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Advances in Bioscience and Biotechnology 2016年第12期7卷 545-563页

作者： Pedro Melillo de Magalhães Glyn Mara.figueira José Maria de Souza Ana Maria Revorêdo Ventura Maria Deise de Oliveira Ohnishi Darci Rodrigues da Silva Luiz Alberto Gonçalves Lobo Fabrício Bezerra Eleres Rosana Libonati Merlin Willcox Eloisa Cavassani Pimentel University of Campinas Campinas Brazil Evandro Chagas Institute Belém Brazil Federal University of Pará Belém Brazil University of Oxford (Research Initiative for Traditional Antimalarial Methods) Oxford UK Campinas Municipal Centre of Health Campinas Brazil

Introduction: The traditional antimalarial tea Artemisia annua, indicated for centuries in China to treat fevers, is again arousing interest for the treatment of malaria due to improvements attained in the plant composition by a few Institutions throughout the world, including the State University of Campinas (UNICAMP), Brazil, increasing its principal component by more than 100 times as from standard varieties, giving 1% in artemisinin and an expressive biomass yield such as 2 tons of dried leaves/hectare. Clinical trials carried out with this material in African countries have proven its therapeutic potential for a new generation of Artemisia tea in the treatment of falciparum malaria. In addition to artemisinin, recent studies have identified and quantified other compounds present in the crude extract and characterized their contributions to the anti-malarial efficacy, including their action against chloroquine-resistant strains. The majority of the clinical trials carried out with Artemisia tea in African countries have shown that the control of the parasitaemia is efficient in the initial treatment period, but few trials have followed the patients up to the 28th day. This first clinical trial carried out in Brazil with the A. annua infusion, after toxicological trials that defined the safety of this form of medication. Methods: The therapeutic efficacy of the tea was measured in patients with falciparum malaria over 28 days, comparing it with the current first-line treatment namely artemether-lumefantrine (Coartem?). The trial was carried out in controlled groups according to official protocol approved by the National Ethics in Research Committee (CONEP: 77/ 2011) and a rigorous control of the 17 patients with non-serious cases of falciparum malaria, recruited in the following three municipalities of the State of Pará, Brazil: Tucuruí, Goianésia do Pará and Anajás. The tea group received the infusion prepared in the proportion of 1.25 g of

关键词： Malaria Herbal Medicine Artemisia annua Clinical Trial

Urban Regeneration Challenge： The Case of Avenidas Novas District in Lisbon

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Journal of Civil Engineering and Architecture 2011年第4期5卷 353-362页

作者： Francisco Manuel Camarinhas Serdoura Helena Susete figueira Freire de Almeida Francisco Manuel Camarinhas Serdoura and Helena Susete figueira Freire de Almeida

This paper aims at presenting the guidelines for an urban regeneration strategy in Lisbon, having in account the principles of urbanity, density, livability and social and territorial cohesion. The case study will be Avenidas Novas district, in Lisbon, Portugal, as it is a paradigmatic example of a central area which coexists with dynamism and decadence. The development model for Avenidas Novas was inspired on French boulevards and was planned to be the modern face of a medium to high social class population, as it was until 1940s. Today, as a consequence of further developments which corrupted the first principles and concept, its urban fabric is becoming less coherent and adequate to the needs of the population who works and lives there. From an analysis to the various components of the urban fabric, the paper will identify the major problems that are happening on the site, related to accessibility, mobility and functional diversity. Once understanding the impacts of an unsustainable territory management and urban design, the goal is to develop the principles for a creative urban regeneration strategy for Avenidas Novas district. The study will be based on the theoretical issues of the compact city and walkable distances in order to develop quantifying parameters of urban quality and to promote human scale public spaces and territorial cohesion on an urban environment.

关键词：城市再生里斯本瓦斯社会阶层城市结构调制解调器组成部分城市设计

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尿液中Zika病毒检测

中国人兽共患病学报 2015年第3期 294-294页

作者： Ann-Claire Gourinat olivia O'Connor Elodie Calvez 赵琳福建省疾病预防控制中心

我们描述了6名病人血清和尿液中Zika病毒检测的动力学。发病10d后,尿液标本中Zika病毒仍然呈现阳性,比血清标本中保持更久。该发现支持可利用尿液标本诊断Zika病毒感染。

关键词：尿液标本病毒检测 Zika

探究西班牙大学生孤独感与抑郁症状之间的关系:以应对策略为中介

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探究西班牙大学生孤独感与抑郁症状之间的关系:以应对策略为中介

Socio-Demographic Determinant of Yellow Fever Patient: A Retrospective Study (2020), Federal Medical Center, Asaba

