as plasmalogens, are peroxisome- derived glycerophospholipids in which the hydrocarbon chain at the sn-1 position of the glycerol backbone is attached by an ether bond, as opposed to an ester bond in the more common diacyl phospholipids. This seem- ingly simple biochemical change has profound structural and functional implications. Notably, the tendency of ether lipids to form non-lamellar inverted hexagonal structures in model membranes suggests that they have a role in facilitating membrane fusion processes. Ether lipids are also important for the organization and stability of lipid raft microdomains, cholesterol-rich membrane regions involved in cellular signaling. In addition to their structural roles, a subset of ether lipids are thought to function as endogenous antioxidants, and emerging studies suggest that they are involved in cell differentiation and signaling pathways. Here, we review the biology of ether lipids and their potential signifi- cance in human disorders, including neurological diseases, cancer, and metabolic disorders.

关键词： ether lipids plasmalogen phospholipid peroxisomes cancer metabolic disorders

Oxidative Degradation of Thermoplastic Starch Induced by UV Radiation

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Journal of Renewable materials 2019年第4期7卷 383-391页

作者： mayte m.Quispe olivia V.López marcelo A.Villar Planta Piloto de Ingeniería Química PLAPIQUI(UNS CONICET)Bahía Blanca(8000)Argentina Departamento de Ingeniería Química Universidad Nacional del Sur(UNS)Bahía Blanca(8000)Argentina

Among biopolymers,thermoplastic starch(TPS)is a good candidate to obtain biomaterials because of its natural origin,biodegradable character,and *** to ultraviolet(UV)radiation causes significant degradation of starch-based materials,inducing photooxidative reactions which result in breaking of polymer chains,production of free radical,and reduction of molar *** changes produce a deterioration of TPS mechanical properties,leading to useless materials after an unpredictable *** this work,changes induced on TPS by UV radiation,analyzing structural properties and mechanical behavior,are *** was obtained through thermo-mechanical processing of native corn starch in the presence of water(45%w/w)and glycerol(30%w/w)as *** were obtained by thermocompression and,before testing,specimens were conditioned to reduce material *** process was performed by exposing TPS to 264 h UV radiation in a weathering test ***’s weight loss was determined *** changes were studied by Fourier Transform Infrared Spectroscopy(FTIR)and morphological modifications were analyzed by Scanning Electron microscopy(SEm).Reduction of weight average molar mass was measured by Static Light Scattering(SLS).Changes in mechanical properties were studied from tensile *** 96 h exposure,TPS specimens presented a weight reduction of 4-6%,mainly attributed to plasticizers lost by *** observations showed that UV radiation induced morphological changes on TPS,evidenced by an increment of specimens *** FTIR,it was detected the presence of an additional band located at 1726 cm-1 in samples submitted to UV radiation,attributed to the formation of-C=O *** average molar mass of native starch was in the order of 107 g *** exposure to UV radiation decreased significantly its molar mass,confirming molecular degradation of the *** TPS was exposed during 48 h,it

关键词： Thermoplastic starch UV radiation structural properties mechanical behavior

TRANSCRANIAL NEAR-INFRARED SPECTROSCOPY OF SmOKING BRAINS

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Journal of Innovative Optical Health Sciences 2009年第3期2卷 227-234页

作者： olivia PUCCI SANDER STEPANOV VLADISLAV TORONOV Department of Physics Ryerson University 350 Victoria StreetTorontoONCanada M5B 2K3

We used a mobile wireless near-infrared sensor for the noninvasive recording of cerebral hemoglobin concentration changes during cigarette *** measurement included 5 min of rest,5 min of smoking imitation,and 5 min of actual *** observed significant effects of the tobacco smoking on temporal changes in the human brain at time scales ranging from 200 ms to about 1 *** most reproducible effects were an increase of the heartbeat rate and a decrease in the heartbeat power spectral density during *** but highly individual changes due to smoking were observed in temporal patterns of hemodynamic fluctuations in 5–50 s time *** have also found statistically significant slow increases in both oxy-and deoxy-hemoglobin concentrations during smoking.