第二十二届全国心理学学术会议

作者：梁芃伟石小轩 Brianna M.McManamon Amaiadela Fuente Olga Carde?oso Natalia S.Rodriguez olivia M.Katamanin Rachel S.Eisner Collin B.Beavan Eliza C.Bourke Deesha D.Shah Abigael G.Lucas olivia D.Chang Mingqi Li Edward C.Chang 北京师范大学心理学部 Department of Psychology University of Michigan Department of Developmental and Educational Psychology University of Basque Country (UPV/EHU) Department of Psychology Skidmore College

孤独感,指受到社会孤立或与他人隔绝的感觉。研究发现,孤独感与消极的情感状况有关,尤其是与年轻人的抑郁症状有关。然而孤独和抑郁症状之间的关联机制尚不清楚。针对这一问题,有研究者提出通过应对策略来调节年轻人孤独感和抑郁症状之... 详细信息

孤独感,指受到社会孤立或与他人隔绝的感觉。研究发现,孤独感与消极的情感状况有关,尤其是与年轻人的抑郁症状有关。然而孤独和抑郁症状之间的关联机制尚不清楚。针对这一问题,有研究者提出通过应对策略来调节年轻人孤独感和抑郁症状之间的关系,应对策略是指为应对压力所做出的认知和行为上的努力。因而本研究旨在探究在西班牙大学生群体中应对策略在孤独感与抑郁症状之间的中介作用。本研究中,我们采用应对策略量表(包含积极(engagement)和消极(disengagement)两个维度,每个维度又包括应对问题(problem engagement)和应对情绪(emotion engagement)两个子维度,每个子维度下包括两种应对策略),R-UCLA孤独感量表以及Beck抑郁量表对364名西班牙大学生(275名女性)进行了抽样调查以检验孤独感、不同应对策略和抑郁症状水平。采用多重中介分析,来确定孤独感和抑郁症状之间的关系是否是由积极应对策略(如解决问题)和消极应对策略(如回避问题)起部分中介作用。结果显示1)问题解决和认知重构的间接效应显著,且与孤独感和抑郁症状均呈负相关;2)问题回避,愿望式思考,自我批评的间接效应显著,且与孤独感呈正相关。3)愿望式思考和自我批评与抑郁症状呈正相关,而问题回避与抑郁症状呈负相关。4)社会支持、情绪表达和孤独感呈负相关,情绪抑制和孤独感呈正相关,但三种应对策略均与抑郁症状无显著相关。中介模型表明,孤独感阻碍了以问题为中心的积极应对策略的使用,从而降低了高孤独感的西班牙大学生的问题解决能力,导致他们出现抑郁症状的风险增加。同时这些结果也表明,在西班牙大学生中,孤独感增加了自我批评和愿望式思考这两种应对策略的使用,使得消极应对策略的使用增加,进而增加了出现抑郁症状的风险。综上,本研究探讨了在西班牙大学生群体中,应对策略在孤独感和抑郁症状之间的中介作用。研究结果发现,减少孤独感、改善积极应对策略、避免消极应对策略、提高问题回避技能是西班牙大学生减少抑郁症状的重要措施。

关键词：孤独感抑郁症状应对策略西班牙大学生

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Journal of Biosciences and Medicines 2022年第12期10卷 225-238页

作者： Ngozi Esther Ezunu Joy Ifeyinwa Egeonu Ajiri Henry Osihro Uyi-Oghosa Onyemushani Said Abdulkareem Omole Clementina Oyakhire Onyema Edith Wayemeru Chidera olivia Okey-Ezufo Chikadibia Eze-Otulaka Faith Inegbejie Clever Ajiri Oghale Diana Chinenye Ofomata Grace Nnenna Onubogu Orhomuromo Paul Okpomo Eguolo Unique Okorhi Onobhase Theresa Agbele Anastacia Okwudili Ojimba Adesuwa Queen Aigbokhaode Francis Chinedu Ugoeze Victor Azubike Osiatuma Emmanuel Okechukwu Ezunu Obianuju Nkemjika Jisieike Erhinyaye Omoyibo Efe Department of Nursing Federal Medical Centre Asaba Nigeria CCDRC Federal Medical Centre Asaba Nigeria Department of Internal Medicine Federal Medical Centre Asaba Nigeria Department of Radiology Federal Medical Centre Asaba Nigeria Department of Health Information Management Federal Medical Centre Asaba Nigeria Department of Pediatrics Federal Medical Centre Asaba Nigeria

Background: Yellow fever is transmitted primarily to humans and non-human primates through the bite of an infected female mosquito Aedes Spp. It is prevented mainly by vaccination. Method: This retrospective observational study at the Center for Communicable Disease Control and Research (CCDCR) Federal Medical Center Asaba (F.M.C) was conducted on all patients diagnosed and managed with yellow fever in the year 2020. We studied a total number of 57 patients’ case files seen within the period. A chi-square test was done to test the null and alternative hypotheses. Result: About 48 (84.2%) males and female 9 (15.8%) females were mostly affected and gender was significant with a chi-squared value of 26.6 and p-value of 0.00. Conclusion: To eradicate this virus, vaccination and health promotions should be encouraged by the health care workers supported by the government. This is to ensure that a greater proportion of the affected community can be immunized.