关键词： Near-infrared spectroscopy hemoglobin brain smoking

Direct evidence of traps controlling the carriers transport in SnO_(2) nanobelts

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Journal of Semiconductors 2017年第12期38卷 8-12页

作者： olivia m.Berengue Adenilson J.Chiquito LCCTnano Departamento de Fisica e Quimica-Universidade Estadual Paulista(Unesp)Faculdade de Engenharia de GuaratinguetfiCampus GuaratinguetfiSgo PauloBrasil NanO LaB-Departamento de Fisica Universidade Federal de Sao CarlosCEP 13565-905CP 676Sgo CarlosSgo PauloBrasil

This work reports on direct evidence of localized states in undoped Sn02 nanobelts. Effects of disorder and electron localization were observed in Schottky barrier dependence on the temperature and in thermally stimulated currents. A transition from thermal activation to hopping transport mechanisms was also observed. The energy levels found by thermally stimulated current experiments were in close agreement with transport data confirming the role of localization in determining the properties of devices.

关键词： trap transport SnO2

An exploration of the relationship between wastewater viral signals and COVID-19 hospitalizations in Ottawa,Canada

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Infectious Disease modelling 2023年第3期8卷 617-631页

作者： K.Ken Peng Elizabeth m.Renouf Charmaine B.dean X.Joan Hu Robert Delatolla Douglas G.manuel Department of Statistics and Actuarial Science Simon Fraser University8888 University DrBurnabyV5A 1S6BCCanada Department of Statistics and Actuarial Science University of Waterloo200 University Ave WWaterlooN2L 3G1ONCanada Department of Civil Engineering University of Ottawa75 Laurier Ave.EOttawaK1N 6N5ONCanada The Ottawa Hospital Research Institute 1053 Carling AveOttawaK1Y 4E9ONCanada Department of Family medicine University of Ottawa75 Laurier Ave.EOttawaK1N 6N5ONCanada School of Epidemiology and Public Health University of Ottawa75 Laurier Ave.EOttawaK1N 6N5ONCanada

monitoring of viral signal in wastewater is considered a useful tool for monitoring the burden of COVID-19,especially during times of limited availability in *** have shown that COVID-19 hospitalizations are highly correlated with wastewater viral signals and the increases in wastewater viral signals can provide an early warning for increasing hospital *** association is likely nonlinear and *** project employs a distributed lag nonlinear model(DLNm)(Gasparrini et al.,2010)to study the nonlinear exposure-response delayed association of the COVID-19 hospitalizations and SARS-CoV-2 wastewater viral signals using relevant data from Ottawa,*** consider up to a 15-day time lag from the average of SARS-CoV N1 and N2 gene concen-trations to COVID-19 *** expected reduction in hospitalization is adjusted for vaccination efforts.A correlation analysis of the data verifies that COVID-19 hospital-izations are highly correlated with wastewater viral signals with a time-varying *** DLNm based analysis yields a reasonable estimate of COVID-19 hospitalizations and enhances our understanding of the association of COVID-19 hospi-talizations with wastewater viral signals.

关键词： Wastewater surveillance COVID-19 vaccination effectiveness Distributed lag nonlinear model Time varying correlation

Global Alliance against Chronic Respiratory Diseases symposium on air pollution:overview and highlights

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Chinese medical Journal 2020年第13期133卷 1546-1551页

作者： dean E.Schraufnagel Division of Pulmonary Critical CareSleepand AllergyDepartment of Medicine M/C 719University of Illinois at Chicago840 S.Wood St.ChicagoIL 60612USA

A 1-day symposium before the annual meeting of the Global Alliance against Chronic Respiratory Diseases,gathered authorities and researchers from around the world to discuss the impact of air pollution on human and planetary *** quality is a high priority for Global Alliance against Chronic Respiratory Diseases and China,the host *** article presents a summary,commentary,and amplification of the 17 *** pollution is closely linked with global warming and harms most body systems even at levels below international *** about the genetic,cellular,and metabolic effects of exposure to air pollution is important for better understanding of individual responses and even potential therapeutic *** air pollution at its source leads to prompt and important benefits and should be the first priority for political and public action.