关键词： Yellow Fever Socio-Demograpic Determinants Asaba

新型冠状病毒肺炎流行期抗生素在呼吸道感染中的合理使用

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英国医学杂志中文版 2021年第6期24卷 350-354页

作者： Jerome A Leis Karen B Born Guylene Theriault olivia Ostrow Allan Grill K Brian Johnston 唐晓(译) Division of Infectious Diseases and General Internal Medicine Sunnybrook Health Sciences CentreTorontoOntarioCanada Department of Medicine University of TorontoTorontoOntarioCanada Institute of Health Policy Management&EvaluationDalla Lana School of Public HealthFaculty of MedicineUniversity of TorontoTorontoOntarioCanada Department of Family Medicine McGill UniversityMontrealQuebecCanada Division of Pediatric Emergency Medicine The Hospital for Sick ChildrenTorontoOntarioCanada Department of Pediatrics University of TorontoTorontoOntarioCanada Centre for Quality Improvement and Patient Safety University of TorontoTorontoOntarioCanada Department of Family Medicine Markham Stouffville HospitalMarkhamOntarioCanada Department of Family&Community Medicine University of TorontoTorontoOntarioCanada Quality of Care NL/Choosing Wisely NL Memorial University of NewfoundlandSt.John′sNewfoundlandCanada 首都医科大学附属北京朝阳医院呼吸与危重症医学科

一名68岁的老年女性,既往有慢性高血压、2型糖尿病病史,因"咳痰、发热3天"致电家庭医生。她起初预约了一次虚拟就诊,医生认为她没有严重的不适或气短,考虑她可能存在病毒性支气管炎。

关键词：呼吸道感染流行期家庭医生老年女性肺炎抗生素 2型糖尿病

Association of Serum Antioxidant Enzymes and Nervous Tissue Markers in Hypertensive Patients

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World Journal of Cardiovascular Diseases 2014年第4期4卷 160-168页

作者： Marisol Pena-Sanchez Sergio Gonzalez-Garcia Gretel Riveron-Forment Otman Fernandez-Concepcion olivia Martinez-Bonne Gisselle Lemus-Molina Isabel Fernandez-Almirall Maria de la Caridad Menendez-Sainz Alina Gonzalez-Quevedo Janis TEells Institute of Neurology and Neurosurgery HavanaCuba National Genetic Center HavanaCuba College of Health Sciences University of Wisconsin-MilwaukeeMilwaukeeUSA

Background and Purpose: Hypertension has serious effects on cerebral blood vessels. Oxidative stress seems to be implicated in blood pressure elevation, through increased reactive oxygen species and/or decreased antioxidant capacity. Recently blood markers indicating damage to the central nervous system were reported to be increased in hypertensive patients. However, it is unknown whether antioxidant capacity is related to these changes. This study was designed to explore if the concentration of blood markers for nervous tissue damage was associated to antioxidant capacity in hypertensive patients. Methods: Twenty hypertensive patients and 23 healthy controls were studied. They were paired by age, sex, ethnicity, or risk factors. Serum neuron specific enolase (NSE) and S100 calcium binding protein B (S100B) were measured as nervous tissue damage markers, as well as the activity of antioxidant enzymes (catalase, glutathione peroxidase, glutathione reductase and gamma-glutamyltransferase). Results: Serum neuronal specific enolase (NSE) and S100 calcium binding protein B (S100B) concentrations determined by immunoassay were significantly increased in patients vs. controls. The activities of antioxidant enzymes measured by spectrophotometry showed that plasmatic catalase and erythrocytic glutathione peroxidase were significantly increased in patients, but erythocytic catalase was decreased. Gamma-glutamyltransferase activity was significantly correlated with S100B in hypertensive patients, while erythrocytic catalase activity was decreased in subjects with higher NSE levels. Conclusion: This preliminary investigation suggested that antioxidant status might be modulated through changes in antioxidant enzymatic activity in hypertensive patients. The association of some of these changes with peripheral markers of damage to the central nervous system could indicate that the increased levels of these proteins in hypertension are partly related to oxidative stress.

关键词： Hypertension Gamma-glutamyltransferase Catalase Neuron Specific Enolase S100 Calcium Binding Protein B

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创意天才的蝴蝶思考术

严重意识障碍患者声源定位的评估:唤名与铃声的比较

作者： (美)奥利维娅·福克斯·卡巴恩(olivia Fox Cabane)，朱达·波拉克(Judah Pollack)

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严重意识障碍患者声源定位的评估:唤名与铃声的比较