关键词： Air pollution Global Alliance against Chronic Respiratory Diseases Symposium World Health Organization

Neutralization of Omicron BA.1,BA.5.1.6,BQ.1.3 and XBB1.1 induced by heterologous vaccination Ad5-nCoV and mRNA-1273

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Signal Transduction and Targeted Therapy 2023年第5期8卷 2085-2087页

作者： Jesús Hernández Freddy Dehesa-Canseco Alma B.Vázquez-López mónica Reséndiz-Sandoval Graciela Caire-Juvera mario Solís-Hernández olivia Valenzuela Bruno Gómez-Gil Verónica mata-Haro Centro de Investigación en Alimentación y Desarrollo A.C.HermosilloSonora83304Mexico Comisión méxico-Estados Unidos para la Prevención de la Fiebre Aftosa y otras Enfermedades Exóticas de los Animales(CPA) SENASICASADERCiudad de México05010Mexico Departamento de Ciencias Químico Biológicas Universidad de SonoraHermosilloSonora83000Mexico

Dear Editor,The emergence of Omicron subvariants has required additional boosters to induce a highly neutralizing antibody response.1 However,the new Omicron subvariants BQ.1 and XBB,evade the humoral response induced by multiple mRNA vaccinations and infections.2,3 CansinoBio(Ad5-nCoV)is a single-dose adenovirus vector-based vaccine with high protection against severe disease4 but lower efficacy and antibody response than mRNA ***,hybrid immunity induced by infection plus vaccine or heterologous vaccines has produced a robust neutralizing antibody response.

关键词： vaccination vaccine immunity

Viability of recalcitrant Araucaria angustifolia seeds in storage and in a soil seed bank

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Journal of Forestry Research 2020年第6期31卷 2413-2422页

作者： Ezequiel Gasparin Jose m.R.Faria Anderson CJose olivia AOTonetti Rodrigo Ade melo Henk W.m.Hilhorst Departamento de Ciencias Florestais Universidade Federal de Santa Maria(UFSM)Avenida Roraima1000CamobiSanta MariaRS 97105-900Brazil Departamento de Ciencias Florestais Universidade Federal de Lavras(UFLA)Caixa Postal 3017LavrasMGBrazi1 Wageningen Seed Lab Laboratory of Plant PhysiologyWageningen UniversityDroevendaalsesteeg 16708 PB WageningenThe Netherlands

Araucaria angustifolia(Bertol.)Kuntze is a representative species of the mixed Ombrophilous Forest in the Atlantic Forest Biome of *** development of a germplasm conservation protocol for long-term seed bank storage is compromised for this species,as it is sensitive to ***,in situ establishment of a soil seed bank in its natural habitat may be *** study evaluates the storability of two provenances of *** seeds and their behavior in an artificial soil seed bank in two forest environments(understory and edge).Results show that both seed provenances may be stored at 5C for approximately 12 months,retaining high *** subsequent decrease in germination was associated with a reduction and an increase in seed water content,as well as with increased electrical *** the understory environment,seed viability was above 85%for the first 60 days,and at the end of the experiment(270 days),seedlings ***,at the forest edge,there was a total loss of seed viability after 120 days associated with a reduction in water content and high *** is concluded,therefore,that short-term storage of *** seeds is possible in a cold room,which is fundamental to supply seed demand outside the production *** cover conservation is important for regeneration and conservation of the species.

关键词： Brazilian pine Desiccation sensitivity Forest cover Soil seed bank Storability